Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: Insights from microbiome and metabolomics DOI Creative Commons
Xinyi Cheng, Yang Hu,

Jun Kuang

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(8), P. 103968 - 103968

Published: June 11, 2024

Berberine (BBR), a well-known quaternary ammonium alkaloid, is recognized for its ability to prevent and alleviate metabolic disorders because of anti-oxidative anti-inflammatory properties. However, the underlying mechanisms BBR mitigate fatty liver hemorrhagic syndrome (FLHS) through modulation gut microbiota their metabolism remained unclear. The results revealed that ameliorates lipid disorder in high-energy low-protein (HELP) diet-induced FLHS laying hens, as evidenced by improved function deposition liver, reduced blood lipids, expression synthesis-related factors. Moreover, alleviated HELP barrier dysfunction, increased microbial population, dysregulated ileum. reshaped HELP-perturbed microbiota, particularly declining abundance Desulfovibrio_piger elevating Bacteroides_salanitronis_DSM_18170. Meanwhile, metabolomic profiling analysis function, reducing levels hydrocinnamic acid, dehydroanonaine, leucinic acid. Furthermore, fecal transplantation (FMT) experiments BBR-enriched hepatic intestinal inflammation compared with those chicks received HELP. Collectively, our study provided evidence effectively induced reshaping homeostasis within liver-gut axis.

Language: Английский

Roles of Traditional and Next-Generation Probiotics on Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH): A Systematic Review and Network Meta-Analysis DOI Creative Commons
Yuezhi Zhu, Jen Kit Tan, Jia Liu

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 329 - 329

Published: March 7, 2024

Non-alcoholic fatty liver disease (NAFLD) and its progressive stage, non-alcoholic steatohepatitis (NASH), are becoming one of the most common chronic diseases globally. Lifestyle interventions such as weight reduction, increased physical activity, maintaining healthy diets play a pivotal role in managing NAFLD/NASH. Recent studies suggest that gut microbiome is associated with pathogenesis NAFLD/NASH, prompting microbiome-targeted therapy to emerge new therapeutic option for We conducted systematic review based on PRISMA statement employed network meta-analysis investigate effects traditional probiotics next-generation (NGPs) Comparative analysis reveals primarily reduce fat deposition inflammation by improving microbiota composition, enhancing intestinal barrier function, modulating immune responses. In contrast, NGPs demonstrate more significant potential, attributed their direct inhibiting oxidative stress ability enhance production short-chain acids (SCFAs), appear potential strategy management NAFLD/NASH through dual action directly SCFA production, highlighting importance understanding utilizing indirect regulatory mechanisms

Language: Английский

Citations

9
Probiotics and Non-Alcoholic Fatty Liver Disease: Unveiling the Mechanisms of Lactobacillus plantarum and Bifidobacterium bifidum in Modulating Lipid Metabolism, Inflammation, and Intestinal Barrier Integrity DOI Creative Commons

Jing Lu,

Dilireba Shataer,

Huizhen Yan

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(18), P. 2992 - 2992

Published: Sept. 21, 2024

In recent years, the prevalence of non-alcoholic fatty liver disease (NAFLD) has risen annually, yet due to intricacies its pathogenesis and therapeutic challenges, there remains no definitive medication for this condition. This review explores intricate relationship between intestinal microbiome NAFLD, emphasizing substantial roles played by

Language: Английский

Citations

9
BefA protein alleviates progression of non-alcoholic fatty liver disease by modulating the AMPK signaling pathway through the gut-liver axis DOI
Jie Luo, Yujie Cai, Chao Jia

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 294, P. 139446 - 139446

Published: Jan. 5, 2025

Language: Английский

Citations

1
Effects of Selected Food Additives on the Gut Microbiome and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) DOI Creative Commons
Sara Jarmakiewicz-Czaja, Aneta Sokal, Rafał Filip

