International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113548 - 113548
Published: Nov. 2, 2024
Language: Английский
Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
1
BMC Pharmacology and Toxicology, Journal Year: 2025, Volume and Issue: 26(1)
Published: Feb. 12, 2025
Language: Английский
Citations
1
Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 218, P. 115909 - 115909
Published: Nov. 4, 2023
Language: Английский
Citations
22
Cells, Journal Year: 2023, Volume and Issue: 12(6), P. 838 - 838
Published: March 8, 2023
Melatonin is a neurohormone that mainly secreted by the pineal gland. It coordinates work of superior biological clock and consequently affects many processes in human body. Disorders waking sleeping period result nervous system imbalance generate metabolic endocrine derangements. The purpose this review to provide information regarding potential benefits melatonin use, particularly kidney diseases. impact on cardiovascular system, diabetes, homeostasis causes be indirectly connected function quality life people with chronic disease. Moreover, there are numerous reports showing plays role as an antioxidant, free radical scavenger, cytoprotective agent. This means supplementation can helpful almost every type injury because inflammation, apoptosis, oxidative stress occur, regardless mechanism. administration has renoprotective effect inhibits progression complications renal failure. very important exogenous well tolerated number side effects caused treatment low.
Language: Английский
Citations
17
Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1163 - 1163
Published: Sept. 25, 2024
Precision medicine is envisioned as the future of cardiovascular healthcare, offering a more tailored and effective method for managing diseases compared to traditional one-size-fits-all approaches. The complex role oxidative stress in chronic within framework precision was carefully explored, delving into cellular redox status its critical involvement pathophysiological complexity (CVDs). review outlines mechanisms reactive oxygen species generation function antioxidants maintaining balance. It emphasizes elevated concentrations observed heart failure their detrimental impact on health. Various sources ROS system are examined, including mitochondrial dysfunction, which contributes DNA degradation. article also addresses stress's myocardial remodeling, process pivotal progression diseases. By integrating these aspects, underscores importance homeostasis identifies molecular biomarkers that can enhance therapy CVDs. insights provided aim pave way targeted therapeutic strategies mitigate stress, thereby improving patient outcomes medicine.
Language: Английский
Citations
6
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 166, P. 115305 - 115305
Published: Aug. 22, 2023
Septic cardiomyopathy (SCM) is a common complication of sepsis contributing to high mortality rates. Its pathophysiology involves complex factors, including inflammatory cytokines, mitochondrial dysfunction, oxidative stress, and immune dysregulation. Despite extensive research, no effective pharmacological agent has been established for sepsis-induced cardiomyopathy. Melatonin, hormone with diverse functions in the body, emerged as potential SCM through its anti-oxidant, anti-inflammatory, anti-apoptotic, cardioprotective roles. Through various molecular levels mechanism action, it counterattacks adverse event sepsis. Experimental studies have mentioned that melatonin protects against many cardiovascular diseases exerts preventive effects on SCM. Moreover, investigated combination other drugs such antibiotics, resveratrol, anti-oxidants showing synergistic reducing inflammation, improving cardiac function. While preclinical demonstrated positive results, clinical trials are required establish optimal dosage, route administration, treatment duration safety profile, low toxicity, natural occurrence human body provide favorable basis use. This review aims an overview current evidence use (SICM). Melatonin appears be promising possible demands further investigation.
