Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
164, P. 114985 - 114985
Published: June 11, 2023
The
gut
microbiota
is
indispensable
for
maintaining
host
health
by
enhancing
the
host's
digestive
capacity,
safeguarding
intestinal
epithelial
barrier,
and
preventing
pathogen
invasion.
Additionally,
exhibits
a
bidirectional
interaction
with
immune
system
promotes
of
to
mature.
Dysbiosis
microbiota,
primarily
caused
factors
such
as
genetic
susceptibility,
age,
BMI,
diet,
drug
abuse,
significant
contributor
inflammatory
diseases.
However,
mechanisms
underlying
diseases
resulting
from
dysbiosis
lack
systematic
categorization.
In
this
study,
we
summarize
normal
physiological
functions
symbiotic
in
healthy
state
demonstrate
that
when
occurs
due
various
external
factors,
are
lost,
leading
pathological
damage
lining,
metabolic
disorders,
barrier
damage.
This,
turn,
triggers
disorders
eventually
causes
systems.
These
discoveries
provide
fresh
perspectives
on
how
diagnose
treat
unrecognized
variables
might
affect
link
between
illnesses
need
further
studies
extensive
basic
clinical
research
will
still
be
required
investigate
relationship
future.
Archives of Microbiology,
Journal Year:
2024,
Volume and Issue:
206(5)
Published: April 25, 2024
Abstract
Bacteriocins
are
highly
diverse,
abundant,
and
heterogeneous
antimicrobial
peptides
that
ribosomally
synthesized
by
bacteria
archaea.
Since
their
discovery
about
a
century
ago,
there
has
been
growing
interest
in
bacteriocin
research
applications.
This
is
mainly
due
to
high
properties,
narrow
or
broad
spectrum
of
activity,
specificity,
low
cytotoxicity,
stability.
Though
initially
used
improve
food
quality
safety,
bacteriocins
now
globally
exploited
for
innovative
applications
human,
animal,
systems
as
sustainable
alternatives
antibiotics.
have
the
potential
beneficially
modulate
microbiota,
providing
viable
microbiome-based
solutions
treatment,
management,
non-invasive
bio-diagnosis
infectious
non-infectious
diseases.
The
use
holds
great
promise
modulation
microbiomes,
packaging,
bio-sanitizers
antibiofilm,
pre/post-harvest
biocontrol,
functional
food,
growth
promotion,
aquaculture.
can
undoubtedly
security,
globally.
review
highlights
current
trends
research,
especially
increasing
outputs
funding,
which
we
believe
may
proportionate
soaring
global
bacteriocins.
cutting-edge
technologies,
such
bioengineering,
further
enhance
exploitation
systems.
Drug Design Development and Therapy,
Journal Year:
2025,
Volume and Issue:
Volume 19, P. 585 - 598
Published: Jan. 1, 2025
The
beneficial
effects
of
probiotics
are
encountered
by
their
low
viability
in
gastrointestinal
conditions
and
insufficient
stability
during
manufacturing,
throughut
the
transit,
storage.
Therefore,
novel
systems
highly
required
to
improve
delivery.
In
this
study,
Lactobacillus
gasseri
(L),
Bifidobacterium
bifidum
(B),
a
combination
L+B
were
encapsulated
chitosan
(CS)-polyacrylic
acid
(PAA)
complex
(CS-PAA).
CS-PAA
analysed
on
basis
morphology,
size,
zeta
potential.
loaded
evaluated
for
particle
zetapotential,
vaiability
both
simulated
gastroic
intestinal
fluids,
at
4°C
storage
temparature.
Moreover,
antibiofilm
activity
probiotics-loaded
againt
Campylobacter
jejuni,
Pseudomonas
aeruginosa
Escherichia
coli.
Probiotic
strains
successfully
incorporated
into
porous
structures
systems,
either
individually
or
combination.
Loaded
L,
B,
showed
higher
size
than
unloaded
particles
excellent
gastric
where
free
probiotic
species
undetected.
Additionally
exhibited
an
anti-biofilm
effect
0.5
mg/mL
concentration
level.
complexes
demonstrate
promising
mechanism
effective
delivery
probiotics.
high
maintain
under
physiological
conditions,
remarkable
activity.
These
characteristics
suggest
that
could
serve
as
alternative
system
probiotics,
enhancing
gut
microbiota
health
offering
robust
protection
against
microbial
pathogens.
Microbiome,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Feb. 10, 2025
At
an
early
age,
chickens
commonly
exhibit
a
rise
in
the
average
daily
gain,
which
declines
as
they
age.
Further
studies
indicated
that
decrease
chicken
growth
performance
at
later
age
is
closely
associated
with
age-related
decline
Lactobacillus
abundance
small
intestines.
Whether
inhibiting
intestine
by
fecal
microbiota
transplantation
(FMT)
could
improve
interesting
question.
16S
rRNA
gene
sequencing
revealed
higher
jejunal
high
body
weight
both
two
different
breeds
(yellow
feather
chickens,
H
vs
L,
85.96%
55.58%;
white
76.21%
31.47%),
significantly
and
positively
breast/leg
muscle
weights
(P
<
0.05).
Moreover,
declined
(30
days,
74.04%;
60
50.80%;
120
34.03%)
gain
rose
(1
to
30
5.78
g;
9.86
90
7.70
3.20
g),
indicating
related
performance.
Transplanting
from
healthy
donor
better
1-day-old
chicks
continuously
improved
(Con
FMT;
288.45
g
314.15
g,
P
0.05;
672.77
758.15
0.01;
1146.08
1404.43
0.0001)
even
after
stopping
4th
week.
