Exploring the Scope of Traditional Chinese Medicinal Plants in battle of antibiotic resistance – A comprehensive review
Pharmacological Research - Modern Chinese Medicine,
Journal Year:
2025,
Volume and Issue:
14, P. 100574 - 100574
Published: Jan. 15, 2025
Language: Английский
Antibiotic resistance and Nanotechnology: A narrative review
Xunxian Zhu,
No information about this author
Qiuhua Tang,
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Xiaohang Zhou
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et al.
Microbial Pathogenesis,
Journal Year:
2024,
Volume and Issue:
193, P. 106741 - 106741
Published: June 11, 2024
Language: Английский
Preliminary Multi-Omics Insights into Green Alternatives to Antibiotics: Effects of Pulsatilla chinensis, Acer truncatum, and Clostridium butyricum on Gut Health and Metabolic Regulation in Chickens
Lin Sun,
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Zhijun Wang,
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Shidi Qin
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et al.
Animals,
Journal Year:
2025,
Volume and Issue:
15(9), P. 1262 - 1262
Published: April 29, 2025
Antibiotic
resistance
has
become
a
global
health
concern,
driving
the
need
for
sustainable
alternatives
in
animal
husbandry.
This
study
explores
potential
of
natural
feed
additives
as
viable
solution
to
enhance
poultry
growth
and
while
reducing
reliance
on
antibiotics.
Chinese
herbal
medicines
probiotics
have
been
widely
studied
green,
healthy,
safe
antibiotic
livestock
production.
A
total
120
chickens
were
randomly
divided
into
four
groups:
control
group
three
treatment
groups
supplemented
with
1%
Pulsatilla
chinensis
powder,
3%
fresh
Acer
truncatum,
or
Clostridium
butyricum.
The
results
showed
that
powder
significantly
increased
gamma-glutamylcysteine
(p
<
0.05),
UDP-N-acetylglucosamine
tyramine
0.01),
leucine
0.05).
truncatum
notably
altered
cecal
metabolites,
including
L-tyrosine
α-ketoisovaleric
acid
myristoleic
glutathione
PGA1
butyricum
modified
metabolites
such
L-glutamine
riboflavin
L-Carnitine
ergocalciferol
α-tocotrienol
Language: Английский
In vitro anti-Helicobacter pylori activity and the underlining mechanism of an empirical herbal formula – Hezi Qingyou
Zhong Feng,
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Hui Li,
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Yajie Hao
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et al.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 19, 2024
Background
Helicobacter
pylori
(
H.
)
is
thought
to
primarily
colonize
the
human
stomach
and
lead
various
gastrointestinal
disorders,
such
as
gastritis
gastric
cancer.
Currently,
main
eradication
treatment
triple
or
quadruple
therapy
centered
on
antibiotics.
Due
antibiotic
resistance,
rate
of
decreasing
gradually.
Therefore,
searching
for
anti-
drugs
from
herbal
sources
has
become
a
strategy
treatment.
Our
team
proposed
Hezi
Qingyou
Formula
(HZQYF),
composed
Chebulae
Fructus,
Ficus
hirta
Vahl
Cloves,
studied
its
activity
mechanism.
Methods
Chemical
components
HZQYF
were
using
UHPLC–MS/MS
HPLC.
Broth
microdilution
method
agar
dilution
used
evaluate
HZQYF’s
antibacterial
activity.
The
effects
expression
adhesion
genes
alpA
,
alpB
babA
),
urease
ureE
ureF
flagellar
flaA,
flaB
explored
Reverse
Transcription-quantitative
Polymerase
Chain
Reaction
(RT-qPCR)
technology.
Effects
morphology
permeability
extracellular
membrane
scanning
electron
microscopy
(SEM)
N-phenylnaphthalen-1-amine
(NPN)
uptake.
Effect
was
kinetics
analysis
in
vitro
.
Immunofluorescence
staining
examine
effect
adhesion.
Western
blot
cagA
protein.
Results
Minimum
inhibitory
concentration
(MIC)
values
formula
against
clinical
strains
standard
80–160
μg/mL,
minimum
bactericidal
(MBC)
160–320
μg/mL.
could
down-regulate
alp
A,
flaA
change
increase
permeability,
decrease
Conclusion
Present
studies
confirmed
that
had
promising
activities
demonstrated
possible
mechanism
action
by
down-regulating
bacterial
adhesion,
urease,
gene
expression,
which
provided
scientific
bases
further
investigations.
Language: Английский
Comparison of Chinese medicine additives for antibiotic resistance risks in the Wuding chickens under high stocking density: Advantages and drawbacks
Honggang Hu,
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Ying Huang,
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Changyou Shi
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et al.
Journal of Cleaner Production,
Journal Year:
2024,
Volume and Issue:
469, P. 143152 - 143152
Published: July 14, 2024
Language: Английский
Rapid Self-Disinfection Nanofiber Film Based on AgPd Hollow Nanospheres
Shuai Pi,
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Minghui Zhan,
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Bianhua Liu
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et al.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 7408 - 7420
Published: March 21, 2024
Bacterial
infection
caused
by
pathogenic
bacteria
can
occur
in
the
human
respiratory
tract,
skin,
blood,
and
other
parts,
seriously
threatening
life
health.