Language: Английский
Citations
15
Antioxidants, Journal Year: 2023, Volume and Issue: 12(10), P. 1844 - 1844
Published: Oct. 10, 2023
The aim of this review is to explore the relationship between melatonin, free radicals, and non-excitatory amino acids, their role in stroke aging. Melatonin has garnered significant attention recent years due its diverse physiological functions potential therapeutic benefits by reducing oxidative stress, inflammation, apoptosis. been found mitigate ischemic brain damage caused stroke. By scavenging radicals damage, melatonin may help slow down aging process protect against age-related cognitive decline. Additionally, acids have shown possess neuroprotective properties, including antioxidant anti-inflammatory aging-related conditions. They can attenuate modulate calcium homeostasis, inhibit apoptosis, thereby safeguarding neurons induced processes. intracellular accumulation certain could promote harmful effects during hypoxia-ischemia episodes thus, blockade acid transporters involved be an alternative strategy reduce damage. On other hand, specifically mitochondrial reactive oxygen nitrogen species, accelerates cellular senescence contributes Recent research suggests a complex interplay actions converge on multiple pathways, regulation modulation reduction inflammation. These mechanisms collectively contribute preservation neuronal integrity functions, making them promising targets for interventions disorders.
Language: Английский
Citations
14
Neurourology and Urodynamics, Journal Year: 2024, Volume and Issue: 43(4), P. 826 - 839
Published: March 8, 2024
Abstract Aim Causes of nocturia may extend beyond primary bladder pathology and it has been commonly associated as a side effect sleep disorders. This led to the study melatonin receptor agonists treatment for hypothesized be secondary We aim systematically review efficacy reported safety in nocturia. Methods A search strategy EMBASE Pubmed/Medline databases was utilized identify eligible studies. Two thousand twenty‐eight unique references were identified concordance with Preferred Reporting Items Systematic Reviews Meta‐Analyses guidelines systematic reviews, which nine papers met inclusion criteria. The Cochrane Collaboration risk bias criteria open label nonplacebo studies used assess bias. Results included 3 randomized double‐blinded placebo‐controlled trials, 2 non‐placebo trial, 4 prospective open‐label trials. Three melatonin‐receptor agonist ramelteon (8 mg) six (four mg extended release, two normal release). Nocturia improved 8 varying from moderate low related reduction episodes. Five evaluated parameters finding improvement both quality. Male subjects represented 76.8% 371 total Ramelteon well tolerated during treatment. meta‐analysis not able performed due heterogeneity diagnoses. Conclusions At this time, there is insufficient evidence routinely recommend an effective given limitations current clinical Randomized trials non‐neurogenic populations report trend towards good tolerability rare effects. Therefore, further larger scale focused urologic diagnoses well‐characterized patient are warranted.
Language: Английский
Citations
5
Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)
Published: Sept. 23, 2024
Abstract The circadian clock is an evolutionarily conserved time-keeper that regulates physiological processes across 24 h. In the cardiovascular system, several parameters, such as blood pressure, heart rate, and metabolism, exhibit time-of-day variations. These features are in part driven by clock. Chronic perturbation of diurnal rhythmicity due to shift work or irregular social schedules has been associated with increased risk hypertension, arrhythmias, myocardial infarction. This review discusses impact rhythms on human health effect disruption occurrence adverse cardiac events. Additionally, we discuss how main factors diseases, obesity, sleep disorders, aging, affect rhythms. Finally, elaborate chronotherapy well targeting highlight novel approaches translate our scientific understanding into clinical practice.
Language: Английский
Citations
5
Metabolites, Journal Year: 2023, Volume and Issue: 13(3), P. 370 - 370
Published: March 1, 2023
Circadian rhythms are generated by the circadian clock, a self-sustained internal timing system that exhibits 24-h in body. Many metabolic, cellular, behavioral and physiological processes regulated clock coordination with environmental cues. The present study is comprehensive review of currently existing evidence concerning relationship between sleep, cardiovascular disorders. We thoroughly searched online databases PubMed, Scopus, Web Science to find clinical studies from last twenty-three years (2000–2023). misalignment was found be associated an increase risk metabolic disorders, diseases, obesity, as well inadequate sleep quality. In this article, all included had strength protocol design them were conducted on humans. However, most common limitations small sample size short time intervention. conclusion, managing factors disrupt optimal function central peripheral clocks can help reduce improving also Future should further explore underlying mechanisms interconnections This may provide new opportunities for advance chronotherapy approach.
Language: Английский
Citations
12