Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 5, 2024
Background:
Chronic
kidney
disease
(CKD)
is
now
globally
recognized
as
a
critical
public
health
concern.
Vascular
calcification
(VC)
represents
significant
risk
factor
for
cardiovascular
events
in
individuals
with
CKD.
It
the
accessible
and
precise
diagnostic
biomarkers
monitoring
progression
of
CKD
concurrent
VC
are
urgently
needed.
Methods:
The
adenine
diet-induced
rat
model
was
utilized
to
investigate
chronic
injury,
thoracic
aorta,
dysregulation
biochemical
indices.
Enzyme-linked
immune
sandwich
assays
were
employed
analyze
changes
calcification-related
proteins.
16S
rRNA
sequencing
performed
delineate
microbiota
characteristics
gut
blood
CKD-afflicted
rats.
Additionally,
transcriptome
tissue
conducted
explore
relationship
between
CKD-associated
features
alterations
function.
Results:
inhibited
body
weight
gain,
led
pronounced
aorta.
both
these
affected
rats
exhibited
significantly
lower
alpha
diversity
distinctive
beta
than
those
their
healthy
counterparts.
resulted
several
indices
(including
elevated
levels
creatinine,
low-density
lipoprotein-cholesterol,
sodium,
phosphorous,
total
cholesterol,
urea
decreased
albumin,
calcium,
lactate
dehydrogenase,
bilirubin).
Moreover,
it
upregulated
factors
(bone
sialoprotein
[BSP],
Klotho,
fibroblast
growth
[FGF]-23,
sclerostin
[SOST])
lipopolysaccharide
(LPS).
Notably,
increased
Acinetobacter
positively
associated
calcifications
addition
positive
correlation
microbiota.
enrichment
increases
(BSP,
FGF-23,
SOST),
LPS,
phosphorous.
Furthermore,
revealed
that
correlated
majority
genes
negatively
downregulated
involved
mineral
absorption
pathway.
Conclusion:
Our
findings,
first
time,
underscore
dysbiosis
symbiotic
microbiota,
blood,
Particularly,
emerges
potential
its
accompanying
VC.
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(5), P. 257 - 257
Published: April 29, 2024
The
fruit
of
Phyllanthus
emblica
L.
(FEPE)
has
a
long
history
use
in
Asian
folk
medicine.
main
bioactive
compounds
FEPE
are
polyphenols,
known
for
their
potent
antioxidant,
anti-inflammatory,
and
hypolipidemic
activities.
present
study
aimed
to
investigate
the
intervention
effect
(100
200
mg/kg)
on
hyperlipidemia
8
weeks
preliminarily
explored
potential
mechanism
by
microbiome-metabolome
analysis.
results
showed
that
high-dose
(200
effectively
alleviated
dyslipidaemic
symptoms
body
weight
gain
hyperlipidemic
mice
induced
high-fat
diet
(HFD).
Microbiome
analysis
altered
structure
intestinal
microbiota,
which
included
an
increase
specific
probiotics
(such
as
Akkermansia,
Anaerovorax,
Bacteroides)
decrease
harmful
bacteria
(including
A2,
Acetitomaculum,
Candidatus_Arthromitus,
Lachnospiraceae_NK4A136_group,
Lachnospiraceae_NK4B4_group,
Rikenella,
Streptococcus),
well
reduction
level
short-chain
fatty
acids
(SCFAs).
In
addition,
significant
changes
hepatic
metabolome
were
observed,
eight
key
metabolites
associated
with
betaine
metabolism,
lysine
degradation,
methionine
acid
metabolism
pathways
primarily
filtered.
correlated
identified
several
“microbiota-metabolite”
axes
treatment
extract.
conclusion,
is
expected
provide
basis
treating
from
perspective
microbiome-liver
axis.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2263 - 2263
Published: Oct. 4, 2024
Background/Objectives:
The
phyla
Firmicutes
and
Bacteroidetes
are
the
main
constituents
of
gut
microbiota.
An
imbalance
in
microbiota
is
a
sign
dysbiosis,
Firmicutes-to-Bacteroidetes
ratio
has
been
proposed
to
be
marker
it,
especially
context
obesity.
