Review: A Contemporary, Multifaced Insight into Psoriasis Pathogenesis DOI Open Access

Rucsandra Cristina Dascălu,

Andreea Lili Bărbulescu,

Loredana Elena Stoica

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(5), P. 535 - 535

Published: May 16, 2024

Psoriasis is a chronic recurrent inflammatory autoimmune pathology with significant genetic component and several interferences of immunological cells their cytokines. The complex orchestration psoriasis pathogenesis related to the synergic effect immune cells, polygenic alterations, autoantigens, other external factors. major act IL-23/IL-17 axis, strongly influencing pattern established during disease activity, visible as continuous perpetuation pro-inflammatory response keratinocyte activation proliferation, leading development psoriatic lesions. Genome-wide association studies (GWASs) offer better view pathogenic pathways, approximately one-third psoriasis’s impact on associated MHC region, loci located chromosome 6. most eloquent factor psoriasis, PSORS1, was identified in I site. Among factors involved its etiology, dysbiosis, due or stimulus, induces burst consequences; both cutaneous gut microbiome get process. Cutting-edge research comprehensive insights into pathogenesis, fostering novel genetic, epigenetic, factors, have generated spectacular improvement over past decades, securing path toward specific targeted immunotherapeutic approach delayed progression arthritis. This review aimed insight various domains that underline how they influence evolution. mechanism multifaceted involves an interplay cellular humoral immunity, which affects susceptible microbiota background. An in-depth understanding role forms basis for developing individualized therapeutic targets can improve management.

Language: Английский

Unveiling Colitis: A Journey through the Dextran Sodium Sulfate-induced Model DOI Creative Commons
Chunhua Yang, Didier Merlin

Inflammatory Bowel Diseases, Journal Year: 2024, Volume and Issue: 30(5), P. 844 - 853

Published: Jan. 27, 2024

Animal models of inflammatory bowel disease (IBD) are valuable tools for investigating the factors involved in IBD pathogenesis and evaluating new therapeutic options. The dextran sodium sulfate (DSS)-induced model colitis is arguably most widely used animal studying potential treatments ulcerative (UC), which a primary form IBD. This offers several advantages as research tool: it highly reproducible, relatively easy to generate maintain, mimics many critical features human Recently, has also been study role gut microbiota development progression investigate effects other factors, such diet genetics, on severity. However, although DSS-induced popular flexible preclinical research, not an exact replica colitis, some results obtained from this cannot be directly applied humans. review aims comprehensively discuss different that may issues should considered when using translational purposes.

Language: Английский

Citations

51
Fecal microbiota transplantation: current challenges and future landscapes DOI
Abbas Yadegar, Haggai Bar‐Yoseph, Tanya Monaghan

et al.

Clinical Microbiology Reviews, Journal Year: 2024, Volume and Issue: 37(2)

Published: May 8, 2024

SUMMARYGiven the importance of gut microbial homeostasis in maintaining health, there has been considerable interest developing innovative therapeutic strategies for restoring microbiota. One such approach, fecal microbiota transplantation (FMT), is main "whole microbiome replacement" strategy and integrated into clinical practice guidelines treating recurrent

Language: Английский

Citations

49
Rational Design of Orally Administered Cascade Nanozyme for Inflammatory Bowel Disease Therapy DOI Open Access
Yixin Yu,

Xianguang Zhao,

Xudong Xu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(44)

Published: Aug. 23, 2023

Inflammatory bowel disease (IBD) affects millions of individuals worldwide annually. Enteric reactive oxygen species (ROS) play critical roles in the physiology and pathology IBD. Nanozymes hold great promise for treatment IBD because their exceptional ability to regulate redox homeostasis during ROS-related inflammation. However, rapid development orally administered, acid-tolerant, antioxidant nanozymes therapy is challenging. Here, a nine-tier high-throughput screening strategy established address multifaceted demands, including intrinsic stability, radioactivity, solubility, gut microbiome toxicity, biomimetic elements, intermediate frontier molecular orbitals, reaction energy barriers, negative charges, acid tolerance. Ni3 S4 selected as best matching material from 146 323 candidates, which exhibits superoxide dismutase-catalase bienzyme-like activity 3.13- 1.80-fold more active than natural enzymes. As demonstrated mouse model, stable gastrointestinal tract without toxicity specifically targets diseased colon alleviate oxidative stress. RNA 16S rRNA sequencing analyses show that effectively inhibits cellular pathways pro-inflammatory factors restores microbiota. This study not develops highly efficient administered cascade nanozyme offers next-generation paradigm rational design nanomedicine through data-driven approaches.

Language: Английский

Citations

44
Heavy arch: from inflammatory bowel diseases to metabolic disorders DOI Creative Commons
Timon E. Adolph,

Moritz Meyer,

A Jukic

et al.

