Preventive treatment of tripdiolide ameliorates kidney injury in diabetic mice by modulating the Nrf2/NF-κB pathway

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Introduction Although tripdiolide has demonstrated a protective role in lupus nephritis, its potential therapeutic and preventive effects on diabetic kidney injury remain inconclusive. Methods In this study, diabetes mice model was used to evaluate the effect of treatment kidney. The study assessed related factors levels, while comparing pathological changes, alterations intestinal microbiota composition, oxidative stress inflammation kidneys, validating cytokine expression protein pathway activation. Results experiment that effectively suppressed hyperglycemia elevated hemoglobin level, attenuated concentrations creatinine blood urea nitrogen, mitigated histopathological kidney, alleviated inflammatory cell infiltration. Tripdiolide regulated affected abundance Allobaculum , Dubosella Prevotella differential metabolic pathways primarily revolve around ubiquinol biosynthesis menaquinol biosynthesis. significantly renal mice, as evidenced by upregulation nuclear factor erythroid 2-related 2 (Nrf2), heme Oxygenase-1, downregulation phosphorylated factor-κB (P-NF-κB), NOD-like receptor 3. Experiments performed RAW264.7 cells tripdiolide. Discussion may play induced changing composition microorganisms, regulating Nrf2/NF-κB activation, inhibiting reaction. This contributes scientific evidence can inform development approaches for nephropathy.

Language: Английский

Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 3, 2024

Diphenyl diselenide (DPDS) ameliorates nephropathy in streptozotocin (STZ)-induced type 1 diabetic rats by inhibiting oxidative stress and inflammatory reactions. However, it has not been clarified whether DPDS alleviates kidney disease (DKD) is related to the inhibition of extracellular matrix (ECM) production regulation intestinal flora disorder.

Language: Английский