The prognostic value of HALP score in predicting in-hospital mortality in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Coronary Artery Disease, Journal Year: 2023, Volume and Issue: 34(7), P. 483 - 488

Published: July 28, 2023

Despite major advances in reperfusion therapies, morbidity and mortality rates associated with cardiovascular disorders remain high, particularly patients ST-segment elevation myocardial infarction (STEMI). Therefore, identifying prognostic variables that can be used to predict STEMI is critical for better disease management. The HALP (hemoglobin, albumin, lymphocyte, platelet) score, a novel index indicating nutritional status systemic inflammation, provides information about prognosis. In this context, study was carried out investigate the relationship between score assessed at admission in-hospital patients.The population of retrospective consisted 1307 consecutive diagnosed who underwent primary percutaneous coronary intervention (pPCI). 1090 included sample were divided into two groups based on median value 3.59. In-hospital all-cause during follow-up obtained from registry.In-hospital rate significantly higher less than 3.59 compared those more (7.5% 0.7%, respectively; P < 0.001). Univariate multivariate Cox proportional hazard analyses revealed independently mortality. optimal cutoff <3.72 predicted 95.56% sensitivity 49.19% specificity.This study's findings indicate may significant independent predictor treated pPCI.

Language: Английский

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Impact of Naples Prognostic Score at Admission on In-Hospital and Follow-Up Outcomes Among Patients with ST-Segment Elevation Myocardial Infarction

Angiology, Journal Year: 2023, Volume and Issue: 74(10), P. 970 - 980

Published: Jan. 9, 2023

The Naples prognostic score (NPS) consists of cholesterol level, albumin concentration, lymphocyte-to-monocyte and neutrophil-to-lymphocyte ratios reflects systemic inflammation, malnutrition, survival for various conditions. We investigated the relationship NPS at admission with in-hospital follow-up outcomes among ST-segment elevation myocardial infarction (STEMI) patients. This retrospective study included 1887 consecutive patients diagnosed STEMI who underwent primary percutaneous coronary intervention between March 2020 May 2022. population was divided by into 2; low (0-1-2) high (3-4). In-hospital adverse events all-cause mortality rates during were extracted from registry. Median time 15 months. overall rate 14.6%. proportions that acute respiratory failure, kidney injury, malignant arrhythmia, significantly higher in group than group. Compared baseline model, full model Cox regression analysis; an independent predictor (adjusted hazard ratio (aHR): 2.49, 95%CI, 1.75-3.50, P < .001), a significant improvement performance (likelihood χ2, .001) better calibration. In conclusion, we found association

Language: Английский

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Non-coding RNAs as biomarkers of myocardial infarction

Clinica Chimica Acta, Journal Year: 2023, Volume and Issue: 540, P. 117222 - 117222

Published: Jan. 7, 2023

Non-coding RNAs (ncRNAs) encompass a family of ubiquitous RNA molecules that lack protein-coding potential and have tissue-specific expression. A significant body evidence indicates ncRNA's aberrant expression plays critical role in disease onset development. NcRNAs' biochemical characteristics such as disease-associated concentration changes, structural stability, high abundance fluids make them promising prognostic diagnostic biomarkers. Myocardial infarction (MI) is leading cause mortality worldwide. Acute myocardial (AMI), the term use to describe MI's early phase, generally diagnosed by physical examination, electrocardiogram (ECG), presence specific In this regard, compared standard MI biomarkers, cardiac troponin isoforms (cTnT & cTnI) Creatinine Kinase (CK), ncRNAs appears provide better sensitivity specificity, ensuring rapid correct diagnosis, an earlier treatment, consequently good prognosis for patients. This review aims summarize discuss most recent data on clinical circulating Specifically, we focused primarily miRNAs lncRNAs, highlighting their specificity sensitivity, discussing limitations, suggesting possible overcoming approaches.

Language: Английский

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Role of fibrinogen, albumin and fibrinogen to albumin ratio in determining angiographic severity and outcomes in acute coronary syndrome

World Journal of Cardiology, Journal Year: 2023, Volume and Issue: 15(1), P. 13 - 22

Published: Jan. 11, 2023

Coronavirus disease 2019 (COVID-19) pandemic unmasked the huge deficit in healthcare resources worldwide. It highlighted need for efficient risk stratification management of cardiovascular emergencies.To study applicability old, available and affordable nonconventional biomarkers: albumin fibrinogen their ability to predict angiographic severity clinical outcomes patients with acute coronary syndrome (ACS).In this prospective, observational study, 166 consecutive ACS were enrolled. Fibrinogen, ratio determined from serum. Patients underlying chronic liver disease, active malignancy, autoimmune COVID-19 infection undergoing thrombolysis excluded.Mean age population was 60.5 ± 1.5 years, 74.1% being males. ST elevation myocardial infarction (STEMI) most common presentation seen 57% patients. Fibrinogen (FAR) ≥ 19.2, had a sensitivity 76.9% specificity 78.9 % [area under receiver operating characteristic curves (AUROC) = 0.8, P 0.001] ≤ (TIMI) 1 flow culprit artery STEMI Even non-STEMI patients, FAR 18.85 predicted same 80% 63% (AUROC 0.715, 0.006).Novel biomarkers, high cost, lack availability long turn over time are impractical real-world use. Identifying TIMI has significant impact outcome. Our shown that readily biomarkers like can help identify these high-risk good accuracy. This allows risk-stratification individualization treatment ACS.

