Emerging role and clinical applications of circular RNAs in human diseases

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 28, 2025

Language: Английский

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Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114817 - 114817

Published: May 2, 2023

Cardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem have high morbidity mortality worldwide, as well substantial health economic burdens, representing urgent clinical need. In recent years, the focus of research has shifted from use mesenchymal stem cells (MSCs) for transplantation to their secretory exosomes (MSC-exosomes) treatment numerous CVDs, including atherosclerosis, myocardial infarction (MI), heart failure (HF), ischemia/reperfusion (I/R), aneurysm, stroke. MSCs are pluripotent with multiple differentiation pathways that exert pleiotropic effects by producing soluble factors, most effective components which exosomes. MSC-exosomes considered be excellent promising cell-free therapy CVDs due higher circulating stability, improved biocompatibility, reduced toxicity, immunogenicity. addition, play critical roles in repairing inhibiting apoptosis, regulating inflammation, ameliorating cardiac remodeling, promoting angiogenesis. Herein, we describe knowledge about biological characteristics MSC-exosomes, investigate mechanism mediate therapeutic repair, summarize advances efficacy a view toward future applications.

Language: Английский

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Circular RNAs in Cardiovascular Diseases: Regulation and Therapeutic Applications

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

Cardiovascular disease is one of the leading causes mortality worldwide. Recent studies have shown that circular RNAs (circRNAs) emerged as important players in prevention and treatment cardiovascular diseases. circRNAs are a class endogenous noncoding generated by back-splicing involved many pathophysiological processes. In this review, we outline current research progress on regulatory roles Further, new technologies methods available for identifying, validating, synthesizing, analyzing circRNAs, well their applications therapeutics, highlighted here. Moreover, summarize increasing insights into potential use circulating diagnostic prognostic biomarkers. Finally, discuss prospects challenges circRNA therapeutic therapy, with particular focus developing synthesis engineering delivery systems.

Language: Английский

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Clinical Significance of MicroRNAs, Long Non-Coding RNAs, and CircRNAs in Cardiovascular Diseases

Cells, Journal Year: 2023, Volume and Issue: 12(12), P. 1629 - 1629

Published: June 14, 2023

Based on recent research, the non-coding genome is essential for controlling genes and genetic programming during development, as well health cardiovascular diseases (CVDs). The microRNAs (miRNAs), lncRNAs (long ncRNAs), circRNAs (circular RNAs) with significant regulatory structural roles make up approximately 99% of human genome, which does not contain proteins. Non-coding RNAs (ncRNA) have been discovered to be novel regulators risk factors cellular processes, making them prospects advanced diagnostics prognosis evaluation. Cases CVDs are rising due limitations in current therapeutic approach; most treatment options based coding transcripts that encode Recently, various investigations shown role nc-RNA early diagnosis CVDs. Furthermore, development diagnoses treatments miRNAs, lncRNAs, could more helpful clinical management patients classified into types heart diseases, including cardiac hypertrophy (CH), failure (HF), rheumatic disease (RHD), acute coronary syndrome (ACS), myocardial infarction (MI), atherosclerosis (AS), fibrosis (MF), arrhythmia (ARR), pulmonary arterial hypertension (PAH). Here, we discuss biological importance their expression profiles manipulation CVDs, will deliver an in-depth knowledge ncRNAs progressing new treatment.

Language: Английский

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The potential role and mechanism of circRNAs in Ferroptosis: A comprehensive review

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155203 - 155203

Published: Feb. 9, 2024

Language: Английский

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Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFκB pathway

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 6, 2023

Abstract Esophageal squamous cell carcinoma (ESCC) is characterized by high morbidity and mortality. Circular RNAs (circRNAs) play an important role in tumor progression. We discovered aberrantly expressed circRNA (hsa_circ_0021727) patients with ESCC. However, the mechanism of action hsa_circ_0021727 tumors unclear. The present study aimed to investigate biological its ESCC screened for expression patients. Patients had shorter survival than those low expression. Hsa_circ_0021727 promoted proliferation, invasion, migration cells. miR-23b-5p inhibited this ability hsa_circ_0021727. MiR-23b-5p acts targeting TAK1-binding protein 1 (TAB1). Upregulation TAB1 can activate nuclear factor kappa B (NFκB) pathway. progression activating TAB1/NFκB pathway sponging miR-23b-5p. In addition, vivo experiments also confirmed that could promote short, promotes These findings might provide potential targets treat

