Updated mechanisms of MASLD pathogenesis

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 22, 2024

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) has garnered considerable attention globally. Changing lifestyles, over-nutrition, and physical inactivity have promoted its development. MASLD is typically accompanied by obesity strongly linked to metabolic syndromes. Given that prevalence on the rise, there an urgent need elucidate pathogenesis. Hepatic lipid accumulation generally triggers lipotoxicity induces or progress steatohepatitis (MASH) mediating endoplasmic reticulum stress, oxidative organelle dysfunction, ferroptosis. Recently, significant been directed towards exploring role of gut microbial dysbiosis in development MASLD, offering a novel therapeutic target for MASLD. Considering are no recognized pharmacological therapies due diversity mechanisms involved difficulty associated with undertaking clinical trials, potential targets remain elusive. Thus, this article aimed summarize evaluate prominent roles lipotoxicity, ferroptosis, microbes underlying their effects. Furthermore, existing advances challenges treatment were outlined.

Language: Английский

---

Endogenous ethanol production in health and disease

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(8), P. 556 - 571

Published: June 3, 2024

Language: Английский

---

From Teeth to Body: The Complex Role of Streptococcus mutans in Systemic Diseases

Molecular Oral Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

ABSTRACT Streptococcus mutans , the principal pathogen associated with dental caries, impacts individuals across all age groups and geographic regions. Beyond its role in compromising oral health, a growing body of research has established link between S. various systemic diseases, including immunoglobulin A nephropathy (IgAN), nonalcoholic steatohepatitis (NASH), infective endocarditis (IE), ulcerative colitis (UC), cerebral hemorrhage, tumors. The pathogenic mechanisms frequently involve collagen‐binding proteins (CBPs) protein antigens (PA) present on bacterial surface. These components facilitate intricate interactions host immune system, thereby potentially contributing to pathological processes. Specifically, CBP is implicated deposition IgA complement component C3, which exhibits characteristics reminiscent IgAN‐like lesions through animal models, recent clinical studies suggest potential involvement IgAN. In addition, binds C1q, effectively inhibiting classical activation pathway system. promotes induction cells produce interferon‐gamma (IFN‐γ). Furthermore, leads direct inhibitory effects platelets matrix metalloproteinase‐9 (MMP‐9) at sites vascular injury. Moreover, PA enhances ability invade hepatic tissue. Through utilization PAc, excessively produces kynurenine (KYNA), development progression squamous cell carcinoma (OSCC). This article synthesizes latest advancements understanding conditions humans, expanding our perspective beyond traditional focus caries.

Language: Английский

---

Deciphering the role of Dietary Modifications and Gut Dysbiosis in Non-Alcoholic Fatty Liver Disease

Human Nutrition & Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 200305 - 200305

Published: Feb. 1, 2025

Language: Английский

---

Gegen-Qinlian Decoction Alleviates Metabolic Dysfunction-Associated Steatohepatitis by Modulating the Microbiota-Bile Acid Axis in Mice

Published: Jan. 1, 2025

Language: Английский

---

Study on the correlation between circadian rhythm, intestinal flora and Liver stiffness in patients with Hepatic fibrosis

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Background: Hepatic fibrosis (HF) is a critical pathological process in chronic liver diseases, and its progression closely associated with gut microbiota dysbiosis circadian rhythm disruption. However, the interplay between these factors HF remains poorly understood. This study aimed to investigate relationship composition, disturbances, HF, providing new insights into potential therapeutic strategies. Methods: A cross-sectional was conducted, enrolling patients healthy controls. Liver stiffness measurement (LSM) assessed using transient elastography. Circadian status evaluated Morningness-Eveningness Questionnaire-5 (MEQ-5). Gut composition analyzed via 16S rRNA sequencing, differences microbial diversity taxa abundance were compared groups. Correlation analyses performed explore associations microbiota, LSM, rhythm. Results: Patients exhibited significant alterations at both phylum genus levels (p<0.05, r = − 0.244). The relative abundances of Escherichia-Shigella, Klebsiella, Pseudomonadota, Ruminococcus gnavus group, Enterocloster significantly increased, while Dorea, Holdemanella, [Ruminococcus] gauvreauii group, [Eubacterium] ventriosum CAG-352, Marvinbryantia markedly decreased. These shifts enhanced intestinal inflammation hepatic immune activation. Notably, Escherichia-Shigella may contribute LPS-TLR4/inflammasome activation, inflammatory cytokine release, reduced short-chain fatty acid (SCFA) production. Conversely, SCFA-producing bacteria Firmicutes showed protective role by mitigating lipid accumulation. Furthermore, disruption negatively correlated an increased Mediterraneibacter observed disturbances. As known produce ethanol, elevated exacerbate injury inflammation, potentially contributing development. Conclusion: reveals association dysbiosis, disruption, severity. Our findings suggest that disturbances influence modulating metabolic activity. highlight strategies, including modulation (e.g., light therapy, timed medication) microbiota-targeted interventions, slow or reverse progression.

