Molecular cross-talk between long COVID-19 and Alzheimer’s disease

GeroScience, Journal Year: 2024, Volume and Issue: 46(3), P. 2885 - 2899

Published: Feb. 23, 2024

Abstract The long COVID (coronavirus disease), a multisystemic condition following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, is one of the widespread problems. Some its symptoms affect nervous system and resemble Alzheimer’s disease (AD)—a neurodegenerative caused by accumulation amyloid beta hyperphosphorylation tau proteins. Multiple studies have found dependence between these two conditions. Patients with greater risk SARS-CoV-2 infection due to increased levels angiotensin-converting enzyme 2 (ACE2), itself promotes generation which enhances AD. Also, molecular pathways are alike—misregulations in folate-mediated one-carbon metabolism, deficit Cq10, disease-associated microglia. Medical imaging both diseases shows decrease volume gray matter, global brain size reduction, hypometabolism parahippocampal gyrus, thalamus, cingulate cortex. In some studies, similar approach applied medication can be seen, including use amino adamantanes phenolic compounds rosemary. significance connections their possible application medical practice still needs further study but there possibility that they will help better understand COVID.

Language: Английский

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Review of organ damage from COVID and Long COVID: a disease with a spectrum of pathology

Medical Review, Journal Year: 2024, Volume and Issue: 5(1), P. 66 - 75

Published: July 1, 2024

Long COVID, as currently defined by the World Health Organization (WHO) and other authorities, is a symptomatic condition that has been shown to affect an estimated 10 %-30 % of non-hospitalized patients after one infection. However, COVID-19 can also cause organ damage in individuals without symptoms, who would not fall under current definition COVID. This damage, whether or not, lead various health impacts such heart attacks strokes. Given these observations, it necessary either expand COVID include recognize COVID-19-induced distinct affecting many asymptomatic infections. It important consider known adverse outcomes, including conditions cancers, be until harm thresholds are reached. Many more medical identified testing than those recognized through reported symptoms. therefore similarly while symptoms associated with there have displaying this characterization monitoring

Language: Английский

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The Challenge of Long COVID-19 Management: From Disease Molecular Hallmarks to the Proposal of Exercise as Therapy

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(20), P. 12311 - 12311

Published: Oct. 14, 2022

Long coronavirus disease 19 (COVID-19) is the designation given to a novel syndrome that develops within few months after infection by severe acute respiratory coronavirus-2 (SARS-CoV-2) and presenting with increasing incidence because of numerous cases infection. COVID-19 characterized sequela clinical symptoms concern different organs tissues, from nervous, respiratory, gastrointestinal, renal systems skeletal muscle cardiovascular apparatus. The main common molecular cause for all long facets appears be related immune dysregulations, persistence inflammatory status, epigenetic modifications, alterations neurotrophin release. prevention management are still inappropriate many aspects need further clarification. Exercise known exert deep action on dysfunctions elicited depending training intensity, duration, continuity. Evidence suggests it could improve quality life patients. This review explores features mechanisms underlying in perspective considering exercise as co-medication management.

Language: Английский

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The Role of Glutathione in Prevention of COVID-19 Immunothrombosis: A Review

Frontiers in Bioscience-Landmark, Journal Year: 2023, Volume and Issue: 28(3), P. 59 - 59

Published: March 20, 2023

Immunothrombosis has emerged as a dominant pathological process exacerbating morbidity and mortality in acute- long-COVID-19 infections. The hypercoagulable state is due part to immune system dysregulation, inflammation endothelial cell damage, well reduction defense systems. One mechanism particular glutathione (GSH), ubiquitously found antioxidant. Evidence suggests that GSH increases viral replication, pro-inflammatory cytokine release, thrombosis, decreases macrophage-mediated fibrin removal. collection of adverse effects result depletion states like COVID-19 suggest immunothrombosis cascade. We aim review the current literature on influence pathogenesis, beneficial novel therapeutic for long-COVID-19.

Language: Английский

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Low avidity circulating SARS-CoV-2 reactive CD8+ T cells with proinflammatory TEMRA phenotype are associated with post-acute sequelae of COVID-19

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: June 2, 2023

The role of adaptive SARS-CoV-2 specific immunity in post-acute sequelae COVID-19 (PASC) is not well explored, although a growing population convalescent patients with manifestation PASC observed. We analyzed the SARS-CoV-2-specific immune response, via pseudovirus neutralizing assay and multiparametric flow cytometry 40 non-specific 15 healthy donors. Although frequencies SARS-CoV-2-reactive CD4+ T cells were similar between studied cohorts, stronger reactive CD8+ cell characterized by IFNγ production predominant TEMRA phenotype but low functional TCR avidity was detected compared to controls. Of interest, high comparable groups demonstrating sufficient cellular antiviral response PASC. In line immunity, capacity inferior conclusion, our data suggest that may be driven an inflammatory triggered expanded pro-inflammatory cells. These are known activated or even without stimulation lead tissue damage. Further studies including animal models required for better understanding underlying immunopathogensis. Summary: A persistent responsible observed patients.

Language: Английский

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