Unveiling the Secrets of Acinetobacter baumannii: Resistance, Current Treatments, and Future Innovations

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6814 - 6814

Published: June 21, 2024

represents a significant concern in nosocomial settings, particularly critically ill patients who are forced to remain hospital for extended periods. The challenge of managing and preventing this organism is further compounded by its increasing ability develop resistance due extraordinary genomic plasticity, response adverse environmental conditions. Its recognition as public health risk has provided impetus the identification new therapeutic approaches infection control strategies. Indeed, currently used antimicrobial agents gradually losing their efficacy, neutralized newer mechanisms bacterial resistance, especially carbapenem antibiotics. A deep understanding underlying molecular urgently needed shed light on properties that allow

Language: Английский

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Reimagining Chitosan‐Based Antimicrobial Biomaterials to Mitigate Antibiotic Resistance and Alleviate Antibiotic Overuse: A Review

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: 309(9)

Published: Feb. 24, 2024

Abstract This paper reports recent advancements in chitosan‐based antimicrobial biomaterials that aim to address the issue of resistance (AMR). Today, AMR is one most significant public health challenges world facing. To combat overuse antibiotics, a range materials, including advanced nanosized polymers, have been explored as potential agents. In this direction, chitosan scores highly because its unique combination properties such biodegradability, biocompatibility, bioactivity, non‐toxic, and, importantly, intrinsic antibacterial and antifungal activity. Herein, an overview derivatives alternatives conventional therapeutics reported. review starts with understanding mechanism, which critical for developing suitable materials treating infectious diseases. Then, inherent characteristics, modes action, factors impact effectiveness are discussed. The authors further summarize various clinical trial results Finally, applications summary, offers new insights into design sustainable applications.

Language: Английский

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Phage therapy: an alternative treatment modality for MDR bacterial infections

Infectious Diseases, Journal Year: 2024, Volume and Issue: 56(10), P. 785 - 817

Published: July 17, 2024

The increasing global incidence of multidrug-resistant (MDR) bacterial infections threatens public health and compromises various aspects modern medicine. Recognising the urgency this issue, World Health Organisation has prioritised development novel antimicrobials to combat ESKAPEE pathogens. Comprising

Language: Английский

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NIAID Workshop Report: Systematic Approaches for ESKAPE Bacteria Antigen Discovery

Vaccines, Journal Year: 2025, Volume and Issue: 13(1), P. 87 - 87

Published: Jan. 18, 2025

On 14–15 November 2023, the National Institute of Allergy and Infectious Diseases (NIAID) organized a workshop entitled “Systematic Approaches for ESKAPE Bacteria Antigen Discovery”. The goal was to engage scientists from diverse relevant backgrounds explore novel technologies that can be harnessed identify address current roadblocks impeding advances in antigen vaccine discoveries pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species). consisted four sessions addressed infections, discovery efforts, new including systems immunology vaccinology approaches. Each session followed by panel discussion. In total, there were over 260 in-person virtual attendees, with high levels engagement. This report provides summary event highlights challenges opportunities field discovery.

Language: Английский

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Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 12, 2025

Drug-resistant bacteria pose an urgent global health threat, necessitating the development of antibacterial compounds with novel modes action. Protein biosynthesis accounts for up to half energy expenditure bacterial cells, and consequently inhibiting efficiency or fidelity ribosome is a major target existing antibiotics. Here, we describe alternative mode action that affects same process: allowing translation proceed but causing co-translational aggregation nascent peptidic chain. We show treatment aggregation-prone peptide induces formation polar inclusion bodies activates SsrA rescue pathway in bacteria. The contain ribosomal proteins hibernation factors, as well mRNAs cognate chains many amyloid-like structures, bias membrane fold rich long-range beta-sheet interactions. bactericidal against wide range pathogenic planktonic growth biofilms, reduces loads mouse models Escherichia coli Acinetobacter baumannii infections. Our results indicate disrupting protein homeostasis via constitutes promising strategy broad-spectrum antibacterials. antibiotics inhibit ribosome. authors synthetic displays activity through different mechanism, inducing chains.

Language: Английский

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An escape from ESKAPE pathogens: A comprehensive review on current and emerging therapeutics against antibiotic resistance

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135253 - 135253

Published: Sept. 6, 2024

Language: Английский

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Gram-Negative ESKAPE Bacteria Surveillance in COVID-19 Pandemic Exposes High-Risk Sequence Types of Acinetobacter baumannii MDR in a Tertiary Care Hospital

Pathogens, Journal Year: 2024, Volume and Issue: 13(1), P. 50 - 50

Published: Jan. 4, 2024

The interruption of bacteriological surveillance due to the COVID-19 pandemic brought serious consequences, such as collapse health systems and possible increase in antimicrobial resistance. Therefore, it is necessary know rate resistance its associated mechanisms bacteria causing hospital infections during pandemic. aim this work was show phenotypic molecular characteristics ESKAPE a Mexican tertiary care second third years For purpose, 2021 2022, two hundred unduplicated strains group (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii) were collected from various clinical sources categorized by according CLSI. An analysis variance (ANOVA) complemented Tukey test performed search for changes susceptibility profiles study period. Finally, involved carbapenem analyzed, efflux pumps high-risk sequence types A. baumannii multilocus (MLST). results showed no K. pneumoniae period analyzed. Decreases quinolone identified E. coli (p = 0.039) P. aeruginosa 0.03). Interestingly, increases penicillins 0.004), aminoglycosides < 0.001, p 0.027), carbapenems folate inhibitors 0.001). Several genes (blaNDM, blaVIM, blaOXA, blaKPC, blaOXA-40, blaOXA-48) with predominance blaOXA-40 adeABCRS pump baumannii. MLST revealed presence globally distributed (ST369 ST758) related outbreaks other parts world. presented demonstrate that has played an important role nosocomial antibiotic-resistant pathogens particular MDR potential reservoir genes. implications mainly are analyzed discussed.

Language: Английский

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Ellagic acid-modified gold nanoparticles to combat multi-drug resistant bacterial infections in vitro and in vivo

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(19), P. 4781 - 4790

Published: Jan. 1, 2024

Gold nanoparticles modified with ellagic acid are prepared via a simple one-pot hydrothermal process, showing high, broad-spectrum antimicrobial activities, and effective biofilm dispersion against antibiotic-resistant ESKAPE pathogens.

Language: Английский

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Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Polymicrobial biofilms adhere to surfaces and enhance pathogen resistance conventional treatments, significantly contributing chronic infections in the respiratory tract, oral cavity, wounds, on medical devices. This review examines antimicrobial peptides (AMPs) as a promising alternative traditional antibiotics for treating biofilm‐associated infections. AMPs, which can be produced part of innate immune response or synthesized therapeutically, have broad‐spectrum activity, often disrupting microbial cell membranes causing death. Many specifically target negatively charged bacterial membranes, unlike host membranes. Research shows AMPs effectively inhibit disrupt polymicrobial antibiotics' efficacy. Preclinical clinical research is advancing, with animal studies trials showing promise against multidrug‐resistant bacteria fungi. Numerous patents indicate increasing interest AMPs. However, challenges such peptide stability, potential cytotoxicity, high production costs must addressed. Ongoing focuses optimizing AMP structures, enhancing developing cost‐effective methods. In summary, offer novel approach combating infections, their unique mechanisms synergistic existing positioning them candidates future treatments.

Language: Английский

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Anti-MRSA mechanism of spirostane saponin in Rohdea pachynema F.T.Wang & Tang

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 331, P. 118327 - 118327

Published: May 13, 2024

Language: Английский

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