The Regulation of Ferroptosis by Noncoding RNAs DOI Open Access
Xiangnan Zheng, Cen Zhang

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13336 - 13336

Published: Aug. 28, 2023

As a novel form of regulated cell death, ferroptosis is characterized by intracellular iron and lipid peroxide accumulation, which different from other death forms morphologically, biochemically, immunologically. Ferroptosis metabolism, antioxidant defense systems as well various transcription factors related signal pathways. Emerging evidence has highlighted that associated with many physiological pathological processes, including cancer, neurodegeneration diseases, cardiovascular ischemia/reperfusion injury. Noncoding RNAs are group functional RNA molecules not translated into proteins, can regulate gene expression in manners. An increasing number studies have shown noncoding RNAs, especially miRNAs, lncRNAs, circRNAs, interfere the progression modulating ferroptosis-related genes or proteins directly indirectly. In this review, we summarize basic mechanisms regulations focus on recent mechanism for types ncRNAs to conditions, will deepen our understanding regulation provide new insights employing ferroptosis-associated therapeutic strategies.

Language: Английский

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases DOI Creative Commons
Yumin Wang, Jing Hu, Shuang Wu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Dec. 10, 2023

Abstract Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other modes, plays pivotal role in regulating tumorigenesis offers new opportunity for modulating anticancer drug resistance. Aberrant epigenetic modifications posttranslational (PTMs) promote resistance, cancer progression, metastasis. Accumulating studies indicate that can transcriptionally translationally determine vulnerability to ferroptosis functions as driver nervous system diseases (NSDs), cardiovascular (CVDs), liver diseases, lung kidney diseases. In this review, we first summarize the core molecular mechanisms ferroptosis. Then, roles processes, including histone PTMs, DNA methylation, noncoding RNA regulation such phosphorylation, ubiquitination, SUMOylation, acetylation, ADP-ribosylation, are concisely discussed. The PTMs genesis cancers, NSD, CVDs, well application PTM modulators therapy these then discussed detail. Elucidating mediated by will facilitate development promising combination therapeutic regimens containing or PTM-targeting agents inducers be used overcome chemotherapeutic resistance could prevent addition, highlight potential approaches chemoresistance halt

Language: Английский

Citations

77
Zooming in and out of ferroptosis in human disease DOI
Xue Wang, Ye Zhou, Junxia Min

et al.

Frontiers of Medicine, Journal Year: 2023, Volume and Issue: 17(2), P. 173 - 206

Published: April 1, 2023

Language: Английский

Citations

54
Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases DOI Open Access
Ying Liu, Wei Ding, Jianxun Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114993 - 114993

Published: June 9, 2023

Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality worldwide seriously threatens human health life. Cardiomyocyte death considered the pathological basis of various CVDs, including myocardial infarction, heart failure, aortic dissection. Multiple mechanisms, such as ferroptosis, necrosis, apoptosis, contribute cardiomyocyte death. Among them, ferroptosis an iron-dependent form programmed cell that plays vital role in physiological processes, from development aging immunity CVD. The dysregulation has been shown be closely associated with CVD progression, yet its underlying mechanisms are still not fully understood. In recent years, growing amount evidence suggests non-coding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular involved regulation thus affecting progression. Some ncRNAs also exhibit potential value biomarker and/or therapeutic target for patients this review, we systematically summarize findings on their We focus clinical applications diagnostic prognostic biomarkers well targets treatment. DATA AVAILABILITY: No new data were created or analyzed study. Data sharing applicable article.

Language: Английский

Citations

51
Ferroptosis mechanisms and regulations in cardiovascular diseases in the past, present, and future DOI Creative Commons

Wenxi Fang,

Saiyang Xie, Wei Deng

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: March 21, 2024

Abstract Cardiovascular diseases (CVDs) are the main that endanger human health, and their risk factors contribute to high morbidity a rate of hospitalization. Cell death is most important pathophysiology in CVDs. As one cell mechanisms, ferroptosis new form regulated (RCD) broadly participates CVDs (such as myocardial infarction, heart transplantation, atherosclerosis, failure, ischaemia/reperfusion (I/R) injury, atrial fibrillation, cardiomyopathy (radiation-induced cardiomyopathy, diabetes sepsis-induced cardiac doxorubicin-induced iron overload hypertrophic cardiomyopathy), pulmonary arterial hypertension), involving regulation, metabolic mechanism lipid peroxidation. This article reviews recent research on regulation its relationship with occurrence treatment CVDs, aiming provide ideas targets for clinical diagnosis by clarifying latest progress research. Graphical • The identification, development history characterization ferroptosis. role different subcellular organelles organelle-specific regulators includes metabolism, amino acid metabolism. cardiovascular cells diseases. efficacy pathological involved

Language: Английский

Citations

22
Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications DOI Open Access
Yuhan Qin, Yong Qiao, Dong Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 141, P. 111872 - 111872

Published: July 7, 2021

Ferroptosis is a type of regulated cell death driven by iron dependent accumulation cellular reactive oxygen species (ROS) when glutathione (GSH)-dependent lipid peroxidation repair systems are compromised. Nuclear receptor co-activator 4 (NCOA4)-mediated selective autophagy ferritin, termed ferritinophagy, involves the regulation ferroptosis. Emerging evidence has revealed that ferritinophagy and ferroptosis exert significant role in occurrence development cardiovascular disease. In present review, we aimed to brief overview focusing on underlying mechanism regulations involved. We summarize discuss relevant research progress diseases accompanied with potential applications modulators treatment ferroptosis-associated diseases.

