Association between gut microbiota dysbiosis and poor functional outcomes in acute ischemic stroke patients with COVID-19 infection DOI Creative Commons
Jiaying Chen, Xuxuan Gao, Jingru Liang

et al.

mSystems, Journal Year: 2024, Volume and Issue: 9(6)

Published: May 3, 2024

ABSTRACT Acute ischemic stroke (AIS) patients with active COVID-19 infection often have more severe symptoms and worse recovery. can cause gut microbiota dysbiosis, which is also a risk factor for poor outcomes in AIS patients. However, the association between functional among has not been fully clarified yet. In this study, we performed 16S rRNA gene sequencing to characterize microbial community acute infection, post-acute without infection. We found that experienced poorer recovery significant characterized by higher levels of Enterobacteriaceae lower Ruminococcaceae Lachnospiraceae . Furthermore, shorter time window (less than 28 days) was identified as COVID-19, enrichment indicated mediator relationship outcomes. Our findings highlight importance early intervention after especially regulating microbiota, plays role prognosis IMPORTANCE The an important respiratory system cerebrovascular through gut-lung axis gut-brain axis. specific connection bacteria understood our observed decrease bacterial diversity shifts abundance key families critical influence outcomes, acted research provides new perspective on complex interplay AIS, dysbiosis. Moreover, recognizing potential offers novel avenue future exploration therapeutic interventions.

Language: Английский

Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications DOI Open Access
Fen Zhang, Raphaela Iris Lau, Qin Liu

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 20(5), P. 323 - 337

Published: Oct. 21, 2022

Language: Английский

Citations

192
Gut and airway microbiota dysbiosis and their role in COVID-19 and long-COVID DOI Creative Commons
Giuseppe Ancona, Laura Alagna, Claudia Alteri

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 8, 2023

The gut microbiota plays a crucial role in human health and disease. Gut dysbiosis is known to be associated with increased susceptibility respiratory diseases modifications the immune response homeostasis of lungs (the so-called gut-lung axis). Furthermore, recent studies have highlighted possible neurological disturbances, introducing notion "gut-brain axis." During last 2 years, several described presence during coronavirus disease 2019 (COVID-19) its relationship severity, SARS-CoV-2 gastrointestinal replication, inflammation. Moreover, persistence after resolution may linked long-COVID syndrome particularly manifestations. We reviewed evidence on association between COVID-19, investigating epidemiologic confounding factors like age, location, sex, sample size, severity disease, comorbidities, therapy, vaccination status airway microbial selected both COVID-19 long-COVID. we analyzed strictly related microbiota, specifically diet investigation previous use antibiotics/probiotics, methodology used study (α- β-diversity parameters relative abundance tools). Of note, only few focused longitudinal analyses, especially for long-term observation Lastly, there lack knowledge regarding transplantation other therapeutic approaches their impact progression severity. Preliminary data seem suggest that might play symptoms. Indeed, development interpretation these could important implications future preventive strategies.

Language: Английский

Citations

65
Diagnostic, Prognostic, and Therapeutic Roles of Gut Microbiota in COVID-19: A Comprehensive Systematic Review DOI Creative Commons
Yeganeh Farsi, Azin Tahvildari,

Mahta Arbabi

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: March 4, 2022

The Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory 2 (SARS-CoV-2) emerged in late December 2019. Considering the important role of gut microbiota maturation, regulation, and induction immune system subsequent inflammatory processes, it seems that evaluating composition COVID-19 patients compared with healthy individuals may have potential value as a diagnostic and/or prognostic biomarker for disease. Also, therapeutic interventions affecting microbial flora open new horizons treatment accelerating their recovery.