Language: Английский

---

A study of correlation of the dietary index for gut microbiota with non-alcoholic fatty liver disease based on 2007–2018 National Health and Nutrition Examination Survey

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 10, 2025

To explore the correlation of dietary index for gut microbiota (DI-GM) with non-alcoholic fatty liver disease (NAFLD). Data 6,711 participants were extracted from National Health and Nutrition Examination Survey (NHANES) during 2007-2018. A weighted logistic regression analysis was employed assessment DI-GM NAFLD, a restricted cubic spline (RCS) implemented to examine potential non-linear associations. Subgroup analyses conducted identify particularly susceptible groups. Additionally, synergistic effects different components on NAFLD risk assessed by quantile sum (WQS) regression. The exhibited statistically significant [OR (95%CI):0.91 (0.85, 0.98), p = 0.015]. results RCS indicated linear (p 0.810 non-linearity). Further stratified that negative consistent all subgroups. WQS revealed soybean (27%), refined grains (17%), coffee (16%), red meat (9%) had highest contribution weights NAFLD. As an important tool influences diet microbiota, is negatively correlated factors. Soybean, grains, coffee, are key factors influencing direct shall be explored effectiveness prevention treatment evaluated improving scores via interventions.

Language: Английский

---

Gut microbiome in non-alcoholic fatty liver disease

Frontiers in Gastroenterology, Journal Year: 2025, Volume and Issue: 3

Published: Jan. 14, 2025

Non-alcoholic fatty liver disease (NAFLD) has a rapidly growing incidence worldwide, affecting approximately one-third of world population. The disturbance gut commensal bacteria impacting host’s homeostasis is referred to as dysbiosis. microbiome contributes the pathogenesis NAFLD through various pathways. Gut microbiota at constant interactions with intestinal epithelial barrier and affects its integrity. Through gut-liver axis, may influence immune function. release lipopolysaccharides (LPS) from intestines portal vein which are transported liver, trigger hepatic inflammation, steatosis even fibrosis. Moreover, induces conversion primary bile acids (BAs) secondary BAs, activates receptors, such FXR TGR5. activation decreases fat absorption thus reduces lipid accumulation, while TGR5 promotes glucagon-like peptide-1 (GLP-1) in blood. Furthermore, ethanol-producing been implicated development. Additionally, there reduction levels short-chain acids, butyrate, propionate acetate. Many bacterial alterations have observed NAFLD, including increased Bacteroidetes decreased Firmicutes . probiotics tried prevention management, plethora strains Lactobacilli , Bifidobacteria Streptococcus some them promising perspectives. There also data administration prebiotics (such inulin fructo-oligosaccharides) symbiotics (probiotics plus prebiotics). Faecal transplantation (FMT) yet be evaluated for efficacy against NAFLD.

Language: Английский

---

The Microbiome and Metabolic Dysfunction-Associated Steatotic Liver Disease

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2882 - 2882

Published: March 22, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition wherein excessive fat accumulates in the liver, leading to inflammation and potential damage. In this narrative review, we evaluate tissue microbiota, how they arise their constituent microbes, role of intestinal hepatic microbiota MASLD. The history bacteriophages (phages) occurrence part causation MASLD, conversely, "phage therapy" for antibiotic resistance, obesity, are all described. metabolism bile acids dietary tryptophan histidine defined, together with impacts individual metabolites on MASLD pathogenesis. Both periodontitis dysbiosis may cause microorganisms involved these processes discussed. Novel treatment opportunities involving exist include fecal transplantation, probiotics, prebiotics, synbiotics, supplements, intermittent fasting, phages or holins endolysins. Although FDA yet approve phage therapy clinical use, there multiple FDA-approved trials, represent new horizon future

Language: Английский

---

Gegen-Qinlian decoction alleviates metabolic dysfunction-associated steatohepatitis by modulating the microbiota-bile acid axis in mice

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119719 - 119719

Published: April 1, 2025

Language: Английский

---