Is Periodontitis Associated with Age-Related Cognitive Impairment? The Systematic Review, Confounders Assessment and Meta-Analysis of Clinical Studies

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 15320 - 15320

Published: Dec. 5, 2022

It has been suggested that molecular pathological mechanisms responsible for periodontitis can be linked with biochemical alterations in neurodegenerative disorders. Hypothetically, chronic systemic inflammation as a response to plays role the etiology of cognitive impairment. This study aimed determine whether (PDS) is risk factor age-related impairment (ACI) based on evidence clinical studies. A comprehensive, structured systematic review existing data adhering Preferred Reporting Items Systematic Review and Meta Analyses (PRISMA) guidelines was carried out. Five electronic databases, PubMed, Embase, Scopus, Web Science, Cochrane, were searched key terms published peer-reviewed journals until January 2021. The Newcastle-Ottawa scale used assess quality studies bias. primary residual confounders explored evaluated. meta-analysis synthesizing quantitative out using random-effects model. Seventeen identified, including 14 cohort, one cross-sectional, two case-control Study samples ranged from 85 262,349 subjects, follow-up between 2 32 years, age above 45 except findings suggesting PDS-ACI relationship revealed substantial differences design methods. noticeable variation related treatment observed. Quality assessment unveiled moderate subgroups pooled sensitivity analysis results seven eligible demonstrated overall presence PDS associated an increased incidence (OR = 1.36, 95% CI 1.03-1.79), particularly dementia 1.39, 1.02-1.88) Alzheimer's disease 1.03 0.98-1.07)). However, considerable heterogeneity synthesized (I

Language: Английский

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Inferring microbial co-occurrence networks from amplicon data: a systematic evaluation

mSystems, Journal Year: 2023, Volume and Issue: unknown

Published: June 20, 2023

Microbes commonly organize into communities consisting of hundreds species involved in complex interactions with each other. 16S ribosomal RNA (16S rRNA) amplicon profiling provides snapshots that reveal the phylogenies and abundance profiles these microbial communities. These snapshots, when collected from multiple samples, can co-occurrence microbes, providing a glimpse network associations However, inference networks data involves numerous steps, requiring specific tools parameter choices. Moreover, extent to which steps affect final is still unclear. In this study, we perform meticulous analysis step pipeline convert sequencing associations. Through process, map how different choices algorithms parameters identify contribute substantially variance. We further determine generate robust develop consensus based on benchmarks mock synthetic sets. The Microbial Co-occurrence Network Explorer, or MiCoNE (available at https://github.com/segrelab/MiCoNE) follows default help explore outcome combinations inferred networks. envisage could be used for integrating sets generating comparative analyses guide our understanding community assembly biomes. IMPORTANCE Mapping interrelationships between important controlling their structure function. surge high-throughput has led creation thousands containing information about abundances. abundances transformed networks, within microbiomes. processing obtain relies several corresponding parameters. options pose questions robustness uniqueness address workflow provide systematic guidelines appropriate tool selection particular set. also algorithm helps more benchmark

Language: Английский

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Gut-brain axis: gut dysbiosis and psychiatric disorders in Alzheimer’s and Parkinson’s disease

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Nov. 13, 2023

Gut dysbiosis and psychiatric symptoms are common early manifestations of Alzheimer's disease (AD) Parkinson's (PD). These diseases, characterised by progressive neuron loss pathological protein accumulation, impose debilitating effects on patients. Recently, these proteins have been linked with gut disorders. The gut-brain axis links the enteric central nervous systems, acting as a bidirectional communication pathway to influence brain function behavior. relationship triad between dysbiosis, disorders, neurodegeneration has investigated in pairs; however, evidence suggests that they all interrelated deeper understanding is required unravel nuances neurodegenerative diseases. Therefore, this review aims summarise current literature roles disorders protein-related We discussed how changes environment can development progression features overlap AD PD. Moreover, research interplay remains its phase. In review, we highlighted potential therapeutic approaches aimed at mitigating gastrointestinal problems alter rate neurodegeneration. Further assess molecular mechanisms underlying PD pathogenesis crucial for developing more effective treatments achieving earlier diagnoses. exploring non-invasive, preventive measures interventions relatively unexplored but important avenue

Language: Английский

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Connecting the Dots: The Cerebral Lymphatic System as a Bridge Between the Central Nervous System and Peripheral System in Health and Disease

Aging and Disease, Journal Year: 2023, Volume and Issue: 15(1), P. 115 - 115

Published: May 23, 2023

As a recently discovered waste removal system in the brain, cerebral lymphatic is thought to play an important role regulating homeostasis of central nervous system. Currently, more and attention being focused on Further understanding structural functional characteristics essential better understand pathogenesis diseases explore therapeutic approaches. In this review, we summarize components More importantly, it closely associated with peripheral gastrointestinal tract, liver, kidney. However, there still gap study believe that critical mediator interactions between

Language: Английский

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Expanding germ-organ theory: Understanding non-communicable diseases through enterobacterial translocation

Pharmacological Research, Journal Year: 2023, Volume and Issue: 194, P. 106856 - 106856

Published: July 17, 2023

Diverse microbial communities colonize different habitats of the human body, including gut, oral cavity, nasal cavity and tissues. These are known as microbiome, plays a vital role in maintaining health. However, changes composition functions microbiome can result chronic low-grade inflammation, which damage epithelial cells allows pathogens their toxic metabolites to translocate into other organs such liver, heart, kidneys, causing metabolic inflammation. This dysbiosis has been directly linked onset several non-communicable diseases. Recent metabolomics studies have revealed that produce uraemic toxins. serve inter-kingdom signals, entering circulatory system altering host metabolism, thereby aggravating variety Interestingly, Enterobacteriaceae, critical member Proteobacteria, commonly associated with diseases, abundance this family positively correlated toxin production. Hence, review provides comprehensive overview Enterobacterial translocation understanding may lead identification novel biomarkers for each disease well development therapeutic drugs.

Language: Английский

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