Journal of Traditional and Complementary Medicine,
Journal Year:
2024,
Volume and Issue:
14(5), P. 501 - 509
Published: Jan. 16, 2024
The
coronavirus
disease
2019
(COVID-19),
caused
by
the
severe
acute
respiratory
syndrome
2
(SARS-CoV-2),
turned
into
a
global
pandemic,
and
there
remains
an
urgent
demand
for
specific/targeted
drugs
disease.
3C-like
protease
(3CLpro)
is
promising
target
developing
anti-coronavirus
drugs.
Schisandra
sphenanthera
fruit
well-known
traditional
Chinese
medicine
(TCM)
with
good
antiviral
activity.
This
study
found
that
ethanolic
extract
displayed
significant
inhibitory
effect
against
SARS-CoV-2
3CLpro.
Forty-four
compounds
were
identified
in
this
using
ultra-performance
liquid
chromatography-quadrupole
time-of-flight
mass
spectrometry
(UPLC-Q-TOF/MS).
Combining
molecular
docking
vitro
experiments,
we
two
epimeric
7,8-secolignans,
rel-(1S,2R)-1-(3,4-dimethoxyphenyl)-2-methyl-3-oxobutyl-3,4-dimethoxybenzoate
(2)
rel-(1S,2S)-1-(3,4-dimethoxyphenyl)-2-methyl-3-oxobutyl-3,4-dimethoxybenzoate
(4),
potently
inhibited
3CLpro
IC50
values
of
4.88
±
0.60
μM
4.75
0.34
μM,
respectively.
Moreover,
vivo
experiments
indicated
4
potent
regulating
inflammatory
response
preventing
lung
injury.
Our
findings
indicate
may
emerge
as
inhibitors
via
inhibition
anti-inflammatory
mechanisms.
Clinical and Experimental Hypertension,
Journal Year:
2023,
Volume and Issue:
45(1)
Published: March 30, 2023
Objectives
Hypertension
is
one
of
the
most
important
risk
factors
for
cardio-cerebral
vascular
diseases,
which
brings
a
heavy
economic
burden
to
society
and
becomes
major
public
health
problem.
At
present,
pathogenesis
hypertension
unclear.
Increasing
evidence
has
proven
that
closely
related
dysbiosis
gut
microbiota.
We
briefly
reviewed
relevant
literature
on
microbiota
summarize
relationship
between
hypertension,
linked
antihypertension
effects
drugs
with
their
modulation
microbiota,
discussed
potential
mechanisms
various
microbes
active
metabolites
alleviate
thus
providing
new
research
ideas
development
drugs.Methods
The
was
collected
systematically
from
scientific
database,
including
Elsevier,
PubMed,
Web
Science,
China
National
Knowledge
Infrastructure
(CNKI),
Baidu
Scholar,
as
well
other
sources,
such
classic
books
herbal
medicine.Results
can
lead
imbalance
barrier
dysfunction,
increased
harmful
bacteria
hydrogen
sulfide
lipopolysaccharide,
decreased
beneficial
short-chain
fatty
acids,
intestinal
tight
junction
proteins
permeability.
Gut
occurrence
hypertension.
main
methods
regulate
include
fecal
transplantation,
supplementation
probiotics,
antibiotics,
diet
exercise,
antihypertensive
drugs,
natural
medicines.Conclusions
Investigating
correlation
may
help
reveal
perspective
great
significance
prevention
treatment
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
160, P. 114344 - 114344
Published: Feb. 2, 2023
All
species
have
a
physiological
need
for
sleep,
and
sleep
is
crucial
the
preservation
restoration
of
many
processes
in
body.
Recent
research
on
effects
gut
microbiota
brain
function
has
produced
essential
data
relationship
between
them.
It
been
discovered
that
dysregulation
gut-brain
axis
related
to
insomnia.
Certain
metabolites
linked
insomnia,
disturbances
can
worsen
Traditional
Chinese
medicine
(TCM)
unique
advantages
treatment
Taking
as
target
determining
scientific
relevance
TCM
prevention
insomnia
may
lead
new
concepts
disorders
improve
therapeutic
effect
sleep.
an
entry
point,
this
paper
reviews
TCM,
mechanism
by
which
regulate
regulates
treatment.
This
review
provides
ideas
through
drug
development.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 6, 2022
Intestinal
macrophages
are
the
main
participants
of
intestinal
immune
homeostasis
and
inflammation.
Under
different
environmental
stimuli,
can
be
polarized
into
classical
activated
pro-inflammatory
phenotype
(M1)
alternative
anti-inflammatory
(M2).
Its
polarization
state
is
“guide”
to
promoting
development
regression
normal
circumstances,
protect
intestine
from
inflammatory
damage.
However,
under
influence
some
genetic
factors,
imbalance
M1/M2
will
lead
in
regulation
inflammation
transform
physiological
response
pathological
injury.
In
UC
patients,
disorder
closely
related
macrophage
polarization.
Therefore,
restoring
balance
may
a
potentially
valuable
therapeutic
strategy
for
UC.
Evidence
has
shown
that
traditional
Chinese
medicine
(TCM)
positive
effects
on
by
This
review
summarizes
clinical
evidence
TCM
UC,
vital
role
pathophysiology
potential
mechanism
regulating
treatment
We
hope
this
provide
new
enlightenment
treatment,
fundamental
research,
research
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 2, 2023
The
coronavirus
disease
2019
(COVID-19)
pandemic
caused
by
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
has
posed
a
global
health
crisis.
