Seminars in Immunopathology,
Journal Year:
2024,
Volume and Issue:
46(1-2)
Published: July 1, 2024
Abstract
The
gut
microbiota,
housing
trillions
of
microorganisms
within
the
gastrointestinal
tract,
has
emerged
as
a
critical
regulator
host
health
and
homeostasis.
Through
complex
metabolic
interactions,
these
produce
diverse
range
metabolites
that
substantially
impact
various
physiological
processes
host.
This
review
aims
to
delve
into
intricate
relationships
microbiota-derived
their
influence
on
We
will
explore
how
affect
crucial
aspects
physiology,
including
metabolism,
mucosal
integrity,
communication
among
tissues.
Moreover,
we
spotlight
potential
therapeutic
applications
targeting
restore
sustain
equilibrium.
Understanding
interplay
between
microbiota
is
for
developing
innovative
strategies
promote
wellbeing
improve
outcomes
chronic
diseases.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 5, 2023
Given
the
emergence
of
resistant
bacterial
strains
and
novel
microorganisms
that
globally
threaten
human
life,
moving
toward
new
treatment
modalities
for
microbial
infections
has
become
a
priority
more
than
ever.
Antimicrobial
photodynamic
therapy
(aPDT)
been
introduced
as
promising
non-invasive
local
adjuvant
in
several
oral
infectious
diseases.
Its
efficacy
elimination
bacterial,
fungal,
viral
key
pathogens
such
Streptococcus
mutans,
Porphyromonas
gingivalis,
Candida
albicans,
Enterococcus
faecalis
have
investigated
by
many
invitro
clinical
studies.
Researchers
also
methods
increasing
amazing
developments
production
natural,
nano
based,
targeted
photosensitizers.
As
studies
an
important
role
paving
way
towards
evidence-based
applications
infection
this
method,
current
review
aimed
to
provide
overall
view
potential
field
summarize
data
available
randomized
controlled
conducted
on
aPDT
dentistry
investigate
its
future
horizons
dental
practice.
Four
databases
including
PubMed
(Medline),
Web
Science,
Scopus
Embase
were
searched
up
September
2022
retrieve
related
There
are
reporting
effective
adjunctive
modality
capable
reducing
pathogenic
loads
periodontal
peri-implant,
persistent
endodontic
infections.
Clinical
evidence
reveals
therapeutic
prevention
reduction
cariogenic
organisms
with
fungal
or
origins,
however,
number
these
groups
much
less.
Altogether,
various
photosensitizers
used
it
is
still
not
possible
recommend
specific
irradiation
parameters
due
heterogenicity
among
Reaching
protocols
difficult
requires
further
high
quality
trials
focusing
PS
shown
able
reduce
sufficient
follow-up
periods.
Journal of Korean Medical Science,
Journal Year:
2023,
Volume and Issue:
38(15)
Published: Jan. 1, 2023
Long
coronavirus
disease
2019
(COVID-19)
in
recovered
patients
(RPs)
is
gradually
recognized
by
more
people.
However,
how
long
it
will
last
and
the
underlining
mechanism
remains
unclear.We
conducted
a
prospective
follow-up
study
to
evaluate
long-term
symptoms
clinical
indices
of
RPs
at
one-year
after
discharge
from
Union
Hospital,
Wuhan,
China
between
December
2020
May
2021.
We
also
performed
16S
rRNA
sequencing
stool
samples
healthy
controls
(HCs)
analyzed
correlation
gut
microbiota
COVID-19.In
total,
187
were
enrolled,
among
them,
84
(44.9%)
reported
COVID-19
discharge.
The
most
common
cardiopulmonary
symptoms,
including
chest
tightness
activity
(39/187,
20.9%),
palpitations
on
exercise
(27/187,
14.4%),
sputum
(21/187,
11.2%),
cough
(15/187,
8.0%)
pain
(13/187,
7.0%),
followed
systemic
fatigue
(34/187,
18.2%)
myalgia
(20/187,
10.7%),
digestive
constipation
(14/187,
7.5%),
anorexia
diarrhea
(8/187,
4.3%).
Sixty-six
(35.9%)
presented
either
anxiety
or
depression
(42/187
[22.8%]
53/187
[28.8%]
respectively),
proportion
symptomatic
group
was
significantly
higher
than
that
asymptomatic
(41/187
[50.6%]
vs.
25/187
[24.3%]).
Compared
with
group,
scores
all
nine
36-Item
Short
Form
General
Health
Survey
domains
lower
(all
P
<
0.05).
One
hundred
thirty
32
HCs
(non-severe
acute
respiratory
syndrome
2
infected
subjects)
fecal
sample
sequencing.
HCs,
had
obvious
dysbiosis
reduced
bacterial
diversities
relative
abundance
short-chain
fatty
acids
(SCFAs)-producing
salutary
symbionts
such
as
Eubacterium_hallii_group,
Subdoligranulum,
Ruminococcus,
Dorea,
Coprococcus,
Eubacterium_ventriosum_group.
Meanwhile,
Ruminococcus
showed
decreasing
tendencies
group.This
demonstrated
presence
which
correlates
discharge,
indicating
may
play
an
important
role
COVID-19.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(16), P. 3647 - 3647
Published: Aug. 20, 2023
The
first
1000
days
after
birth
represent
a
critical
window
for
gut
microbiome
development,
which
is
essential
immune
system
maturation
and
overall
health.
undergoes
major
changes
during
this
period
due
to
shifts
in
diet
environment.
Disruptions
the
microbiota
early
life
can
have
lasting
health
effects,
including
increased
risks
of
inflammatory
disorders,
autoimmune
diseases,
neurological
obesity.
Maternal
environmental
factors
pregnancy
infancy
shape
infant
microbiota.
In
article,
we
will
review
how
maintaining
healthy
important
long-term
Furthermore,
briefly
include
fungal
colonization
its
effects
on
host
function,
are
discussed
as
part
ecosystem.
Additionally,
describe
potential
approaches
such
hydrogels
enriched
with
prebiotics
probiotics,
transplantation
(GMT)
pregnancy,
age-specific
microbial
ecosystem
therapeutics,
CRISPR
therapies
targeting
hold
advancing
research
development.
Nevertheless,
thorough
evaluation
their
safety,
effectiveness,
impacts
crucial
prior
application
clinical
approach.
article
emphasizes
need
continued
optimize
development
through
targeted
early-life
interventions.
Seminars in Immunopathology,
Journal Year:
2024,
Volume and Issue:
46(1-2)
Published: July 1, 2024
Abstract
The
gut
microbiota,
housing
trillions
of
microorganisms
within
the
gastrointestinal
tract,
has
emerged
as
a
critical
regulator
host
health
and
homeostasis.
Through
complex
metabolic
interactions,
these
produce
diverse
range
metabolites
that
substantially
impact
various
physiological
processes
host.
This
review
aims
to
delve
into
intricate
relationships
microbiota-derived
their
influence
on
We
will
explore
how
affect
crucial
aspects
physiology,
including
metabolism,
mucosal
integrity,
communication
among
tissues.
Moreover,
we
spotlight
potential
therapeutic
applications
targeting
restore
sustain
equilibrium.
Understanding
interplay
between
microbiota
is
for
developing
innovative
strategies
promote
wellbeing
improve
outcomes
chronic
diseases.
