Biomedical Engineering Letters, Journal Year: 2023, Volume and Issue: 14(2), P. 245 - 254
Published: Dec. 4, 2023
Language: Английский
Cardiovascular Research, Journal Year: 2024, Volume and Issue: unknown
Published: July 31, 2024
Atherosclerosis remains the leading cause of death globally. Although its focal pathology is atheroma that develops in arterial walls, atherosclerosis a systemic disease involving contributions by many organs and tissues. It now established immune system causally contributes to all phases atherosclerosis. Recent emerging evidence positions nervous as key modulator inflammatory processes underly This neuro-immune crosstalk, we are learning, bidirectional, regulated afferent signaling becoming increasingly recognized Here, summarize data concepts link systems focusing on two important sites, vessel bone marrow.
Language: Английский
Citations
2
Journal of Neural Engineering, Journal Year: 2022, Volume and Issue: 19(6), P. 066031 - 066031
Published: Nov. 10, 2022
Objective.Vagus nerve stimulation (VNS) is a promising approach for the treatment of wide variety debilitating conditions, including autoimmune diseases and intractable epilepsy. Much remains to be learned about molecular mechanisms involved in vagus regulation organ function. Despite an abundance well-characterized rodent models common chronic diseases, currently available technologies are rarely suitable required long-term experiments freely moving animals, particularly experimental mice. Due challenging anatomical limitations, many relevant require miniaturized, less invasive, wireless devices precise other peripheral nerves interest. Our objective outline possible solutions this problem by using nongenetic light-based stimulation.Approach.We describe how design benchmark new microstimulation that based on transcutaneous photovoltaic stimulation. The use wired multielectrode cuffs test different patterns, then build stimulators generate most optimal patterns. We validate through heart rate analysis.Main results.A range geometries explored with large differences performance. Two types fabricated deliver stimulation: photocapacitors flags. former simple more compact, but has limited efficiency. flag elaborate, highly efficient. Both can used actuation light impulses.Significance.These approaches enable studies small animals were previously challenging, such as long-termin vivostudies mapping functional innervation. This knowledge may have potential support clinical translation VNS select inflammatory neurologic diseases.
Language: Английский
Citations
11
Journal of Cardiology, Journal Year: 2023, Volume and Issue: 83(5), P. 318 - 322
Published: Dec. 21, 2023
Language: Английский
Citations
5
Annals of Translational Medicine, Journal Year: 2022, Volume and Issue: 10(24), P. 1314 - 1314
Published: Dec. 1, 2022
Background: Parkinson's disease (PD) is a common movement disorder disease. Left vagus nerve stimulation (LVNS) potential treatment option for PD. Compared with the left nerve, right more closely connected midbrain dopaminergic neurons, which are lesion locations of However, whether (RVNS) has therapeutic effect on PD not yet been studied. Therefore, in this study, we studied and underlying mechanism RVNS using rat model.
Language: Английский
Citations
8
IEEE Journal of Biomedical and Health Informatics, Journal Year: 2023, Volume and Issue: 28(3), P. 1285 - 1296
Published: Dec. 18, 2023
Motor learning plays a crucial role in human life, and various neuromodulation methods have been utilized to strengthen or improve it. Transcutaneous auricular vagus nerve stimulation (taVNS) has gained increasing attention due its non-invasive nature, affordability ease of implementation. Although the potential taVNS on regulating motor suggested, actual regulatory effect yet fully explored. Electroencephalogram (EEG) analysis provides an in-depth understanding cognitive processes involved so as offer methodological support for regulation learning. To investigate learning, this study recruited 22 healthy subjects participate single-blind, sham-controlled, within-subject serial reaction time task (SRTT) experiment. Every subject two sessions at least one week apart received 20-minute active/sham each session. Behavioral indicators well EEG characteristics during state, were extracted analyzed. The results revealed that compared sham group, active group showed higher performance. Additionally, indicated after taVNS, motor-related cortical amplitudes alpha-gamma modulation index decreased significantly functional connectivity based partial directed coherence towards frontal lobe was enhanced. These findings suggest can mainly through enhancing memory functions rather than simple movement This confirms positive which is particularly promising it offers avenue skills facilitating rehabilitation.
