Unraveling the Immunometabolism Puzzle: Deciphering Systemic Sclerosis Pathogenesis DOI Creative Commons
Maryam Masoumi,

Ali Bodaghi,

Hossein Khorramdelazad

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35445 - e35445

Published: July 31, 2024

The article delves into the pathogenesis of systemic sclerosis (SSc) with an emphasis on immunometabolism dysfunctions. SSc is a complex autoimmune connective tissue disorder skin and organ fibrosis manifestation, vasculopathy, immune dysregulation. A growing amount research indicates that plays significant role in diseases, including SSc. review explores intricate interplay between dysfunction metabolic alterations, focusing metabolism glucose, lipids, amino acids, TCA (tricarboxylic acid) cycle, oxidative stress disease. According to recent research, there are changes various pathways could trigger or perpetuate Glycolysis play pivotal through inducing fibrosis. Dysregulated fatty acid β-oxidation (FAO) consequent lipid result dysregulated extracellular matrix (ECM) breakdown induction. altered acids can significantly be involved mechanisms. Reactive oxygen species (ROS) production has crucial damage patients. Indeed, involvement highlighted, which offers potential therapeutic avenues. underscores need for comprehensive studies unravel multifaceted mechanisms driving progression.

Language: Английский

Advances in fecal microbiota transplantation for the treatment of diabetes mellitus DOI Creative Commons
Juan Zhang, Honggang Wang, Ying Liu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: April 10, 2024

Diabetes mellitus (DM) refers to a group of chronic diseases with global prevalence, characterized by persistent hyperglycemia resulting from various etiologies. DM can harm organ systems and lead acute or complications, which severely endanger human well-being. Traditional treatment mainly involves controlling blood sugar levels through replacement therapy drugs insulin; however, some patients still find satisfactory curative effect difficult achieve. Extensive research has demonstrated close correlation between enteric dysbacteriosis the pathogenesis types DM, paving way for novel therapeutic approaches targeting gut microbiota manage DM. Fecal transplantation (FMT), method re-establishing intestinal microbiome balance, offers new possibilities treating diabetes. This article provides comprehensive review microbiota, as well current advancements in FMT using an illustrative example. study aims offer perspectives establish theoretical foundation clinical diagnosis management

Language: Английский

Citations

5
Integrated metabolomic and transcriptomic analysis reveals the effects and mechanisms of Jinqi jiangtang tablets on type 2 diabetes DOI

Zhihui Song,

Yan An, Zhenzhen Li

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 134, P. 155957 - 155957

Published: Aug. 18, 2024

Language: Английский

Citations

3
Unravelling the Crosstalk between Estrogen Deficiency and Gut-biota Dysbiosis in the Development of Diabetes Mellitus DOI

Rishabh,

Seema Bansal,

Akriti Goel

et al.

Current Diabetes Reviews, Journal Year: 2024, Volume and Issue: 20(10)

Published: Jan. 25, 2024

Abstract: Estrogens are classically considered essential hormonal signals, but they exert profound effects in a number of physiological and pathological states, including glucose homeostasis insulin resistance. Estrogen deficiency after menopause most women leads to increased androgenicity changes body composition, it is recommended manipulate the β-cell function pancreas, insulin-induced transport, hepatic output, hence, increasing incidence type 2 diabetes mellitus. Recently, studies have reported that gut biota alteration due estrogen contributes altered energy metabolism and, accentuates pathology Emerging research suggests via genetic disposition or failure ovaries old age modulates resistance secretion workload on pancreatic beta cells by decreasing levels good bacteria such as Akkermansia muciniphila, Bifidobacterium spp., Lactobacillus Faecalibacterium prausnitzii, Roseburia Prevotella bad bacteria’s Bacteroides Clostridium difficile, Escherichia coli, Enterococcus spp. Alteration these bacteria's concentrations further development impaired uptake muscles, gluconeogenesis liver, lipolysis inflammation adipose tissues. Thus, present review paper aims clarify intricate interactions between deficiency, microbiota regulation,

Language: Английский

Citations

2
Interaction of Molecular Mechanisms of Plant-Derived Metabolites in Type 2 Diabetes Mellitus: A Network Pharmacology and Docking and Molecular Dynamics Approach on AKT1 kinase DOI Creative Commons

Ekambaram Gayathiri,

Palanisamy Prakash, Somdatta Y. Chaudhari

et al.

Energy Nexus, Journal Year: 2024, Volume and Issue: unknown, P. 100351 - 100351

Published: Nov. 1, 2024

Language: Английский

Citations

0
Unraveling the Immunometabolism Puzzle: Deciphering Systemic Sclerosis Pathogenesis DOI Creative Commons
Maryam Masoumi,

Ali Bodaghi,

Hossein Khorramdelazad

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35445 - e35445

Published: July 31, 2024

The article delves into the pathogenesis of systemic sclerosis (SSc) with an emphasis on immunometabolism dysfunctions. SSc is a complex autoimmune connective tissue disorder skin and organ fibrosis manifestation, vasculopathy, immune dysregulation. A growing amount research indicates that plays significant role in diseases, including SSc. review explores intricate interplay between dysfunction metabolic alterations, focusing metabolism glucose, lipids, amino acids, TCA (tricarboxylic acid) cycle, oxidative stress disease. According to recent research, there are changes various pathways could trigger or perpetuate Glycolysis play pivotal through inducing fibrosis. Dysregulated fatty acid β-oxidation (FAO) consequent lipid result dysregulated extracellular matrix (ECM) breakdown induction. altered acids can significantly be involved mechanisms. Reactive oxygen species (ROS) production has crucial damage patients. Indeed, involvement highlighted, which offers potential therapeutic avenues. underscores need for comprehensive studies unravel multifaceted mechanisms driving progression.

Language: Английский

Citations

0