Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Language: Английский
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: May 28, 2024
The novel coronavirus disease 2019 (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has garnered unprecedented global attention. It over 2.47 million deaths through various syndromes such as distress, hypercoagulability, and multiple organ failure. viral invasion proceeds the ACE2 receptor, expressed in cell types, some patients serious damage to tissues, organs, immune cells, microbes that colonize gastrointestinal tract (GIT). Some who survived SARS-CoV-2 infection have developed months of persistent long-COVID-19 symptoms or post-acute sequelae COVID-19 (PASC). Diagnosis these revealed biological effects, none which are mutually exclusive. However, severity also depends on numerous comorbidities obesity, age, diabetes, hypertension care must be taken with respect other morbidities, host immunity. Gut microbiota relation immunopathology is considered evolve progression via mechanisms biochemical metabolism, exacerbation inflammation, intestinal mucosal secretion, cytokine storm, immunity regulation. Therefore, modulation gut microbiome equilibrium food supplements probiotics remains a hot topic current research debate. In this review, we discuss complications physio-pathological effects infection, GIT response, therapeutic pharmacological strategies. We summarize targets probiotics, their limitations, efficacy preclinical clinical drugs effectively inhibit spread SARS-CoV-2.
Language: Английский
Citations
11
Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 645 - 645
Published: March 14, 2024
The gut microbiota is emerging as an important contributor to the homeostasis of human body through its involvement in nutrition and metabolism, protection against pathogens, development modulation immune system. It has therefore become research topic recent decades. Although association between intestinal dysbiosis numerous digestive pathologies been thoroughly researched, pancreatic diseases constitutes a novelty specialized literature. In years, growing evidence pointed critical pancreas regulating microbiota, well impact on physiology, which implies existence bidirectional connection known "gut-pancreas axis". theorized that any change at either these levels triggers response other component, hence leading evolution pancreatitis. However, there are not enough data determine whether underlying cause or result pancreatitis; therefore, more needed this area. purpose narrative review highlight role pathogenesis acute chronic pancreatitis, evolution, prospect employing therapeutic intervention for
Language: Английский
Citations
9
Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13
Published: Jan. 21, 2025
The first 1, 000 days of life, from the fetal stage a woman's pregnancy to 2 years age after baby is born, critical period for microbial colonization body and development immune system. system microbiota exhibit great plasticity at this play crucial role in subsequent future health. Two-way communication interaction between helpful maintain human microecological balance homeostasis. Currently, there growing interest important newborn, it believed that absence or dysbiosis commensal early life can have lasting health consequences. Thus, paper summarizes research advances establishment oral intestinal microbiome emphasizing substantial impact diversity prenatal postnatal periods, maternal microbes, mode delivery, feeding practices, antibiotics, probiotics, environment shape infants their association with
Language: Английский
Citations
1
EMBO Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Abstract Changes in gut microbiota composition have been linked to anxiety behavior rodents. However, the underlying neural circuitry linking and their metabolites remains unknown. Using male C57BL/6J germ-free (GF) mice, not exposed live microbes, increased anxiety-related was observed correlating with a significant increase immediate early c-Fos gene basolateral amygdala (BLA). This phenomenon coincided intrinsic excitability spontaneous synaptic activity of BLA pyramidal neurons associated reduced small conductance calcium-activated potassium (SK) channel currents. Importantly, colonizing GF mice microbes or microbial-derived metabolite indoles reverted SK activities behavioral phenotype. These results are consistent molecular mechanism by which indoles, regulate functional changes neurons. Moreover, this microbe regulation links these ancient evolutionarily conserved defense mechanisms behaviors mammals.
Language: Английский
Citations
1
Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2480 - 2480
Published: Sept. 7, 2023
The gut microbiota (GM) plays a vital role in human health, with increasing evidence linking its imbalance to chronic kidney disease and end-stage disease. Although the exact methods underlying kidney-GM crosstalk are not fully understood, interventions targeting GM were made lay three aspects: diagnostic, predictive, therapeutic interventions. While these show promising results reducing uremic toxins inflammation, challenges remain form of patient-specific variability, potential side effects, safety concerns. Our understanding GMs is still evolving, necessitating further research elucidate causal relationship mechanistic interactions. Personalized focusing on specific signatures could enhance patient outcomes. However, comprehensive clinical trials needed validate approaches’ safety, efficacy, feasibility.
