Metagenomic analysis reveals the novel role of vaginal Lactobacillus iners in Chinese healthy pregnant women DOI Creative Commons
Xudong Wang, Qingru Jiang, Xiaohui Tian

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: May 30, 2025

This study investigated the relationship between vaginal microbiota and women's health conditions in 95 Chinese pregnant women their third trimester. We conducted metagenomic analysis, examining species, functional pathways, genes, utilized correlation LEfSe analyses to link conditions. Results revealed that healthy participants exhibited higher levels of Lactobacillus iners, with its abundance associated tetrahydrofolate biosynthesis pathways. They also possessed more glycosyltransferase ErmB antibiotic resistance genes compared diagnosed Comparative genomics demonstrated L. iners strains linked bacterial vaginosis (BV) encoding biofilm-associated YhgE/Pip domain-containing proteins than healthy-associated strains. Notably, three BV-associated stronger biofilm formation abilities four isolated this study. Also, out seven inhibited growth Gardnerella vaginalis. Overall, may help maintain ecosystem stability women.

Language: Английский

Bacterial persisters: molecular mechanisms and therapeutic development DOI Creative Commons
Hongxia Niu, Jiaying Gu, Ying Zhang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 17, 2024

Abstract Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing) bacteria that survive in stress environments such as antibiotic exposure, acidic and starvation conditions. These cells can regrow after removal remain the same stress. are underlying problems of treating chronic persistent infections relapse treatment, resistance development, biofilm infections, pose significant challenges for effective treatments. Understanding characteristics exact mechanisms persister formation, especially key molecules affect formation survival persisters is critical more treatment infections. Currently, genes related being discovered confirmed, but by which form very complex, there still many unanswered questions. This article comprehensively summarizes historical background bacterial persisters, details their complex relationship with tolerant resistant bacteria, systematically elucidates interplay between various biological processes cells, well consolidates diverse anti-persister compounds We hope provide theoretical in-depth research on suggest new ideas choosing strategies

Language: Английский

Citations

61
Metagenomic analysis reveals the novel role of vaginal Lactobacillus iners in Chinese healthy pregnant women DOI Creative Commons
Xudong Wang, Qingru Jiang, Xiaohui Tian

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: May 30, 2025

This study investigated the relationship between vaginal microbiota and women's health conditions in 95 Chinese pregnant women their third trimester. We conducted metagenomic analysis, examining species, functional pathways, genes, utilized correlation LEfSe analyses to link conditions. Results revealed that healthy participants exhibited higher levels of Lactobacillus iners, with its abundance associated tetrahydrofolate biosynthesis pathways. They also possessed more glycosyltransferase ErmB antibiotic resistance genes compared diagnosed Comparative genomics demonstrated L. iners strains linked bacterial vaginosis (BV) encoding biofilm-associated YhgE/Pip domain-containing proteins than healthy-associated strains. Notably, three BV-associated stronger biofilm formation abilities four isolated this study. Also, out seven inhibited growth Gardnerella vaginalis. Overall, may help maintain ecosystem stability women.

Language: Английский

Citations

0