Overview of the Circadian Clock in the Hair Follicle Cycle

Biomolecules, Journal Year: 2023, Volume and Issue: 13(7), P. 1068 - 1068

Published: July 3, 2023

The circadian clock adapts to the light–dark cycle and autonomously generates physiological metabolic rhythmicity. Its activity depends on central suprachiasmatic pacemaker. However, it also has an independent function in peripheral tissues such as liver, adipose tissue, skin, which integrate environmental signals energy homeostasis. Hair follicles (HFs) maintain homeostasis through HF cycle, heavily stem cell self-renewal related reprogramming. Studies have shown that dysregulation HFs perturbs progression. Moreover, there is increasing evidence exerts a significant influence glucose metabolism, feeding/fasting, differentiation, senescence. This suggests crosstalk plays essential role regulating regeneration. An improved understanding of may facilitate discovery new drug targets for hair loss. Therefore, present review provides discussion relationship between regeneration, mainly from perspective summarizes current mechanisms by function.

Language: Английский

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Potential Role of Bmal1 in Lipopolysaccharide-Induced Depression-Like Behavior and its Associated "Inflammatory Storm"

Journal of Neuroimmune Pharmacology, Journal Year: 2024, Volume and Issue: 19(1)

Published: Feb. 2, 2024

Language: Английский

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Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 727 - 747

Published: March 14, 2024

The blood-brain barrier (BBB) is a critical interface separating the central nervous system from peripheral circulation, ensuring brain homeostasis and function. Recent research has unveiled profound connection between BBB circadian rhythms, endogenous oscillations synchronizing biological processes with 24-hour light-dark cycle. This review explores significance of rhythms in context functions, an emphasis on substrate passage through BBB. Our discussion includes efflux transporters molecular timing mechanisms that regulate their activities. A significant focus this potential implications chronotherapy, leveraging our knowledge for improving drug delivery to brain. Understanding temporal changes can lead optimized administration, enhance therapeutic efficacy neurological disorders while reducing side effects. By elucidating interplay transport across BBB, offers insights into innovative interventions.

Language: Английский

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Ultrasound and neuroinflammation: immune modulation via the heat shock response

Theranostics, Journal Year: 2024, Volume and Issue: 14(8), P. 3150 - 3177

Published: Jan. 1, 2024

Current pharmacological therapeutic approaches targeting chronic inflammation exhibit transient efficacy, often with adverse effects, limiting their widespread use -especially in the context of neuroinflammation.Effective interventions require consideration homeostatic function, pathway dysregulation, and pleiotropic effects when evaluating targets.Signalling molecules have multiple functions dependent on immune context, this complexity results therapeutics a single signalling molecule failing clinical translation.Additionally, administration non-physiologic levels neurotrophic or anti-inflammatory factors can alter endogenous signalling, resulting unanticipated effects.Exacerbating these challenges, central nervous system (CNS) is isolated by blood brain barrier (BBB), restricting infiltration many pharmaceutical compounds into tissue.Consequently, there has been marked interest techniques capable modulating response manner; ultrasound remains frontier.While used therapeutically peripheral tissues -accelerating healing wounds, bone fractures, reducing -it only recently that it applied to CNS.The transcranial application low intensity pulsed (LIPUS) successfully mitigated neuroinflammation vivo, models neurodegenerative disease across broad spectrum parameters.To date, underlying biological pathways modulated are poorly understood, diverse array reported implicated.The distributed nature beneficial LIPUS implies involvement an, as yet, undetermined upstream pathway, homologous protective effect febrile range hyperthermia inflammation.As such, we review heat shock (HSR), activated thermal mechanical stress, possible regulator ultrasound.