Increasing
evidence
underlines
the
key
role
of
competent
immune
responses
in
resisting
SARS-CoV-2
infection
and
manifests
disastrous
consequence
host
dysregulation.
Elucidating
mechanisms
responsible
for
deregulated
immunity
COVID-19
may
provide
theoretical
basis
further
research
on
new
treatment
modalities.
Gut
microbiota
comprises
trillions
microorganisms
colonizing
human
gastrointestinal
tract
vital
homeostasis
gut-lung
crosstalk.
Particularly,
can
lead
to
disruption
gut
equilibrium,
condition
called
dysbiosis.
Due
its
regulatory
effect
immunity,
recently
received
considerable
attention
field
immunopathology.
Imbalanced
fuel
progression
through
production
bioactive
metabolites,
intestinal
metabolism,
enhancement
cytokine
storm,
exaggeration
inflammation,
regulation
adaptive
other
aspects.
In
this
review,
we
an
overview
alterations
patients,
their
effects
individuals’
susceptibility
viral
progression.
Moreover,
summarize
currently
available
data
critical
bidirectional
between
microbes
SARS-CoV-2-induced
pathology,
highlight
immunomodulatory
contributing
pathogenesis.
addition,
discuss
therapeutic
benefits
future
perspectives
microbiota-targeted
interventions
including
faecal
transplantation
(FMT),
bacteriotherapy
traditional
Chinese
medicine
(TCM)
treatment.
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(9), P. 3598 - 3637
Published: June 5, 2023
Coronavirus
disease
2019
(COVID-19),
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
has
spread
worldwide.
Effective
treatments
against
COVID-19
remain
urgently
in
need
although
vaccination
significantly
reduces
the
incidence,
hospitalization,
and
mortality.
At
present,
antiviral
drugs
including
Nirmatrelvir/Ritonavir
(Paxlovid
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: May 7, 2024
Gallbladder
cancer
(GBC)
is
the
most
common
malignant
tumor
of
biliary
system
with
worst
prognosis.
Even
after
radical
surgery,
majority
patients
GBC
have
difficulty
achieving
a
clinical
cure.
The
risk
recurrence
remains
more
than
65%,
and
overall
5-year
survival
rate
less
5%.
gut
microbiota
refers
to
variety
microorganisms
living
in
human
intestine,
including
bacteria,
viruses
fungi,
which
profoundly
affect
host
state
general
health,
disease
even
cancer.
Over
past
few
decades,
substantial
evidence
has
supported
that
plays
critical
role
promoting
progression
GBC.
In
this
review,
we
summarize
functions,
molecular
mechanisms
recent
advances
intestinal
We
focus
on
driving
bacteria
pivotal
pathways,
such
as
virulence
factors,
metabolites
derived
from
chronic
inflammatory
responses
ecological
niche
remodeling.
Additionally,
emphasize
high
level
correlation
between
especially
EBV
Candida
spp.,
general,
review
not
only
provides
solid
theoretical
basis
for
close
relationship
but
also
highlights
potential
research
directions
further
future.
International Journal of Biological Sciences,
Journal Year:
2023,
Volume and Issue:
19(10), P. 2974 - 2998
Published: Jan. 1, 2023
The
gut-brain
axis
has
been
a
subject
of
significant
interest
in
recent
years.Understanding
the
link
between
gut
and
brain
is
crucial
for
treatment
disorders.Here,
intricate
components
unique
relationship
microbiota-derived
metabolites
are
explained
detail.Additionally,
association
integrity
blood-brain
barrier
health
emphasized.Meanwhile,
with
their
applications,
challenges
opportunities
pathways
on
different
disease
focus
discussed.The
prospective
strategy
potential
applies
to
treatments,
such
as
Parkinson's
Alzheimer's
disease,
proposed.This
review
provides
broad
perspective
characteristics
facilitate
understand
connection
pave
way
development
new
medication
delivery
system
metabolites.
Stem Cells and Development,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Hypertension,
commonly
known
as
high
blood
pressure,
is
a
significant
health
issue
that
increases
the
risk
of
cardiovascular
diseases,
stroke,
and
renal
failure.
This
condition
broadly
encompasses
both
primary
secondary
forms.
Despite
extensive
research,
underlying
mechanisms
systemic
arterial
hypertension-particularly
hypertension,
which
has
no
identifiable
cause
affected
by
genetic
lifestyle
agents-remain
complex
not
fully
understood.
Recent
studies
indicate
an
imbalance
in
gut
microbiota,
referred
to
dysbiosis,
may
promote
affecting
pressure
regulation
through
metabolites
such
short-chain
fatty
acids
trimethylamine
N-oxide.
Current
antihypertensive
medications
face
limitations,
including
resistance
adherence
issues,
highlighting
need
for
novel
therapeutic
approaches.
Stem
cell
therapy,
emerging
field
regenerative
medicine,
shows
promise
addressing
these
challenges.
cells,
with
mesenchymal
stem
cells
being
prime
example,
have
regenerative,
anti-inflammatory,
immunomodulatory
properties.
Emerging
research
indicates
can
modulate
reduce
inflammation,
improve
vascular
health,
potentially
aiding
management.
Research
shown
positive
impact
on
microbiota
various
disorders,
suggesting
their
potential
role
treating
hypertension.
review
synthesizes
recent
interactions
between
By
offering
thorough
analysis
current
literature,
it
highlights
key
insights,
uncovers
critical
gaps,
identifies
trends
will
inform
guide
future
investigations
this
rapidly
advancing
field.