Four-week
FMT
inhibited
FMT,
65.07%
85.68%,
38.87%
82.71%,
0.0001
34.23%
60.86%,
0.01).
numbers
of
goblet
Paneth
cells
were
also
found
groups
three
time
points
Besides,
triggered
GH/IGF-1
underlying
signaling
increasing
expressions
GH,
GHR,
IGF-1
liver
IGF-1R
muscles
along
These
findings
compromised
performance,
while
decline,
promoting
integrity
mucosal
barrier
up-regulating
expression
level
genes
axis.
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(1), P. 141 - 141
Published: Jan. 10, 2023
The
prospective
application
of
probiotics
is
an
adjuvant
for
the
advancement
novel
antimicrobial
and
wound-healing
agents.
Currently,
probiotic
bacteria
are
utilized
biosynthesis
nanoparticles
in
development
innovative
therapeutics.
present
study
aimed
at
using
nanoparticle-conjugated
enhanced
antibacterial
activity.
In
investigation,
were
isolated
from
a
dairy
source
(milk
domestic
herbivores).
They
screened
activity
against
infection-causing
Gram-negative
(Pseudomonas
aeruginosa
Escherichia
coli)
Gram-positive
(Bacillus
subtilis
Staphylococcus
aureus)
pathogens.
Further,
strain
with
higher
bactericidal
was
used
to
synthesize
silver,
selenium,
copper
nanoparticles.
found
be
Lactiplantibacillus
plantarum
it
only
has
ability
silver
This
verified
Ultra
violet-Visible
(UV-Vis)
spectroscopy,
where
test
solution
turned
brown
greatest
UV-Vis
absorptions
peaked
425
nm.
Optimization
studies
on
synthesis
AgNPs
(silver
nanoparticles)
presented
results
show
that
stable
obtained
by
concentration
1mM
nitrate
(AgNO3)
temperature
37
°C
pH
8.
FTIR
(Fourier
transform
infrared
spectroscopy)
confirmed
involvement
functional
groups
cell
biomass
involved
reduction
process.
Additionally,
biosynthesized
showed
increased
antioxidant
activities.
nano
had
size
distribution
14
nm
recorded
HR-TEM
(high-resolution
transmission
electron
microscopy)
examination.
EDX
(energy
dispersive
X-ray)
analysis
revealed
57%
nanoparticle
production.
significant
capabilities
96%
wound
closure
(fibroblast
cells)
being
observed
through
vitro
scratch-wound
assay.
cytotoxic
experiments
demonstrated
not
extremely
hazardous
fibroblast
cells.
provides
new
platform
green
bacteria,
showing
potentials
infectious
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 6, 2023
This
systematic
review
and
meta-analysis
study
aimed
to
evaluate
the
effectiveness
of
probiotics
supplementation
on
glycaemic
control
in
patients
with
type
2
diabetes
mellitus
(T2DM)
based
data
from
randomised
clinical
trials
(RCTs).PubMed,
Web
Sciences,
Embase,
Cochrane
Library
were
searched
inception
October
2022,
RCTs
about
T2DM
collected.
The
standardised
mean
difference
(SMD)
95%
confidence
interval
(CI)
was
used
estimate
effects
related
parameters,
e.g.
fasting
blood
glucose
(FBG),
insulin,
haemoglobin
A1c
(HbA1c),
homeostasis
model
assessment
insulin
resistance
(HOMA-IR).Thirty
including
1,827
T2MD
identified.
Compared
placebo
group,
group
had
a
significant
decrease
parameters
control,
FBG
(SMD
=
-
0.331,
CI
0.424
0.238,
Peffect
<
0.001),
0.185,
0.313
0.056,
0.005),
HbA1c
0.421,
0.584
0.258,
HOMA-IR
0.224,
0.342
0.105,
0.001).
Further
subgroup
analyses
showed
that
effect
larger
subgroups
Caucasians,
high
baseline
body
mass
index
(BMI
≥
30.0
kg/m2),
Bifidobacterium
food-type
(Psubgroup
0.050).This
supported
favourable
patients.
It
may
be
promising
adjuvant
therapy
for
T2DM.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
161, P. 114447 - 114447
Published: March 1, 2023
The
symptoms
of
acute
kidney
injury
(AKI)
include
a
sudden
drop-in
glomerular
filtration
rate
(GFR),
rise
in
serum
creatinine
(sCr),
blood
urea
nitrogen
(BUN),
and
electrolytes,
which
leads
to
rapid
loss
function.
Chronic
disease
progresses
when
AKI
persist
for
over
three
months
or
90
days.
Numerous
prevalent
secondary
risk
factors,
including
diabetes,
hypertension,
obesity,
heart
illness,
are
directly
indirectly
linked
the
development
switch
from
CKD.
Recently,
change
intestinal
bacteria
known
as
"gut
dysbiosis"
has
been
distant
organ
dysfunction,
heart,
lungs,
kidneys,
brain.
Indirectly
directly,
gut
dysbiosis
contributes
progression
CKD
AKI.
However,
effects
mechanism
action
unknown
need
further
investigation.
by
initiates
AKI's
should
be
explicitly
concerned.
review
primarily
focuses
on
disease,
dysbiosis,
characterisation
its
pathogenic
products,
various
routes
involved
expediting
transition
Conclusion:
We
identified
briefly
reviewed
impacts
situations
such
hypoxia,
mitochondrial
induced
reactive
oxygen
species
(mtROS),
aryl
hydrocarbon
receptor
(AhR)
activation
microbiota
derived
uremic
toxemic
substances
profoundly
push
conditions.