Language: Английский

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Rhythms in Remodeling: Posttranslational Regulation of Bone by the Circadian Clock

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 705 - 705

Published: March 13, 2025

The circadian clock is a fundamental timekeeping system that regulates rhythmic biological processes in response to environmental light–dark cycles. In mammals, core genes (CLOCK, BMAL1, PER, and CRY) orchestrate these rhythms through transcriptional–translational feedback loops, influencing various physiological functions, including bone remodeling. Bone homeostasis relies on the coordinated activities of osteoblasts, osteoclasts, osteocytes, with increasing evidence highlighting role regulation maintaining skeletal integrity. Disruptions are linked disorders such as osteoporosis. Posttranslational modifications (PTMs), phosphorylation, acetylation, ubiquitination, serve crucial regulators both mechanisms metabolism. However, specific PTMs integrating timing remodeling remains underexplored. This review examines intersection biology, elucidating their impact cell function homeostasis. Understanding interactions may uncover novel therapeutic targets for diseases associated disruptions.

Language: Английский

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Polyphenol extracts from rambutan peel promote longevity via the attenuation of the Toll/Imd pathway

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Rambutan peel polyphenols effectively improve the lifespan and health of Drosophila . It may exert life-extending effect through preservation balanced redox status gut barrier integrity, as well attenuation Toll/Imd pathway.

Language: Английский

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Linkage of circadian rhythm disruptions with Alzheimer’s disease and therapeutic interventions

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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The effects of time-restricted eating on sleep, cognitive decline, and Alzheimer's disease

Experimental Gerontology, Journal Year: 2022, Volume and Issue: 171, P. 112033 - 112033

Published: Nov. 17, 2022

According to the United Nations, by 2050, one in six individuals will be over age 65 globally, and four people would aged older western countries. The unprecedented growth of aging population is associated with increased age-related disorders like Alzheimer's disease (AD) Mild cognitive impairment (MCI). To date, no cure known for AD, thus lifestyle interventions including calorie restriction (CR) time-restricted eating (TRE) are proposed as potential approach delay onset progression disease. Sleep disturbances common MCI AD. Moreover, accumulating data indicates that pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), IL-6, IL-8 IL-10 increase AD versus healthy subjects. Thus, purpose present review describe effects TRE on sleep, cognition decline, neuroinflammatory markers humans. Preliminary evidence suggests may produce neuroprotective reduce related studies investigated sleep patients Thereby, impact decline needs further randomized controlled trials (RCTs).

Language: Английский

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Aryl hydrocarbon receptor impairs circadian regulation in Alzheimer's disease: Potential impact on glymphatic system dysfunction

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(2), P. 3901 - 3920

Published: June 25, 2024

Circadian clocks maintain diurnal rhythms of sleep-wake cycle 24 h that regulate not only the metabolism an organism but also many other periodical processes. There is substantial evidence circadian regulation impaired in Alzheimer's disease. properties known to be disturbed patients, such as integrity blood-brain barrier (BBB) well glymphatic flow controls waste clearance from brain. Interestingly, evolutionarily conserved transcription factor, is, aryl hydrocarbon receptor (AhR), impairs function core clock proteins and thus could disturb rhythmicity BBB. abundant activation AhR signalling inhibits expression major proteins, brain muscle arnt-like 1 (BMAL1), regulator (CLOCK) period (PER1) different experimental models. The robustly increased brains protein level enriched astrocytes It seems since it (i) BBB, which cooperatively interconnected with system brain, (ii) neuroinflammation dysbiosis gut microbiota generate potent activators AhR, are able impair flow. I will examine current indicating functions BBB involved development pathology.

Language: Английский

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Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s Disease

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1672 - 1672

Published: April 8, 2025

Parkinson's disease (PD) is a complex neurodegenerative disorder with debilitating non-motor symptoms, including gastrointestinal dysfunction, cardiovascular abnormalities, mood and anxiety disorders, cognitive decline, sleep disturbances, respiratory pain. Despite their significant impact on quality of life, these symptoms are often inadequately addressed. Propolis natural bee-derived product, rich in bioactive compounds anti-inflammatory, antioxidant, immunomodulatory, neuroprotective properties, which holds potential PD due to its multitarget multipathway actions, addressing various underlying mechanisms symptom diseases. Preclinical clinical studies suggest that propolis may influence key pathological PD's symptoms. Evidence points benefits improving cognition, health, alleviating sleep-related issues. Although research remains scarce, findings from related conditions ability associated This review underscores the underexplored therapeutic PD, drawing existing evidence advocating for further fully assess role patient outcomes.

Language: Английский

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