Language: Английский

Citations

95
The Link Between Ferroptosis and Cardiovascular Diseases: A Novel Target for Treatment DOI Creative Commons
Huilin Hu, Yunqing Chen,

Lele Jing

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2021, Volume and Issue: 8

Published: July 22, 2021

Ferroptosis is an iron-dependent cell death, which characterized by iron overload and lipid peroxidation. distinct from apoptosis, necroptosis, autophagy, other types of death in morphology function. regulated a variety factors controlled several mechanisms, including mitochondrial activity metabolism iron, lipid, amino acids. Accumulating evidence shows that ferroptosis closely related to majority cardiovascular diseases (CVDs), cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, heart failure, atherosclerosis. This review summarizes the current status discusses as potential therapeutic target for CVDs.

Language: Английский

Citations

79
ROS and iron homeostasis dependent ferroptosis play a vital role in 5-Fluorouracil induced cardiotoxicity in vitro and in vivo DOI
Dongning Li,

Chengzhu Song,

Jie Zhang

et al.

Toxicology, Journal Year: 2022, Volume and Issue: 468, P. 153113 - 153113

Published: Jan. 29, 2022

Language: Английский

Citations

52
Ferroptosis: A Potential Target in Cardiovascular Disease DOI Creative Commons

Yanlong Leng,

Xing Luo,

Jiaying Yu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 9

Published: Jan. 20, 2022

Ferroptosis is a new form of regulatory cell death characterized by iron-dependent and intracellular lipid peroxidation. can be divided into two stages. The first stage iron overload in the cell, which generates large amount reactive oxygen species through Fenton reaction, second results from an imbalance antioxidant system. Excessive phospholipid hydroperoxides cannot removed reduction reactions, as this could destroy membrane structure interfere with mitochondrial function, eventually leading to ferroptosis cell. Cardiovascular diseases have gradually become cause modern society. relationship between occurrence progression cardiovascular disease has research hotspot recent years. In review, we summarize mechanism its specific role disease.

Language: Английский

Citations

42
CircP4HB regulates ferroptosis via SLC7A11-mediated glutathione synthesis in lung adenocarcinoma DOI Open Access
Chunfeng Pan, Ke Wei, Zijian Ma

et al.

Translational Lung Cancer Research, Journal Year: 2022, Volume and Issue: 11(3), P. 366 - 380

Published: March 1, 2022

Circular ribonucleic acids (circRNAs) play a key role in the development of different types cancer. Ferroptosis is type programmed cell death that contributes to cancer progression. However, circRNAs lung adenocarcinoma (LUAD) ferroptosis remains unclear.The gene expression levels circRNA P4HB (circP4HB), microRNA-1184 (miR-1184) and Solute carrier family 7 member 11 (Slc7a11), also known as Xct were detected using quantitative real-time polymerase chain reaction (qRT-PCR). established LUAD cells was induced by erastin. Cell viability examined via Counting Kit 8 assays. evaluated malondialdehyde (MDA), Prostaglandin-endoperoxide Synthase 2 (Ptgs2), lipid reactive oxygen species (lipid ROS), JC-1 detection. The mechanism circP4HB/miR-1184/SLC7A11 investigated luciferase reporter assays, RNA immunoprecipitation, pull-down, western blot A functional for circP4HB vivo determined xenograft nude mice models.CircP4HB increased LUAD. It triggered glutathione (GSH) synthesis and, therefore protected from CircP4HB may function competing endogenous modulating miR-1184 regulate SLC7A11. inhibited regulating miR-1184/ SLC7A11-mediated GSH synthesis. In vivo, overexpression promoted tumor growth ferroptosis.The circRNA, acts novel suppressor Furthermore, protects modulation miR-1184/SLC7A11 axis. Our findings identified biomarker warrants further investigation early diagnosis treatment

Language: Английский

Citations

40
circRNA circSnx12 confers Cisplatin chemoresistance to ovarian cancer by inhibiting ferroptosis through a miR-194-5p/SLC7A11 axis DOI Creative Commons

Kaiyun Qin,

Fenghua Zhang, Hongxia Wang

et al.

BMB Reports, Journal Year: 2023, Volume and Issue: 56(7), P. 416 - 416

Published: Jan. 27, 2023

Ovarian cancer (OC) is the most common gynecological malignancy worldwide, and chemoresistance occurs in patients, resulting treatment failure. A better understanding of molecular processes underlying drug resistance crucial for development efficient therapies to improve OC patient outcomes. Circular RNAs (circRNAs) ferroptosis play roles tumorigenesis chemotherapy. However, little known about role(s) circRNAs regulating OC. To gain insights into cisplatin OC, we studied ferroptosis-associated circRNA circSnx12. We evaluated circSnx12 expression cell lines tissues that were susceptible or resistant using quantitative real-time PCR. also conducted vitro vivo assays examining function mechanism lnc-LBCSs. Knockdown rendered cisplatin-resistant cells more sensitive by activating ferroptosis, which was at least partially abolished downregulation miR-194-5p. Molecular mechanics studies indicate can be a sponge miR-194-5p, targets SLC7A11. According our findings, ameliorates blocking via miR-194-5p/SLC7A11 pathway. CircARNT2 may thus serve as an effective therapeutic target overcoming [BMB Reports 2023; 56(3): 184-189].

Language: Английский

Citations

34