Language: Английский
Citations
20
Food Bioengineering, Journal Year: 2024, Volume and Issue: 3(1), P. 126 - 147
Published: March 1, 2024
Abstract The establishment of a healthy microbiota, particularly during infancy, profoundly influences psychological health and neurological function through the gut‐brain axis. This review delves into intricate connections between probiotics, gut microbiome development, their impact on disorders. Biotics, live microorganisms with proven benefits, have emerged as promising intervention, critical developmental stages. Administering specific probiotic strains ( Lactobacillus species Bifidobacterium ) in infancy has shown promise preventing alleviating disorders, implications for well‐being. bidirectional communication along axis underscores potential probiotics influencing outcomes, ranging from anxiety to neurodevelopmental Additionally, this explores emerging food engineering techniques (microencapsulation, genome editing, fermentation, protein engineering, immobilization, etc.) employed preparing probiotic‐based foods, ensuring viability targeted release gastrointestinal tract.
Language: Английский
Citations
7
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: April 23, 2024
Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially pediatrics, celiac disease (also called gluten enteropathy), is gaining more and ground terms of diagnosis, also interest research. The data from the literature last decades attest chameleonic way its presentation, there may be both classic onset symptoms atypical symptoms. Given impact played by disease, optimal growth development children, current narrative review aims to highlight presentation methods, intended guide clinician towards inclusion pathology differential diagnosis scheme. To these we add summary general therapeutic lines regarding underlying condition existing comorbidities. In order place related information up date, performed a recent articles published international databases. We bring forward theories approaches manifestations. Among note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, disorders biological constants association with multiple autoimmunities. Knowing correlating them key management patients, thus reducing subsequent burden disease.
Language: Английский
Citations
7
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 8, 2024
Despite the early recognition of obesity as an epidemic with global implications, research on its pathogenesis and therapeutic approach is still rise. The literature 21st century records excess weight found in up to 1/3 children. Both determining factors systemic effects are multiple variable. Regarding involvement potentiation cardio-vascular, pulmonary, digestive, metabolic, neuro-psychic or even dermatological diseases, information already broadly outlined. connection between underlying disease associated comorbidities seems be partially attributable oxidative stress. In addition these, light recent COVID-19 pandemic, role played by stress induction, maintenance chronic inflammation among overweight children adolescents becomes a topic interest again. Thus, this review’s purpose update general data obesity, emphasis physiopathological mechanisms that underlie it involve At same time, we briefly present latest principles pathology diagnosis management. Among will mainly emphasize impact endogenous exogenous antioxidants evolutionary course pediatric obesity. order achieve our objectives, refer most studies published specialized literature.
Language: Английский
Citations
7
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: April 23, 2024
Having increased popularity during the Covid-19 pandemic, vitamin D3 is currently impressing thanks to numerous researches aimed at its interactions with body’s homeostasis. At same time, there a peak in terms of recommendations for supplementation it. Some studies focus on link between autoimmune diseases and nutritional deficiencies, especially D3. Since specialized literature children (patients 0-18 years old) far from equal informational diversity adult-centered branch, this review aims bring up date relationship microbial balance activity pediatric systemic lupus erythematosus (pSLE). The desired practical purpose resides better understanding an adequate, individualized management affected persons reduce morbidity. center summary establish impact hypovitaminosis D development evolution erythematosus. We will address aspects related two entities played by pathophysiological cascade lupus, but also risk toxicity effects when deficiency over supplemented (hypervitaminosis D). debate modulation immune function, potentiation inflammatory processes, increase oxidative stress, perfusion cognitive brain areas, seasonal incidence SLE severity. Finally, we current knowledge, post-pandemic, regarding – pSLE relationship.
Language: Английский
Citations
6
Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1938 - 1938
Published: June 19, 2024
Type 2 diabetes is a disease with significant health consequences for the individual. Currently, new mechanisms and therapeutic approaches that may affect this are being sought. One of them association type microbiota. Through enteric nervous system gut–microbiota axis, microbiota affects functioning body. It has been proven to have real impact on influencing glucose lipid metabolism insulin sensitivity. With dysbiosis, there increased bacterial translocation through disrupted intestinal barrier inflammation in In diabetes, microbiota’s composition altered with, example, more abundant class Betaproteobacteria. The these disorders linked involving short-chain fatty acids, branched-chain amino lipopolysaccharide, among others. Interventions focusing gut gaining traction as promising approach management. Studies currently conducted effects supply probiotics prebiotics, well fecal transplantation, course diabetes. Further research will allow us fully develop our knowledge subject possibly best treat prevent
Language: Английский
Citations
6