Language: Английский

Citations

62
Traditional Chinese medicine against COVID-19: Role of the gut microbiota DOI Open Access
Zhihua Yang,

Yangxi Liu,

Lin Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 149, P. 112787 - 112787

Published: March 8, 2022

Coronavirus disease 2019 (COVID-19) is an acute respiratory infectious caused by severe syndrome coronavirus 2 (SARS-CoV-2), and it has become a public health concern worldwide. In addition to symptoms, some COVID‑19 patients also show various gastrointestinal symptoms even consider be the first manifestation. A large amount of evidence shown that SARS-CoV-2 infection could disrupt gut microbiota balance, disorders aggravate condition COVID-19 patients. Therefore, maintaining balance expected potential new therapeutic target for treating COVID-19. Traditional Chinese medicine (TCM) significant effects in all stages prevention treatment It can adjust ideal intestinal microecological regulator. This review summarizes advantages clinical efficacy TCM expounds on relationship between microbiota, mechanism induced SARS-CoV-2, cytokine storms role preventing regulating provide research ideas

Language: Английский

Citations

45
Dissecting the role of the human microbiome in COVID-19 via metagenome-assembled genomes DOI Creative Commons
Shanlin Ke, Scott T. Weiss, Yang‐Yu Liu

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 6, 2022

Abstract Coronavirus disease 2019 (COVID-19), primarily a respiratory caused by infection with Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), is often accompanied gastrointestinal symptoms. However, little known about the relation between human microbiome and COVID-19, largely due to fact that most previous studies fail provide high taxonomic resolution identify microbes likely interact SARS-CoV-2 infection. Here we used whole-metagenome shotgun sequencing data together assembly binning strategies reconstruct metagenome-assembled genomes (MAGs) from 514 COVID-19 related nasopharyngeal fecal samples in six independent cohorts. We reconstructed total of 11,584 medium-and high-quality microbial MAGs obtained 5403 non-redundant (nrMAGs) strain-level resolution. found there significant reduction strain richness for many species gut patients. The signatures can accurately distinguish cases healthy controls predict progression COVID-19. Moreover, identified set nrMAGs putative causal role clinical manifestations revealed their functional pathways potentially Finally, demonstrated main findings our study be validated three presented results highlight importance incorporating understanding progression.

Language: Английский

Citations

42
Enterococcus Virulence and Resistant Traits Associated with Its Permanence in the Hospital Environment DOI Creative Commons
Catarina Geraldes, Luís Tavares, Solange Gil

et al.

Antibiotics, Journal Year: 2022, Volume and Issue: 11(7), P. 857 - 857

Published: June 26, 2022

Enterococcus are opportunistic pathogens that have been gaining importance in the clinical setting, especially terms of hospital-acquired infections. This problem has mainly associated with fact these bacteria able to present intrinsic and extrinsic resistance different classes antibiotics, a great deal being attributed vancomycin-resistant enterococci. However, other aspects, such as expression virulence factors including biofilm-forming ability, its capacity trading genetic information, makes this bacterial genus more capable surviving harsh environmental conditions. All characteristics, some reports decreased susceptibility biocides, all described literary review, allow enterococci longer survival ability hospital environment, consequently giving them opportunities disseminate settings be responsible for difficult-to-treat

Language: Английский

Citations

40
Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19 DOI Creative Commons
Marius Trøseid, Jan Cato Holter, Kristian Holm

et al.

Critical Care, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 23, 2023

Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered composition related to respiratory failure. However, data regarding gut mortality are scarce.Rectal swabs for analyses were collected within 48 h after hospital admission (baseline; n = 123) three-month post-admission (n 50) a subset of patients included the Norwegian SARS-CoV2 cohort study. Samples analysed by sequencing 16S rRNA gene. at baseline assessed relation need intensive care unit (ICU) during hospitalization. The primary objective was investigate whether ICU-related associated 60-day mortality.Gut (Shannon index) lower requiring ICU hospitalization than those managed general wards. A dysbiosis index representing balance enriched taxa compared ward including decreased abundance butyrate-producing microbes enrichment partly oral bacterial flora, independent antibiotic use, dexamethasone chronic pulmonary disease, PO2/FiO2 ratio, C-reactive protein, neutrophil counts or creatinine levels (adjusted p < 0.001). correlated systemic inflammation univariate (Hazard ratio 3.70 [2.00-8.6], 0.001), as well separate adjustment covariates. At follow-up, remained elevated 0.007).Although our should be regarded exploratory due low number clinical end points, they suggest that could poor prognosis severe COVID-19. Larger studies involvement long-term outcome warranted. Trial registration NCT04381819 . Retrospectively registered May 11, 2020.