Language: Английский
Citations
4
Healthcare, Journal Year: 2023, Volume and Issue: 12(1), P. 31 - 31
Published: Dec. 22, 2023
Studies suggest non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) as a potential therapeutic option for various pathological conditions, such epilepsy and depression. Exhalation-controlled taVNS, which synchronizes with internal body rhythms, holds promise enhanced neuromodulation, but there is no closed-loop system in the literature capable of performing integration real time. In this context, objective was to develop real-time signal processing techniques an integrated device sensors acquire physiological data. After conditioning stage, processed delivers synchronized electrical during patient’s expiratory phase. Additional modules were designed processing, software-controlled selectors, remote autonomous operation, improved analysis, graphical visualization. The method effectively extracted respiratory cycles successfully attenuated noise. Heart rate variability assessed time, using linear statistical evaluation. prototype feedback stimulator physically constructed. Respiratory peak detection achieved accuracy 90%, resulted small delay up 150 ms Thus, preliminary results show promising accuracy, indicating need additional tests optimize application clinical studies.
Language: Английский
Citations
4
IEEE Transactions on Antennas and Propagation, Journal Year: 2024, Volume and Issue: 72(9), P. 6908 - 6918
Published: Aug. 1, 2024
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: April 24, 2024
Implantable neural interfaces with the central and peripheral nervous systems are currently used to restore sensory, motor, cognitive functions in disabled people very promising results. They have also been modulate autonomic activities treat diseases such as diabetes or hypertension. Here, this study proposes extend use of these technologies (re-)establish connection between new (transplanted artificial) organs system order increase long-term efficacy effective biointegration solutions. In perspective paper, some clinically relevant applications approach briefly described. Then, choices that engineers must implement about type, implantation location, closed-loop control algorithms successfully realize highlighted. It is believed "organ neuroprostheses" going become more valuable solutions years come.
Language: Английский
Citations
1
Journal of Neural Engineering, Journal Year: 2022, Volume and Issue: 19(4), P. 046033 - 046033
Published: July 27, 2022
Objective.Bioelectronic medicine is an emerging field that aims at developing closed-loop neuromodulation protocols for the autonomic nervous system (ANS) to treat a wide range of disorders. When designing protocol real time modulation ANS, computational execution and memory power demands decoding step are important factors consider. In context cardiovascular respiratory diseases, these requirements may partially explain why clinical adapt stimulation parameters on patient's characteristics currently missing.Approach.Here, we developed lightweight learning-based decoder classification functional challenges from neural signals acquired through intraneural electrodes implanted in cervical vagus nerve (VN) five anaesthetized pigs. Our algorithm based signal temporal windowing, nine handcrafted features, random forest (RF) model classification. Temporal windowing ranging 50 ms 1 s, compatible duration with cardio-respiratory dynamics, was applied data order mimic pseudo real-time scenario.Main results.We were able achieve high balanced accuracy (BA) values over whole duration. We identified 500 as optimal both BA processing, achieving more than 86% only ∼6.8 ms. outperformed terms state art tested same dataset (Valloneet al2021J. Neural Eng.180460a2). found RF other machine learning models such support vector machines, K-nearest neighbors, multi-layer perceptrons.Significance.Our approach could represent towards implementation relying single interface perform tasks selective VN.
Language: Английский
Citations
5
DO - Deutsche Zeitschrift für Osteopathie, Journal Year: 2024, Volume and Issue: 22(02), P. 25 - 33
Published: March 27, 2024
Interozeptive Afferenzen vermitteln dem Gehirn den Zustand des „inneren Milieus“, das geeignete Reaktionen einleitet, um die Homöostase zu sichern bzw. ihre Störung allostatisch korrigieren. In diesem Artikel wird u. a. Möglichkeit diskutiert, dass Interozeptoren auch zwischen Brust- und Bauchorganen wirkenden Adhäsionskräfte detektieren deren zentralnervöse Integration wesentlich zum Bewusstsein unseres „materiellen Selbst“ beiträgt. Osteopathische viszerale Techniken greifen in dieses Kräftespiel ein beeinflussen so Interozeption Patienten.
Citations
0