SARS-CoV-2 and the spike protein in endotheliopathy

Trends in Microbiology, Journal Year: 2023, Volume and Issue: 32(1), P. 53 - 67

Published: June 12, 2023

Language: Английский

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Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+β7 integrin+ T cells and anti-SARS-CoV-2 IgA response

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 30, 2023

Abstract Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2 condition (PASC) that persists for months after infection. Here we evaluate the immune response in convalescent with PASC compared asymptomatic and uninfected participants, six following their COVID-19 diagnosis. Both cases characterised by higher CD8 + T cell percentages, however, proportion blood cells expressing mucosal homing receptor β7 is low patients. show increased expression PD-1, perforin granzyme B PASC, plasma levels type I III (mucosal) interferons elevated. The humoral characterized IgA against N S viral proteins, particularly those who had severe acute disease. Our results also consistently elevated IL-6, IL-8/CXCL8 IP-10/CXCL10 during disease increase risk PASC. In summary, our study indicates defined persisting immunological dysfunction as late infection, including alterations parameters, redistribution β7Integrin IgA, indicative potential persistence involvement etiopathology

Language: Английский

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Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation

Angiogenesis, Journal Year: 2023, Volume and Issue: 26(4), P. 547 - 563

Published: July 28, 2023

Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in high impact on the daily life of patients. Understanding pathophysiology PCS public health priority, it still poses diagnostic treatment challenge for physicians.In this prospective observational cohort study, we analyzed retinal microcirculation using Retinal Vessel Analysis (RVA) patients compared to an age- gender-matched healthy (n = 41, matched out n 204).PCS exhibit persistent endothelial dysfunction (ED), indicated by significantly lower venular flicker-induced dilation (vFID; 3.42% ± 1.77% vs. 4.64% 2.59%; p 0.02), narrower central artery equivalent (CRAE; 178.1 [167.5-190.2] 189.1 [179.4-197.2], 0.01) arteriolar-venular ratio (AVR; (0.84 [0.8-0.9] 0.88 [0.8-0.9], 0.007). When combining AVR vFID, predicted scores reached good ability discriminate groups (area under curve: 0.75). Higher severity correlated (R - 0.37 0.017). The association microvascular changes were amplified exhibiting higher levels inflammatory parameters.Our results demonstrate that prolonged hallmark PCS, impairments seem explain As potential therapies emerge, RVA parameters may become relevant clinical biomarkers diagnosis therapy management.This study was previously registered at ClinicalTrials ("All Eyes PCS-Analysis Microvasculature Patients Syndrome". NCT05635552. https://clinicaltrials.gov/ct2/show/NCT05635552 ). Persistent post-COVID-19 syndrome. Acute SARS-CoV-2 infection indirectly or directly causes endotheliitis N 41 recruited vessel analysis performed assess function. Images SVA DVA are illustrative data analysis. For each patient cohort, diameter three measurement cycles calculated plotted diameter-time curve. exhibited reduced veins (vFID) measured dynamic (DVA) arteriolar (CRAE) (AVR) tendency towards (CRVE) when naïve participants. Created BioRender.com.

Language: Английский

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Clinical improvement of Long-COVID is associated with reduction in autoantibodies, lipids, and inflammation following therapeutic apheresis

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(7), P. 2872 - 2877

Published: May 2, 2023

Abstract In the aftermath of COVID-19 pandemic, we are witnessing an unprecedented wave post-infectious complications. Most prominently, millions patients with Long-Covid complain about chronic fatigue and severe post-exertional malaise. Therapeutic apheresis has been suggested as efficient treatment option for alleviating mitigating symptoms in this desperate group patients. However, little is known mechanisms biomarkers correlating outcomes. Here, have analyzed different cohorts specific before after therapeutic apheresis. that reported a significant improvement following two cycles apheresis, there was reduction neurotransmitter autoantibodies, lipids, inflammatory markers. Furthermore, observed 70% fibrinogen, erythrocyte rouleaux formation fibrin fibers largely disappeared demonstrated by dark field microscopy. This first study demonstrating pattern clinical patient group. It may therefore form basis more objective monitoring score other postinfectious syndromes.

Language: Английский

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Overview of autoantibodies in COVID‐19 convalescents

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(6)

Published: June 1, 2023

Abstract Accumulating evidence shows that SARS‐CoV‐2 can potentially trigger autoimmune processes, which be responsible for the long‐term consequences of COVID‐19. Therefore, this paper aims to review autoantibodies reported in COVID‐19 convalescents. Six main groups were distinguished: (i) against components immune system, (ii) cardiovascular (iii) thyroid autoantibodies, (iv) specific rheumatoid diseases, (v) antibodies G‐protein coupled receptors, and (vi) other autoantibodies. The reviewed here clearly highlights infection may induce humoral responses. However, available studies share number limitations, such as: (1) sole presence does not necessarily implicate clinically‐relevant risks, (2) functional investigations rarely performed it is often unknown whether observed are pathogenic, (3) control seroprevalence, healthy, noninfected individuals was reported; thus sometimes detected result or accidental post‐COVID‐19 detection, (4) correlated with symptoms syndrome, (5) size studied small, (6) focused predominantly on adult populations, (7) age‐ sex‐related differences seroprevalence explored, (8) genetic predispositions involved generation during infections investigated, (9) reactions following variants vary clinical course remain unexplored. Further longitudinal advocated assess link between identified particular outcomes

Language: Английский

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