Language: Английский

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Circ_0008146 Exacerbates Ferroptosis via Regulating the miR-342-5p/ACSL4 Axis After Cerebral Ischemic/Reperfusion

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 4957 - 4973

Published: July 1, 2024

Purpose: Acute ischemic stroke (AIS) has seriously threatened people's health worldwide and there is an urge need for early diagnosis effective treatment of AIS. This research intended to clarify the regulatory role circ_0008146/miR-342-5p/ACSL4 axis in Methods: High-throughput small RNA sequencing analysis was adapted identify differentially expressed miRNAs between AIS control group. The circ_0008146, miR-342-5p, ACSL4 levels were detected by qRT-PCR. Middle cerebral artery occlusion/reperfusion (MCAO/R) models constructed C57BL/6J mice. Assay kits used determine Fe 2+ a battery oxidative stress lipid peroxidation indicators, including ROS, MDA, LPO, SOD GSH/GSSG ratio. protein measured Western blot. behavioral function assessed using neurobehavioral tests. TTC staining employed visualize infarction size. Nissl detect histopathological changes. Receiver operating characteristic curve correlation applied investigate clinical value association miR-342-5p ACSL4. Results: A total 44 patients 49 healthy controls enrolled our study. unveiled significant decrease patients. MiR-342-5p inhibited RSL3-induced ferroptosis after ischemic/reperfusion injury vivo targeting ferroptosis-related gene Circ_0008146 acted as sponge overexpression circ_0008146 increased neurological deficits brain contributed via sponging regulate Plasma demonstrated good diagnostic Conclusion: study provides first evidence show that exacerbates neuronal miR-342-5p/ACSL4 axis. Furthermore, holds promise viable therapeutic target practical biomarkers Keywords: stroke, miRNA, circRNA, ferroptosis, biomarker

Language: Английский

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Circular RNA ITCH: An Emerging Multifunctional Regulator

Biomolecules, Journal Year: 2022, Volume and Issue: 12(3), P. 359 - 359

Published: Feb. 24, 2022

In the last decade, numerous circRNAs were discovered by virtue of RNA-Seq technique. With deepening experimental research, have brought to light key biological functions and progression human diseases. CircRNA ITCH has been demonstrated be a tumor suppressor in cancers, recently it was found play an important role bone diseases, diabetes mellitus, cardiovascular However, circ-ITCH not completely understood. this review, we comprehensively provide conceptual framework elucidate cell proliferation, apoptosis differentiation, pathological mechanisms inflammation, drug resistance/toxicity, tumorigenesis. Finally, summarize its clinical applications various This research aimed at clarifying circ-ITCH, which could promising therapeutic target.

Language: Английский

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The Targeting of Noncoding RNAs by Quercetin in Cancer Prevention and Therapy

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 15

Published: May 24, 2022

The dietary flavonoid quercetin is ubiquitously distributed in fruits, vegetables, and medicinal herbs. Quercetin has been a focal point recent years due to its versatile health-promoting benefits high pharmacological values. It well documented that exerts anticancer actions by inhibiting cell proliferation, inducing apoptosis, retarding the invasion metastasis of cancer cells. However, exact mechanism quercetin-mediated chemoprevention still not fully understood. With advances high-throughput sequencing technologies, intricate oncogenic signaling networks have gradually characterized. Increasing evidence on close association between noncoding RNA (ncRNAs) etiopathogenesis emphasizes potential ncRNAs as promising molecular targets for treatment. Available experimental studies indicate can dominate multiple cancer-associated ncRNAs, hence repressing carcinogenesis development. Thus, modulation serves key responsible effects quercetin. In this review, we focus chemopreventive pathogenesis targeting cancer-relevant supporting viewpoint holds promise drug candidate chemotherapy. An in-depth comprehension interplay inhibition development progression will raise possibility developing bioactive compound an agent could be highly efficacious safe clinical practice.

Language: Английский

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Fertilizer-responsive non-coding RNA and their significance

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 77 - 97

Published: Jan. 1, 2025

Language: Английский

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