Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426,
Journal Year:
2024,
Volume and Issue:
7(5), P. 245 - 264
Published: May 24, 2024
The
infection
and
chronic
inflammatory
response
generated
by
Helicobacter
pylori
is
a
global
health
concern.
This
pathogen
characterized
as
major
risk
factor
in
the
development
of
gastric
cancer
other
diseases.
Conventional
eradication
therapies
are
based
on
antibiotic
regimens
consequence
there
an
increase
antimicrobial
resistance
strains,
besides
potential
side
effects
for
host.
Therefore,
it
necessary
to
explore
new
alternatives.
review
delves
into
realm
peptides,
exploring
their
efficacy
against
H.
sourced
from
diverse
origins.
Furthermore,
sheds
light
food-derived
peptides
exhibiting
remarkable
biological
activity.
These
exhibit
promising
biomarkers
associated
with
infection,
demonstrating
anti-inflammatory
antioxidant
properties
validated
through
rigorous
testing
both
cell
animal
models.
Regarding
activity,
peptide
VPY
derived
soybean
sources
such
meat
(β-Ala-His),
egg
(DEDTQAMPFR,
DEDTQAMPF,
MLGATSL,
MSYSAGF,
CR,
FL,
HC,
LL,
MK)
milk
(IPAV)
have
reported
reduction
cytokine
IL-8,
biomarker
directly
related
infection.
For
(EAMAPK,
AVPYPQ)
Spirulina
maxima
(LDAVNR,
MMLDF)
reduced
ROS
levels
could
positive
effect
control
Food-derived
bioactive
anti-adhesive
were
also
discussed.
They
derive
vegetable
(corn,
pea
wheat)
capable
interacting
host
cells,
interfering
adherence
pylori.
avoid
and/or
mitigate
undesired
outcomes
infectious
diseases
due
possibility
its
application
nutraceuticals
food
products,
resulting
preventive
approach.
Keywords:
pylori,
resistance,
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7083 - 7083
Published: June 27, 2024
Impaired
E-cadherin
(Cdh1)
functions
are
closely
associated
with
cellular
dedifferentiation,
infiltrative
tumor
growth
and
metastasis,
particularly
in
gastric
cancer.
The
class-I
carcinogen
Helicobacter
pylori
(H.
pylori)
colonizes
epithelial
cells
induces
Cdh1
shedding,
which
is
primarily
mediated
by
the
secreted
bacterial
protease
high
temperature
requirement
A
(HtrA).
In
this
study,
we
used
human
primary
cell
lines
derived
from
gastroids
mucosoids
different
healthy
donors
to
investigate
HtrA-mediated
cleavage
subsequent
impact
on
pathogenesis
a
non-neoplastic
context.
We
found
severe
impairment
of
HtrA-induced
ectodomain
2D
mucosoids.
Since
exhibit
an
intact
apico-basal
polarity,
investigated
transmigration
across
monolayer,
was
partially
depolarized
HtrA,
as
indicated
microscopy,
analyses
transepithelial
electrical
resistance
(TEER)
colony
forming
unit
(cfu)
assays.
Finally,
CagA
injection
observed
efficient
translocation
tyrosine
phosphorylation
and,
lesser
extent,
similar
effects
summary,
HtrA
crucially
important
factor
promoting
multistep
H.
non-transformed
organoid-based
models.
Cells,
Journal Year:
2024,
Volume and Issue:
13(11), P. 901 - 901
Published: May 24, 2024
Helicobacter
pylori
has
been
implicated
in
various
gastrointestinal
disorders,
including
functional
dyspepsia.
This
study
aimed
to
compare
the
anti-H.
activity
and
gastroprotective
effects
of
three
typical
herbal
formulas
used
for
disorders
Korea:
Shihosogan-tang
(ST),
Yijung-tang
(YT),
Pyeongwi-san
(PS).
Firstly,
we
assessed
total
phenolic
flavonoid
contents,
as
well
antioxidative
capacity.
Additionally,
evaluated
antibacterial
effect
on
H.
using
an
ammonia
assay,
minimum
inhibitory
concentration
(MIC)
test,
disk
agar
diffusion
method.
