Italian Journal of Animal Science, Journal Year: 2025, Volume and Issue: 24(1), P. 521 - 528
Published: Feb. 8, 2025
Language: Английский
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: July 5, 2023
Objective There is some evidence for an association between gut microbiota and nonalcoholic fatty liver disease (NAFLD), alcoholic (ALD), viral hepatitis, but no studies have explored their causal relationship. Methods Instrumental variables of the (N = 13266) microbiota-derived metabolites 7824) were acquired, a Mendelian randomization study was performed to explore influence on NAFLD (1483 European cases 17,781 controls), ALD (2513 332,951 hepatitis risk (1971 340,528 controls). The main method examining causality inverse variance weighting (IVW). Results IVW results confirmed that Anaerotruncus ( p 0.0249), Intestinimonas 0.0237), Lachnoclostridium 0.0245), Lachnospiraceae NC2004 group 0.0083), Olsenella 0.0163), Peptococcus 0.0472) protective factors NAFLD, Ruminococcus 1 0.0120) detrimental NAFLD. higher abundance three genera, Lachnospira 0.0388), Desulfovibrio 0.0252), torques 0.0364), correlated with lower ALD, while Ruminococcaceae UCG 002 level associated 0.0371). Alistipes 0.0069) NK4A214 0.0195) related hepatitis. Besides, alanine 0.0076) phenyllactate 0.0100) found be negatively stachydrine (O 0.0244) positively phenylacetate 0.0353) ursodeoxycholate 0.0144) had effect threonate 0.0370) exerted ALD. estimates 0.0408) cholate 0.0293) showed suggestive harmful effects against 0.0401) displayed its Conclusion In conclusion, our research supported links microbiome
Language: Английский
Citations
24
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 326, P. 117990 - 117990
Published: Feb. 27, 2024
Language: Английский
Citations
14
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 7, 2025
Ensuring companion animal welfare is a top priority for the pet industry and owners alike. The health of pets can be directly effectively improved through diet. Chenpi includes beneficial ingredients with proven anti-inflammatory, antioxidant, immunomodulatory properties. present investigation involved feeding snacks infused powder (CPP) to dogs 42 days examine potential benefits CPP. research evidenced notable increase in serum superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activity dogs, accompanied by decrease malondialdehyde (MDA), interleukin-8 (IL-8), interferon-gamma (IFN-γ) level. Additionally, CPP increased fecal scores significantly reduced odors due inhibition 3-methylindole, hydrogen sulfide (H2S), ammonia nitrogen (NH4 +-N), also raised levels secretory immunoglobulin A (SIgA). Analysis microbial composition via 16S rRNA sequencing showed that Bacteroidota decreased Firmicutes gut flora at phylum Functional prediction study communities group enriched metabolic genetic information processing pathways. In addition, there were significant correlations between indicators several altered microorganisms. These findings suggest potentially enhance overall reducing odorants, enhancing antioxidant immunological capabilities, modulating intestinal flora. This establishes solid scientific foundation regarding application functional foods.
Language: Английский
Citations
1
Rhizosphere, Journal Year: 2025, Volume and Issue: unknown, P. 101027 - 101027
Published: Feb. 1, 2025
Language: Английский
Citations
1
Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(2)
Published: Feb. 1, 2025
Abstract To prepare functional yacon juice, this study investigates the optimal fermentation duration, shelf‐life, chemical composition, and flavor volatiles of juice fermented by Lactiplantibacillus plantarum QS7T capable utilizing fructo‐oligosaccharides (FOS), along with its effects on gut microbiota. The period was determined as 30 h, resulting in essential parameters: 3.46 g L −1 for total acids a viable lactic acid bacteria (LAB) count 2.3 × 10 8 CFU mL . predicted shelf life when stored at 4°C is 28 days. Throughout storage, maintained significant FOS LAB (8.0 7 ). Total short‐chain fatty significantly increased post‐fermentation reaching 177.86 µg content types volatile components after L. increased, thus altering improving juice's appeal. Functional also induced alterations microbiota structure abundance mice, including increasing beneficial microbes such Firmicutes, Actinobacteriota, Faecalibaculum, Dubosiella, Bifidobacterium, Akkermansia These results indicate potential food modulation anti‐inflammatory benefits.
