Current Problems in Cardiology, Journal Year: 2023, Volume and Issue: 49(3), P. 102128 - 102128
Published: Oct. 5, 2023
Language: Английский
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: March 21, 2024
Cardiac fibrosis is a major and complex pathophysiological process that ultimately culminates in cardiac dysfunction heart failure. This phenomenon includes not only the replacement of damaged tissue by fibrotic scar produced activated fibroblasts/myofibroblasts but also spatiotemporal alteration structural, biochemical, biomechanical parameters ventricular wall, eliciting reactive remodeling process. Though mechanical stress, post-infarct homeostatic imbalances, neurohormonal activation are classically attributed to fibrosis, emerging evidence supports roles immune system modulation, inflammation, metabolic dysregulation initiation progression fibrogenesis has been reported. Adaptive changes, cell phenoconversions, shifts nonmyocyte population provide initial protection, persistent altered demand eventually contributes adverse heart. Altered energy metabolism, mitochondrial dysfunction, various cells, mediators, cross-talks between cells cardiomyocytes play crucial orchestrating transdifferentiation fibroblasts ensuing Manipulation plasticity, fibroblast–myofibroblast transition, modulation response may hold promise for favorably modulating following different cardiovascular pathological processes. Although immunologic perspectives being reported literature, they lack comprehensive sketch bridging these two arenas illustrating synchrony them. review aims overview intricate relationship pathways as well summarizes current understanding involvement immune–metabolic attempts identify some previously unaddressed questions require further investigation. Moreover, potential therapeutic strategies pharmacological interventions, including modulators, show preventing or attenuating restoring function will be discussed.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6389 - 6389
Published: June 9, 2024
Long COVID (LC), also referred to as Post COVID-19 Condition, Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), and other terms, represents a complex multisystem disease persisting after the acute phase COVID-19. Characterized by myriad symptoms across different organ systems, LC presents significant diagnostic management challenges. Central disorder is role low-grade inflammation, non-classical inflammatory response that contributes chronicity diversity observed. This review explores pathophysiological underpinnings LC, emphasizing importance inflammation core component. By delineating pathogenetic relationships clinical manifestations this article highlights necessity for an integrated approach employs both personalized medicine standardized protocols aimed at mitigating long-term consequences. The insights gained not only enhance our understanding but inform development therapeutic strategies could be applicable chronic conditions with similar features.
Language: Английский
Citations
8
Cells, Journal Year: 2022, Volume and Issue: 11(2), P. 240 - 240
Published: Jan. 11, 2022
The incidence and prevalence of diabetes mellitus (DM) are increasing worldwide, the resulting cardiac complications leading cause death. Among these is diabetes-induced cardiomyopathy (DCM), which consequence a pro-inflammatory condition, oxidative stress fibrosis caused by hyperglycemia. Cardiac remodeling will lead to an imbalance in cell survival death, can promote dysfunction. Since conventional treatment DM generally does not address prevention remodeling, it important develop new alternatives for cardiovascular induced DM. Thus, therapy with mesenchymal stem cells has been shown be promising approach DCM because their anti-apoptotic, anti-fibrotic anti-inflammatory effects, could improve function patients
Language: Английский
Citations
23
Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 442 - 442
Published: Feb. 2, 2023
Heart failure with preserved ejection fraction (HFpEF) is a disease for which there no definite and effective treatment, the number of patients more than 50% heart (HF) patients. Gut microbiota (GMB) general term group living in humans’ intestinal tracts, has been proved to be related cardiovascular diseases, including HFpEF. In HFpEF patients, composition GMB significantly changed, tendency toward dysbacteriosis. Metabolites GMB, such as trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs) bile (BAs) mediate various pathophysiological mechanisms crucial influential factor inflammation, considered one main causes The role its important comorbidity—metabolic syndrome—also mediates Moreover, HF would aggravate barrier impairment microbial translocation, further promoting progression. view these mechanisms, drugs targeting may ways treat This review focuses on interaction analyzes potential therapies.
Language: Английский
Citations
14
Cancers, Journal Year: 2023, Volume and Issue: 15(2), P. 512 - 512
Published: Jan. 13, 2023
Anthracyclines form the backbone of many systemic chemotherapy regimens but are accompanied by dose-limiting cardiotoxicity. We elucidate progression and severity cardiac function over time, in absence cardioprotection, which less is known about.