Language: Английский

Citations

33
The relationship between gut microbiota and COVID-19 progression: new insights into immunopathogenesis and treatment DOI Creative Commons
Man Wang, Yuan Zhang, Chunmei Li

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 2, 2023

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has posed a global health crisis. Increasing evidence underlines the key role of competent immune responses in resisting SARS-CoV-2 infection and manifests disastrous consequence host dysregulation. Elucidating mechanisms responsible for deregulated immunity COVID-19 may provide theoretical basis further research on new treatment modalities. Gut microbiota comprises trillions microorganisms colonizing human gastrointestinal tract vital homeostasis gut-lung crosstalk. Particularly, can lead to disruption gut equilibrium, condition called dysbiosis. Due its regulatory effect immunity, recently received considerable attention field immunopathology. Imbalanced fuel progression through production bioactive metabolites, intestinal metabolism, enhancement cytokine storm, exaggeration inflammation, regulation adaptive other aspects. In this review, we an overview alterations patients, their effects individuals’ susceptibility viral progression. Moreover, summarize currently available data critical bidirectional between microbes SARS-CoV-2-induced pathology, highlight immunomodulatory contributing pathogenesis. addition, discuss therapeutic benefits future perspectives microbiota-targeted interventions including faecal transplantation (FMT), bacteriotherapy traditional Chinese medicine (TCM) treatment.

Language: Английский

Citations

30
Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases DOI Creative Commons
María José Mendoza-León, Ashutosh K. Mangalam, Alejandro Regaldiz

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: June 30, 2023

Thyroid disorders are clinically characterized by alterations of L-3,5,3’,5’-tetraiodothyronine (T 4 ), L-3,5,3’-triiodothyronine 3 and/or thyroid-stimulating hormone (TSH) levels in the blood. The most frequent thyroid hypothyroidism, hyperthyroidism, and hypothyroxinemia. These conditions affect cell differentiation, function, metabolism. It has been reported that 40% world’s population suffers from some type disorder several factors increase susceptibility to these diseases. Among them iodine intake, environmental contamination, smoking, certain drugs, genetic factors. Recently, intestinal microbiota, composed more than trillions microbes, emerged as a critical player human health, dysbiosis linked microbiota can host physiology producing metabolites derived dietary fiber, such short-chain fatty acids (SCFAs). SCFAs have local actions intestine central nervous system immune system. Modulation SCFAs-producing bacteria also connected metabolic diseases, obesity diabetes. In this review, we discuss how production due patients could be related disorders. studies reviewed here may significant interest endocrinology researchers medical practitioners.

Language: Английский

Citations

27
The Gut–Organ Axis within the Human Body: Gut Dysbiosis and the Role of Prebiotics DOI Creative Commons

Georgia Saxami,

Evangelia N. Kerezoudi, Christos Eliopoulos

et al.

Life, Journal Year: 2023, Volume and Issue: 13(10), P. 2023 - 2023

Published: Oct. 8, 2023

The human gut microbiota (GM) is a complex microbial ecosystem that colonises the gastrointestinal tract (GIT) and comprised of bacteria, viruses, fungi, protozoa. GM has symbiotic relationship with its host fundamental for body homeostasis. not limited to scope GIT, but there are bidirectional interactions between other organs, highlighting concept "gut-organ axis". Any deviation from normal composition GM, termed "microbial dysbiosis", implicated in pathogenesis various diseases. Only few studies have demonstrated modifications disease phenotypes, it still unknown whether an altered contributes or simply reflects status. Restoration probiotics prebiotics been postulated, evidence effects limited. Prebiotics substrates "selectively utilized by microorganisms, conferring health benefit". This study highlights vital organs demonstrates dysbiosis emergence certain representative Finally, this article focuses on potential as target therapy manipulate presents gaps literature research.

Language: Английский

Citations

27