From multi-omics approaches to personalized medicine in myocardial infarction

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 30, 2023

Myocardial infarction (MI) is a prevalent cardiovascular disease characterized by myocardial necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe complications such as arrhythmia, cardiac rupture, heart failure, sudden death. Despite being research hotspot, the etiological mechanism of MI remains unclear. The emergence widespread use omics technologies, including genomics, transcriptomics, proteomics, metabolomics, other omics, have provided new opportunities for exploring molecular identifying large number biomarkers. However, single-omics approach has limitations in understanding complex biological pathways diseases. multi-omics reveal interaction network among molecules at various levels overcome approaches. This review focuses on studies MI, epigenomics, omics. exploration extended into domain integrative analysis, accompanied compilation diverse online resources, databases, tools conducive these investigations. Additionally, we discussed role prospects approaches personalized medicine, highlighting potential improving diagnosis, treatment, prognosis MI.

Language: Английский

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Zinc Finger Proteins in the War on Gastric Cancer: Molecular Mechanism and Clinical Potential

Cells, Journal Year: 2023, Volume and Issue: 12(9), P. 1314 - 1314

Published: May 4, 2023

According to the 2020 global cancer data released by World Cancer Research Fund (WCRF) International, gastric (GC) is fifth most common worldwide, with yearly increasing incidence and second-highest fatality rate in malignancies. Despite contemporary ambiguous molecular mechanisms GC pathogenesis, numerous in-depth studies have demonstrated that zinc finger proteins (ZFPs) are essential for development progression of GC. ZFPs a class transcription factors finger-like domains bind Zn2+ extensively participate gene replication, cell differentiation tumor development. In this review, we briefly outline roles, latest advances GC, including eight principal aspects, such as proliferation, epithelial–mesenchymal transition (EMT), invasion metastasis, inflammation immune infiltration, apoptosis, cycle, DNA methylation, stem cells (CSCs) drug resistance. Intriguingly, myeloid 1 (MZF1) possesses reversely dual roles promoting proliferation or impeding via apoptosis. Therefore, thorough understanding mechanism on will pave solid way screening potentially effective diagnostic indicators, prognostic biomarkers therapeutic targets

Language: Английский

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Epigenetics is involved in the pleiotropic effects of statins

Expert Opinion on Drug Metabolism & Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Statins have significantly reduced mortality from cardiovascular diseases by lowering serum cholesterol levels. Beyond their lipid-lowering effects, statins improve vascular function, reduce inflammation, decrease reactive oxygen species (ROS) formation, and stabilize atherosclerotic plaques. However, the mechanisms underlying these pleiotropic effects remain unclear. This narrative review summarizes discusses epigenetic that may explain part of statins. approach allows for a reevaluation statin use beyond its cholesterol-lowering benefits. A structured search was conducted in PubMed Scopus databases using specific terms, including articles published up to August 2024. The statins, those mediated isoprenoid pathway, partially clinical By inhibiting histone deacetylases (HDACs, "erasers") DNA methyltransferases (DNMTs, "writers"), promote increased acetylation methylation at gene promoter regions. These modifications enhance chromatin accessibility, facilitating transcription protecting system. Further investigation into could support repositioning broader therapeutic applications. extend role managing hypercholesterolemia, potentially becoming first-line treatment preventing disease-related mortality.

Language: Английский

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A review on regulation of DNA methylation during post-myocardial infarction

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 13, 2024

Myocardial infarction (MI) imposes a huge medical and economic burden on society, cardiac repair after MI involves complex series of processes. Understanding the key mechanisms (such as apoptosis, autophagy, inflammation, fibrosis) will facilitate further drug development patient treatment. Presently, substantial body evidence suggests that regulation epigenetic processes contributes to following MI, with DNA methylation being among notable factors involved. This article review research mechanism provide some insights for future related drugs.

Language: Английский

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KATP channels and cardioprotection

Arhiv za farmaciju, Journal Year: 2024, Volume and Issue: 74(5), P. 625 - 657

Published: Jan. 1, 2024

This review discusses ATP-sensitive potassium (KATP) channels, which connect intracellular energy metabolism to cellular electrical activity and play crucial roles in various physiological processes, particularly the pancreas cardiovascular system. KATP channels open when ATP levels decrease during metabolic stress, such as ischemia, helping protect heart from injury by maintaining membrane potential preventing calcium overload. These are found multiple cell types across system, influencing vascular tone cardiac excitability. The highlights need for further research into specific expression of channel subunits humans consequences ischemic events on their functionality. Additionally, it explores interplay between glycolysis suggesting that glycolytic can modulate while emphasizing cardioprotective effects events. openers (KCOs) therapeutic agents disease is noted, improving outcomes patients undergoing procedures. Challenges remain developing KCOs with minimal side effects, but advances precision medicine may enhance targeted therapies future. Overall, represent promising targets enhancing health.

Language: Английский

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Association between weight-adjusted waist circumference index and myocardial infarction: results from the national health and nutrition examination survey, 1999–2014

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 18, 2024

Background Weight-adjusted waist circumference index (WWI) is a novel related to obesity and has been associated with the risk prognosis of several diseases. The aim study was determine association between WWI myocardial infarction. Methods analyzed cross-sectional data from 31,535 participants derived 1999–2014 National Health Nutrition Examination Survey (NHANES) dataset. Multiple logistic regression restricted cubic spline (RCS) analyses were conducted assess both linear nonlinear associations Subgroup interaction tests also performed. Results Among analyzed, 1,449 (4.82%) had experienced fully adjusted models demonstrated positive infarction [odds ratio (OR) = 1.34, 95% confidence interval (CI): 1.13–1.58]. Individuals in highest quartile 81% more likely suffer compared those lowest (OR 1.81, CI: 1.24–2.63). analysis employing modeling indicated correlation 1.29 times higher when below 10.97 cm/√kg 2.29, 1.37–3.84). When exceeded cm/√kg, upward trend significantly slowed increasing 1.26, 95%CI:1.03–1.56). A threshold value greater than 11.15 identified for predicting infarction, outperforming body mass (BMI). revealed that impact on varied across different populations. Interaction significant interactions incidence age, hypertension, coronary heart disease, angina pectoris, stroke ( P <0.05), but not gender, race, obesity, diabetes, or prediabetes failure >0.05). Conclusions findings suggest there non-linear We recommend incorporating into routine physical examinations cardiovascular screening as an early warning mechanism. This may facilitate identification high-risk individuals promote earlier preventive interventions.

Language: Английский

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Gene expression patterns and related pathways in the hearts of rhesus monkeys subjected to prolonged myocardial ischemia

Experimental Biology and Medicine, Journal Year: 2023, Volume and Issue: 248(4), P. 350 - 360

Published: Feb. 1, 2023

After myocardial infarction (MI) occurs, progressive pathological cardiac remodeling results in heart dysfunction and even failure during the following months or years. The present study explored molecular mechanisms underlying late phase of MI at global transcript level. A rhesus monkey model ischemia induced by left anterior descending (LAD) artery ligation was established, tissue collected eight weeks after for transcriptome analysis DNA microarray technology. Differentially expressed genes core infarcted area remote ischemic were detected with significance (SAM), related pathways Gene Ontology (GO)/pathway analysis. We found that compared to sham condition, prolonged increased levels 941 transcripts, decreased 380 transcripts area, 8 tissue. Loss coordination between expression genes, including natriuretic peptide ( NPPA), NPPB, corin (Corin, serine peptidase), may aggravate remodeling. Furthermore, imbalance enriched significantly changed pathways, fibrosis-related cardioprotective systolic pathway, likely also plays a key role regulating development

Language: Английский

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