Language: Английский

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Naples Prognostic Score and Prediction of Left Ventricular Ejection Fraction in STEMI Patients

Angiology, Journal Year: 2023, Volume and Issue: 75(1), P. 36 - 43

Published: March 2, 2023

The Naples score is a new prognostic developed according to inflammatory and nutritional status frequently evaluated in cancer patients. present study aimed evaluate using the (NPS) predict development of decreased left ventricular ejection fraction (LVEF) after acute ST-segment elevation myocardial infarction (STEMI). has multicenter retrospective design included 2280 patients with STEMI who underwent primary percutaneous coronary intervention (pPCI) between 2017 2022. All participants were divided into 2 groups their NPS. relationship these LVEF was evaluated. low-Naples risk group (Group-1) 799 patients, high-Naples (Group-2) had 1481 Hospital mortality, shock, no-reflow rates found be higher Group compared 1 (P < .001, P = .032, .004). NPS significantly inversely associated discharge (B coefficient: -1.51, 95% CI-2.26; -.76, .001). NPS, simple easily calculated score, may help identify high-risk To best our knowledge, first demonstrate low STEMI.

Language: Английский

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Heat stress affects swimming performance and induces biochemical, structural, and transcriptional changes in the heart of Gymnocypris eckloni

Aquaculture Reports, Journal Year: 2024, Volume and Issue: 35, P. 101998 - 101998

Published: Feb. 29, 2024

Global warming has heightened the severity and frequency of extreme high-temperature events, presenting challenges to fish survival negatively affecting production fishery. Gymnocypris eckloni, native Tibetan Plateau, is widely cultured in southwest China. Its sensitivity heat makes it a suitable model for studying impact high temperatures on fish. The heart vital organ survival, while relatively understudied concerning hearts. In this study, G. eckloni was subjected seven-day exposure 27 °C followed by transfer 18 recovery period. Behavioral tests revealed significant increase locomotor speed, distance, respiratory rate at °C. Serum indices exhibited significantly elevated stress indicators (cortisol) kinases associated with damage (lactate dehydrogenase, lactate dehydrogenase isoenzyme 1, creatine kinase, kinase isoenzyme, aspartate transaminase) °C, histological analyses have confirmed occurrence temperatures. After 7 days recovery, most these showed decrease compared group, no differences observed control group. Transcriptomic widespread involvement ferroptosis, P53 signaling pathway, oxidative phosphorylation, myocardial contraction, DNA repair pathway response Our study offers systematic exploration effects providing valuable insights cultivation high-altitude

Language: Английский

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Cardiac biomarkers and detection methods for myocardial infarction

Molecular & Cellular Toxicology, Journal Year: 2022, Volume and Issue: 18(4), P. 443 - 455

Published: Sept. 10, 2022

Language: Английский

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Preservation of cardiac functions post myocardial infarction in vivo by a phenylboric acid-grafted hyaluronic hydrogel with anti-oxidation and accelerated degradation under oxidative microenvironment

Composites Part B Engineering, Journal Year: 2022, Volume and Issue: 238, P. 109941 - 109941

Published: April 27, 2022

Language: Английский

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Endothelial Glycocalyx and Cardiomyocyte Damage Is Prevented by Recombinant Syndecan-1 in Acute Myocardial Infarction

American Journal Of Pathology, Journal Year: 2023, Volume and Issue: 193(4), P. 474 - 492

Published: Jan. 18, 2023

Language: Английский

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Serum malondialdehyde levels at admission as a predictor of inhospital mortality in patients with acute coronary syndrome

Coronary Artery Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Introduction and objective Malondialdehyde (MDA) is a predictive marker of cardiovascular events in patients with stable angina pectoris. However, there limited information available regarding this acute coronary syndrome (ACS). The aim the study was to explore association MDA levels inhospital mortality among ACS. Materials Methods sample consisted 556 ACS patients. leftover plasma samples collected EDTA vials for troponin T estimation within 24 h chest pain were used analysis. Blood into tubes MDA, nitric oxide (NO), inducible synthase (i-NOS), endothelial (e-NOS), total sialic acid (TSA), NT-proBNP, ANP, homocysteine, cardiac I (cTnI). blood centrifuged (4000 g , 4 °C) 10 min, obtained serum then kept at −25 °C until analyses carried out. relationship between these markers investigated. Results Univariate logistic regression analysis revealed significant correlations sex, age, creatine, cTnI, NO, e-NOS, i-NOS, TSA. Further variables using multivariate indicated that NT-proBNP independent predictors. Optimal cutoff value >33.1 predicted 85% sensitivity 88.17% specificity [AUC: 0.905 (95% CI: 0.878–0.928, P < 0.001)]. Conclusion We demonstrated elevated cases optimal specificity.

Language: Английский

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