Language: Английский
Citations
1
Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 321 - 321
Published: March 6, 2025
The potential of microbial-derived antioxidants to modulate intestinal inflammation is increasingly recognized, which especially important in inflammatory bowel diseases (IBD). Oxidative stress, a major contributor chronic inflammation, the result an imbalance between production reactive oxygen species (ROS) and body's antioxidant defenses. This systematic review explores role alleviating IBD. Among main findings are certain compounds, such as exopolysaccharides (EPS) short-chain fatty acids (SCFAs), have demonstrated their ability neutralize ROS strengthen integrity barrier, thereby attenuating responses. These offer dual benefit mitigating oxidative stress rebalancing gut microbiota, often disrupted Evidence from preclinical clinical studies provides better understanding mechanisms involved effects these microbial antioxidants. Conventional treatments for IBD primarily focus on immune modulation. In this context, integration could complementary approach by addressing both damage dysbiosis. Further research trials essential establish standardized treatment guidelines clarify long-term efficacy promising therapeutic agents.
Language: Английский
Citations
1
Food & Function, Journal Year: 2022, Volume and Issue: 13(20), P. 10574 - 10586
Published: Jan. 1, 2022
Linarin is a natural flavonoid compound found in Chrysanthemum indicum, Mentha species and other plants with various biological activities. The study aimed to investigate the protective effect of linarin supplementation on dextran sulfate sodium (DSS)-induced colitis C57BL/6J mice its potential mechanisms. results showed that doses at 25 50 mg kg-1 day-1 alleviated DSS-induced histopathological damage, improved mucosal layer intestinal barrier function. Importantly, significantly suppressed levels myeloperoxidase activity pro-inflammatory cytokines (IL-6, TNF-α, IFN-γ IL-1β) colon, enhanced mRNA level anti-inflammatory cytokine (IL-10). Moreover, reversed gut microbiota damaged by DSS, including Alistipes, Rikenella Clostridia UCG-014_norank. also partly increased relative abundance short-chain fatty acids (SCFAs)-producing bacteria, Lactobacillus, Roseburia, Parabacteroides Blautia, elevated contents SCFAs. Collectively, attenuates mice, suggesting may be promising nutritional strategy for reducing inflammatory bowel disease.
Language: Английский
Citations
30
Molecules, Journal Year: 2023, Volume and Issue: 28(17), P. 6182 - 6182
Published: Aug. 22, 2023
Plant-derived extracellular vesicles are functional nanovesicles that have significant applications in both disease prevention and treatment, as well for use drug carriers. Momordica charantia is a widely consumed food has medicinal nutritional properties shown intervention diabetes inflammation caused by oxidative damage. In this study, charantia-derived (MCEVs) were extracted demonstrated to excellent antioxidant activity characterization, lipid composition analysis, protein domain vitro measurement. addition, vivo studies indicated the MCEVs could restore ulcerative colitis regulating oxidation inflammatory factors. Therefore, of may be important protecting colon from inflammation, which provides new insights into application drugs or vectors colitis.
Language: Английский
Citations
21
Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e30594 - e30594
Published: May 1, 2024
Disturbed intestinal microbiota has been implicated in the inflammatory microenvironment of colon, which usually results ulcerative colitis (UC). Given limitations these drugs, it is important to explore alternative means protecting gut health from UC. This study aimed investigate potential polysaccharides as beneficial nutrients regulation microbiota, determines colon.
Language: Английский
Citations
8
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 112027 - 112027
Published: April 11, 2024
Osteoporosis (OP) is a frequent clinical problem for the elderly. Traditional Chinese Medicine (TCM) has achieved beneficial results in treatment of OP. Ziyuglycoside II (ZGS II) major active compound Sanguisorba officinalis L. that shown anti-inflammation and antioxidation properties, but little information concerning its anti-OP potential available. Our research aims to investigate mechanism ZGS ameliorating bone loss by inflammatory responses regulation gut microbiota short chain fatty acids (SCFAs) ovariectomized (OVX) mice. We predicted mode action on OP through network pharmacology molecular docking, an OVX mouse model was employed validate efficacy. Then we analyzed impact microstructure, levels cytokines pain mediators serum, inflammation colon, intestinal barrier, composition SCFAs feces. Network identified 55 intersecting targets related Of these, IGF1 may be core target, which successfully docked with showed excellent binding ability. vivo alleviated mice, attenuated systemic inflammation, enhanced reduced threshold, modulated abundance involving norank_f__Muribaculaceae Dubosiella, increased content acetic acid propanoic SCFAs. data indicated mice relieving regulating
Language: Английский
Citations
7