Since
Croatia
country
with
one
highest
obesity
rates
Europe,
pilot
observational
study
was
conducted.
aim
investigate
validity
this
potential
biomarker
methodological
using
sample
processing,
DNA
sequence
analysis
characterization
recruited
participants,
including
various
health
factors.
Methods:
A
involving
Croatian
population
Participants
age,
body
weight,
gender,
history
lifestyle
factors
were
recorded.
Gut
composition
analyzed
16S
rRNA
sequencing.
F/B
calculated
evaluated
Statistical
performed
detect
possible
association
excess
weight
(kg)
impact
certain
Results:
No
between
found.
Excess
significantly
associated
higher
male
appendectomy.
significant
predictors
found,
but
gain
positively
average
ratio.
Conclusions:
Although
could
not
confirm
predictive
value
or
any
other
phyla-related
for
population,
it
demonstrated
interesting
insights
into
obesity-associated
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(11), P. 3033 - 3033
Published: Nov. 12, 2023
Chronic
kidney
disease
(CKD)
is
a
severe
condition
and
significant
public
health
issue
worldwide,
carrying
the
burden
of
an
increased
risk
cardiovascular
events
mortality.
The
traditional
factors
that
promote
onset
progression
CKD
are
cardiometabolic
like
hypertension
diabetes,
but
non-traditional
contributors
escalating.
Moreover,
gut
dysbiosis,
inflammation,
impaired
immune
response
emerging
as
crucial
mechanisms
in
pathology.
microbiome
exert
reciprocal
influence
commonly
referred
to
"the
gut-kidney
axis"
through
induction
metabolic,
immunological,
endocrine
alterations.
Periodontal
diseases
strictly
involved
axis
for
their
impact
on
microbiota
composition
metabolic
immunological
alterations
occurring
reciprocally
affecting
both
conditions.
This
review
aims
provide
overview
dynamic
biological
interconnections
between
oral
status,
gut,
renal
pathophysiology,
spotlighting
oral-gut-kidney
raising
whether
periodontal
can
be
modifiers
CKD.
By
doing
so,
we
try
offer
new
insights
into
therapeutic
strategies
may
enhance
clinical
trajectory
patients,
ultimately
advancing
our
quest
improved
patient
outcomes
well-being.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 5, 2024
Background:
Chronic
kidney
disease
(CKD)
is
now
globally
recognized
as
a
critical
public
health
concern.
Vascular
calcification
(VC)
represents
significant
risk
factor
for
cardiovascular
events
in
individuals
with
CKD.
It
the
accessible
and
precise
diagnostic
biomarkers
monitoring
progression
of
CKD
concurrent
VC
are
urgently
needed.
Methods:
The
adenine
diet-induced
rat
model
was
utilized
to
investigate
chronic
injury,
thoracic
aorta,
dysregulation
biochemical
indices.
Enzyme-linked
immune
sandwich
assays
were
employed
analyze
changes
calcification-related
proteins.
16S
rRNA
sequencing
performed
delineate
microbiota
characteristics
gut
blood
CKD-afflicted
rats.
Additionally,
transcriptome
tissue
conducted
explore
relationship
between
CKD-associated
features
alterations
function.
Results:
inhibited
body
weight
gain,
led
pronounced
aorta.
both
these
affected
rats
exhibited
significantly
lower
alpha
diversity
distinctive
beta
than
those
their
healthy
counterparts.
resulted
several
indices
(including
elevated
levels
creatinine,
low-density
lipoprotein-cholesterol,
sodium,
phosphorous,
total
cholesterol,
urea
decreased
albumin,
calcium,
lactate
dehydrogenase,
bilirubin).
Moreover,
it
upregulated
factors
(bone
sialoprotein
[BSP],
Klotho,
fibroblast
growth
[FGF]-23,
sclerostin
[SOST])
lipopolysaccharide
(LPS).
Notably,
increased
Acinetobacter
positively
associated
calcifications
addition
positive
correlation
microbiota.
enrichment
increases
(BSP,
FGF-23,
SOST),
LPS,
phosphorous.
Furthermore,
revealed
that
correlated
majority
genes
negatively
downregulated
involved
mineral
absorption
pathway.
Conclusion:
Our
findings,
first
time,
underscore
dysbiosis
symbiotic
microbiota,
blood,
Particularly,
emerges
potential
its
accompanying
VC.
