Alterations of gut microbiota during the development of a hyperuricemia rat model DOI Creative Commons
Cunlong Lu,

Long Li,

Tuo Shi

et al.

Medicine in Microecology, Journal Year: 2025, Volume and Issue: unknown, P. 100120 - 100120

Published: Feb. 1, 2025

Language: Английский

Alterations of gut microbiota in biopsy-proven diabetic nephropathy and a long history of diabetes without kidney damage DOI Creative Commons
Xiao Lu, Junjun Ma, Rongshan Li

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 27, 2023

The gut microbiota is closely related to parenteral noncommunicable diseases through intestinal immunity and plays an important role in the occurrence of diabetes diabetic nephropathy. aim study was understand gut-kidney axis by analysis composition among patients with biopsy-proven nephropathy (DN), type 2 for more than 10 years without kidney damage (DM), healthy controls (NC). Thirty-five DN patients, 40 DM subjects matched age sex were enrolled between January 2022 December 2022. Baseline information clinical parameters collected. 16S rDNA sequencing performed characterize microbiome identify microbes that differentially abundant controls. relationship relative abundance specific bacterial taxa phenotype pathological indicators evaluated. Substantial differences found richness variation population could be accurately distinguished from age- sex-matched variations g_Clostridium-XVIII (AUC = 0.929), g_Gemmiger 0.842). g_Flavonifractor or g_Eisenbergiella 0.909 0.886, respectively). also phenotypes indicators. explored determine its a long history damage. renal progression may delayed regulating changes microbiota.

Language: Английский

Citations

12
Baseline gut microbiome as a predictive biomarker of response to probiotic adjuvant treatment in gout management DOI Creative Commons
Feiyan Zhao,

Ning Tie,

Lai‐Yu Kwok

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107445 - 107445

Published: Oct. 11, 2024

Gout is characterized by dysregulation of uric acid (UA) metabolism, and the gut microbiota may serve as a regulatory target. This two-month randomized, double-blind, placebo-controlled trial aimed to investigate additional benefits coadministering Probio-X alongside febuxostat. A total 160 patients with gout were randomly assigned either probiotic group (n = 120; [3 × 10

Language: Английский

Citations

4
Progress in modeling avian hyperuricemia and gout (Review) DOI Open Access

Linlin Wang,

Jialin Li,

Bo Wang

et al.

Biomedical Reports, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 14, 2024

Human organ tissue is vulnerable to hyperuricemia (HUA), which negatively impacts quality of life, particularly when it progresses gout. Chicken uric acid formation and metabolism are similar human metabolism; therefore, theoretically, the genesis progression HUA gout may be those poultry models. The present review explored progress poultry-induced study reviewed procedures modelling chicken detection indices current concerns regarding these Notably, In production model, combined method water food induction has a higher success rate stability. Compared with mice induced models, models had less kidney damage, were stable long-lasting.

Language: Английский

Citations

4
The Role of Dietary Polysaccharides in Uric Acid Regulation: Mechanisms and Benefits in Managing Hyperuricemia DOI

Wenchen Yu,

Jia‐Ren Liu, Denis Baranenko

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104902 - 104902

Published: Feb. 1, 2025

Language: Английский

Citations

0
Alterations of gut microbiota during the development of a hyperuricemia rat model DOI Creative Commons
Cunlong Lu,

Long Li,

Tuo Shi

et al.

Medicine in Microecology, Journal Year: 2025, Volume and Issue: unknown, P. 100120 - 100120

Published: Feb. 1, 2025

Language: Английский

Citations

0