Gut, Journal Year: 2024, Volume and Issue: 73(8), P. 1376 - 1387

Published: May 22, 2024

Background Metabolic disorders and inflammatory bowel diseases (IBD) have captured the globe during Westernisation of lifestyle related dietary habits over last decades. Both disease entities are characterised by complex heterogeneous clinical spectra linked to distinct symptoms organ systems which, on a first glimpse, do not many commonalities in practice. However, experimental studies indicate common backbone mechanisms metabolic gut inflammation, emerging evidence suggests an intricate interplay between IBD. Objective We depict parallels IBD diseases, easily overlooked routine. Design provide overview recent literature discuss implications morbidity patients with for researchers, clinicians healthcare providers. Conclusion The Western diet microbial perturbation serve as fuel inflammation beyond gut. syndrome increasingly affect IBD, expected negative impact both risk complications. This concept implies that tackling obesity pandemic exerts beneficial effects health.

Language: Английский

Citations

19
Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals DOI Creative Commons
Gloria Fackelmann, Paolo Manghi, Niccolò Carlino

et al.

Nature Microbiology, Journal Year: 2025, Volume and Issue: 10(1), P. 41 - 52

Published: Jan. 6, 2025

Abstract As plant-based diets gain traction, interest in their impacts on the gut microbiome is growing. However, little known about diet-pattern-specific metagenomic profiles across populations. Here we considered 21,561 individuals spanning 5 independent, multinational, human cohorts to map how differences diet pattern (omnivore, vegetarian and vegan) are reflected microbiomes. Microbial distinguished these common patterns well (mean AUC = 0.85). Red meat was a strong driver of omnivore microbiomes, with corresponding signature microbes (for example, Ruminococcus torques , Bilophila wadsworthia Alistipes putredinis ) negatively correlated host cardiometabolic health. Conversely, vegan were favourable markers enriched omnivores consuming more foods. Diet-specific partially overlapped food especially dairy microbes, for Streptococcus thermophilus typical soil vegans. The signatures western can support future nutritional interventions epidemiology.

Language: Английский

Citations

10
Gut microbiota and their metabolites in the immune response of rheumatoid arthritis: Therapeutic potential and future directions DOI
Xiaoyu Cai,

Fujia Ren,

Yao Yao

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114034 - 114034

Published: Jan. 12, 2025

Language: Английский

Citations

2
Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics DOI Creative Commons
Monica Profir, Robert Mihai Enache,

Oana Alexandra Roşu

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 179 - 179

Published: Jan. 13, 2025

In the current era, malnutrition is seen as both undernutrition and overweight obesity; conditions are caused by nutrient deficiency or excess improper use imbalance in intake of macro micronutrients. Recent evidence suggests that alters intestinal microbiota, known dysbiosis. Secretory immunoglobulin A (sIgA) plays an important role maintaining increasing beneficial microbiota populations protecting against pathogenic species. Depletion bacterial throughout life also conditioned malnutrition. This review aims to synthesize establishes interrelationship between diet, malnutrition, changes flora, sIgA levels. Targeted nutritional therapies combined with prebiotic, probiotic, postbiotic administration can restore immune response intestine host’s homeostasis.

Language: Английский

Citations

2
Causal relationship between gut microbiota and ageing: A multi-omics Mendelian randomization study DOI

Guolin Zhang,

Yuqing Lu,

Zhenhong Wang

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 131, P. 105765 - 105765

Published: Jan. 20, 2025

Language: Английский

Citations

2
Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms DOI
Najmeh Oliyaei, S. Zekri, Aida Iraji

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106690 - 106690

Published: Jan. 28, 2025

Language: Английский

Citations

2
Crosstalk between gut microbiotas and fatty acid metabolism in colorectal cancer DOI Creative Commons
Hao Zhang, Yuan Tian, Chunjie Xu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 26, 2025

Abstract Colorectal cancer (CRC) is the third most common malignancy globally and second leading cause of cancer-related mortality. Its development a multifactorial multistage process influenced by dynamic interplay between gut microbiota, environmental factors, fatty acid metabolism. Dysbiosis intestinal microbiota abnormalities in microbiota-associated metabolites have been implicated colorectal carcinogenesis, highlighting pivotal role microbial metabolic interactions. Fatty metabolism serves as critical nexus linking dietary patterns with activity, significantly impacting health. In CRC patients, reduced levels short-chain acids (SCFAs) SCFA-producing bacteria consistently observed. Supplementation probiotics has demonstrated tumor-suppressive effects, while therapeutic strategies aimed at modulating SCFA shown potential enhancing efficacy radiation therapy immunotherapy both preclinical clinical settings. This review explores intricate relationship metabolism, CRC, offering insights into underlying mechanisms their translational applications. Understanding this could pave way for novel diagnostic, therapeutic, preventive management CRC.

Language: Английский

Citations

2