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 192 - 192

Published: Jan. 22, 2025

The purpose of this article is to present selected food additives as disruptors normal intestinal homeostasis with a potential impact on the development metabolic dysfunction-associated steatotic liver disease (MASLD). A comprehensive literature search was conducted in three major electronic databases: PubMed, ScienceDirect, and Google Scholar. MASLD prevalent condition that closely related global rise obesity. Its pathogenesis multifactorial, genetic, environmental, factors playing key role. “multiple-hit” hypothesis suggests Western-style diet, rich ultra-processed foods, saturated fats, additives, combined low physical activity, contributes obesity, which promotes lipid accumulation liver. Recent studies underscore role impaired MASLD. Food including preservatives, emulsifiers, sweeteners, affect gut health function. Selected preservatives inhibit pathogenic microorganisms but disrupt microbiota, leading changes permeability dysfunction. Some emulsifiers thickeners can cause inflammation alter microbiome, contributing steatosis. Furthermore, use sweeteners such sucralose aspartame has been linked metabolism microbial composition, turn disorders.

Language: Английский

Citations

1
The association between the dietary index for gut microbiota and non-alcoholic fatty liver disease and liver fibrosis: evidence from NHANES 2017–2020 DOI Creative Commons
Ce Zheng, Zeming Qi, Rui Chen

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 12, 2025

Imbalance in the gut microbiota is a key factor pathogenesis of non-alcoholic fatty liver disease (NAFLD) and fibrosis. The Dietary Index for Gut Microbiota (DI-GM) integrates potential relationship between diet diversity. This study aims to investigate association DI-GM risk NAFLD fibrosis, providing theoretical support dietary intervention strategies. utilized data from NHANES 2017–2020, including 6,181 eligible adult participants. fibrosis was assessed using quartiles, multivariate logistic regression, restricted cubic spline (RCS) analysis. Subgroup analysis performed explore predictive role different populations. All analyses were weighted ensure representativeness results. negatively associated with risks As scores increased, significantly decreased (52.81%, 43.16%, 40.40%, 31.98%, p < 0.05; 17.52%, 9.04%, 7.21%, 6.78%, 0.05). Multivariate regression revealed that, unadjusted model (Model 1), each unit increase DI-GM, by 6.9% (OR = 0.931, 95% CI: 0.886–0.979, 0.001), while 15.6% 0.844, 0.757–0.941, In quartile analysis, individuals highest (Q4) had 58% lower compared those lowest (Q1) 0.42, 0.219–0.806, 0.001). results remained significant even after adjusting covariates. RCS showed that nonlinear inflection points at 2 5, indicating enhanced protective effects. reveals negative highlighting healthy patterns prevention management through modulation, basis interventions.

Language: Английский

Citations

1
Journey of the Probiotic Bacteria: Survival of the Fittest DOI Creative Commons
Allyson Andrade Mendonça, Walter de Paula Pinto Neto,

Giselle Alves da Paixão

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 11(1), P. 95 - 95

Published: Dec. 30, 2022

This review aims to bring a more general view of the technological and biological challenges regarding production use probiotic bacteria in promoting human health. After brief description current concepts, for at an industrial level are presented from physiology central metabolism ability face main forms stress process. Once produced, these cells processed be commercialized suspension or dried added food matrices. At this stage, maintenance cell viability vitality is paramount quality product. Powder products requires development strategies that ensure integrity components cellular functions allow complete recovery time consumption. Finally, once consumed, must very powerful set physicochemical mechanisms within body, which include enzymes, antibacterial molecules sudden changes pH. Understanding action agents induction tolerance fundamental selection increasingly efficient strains order survive colonization intestinal tract promote desired health benefits.

Language: Английский

Citations

38
Polysaccharides: The Potential Prebiotics for Metabolic Associated Fatty Liver Disease (MAFLD) DOI Open Access
Qin Guo, Yun Li, Xin Dai