There
is
an
urgent
need
to
develop
a
durable,
internal,
fast,
effective
sterilization
protective
mask
limit
proliferation
rapid
spread
of
microorganisms,
thereby
ensuring
health
issues.
Therefore,
we
have
ingeniously
designed
spherical
hollow
silver–palladium
nanoalloy-based
polyacrylonitrile
nanofiber
film
(AgPd-PAN
film)
displacement
reaction
electrospinning
technology,
which
exhibited
outstanding
quad-mode
synergistic
antibacterial
effect.
Pd-modified
Ag
nanospheres,
especially
AgPd0.4,
possessed
strong
inherent
ability
generate
reactive
oxygen
species
(ROS).
Surprisingly,
synthesized
AgPd0.4
nanospheres
showed
excellent
photothermal
conversion
performance
(28.16%),
oxidase-like
was
significantly
enhanced
under
visible
light
irradiation,
resulting
20%
increase
production
1O2.
The
prepared
AgPd-PAN
also
performance,
instantly
rising
58.5
°C
1
min.
Meanwhile,
had
prominent
self-disinfection
could
completely
kill
within
3
h.
Notably,
once
exposed
sunlight,
time
drastically
shortened
4
ROS,
sharp
rise
solar
irradiation
temperature,
release
Ag+
contributed
film.
In
addition,
almost
negligible
biological
toxicity
were
suitable
for
further
application
equipment.
strategy
great
prospects
timely
mask.
Language: Английский
Revealing the antimicrobial potential of traditional Chinese medicine through text mining and molecular computation
Meng‐Chi Chung,
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Li Su,
No information about this author
Chien-Lin Chen
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et al.
Briefings in Bioinformatics,
Journal Year:
2024,
Volume and Issue:
26(1)
Published: Nov. 22, 2024
Abstract
Traditional
Chinese
Medicine
(TCM),
with
its
extensive
knowledge
base
documented
in
ancient
texts,
offers
a
unique
resource
for
contemporary
drug
discovery,
particularly
combatting
microbial
infections.
The
success
of
antimalarial
drugs
like
artemisinin
and
artesunate,
derived
from
the
TCM
herb
Artemisia
annua
L.,
exemplifies
potential
TCM-derived
small
molecules.
This
rich
repository
natural
products
intricate
molecular
structures
could
reveal
novel
compounds
unexplored
mechanisms
action.
Our
study
employs
multifaceted
approach
that
combines
text
mining,
detailed
textual
analysis,
modern
antibacterial
prediction
methodologies
to
unlock
remedies.
We
use
external
maps,
which
include
databases
known
bioactive
their
targets,
identify
promising
candidates.
leverages
both
historical
texts
scientific
data
explore
therapeutic
TCM.
discovered
patterns
DiYu→ZeXie
Kushen→ShengJiang
potentially
combat
Grams-positive
Grams-negative
bacteria.
utilized
AntiBac-Pred
online
tool
analyze
chemical
components
herbs,
integrating
TCMDB@Taiwan
graph.
groups
showed
antimicrobial
against
resistant
Staphylococcus
simulans,
while
exhibited
dual
effects
Bacillus
subtilis.
Exploring
TCM’s
numerous
opportunities
discovering
therapeutically
active
compounds.
synergistic
approach,
wisdom
science,
holds
significant
promise
enhancing
our
ability
infectious
diseases.
method
pave
way
new
era
personalized
medicine,
addressing
urgent
need
innovative
treatments
multidrug-resistant
bacteria
viruses.
Language: Английский
Investigation of the contamination rate of guinea fowl meats and its related samples by Escherichia coli using one health approach
Stephen K.K. Monten,
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Frederick Adzitey,
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Juliana Bawah
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et al.
Indonesian Food Science and Technology Journal,
Journal Year:
2024,
Volume and Issue:
8(1), P. 126 - 137
Published: Dec. 31, 2024
Guinea
fowl
meat
is
an
important
source
of
protein
and
other
nutrients
for
humans.
Their
contamination
by
bacteria
a
threat
to
public
health
one
approach
tackling
this
warranted.
This
study
investigated
the
rate
guinea
meats
it
related
samples
Escherichia
coli
using
approach.
It
also
antibiotic
resistance
from
sources.
A
total
200
were
randomly
collected
wet
markets
in
Ghana
sources
was
done
procedures
Bacteriological
Analytical
Manual
USA-FDA.
The
disc
diffusion
method
used
test
following
confirmation
polymerase
chain
reaction.
highest
processing
knife
(96.0%)
least
water
main
(28.0%).
Faeces,
floor,
processor's
hands,
meat,
washing
table
all
contaminated
with
coli.
partial
fragment
analysis
uidA
gene
PCR
yielded
band
~147
bp
isolates
exhibited
ceftriaxone
(60.5%),
but
susceptibility
azithromycin
(94.7%).
Intermediate
gentamicin
(34.2%).
MAR
index
ranged
0.0
(resistant
0
antibiotic)
0.8
7
antibiotics)
24
different
profiles.
confirms
that
some
market
resistant
antibiotics.
Appropriate
handling
considering
sale
points
are
recommended
prevent
spread
foodborne
infections.
Language: Английский