Language: Английский
Citations
12
Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)
Published: Nov. 13, 2023
Metabolic cardiomyopathy (MCM), characterized by intramyocardial lipid accumulation, drives the progression to heart failure with preserved ejection fraction (HFpEF). Although evidence suggests that mammalian silent information regulator 1 (Sirt1) orchestrates myocardial metabolism, it is unknown whether its exogenous administration could avoid MCM onset. We investigated chronic treatment recombinant Sirt1 (rSirt1) halt progression.db/db mice, an established model of MCM, were supplemented intraperitoneal rSirt1 or vehicle for 4 weeks and compared their db/ + heterozygous littermates. At end treatment, cardiac function was assessed ultrasound left ventricular samples collected processed molecular analysis. Transcriptional changes evaluated using a custom PCR array. Lipidomic analysis performed mass spectrometry. H9c2 cardiomyocytes exposed hyperglycaemia treated used as in vitro investigate ability directly target modulate malondialdehyde levels caspase 3 activity. Myocardial from diabetic nondiabetic patients analysed explore expression signaling pathways.rSirt1 restored performance improving fraction, fractional shortening diastolic (E/A ratio). In rSirt1-treated db/db modulated lipidome: medium long-chain triacylglycerols, triacylglycerols containing only saturated fatty acids reduced, while those docosahexaenoic acid increased. Mechanistically, several genes involved trafficking, metabolism inflammation, such Cd36, Acox3, Pparg, Ncoa3, Ppara downregulated both vivo. humans, reduced associated higher PPARG-related genes.In mouse supplementation rescued function. This modulation lipidome downregulation PPARG signaling. These findings confirmed human myocardium. Treatments increase may represent promising strategy prevent abnormalities development.
Language: Английский
Citations
11
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: Nov. 22, 2022
The incidence of heart failure with preserved ejection fraction is increasing in patients obesity, diabetes, hypertension, and the aging population. However, there a lack adequate clinical treatment. Patients obesity-related display unique pathophysiological phenotypic characteristics, suggesting that obesity could be one its specific phenotypes. There has been an recognition overnutrition causes adipose tissue expansion local systemic inflammation, which consequently exacerbates cardiac remodeling leads to development obese fraction. Furthermore, cellular metabolic reprogramming activates inflammatory signaling cascades various cells, thereby promoting maladaptive remodeling. Growing evidence indicates innate immune response pathway from NLRP3 inflammasome, interleukin-1 interleukin-6, involved generation inflammation This review established existence based on structural functional changes, elaborated mechanisms fraction, proposed inflammasome activation may play important role adiposity-induced summarized potential therapeutic approaches.
Language: Английский
Citations
18
Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: March 13, 2025
Heart failure with preserved left ventricular ejection fraction (HFpEF) is a disease that affects multiple organs throughout the body, accounting for over 50% of heart cases. HFpEF has significant impact on individuals’ life expectancy and quality life, but exact pathogenesis remains unclear. Emerging evidence implicates low-grade systemic inflammation as crucial role in onset progression HFpEF. Gut microbiota dysregulation associated metabolites alteration, including short-chain fatty acids, trimethylamine N-oxides, amino bile acids can exacerbate chronic inflammatory responses potentially contribute to In light these findings, we propose hypothesis “gut microbiota-inflammation-HFpEF axis”, positing interplay within this axis could be factor development This review focuses gut dysregulation-induced HFpEF’s etiology. It explores potential mechanisms linking cardiac dysfunction evaluates therapeutic restoring balance mitigating severity. The objective offer novel insights strategies management
Language: Английский
Citations
0
Journal of Multidisciplinary Healthcare, Journal Year: 2025, Volume and Issue: Volume 18, P. 1711 - 1719
Published: March 1, 2025
The relationship between a low TyG index and mortality risk in Acute Decompensated Heart Failure (ADHF) also remains unclear. This study aimed to investigate the association 1-year ADHF patients without diabetes. A total of 652 hospitalized with diabetes from January, 2020 May, 2023 were included this retrospective study. primary outcomes all-cause cardiovascular within one year. both was investigated using restricted cubic splines multivariate Cox proportional hazards models. enrolled acute decompensated heart failure who free (70.6% male). Within year, there 72 deaths all causes 40 disease. In models, significant negative observed (hazard ratio [HR] = 0.371, 95% confidence interval [CI] 0.201-0.685) (HR 0.336, CI 0.151-0.744). spline analysis illustrated decrease as increased. Hypertension, BMI, age, atrial fibrillation significantly interacted relation mortality, while hypertension specifically regarding mortality. diagnosed diabetes, lower is strongly related higher Therefore, it important pay close attention levels implement appropriate measures clinical practice.
Language: Английский
Citations
0