Furthermore,
examined
alterations
gene
expression
tight
junction
proteins,
pro-inflammatory
cytokines,
cellular
vacuolation
AGS
cell
model
infected
with
pylori.
While
ST
exhibited
a
higher
content,
superior
free
radical
scavenging,
inhibition
compared
YT
PS,
more
evidently
inhibited
gastric
morphological
changes
such
vacuolation.
All
formulations
significantly
ameliorated
inflammatory
inflammation-related
genes
induced
by
infection.
Overall,
present
vitro
suggests
that
all
possess
potential
ameliorating
relatively
excelling
inhibiting
infection
inflammation,
while
potentially
shows
greater
efficacy
directly
protecting
mucosa.
Heliyon,
Journal Year:
2024,
Volume and Issue:
11(1), P. e41533 - e41533
Published: Dec. 27, 2024
Contamination
of
drinking
water
by
Helicobacter
pylori
can
cause
serious
diseases,
including
cancer.
The
determinants
the
infection
rate
are
socioeconomic
status,
low
standard
living
and
overcrowding.
In
addition,
exposure
to
environmental
sources
contaminated
with
feces,
such
as
vegetables,
is
another
risk
factor
for
infection.
We
analyzed
occurrence
H.
in
antimicrobial
resistance
profile
central
Peru.
Water
samples
were
collected
from
taps
four
provinces
Junín
region.
Previously,
biofilm
sampling
was
performed
internal
surface
taps.
cultured
on
modified
brain
heart
infusion
blood
agar
at
37
°C
under
microaerophilic
conditions
seven
days.
Antibiotic
sensitivity
determined
Kirby
Bauer
diffusion
method.
results
revealed
that
pH
(9.25)
turbidity
(5.15
NTU)
exceeded
Peruvian
quality
standards
water.
amount
free
chlorine
residual
positive
ranged
0.02
0.12
mg/L.
present
2/192
tap
(1.04
%)
3/192
(1.56
%).
It
observed
100
%
isolates
Chilca
district
showed
nalidixic
acid
66.67
both
amoxicillin
chloramphenicol.
Resistance
obtained
El
Tambo
%.
study
findings
reveal
biofilms
Chilca,
Huamancaca
chico
districts
region
harbor
pylori.
They
also
variability
pattern
more
than
one
antibiotic
tested
another.
Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426,
Journal Year:
2024,
Volume and Issue:
7(5), P. 245 - 264
Published: May 24, 2024
The
infection
and
chronic
inflammatory
response
generated
by
Helicobacter
pylori
is
a
global
health
concern.
This
pathogen
characterized
as
major
risk
factor
in
the
development
of
gastric
cancer
other
diseases.
Conventional
eradication
therapies
are
based
on
antibiotic
regimens
consequence
there
an
increase
antimicrobial
resistance
strains,
besides
potential
side
effects
for
host.
Therefore,
it
necessary
to
explore
new
alternatives.
review
delves
into
realm
peptides,
exploring
their
efficacy
against
H.
sourced
from
diverse
origins.
Furthermore,
sheds
light
food-derived
peptides
exhibiting
remarkable
biological
activity.
These
exhibit
promising
biomarkers
associated
with
infection,
demonstrating
anti-inflammatory
antioxidant
properties
validated
through
rigorous
testing
both
cell
animal
models.
Regarding
activity,
peptide
VPY
derived
soybean
sources
such
meat
(β-Ala-His),
egg
(DEDTQAMPFR,
DEDTQAMPF,
MLGATSL,
MSYSAGF,
CR,
FL,
HC,
LL,
MK)
milk
(IPAV)
have
reported
reduction
cytokine
IL-8,
biomarker
directly
related
infection.
For
(EAMAPK,
AVPYPQ)
Spirulina
maxima
(LDAVNR,
MMLDF)
reduced
ROS
levels
could
positive
effect
control
Food-derived
bioactive
anti-adhesive
were
also
discussed.
They
derive
vegetable
(corn,
pea
wheat)
capable
interacting
host
cells,
interfering
adherence
pylori.
avoid
and/or
mitigate
undesired
outcomes
infectious
diseases
due
possibility
its
application
nutraceuticals
food
products,
resulting
preventive
approach.
Keywords:
pylori,
resistance,
