The role of epithelial-mesenchymal transition in pulmonary fibrosis: lessons from idiopathic pulmonary fibrosis and COVID-19

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 13, 2024

Despite the tremendous advancements in knowledge of pathophysiology and clinical aspects SARS-CoV-2 infection, still many issues remain unanswered, especially long-term effects. Mounting evidence suggests that pulmonary fibrosis (PF) is one most severe complications associated with COVID-19. Therefore, understanding molecular mechanisms behind its development helpful to develop successful therapeutic strategies. Epithelial mesenchymal transition (EMT) cell specific variants endothelial (EndMT) mesothelial (MMT) are physio-pathologic cellular reprogramming processes induced by several infectious, inflammatory biomechanical stimuli. Cells undergoing EMT acquire invasive, profibrogenic proinflammatory activities secreting extracellular mediators. Their activity has been implicated pathogenesis PF a variety lung disorders, including idiopathic (IPF) Aim this article provide an updated survey mechanisms, emphasis on EMT-related processes, genesis IFP

Language: Английский

Effects of Dietary Zinc Oxide Nanoparticles on Growth Performance, Zinc in Tissues and Immune Response in the Rare Minnow (Gobiocypris Rarus)

Published: Jan. 1, 2024

In recent years, zinc oxide nanoparticles (ZnO NPs) has been widely used in feed additives due to its excellent bioavailability. However, there is little research on effects fish species growth and health as additive. To investigate the influences of dietary supplementation with ZnO NPs performance immune function rare minnow, minnows were fed diets different content. Growth analysis showed that negatively affected weight decreasing then increasing condition factors specific rate. Additionally, accumulated level supplement groups significantly higher controls (P < 0.05). The number erythrocytes leukocytes blood increased decreased after treatment NPs. It was further found content down-regulated expression growth-related genes 60 d accumulation muscle tissues, liver tissue for up-regulated immune-modulation-related results indicated short-term could overcome deficiency positively affect function. prolonged resulted reduced body compromised various tissues. Thus, studies are essential explore long-term species.

Language: Английский

The Effect of Dietary Zinc Oxide Nanoparticles on Growth Performance, Zinc in Tissues, and Immune Response in the Rare Minnow (Gobiocypris rarus)

Aquaculture Nutrition, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

In recent years, zinc oxide nanoparticles (ZnO NPs) have gained attention as feed additives due to their high bioavailability. However, research on impact fish growth and health is limited. To investigate the influences of dietary addition ZnO NPs performance immune function rare minnow, minnows were fed diets with different content. Growth analysis showed that had a negative effect weight decreasing then increasing condition factors (CFs) specific rate. Additionally, accumulated (Zn) level was significantly higher ( p < 0.05), liver injury index 0.05) in group compared control group. The number erythrocytes leukocytes blood samples increased decreased after treatment NPs. It further found supplement Zn content markedly repressed expression growth‐related genes 60 days accumulation muscle tissues, tissues for enhanced modulation–related 0.05). findings suggested short‐term supplementation could positively affect function. prolonged resulted reduced body compromised owing buildup tissues.

Language: Английский