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3722 - 3722

Published: Aug. 25, 2023

Metabolic (dysfunction) associated fatty liver disease (MAFLD) is recognized as the most prevalent chronic globally. However, its pathogenesis remains incompletely understood. Recent advancements in gut-liver axis offer novel insights into development of MAFLD. Polysaccharides, primarily derived from fungal and algal sources, abundantly exist human diet exert beneficial effects on glycometabolism, lipid metabolism, inflammation, immune modulation, oxidative stress, release Numerous studies have demonstrated that these bioactivities polysaccharides are with their prebiotic properties, including ability to modulate gut microbiome profile, maintain barrier integrity, regulate metabolites produced by microbiota such lipopolysaccharide (LPS), short-chain acids (SCFAs), bile (BAs), contribute intestinal homeostasis. This narrative review aims present a comprehensive summary current understanding protective MAFLD through interactions metabolites. Specifically, we highlight potential molecular mechanisms underlying polysaccharides, which may give new avenues for prevention treatment

Language: Английский

Citations

19
Prebiotics and Probiotics: Therapeutic Tools for Nonalcoholic Fatty Liver Disease DOI Open Access

Alejandra Mijangos-Trejo,

Natalia Nuño‐Lámbarri,

Varenka J. Barbero-Becerra

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14918 - 14918

Published: Oct. 5, 2023

Alterations in the gut–liver axis and changes gut microbiome are among risk factors for pathogenesis of non-alcoholic fatty liver disease (NAFLD). These patients show increased bacterial overgrowth small intestine impaired intestinal permeability. Therefore, therapeutic options such as probiotics or prebiotics have been investigated to modulate microbiota composition improve NAFLD. Most vivo vitro probiotic studies focused on reducing hepatic fat accumulation. The beneficial effects NAFLD demonstrated animal models, most widely used microorganisms those Lactobacillus Bifidobacterium genera. In help restore integrity barrier. This narrative review summarizes published evidence likely benefits a option with

Language: Английский

Citations

18
Gut microbiota and eye diseases: a bibliometric study and visualization analysis DOI Creative Commons
Xiangyu Fu,

Haishan Tan,

Ling Huang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Aug. 9, 2023

Introduction Recently the role of gut microbial dysbiosis in many ocular disorders, including but not limited to uveitis, age-related macular degeneration (AMD), diabetic retinopathy (DR), dry eye, keratitis and orbitopathy is a hot research topic field. Targeting microbiota treat these diseases has become an unstoppable trend. Bibliometric study visualization analysis have essential methods for literature medical We aim depict this area's hotspots future directions by bibliometric software methods. Methods search all related publications from Web Science Core Collection. Then, CiteSpace was applied analyze visualize country distributions, dual-map overlay journals, keyword bursts, co-cited references. VOSviewer employed identify authors, journals display co-occurrence networks. Results A total 284 relevant were identified 2009 2023. The number studies been small first five years grown steadily since 2016. These completed 1,376 authors 41 countries worldwide, with United States lead. Lin P published most papers while Horai R author. top journal are both Investigative Ophthalmology &amp; Visual Science. In network, except microbiota, inflammation becomes highest frequency. Co-citation analyses reveal that involved common immune- inflammation-mediated eye diseases, retinopathy, degeneration, Graves' orbitopathy, microbiomes no longer bacterial populations. Therapeutic strategies target such as probiotics, healthy diet patterns, fecal transplantation, effective critical research. Conclusions conclusion, displays developmental involvement pathogenesis treatment some diseases. It provides overview field's dynamic evolution structural relationships.

Language: Английский

Citations

17
Gut commensal Kineothrix alysoides mitigates liver dysfunction by restoring lipid metabolism and gut microbial balance DOI Creative Commons
Kyoung Jin Choi, Mi Young Yoon, Ji‐Eun Kim

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 6, 2023

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease, is a widespread condition characterized by excessive fat buildup in hepatocytes without significant alcohol consumption. Manipulation of the gut microbiome has been considered to prevent and improve occurrence progression MASLD, particularly through gut-liver axis. This study aimed investigate correlation between function determine whether can ameliorate MASLD. We comparatively analyzed composition mice fed normal chow those high-fat diet observed that abundance Kineothrix alysoides decreased group. Further analysis showed treatment with K. group led weight loss, MASLD attenuation. Importantly, attenuated high-fat, high-fructose (HFHF), which cause advanced damage. Furthermore, administration altered microbial HFHF improved Overall, these findings demonstrate potential restoring health facilitating lipid metabolism treat

Language: Английский

Citations

17