BMC Nephrology,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Jan. 3, 2024
Abstract
Background
Chronic
inflammatory
disorders
in
peritoneal
dialysis
(PD)
contribute
to
the
adverse
clinical
outcome.
Systemic
immune
inflammation
index
(SII)
is
novel
and
convenient
measurement
that
positively
associated
with
various
diseases.
However,
scarce
known
regarding
association
between
SII
all-cause
mortality
among
PD
patients.
Methods
In
this
multi-center
retrospective
cohort
study,
1,677
incident
patients
were
enrolled.
Eligible
stratified
into
groups
based
on
level:
tertile
1(<
456.76),
2(456.76
819.03),
3(>
819.03).
The
primary
endpoint
was
mortality.
Both
Cox
regression
analysis
competing
risk
models
used
examine
Subgroup
performed
assess
influence
of
tertiles
different
subgroups.
Results
During
follow-up
period
30.5
±
20.0
months,
26.0%
(437/1,677)
died,
whom
3
group
accounted
for
39.1%
(171/437)
deaths.
Patients
had
a
higher
rate
than
1
2
(log-rank
=
13.037,
P
<
0.001).
significantly
80%
greater
(95%
confidence
interval:1.13
2.85;
0.013)
compared
multivariable
analysis.
model
also
indicated
relationship
remains
(subdistribution
hazard
ratio:
1.86;
95%
interval:
1.15
2.02,
0.011).
Furthermore,
log-transformed
nearly
linear
(
0.124).
Conclusion
A
close
observed
undergoing
PD,
suggesting
more
attention
should
be
paid
SII,
which
effective
practice.
Arthritis Research & Therapy,
Journal Year:
2023,
Volume and Issue:
25(1)
Published: March 4, 2023
We
aimed
to
explore
the
relationship
between
systemic
immune-inflammation
index
(SII)
and
rheumatoid
arthritis
(RA)
using
NHANES
from
1999
2018.We
collected
data
database
2018.
The
SII
is
calculated
counts
of
lymphocytes
(LC),
neutrophils
(NC),
platelets
(PC).
RA
patients
were
derived
questionnaire
data.
used
weighted
multivariate
regression
analysis
subgroup
RA.
Furthermore,
restricted
cubic
splines
non-linear
relationships.Our
study
included
a
total
37,604
patients,
which
2642
(7.03%)
had
arthritis.
After
adjusting
for
all
covariates,
logistic
showed
that
high
(In-transform)
levels
associated
with
an
increased
likelihood
(OR=1.167,
95%
CI=1.025-1.328,
P=0.020).
interaction
test
revealed
no
significant
effect
on
this
connection.
In
spline
model,
ln-SII
was
non-linear.
cutoff
value
578.25.
risk
increases
rapidly
when
exceeds
value.In
general,
there
positive
correlation
Our
shows
novel,
valuable,
convenient
inflammatory
marker
can
be
predict
in
US
adults.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Feb. 21, 2023
Background
The
incidence
rate
of
kidney
stones
increased
over
the
past
decades
globally,
which
brought
medical
expenditure
and
social
burden.
systemic
immune-inflammatory
index
(SII)
was
initially
identified
as
a
prognosis
multiple
diseases.
We
performed
an
updated
analysis
on
impact
SII
stones.
Methods
This
compensatory
cross-sectional
study
enrolled
participants
from
National
Health
Nutrition
Examination
Survey
2007-2018.
Univariate
multivariate
logistic
regression
analyses
were
to
investigate
association
between
Results
Of
22220
participants,
mean
(SD)
age
49.45
±
17.36
years
old,
with
9.87%
A
fully
adjusted
model
showed
that
higher
than
330
x
10
9
/L
parallel
associated
(Odds
ratio
[OR]
=
1.282,
95%
Confidence
interval
[CI]
1.023
1.608,
P
0.034)
in
adults
aged
20-50.
However,
no
difference
found
elderly
subgroup.
Multiple
imputation
confirmed
robustness
our
results.
Conclusions
Our
findings
suggested
positively
high
risk
US
less
50.
outcome
compensated
for
previous
studies
still
needed
more
large-scale
prospective
cohorts
validation.
Journal of Inflammation Research,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 941 - 961
Published: March 1, 2023
Our
research
was
designed
to
investigate
the
relationship
between
systemic
immune
inflammation
(SII)
index
and
all-cause,
cardiovascular
disease
(CVD),
cancer-related
mortality
in
patients
with
CVD.
We
used
National
Health
Nutrition
Examination
Survey
data
from
1999
2018
conduct
this
study.
The
association
SII
CVD,
CVD
examined
using
restricted
cubic
splines
(RCS),
Cox
proportional
hazard
models,
subgroup
analysis,
respectively.
defined
as
a
composite
of
five
outcomes
including
coronary
heart
(CHD),
congestive
failure
(CHF),
angina
pectoris,
myocardial
infarction,
stroke.
Additionally,
link
also
explored.
In
total,
5329
participants
were
included.
RCS
showed
U-curve
correlation
As
compared
individuals
lowest
quartile
index,
ratios
95%
confidence
intervals
for
across
quartiles
(1.202
(0.981,
1.474),
1.184
(0.967,
1.450),
1.365
(1.115,
1.672)),
(1.116
(0.815,
1.527),
1.017
(0.740,
1.398),
1.220
(0.891,
1.670)),
respectively,
full-adjusted
model.
had
U-shaped
CHD,
angina,
infarction.
exists
CHF,
However,
there
positive
linear
United
States
general
population,
curve
Annals of Medicine,
Journal Year:
2023,
Volume and Issue:
55(1)
Published: April 13, 2023
Objective
Systemic
immune-inflammation
index
(SII),
a
novel
inflammatory
indicator
based
on
platelets,
neutrophils
and
lymphocytes,
has
been
shown
to
be
associated
with
prognostic
value
in
several
solid
tumors.
However,
its
nonalcoholic
fatty
liver
disease
(NAFLD)
not
reported
yet.
Therefore,
the
present
study
aimed
investigate
of
SII
individuals
NAFLD.Methods
Data
was
collected
from
2005
2014
National
Health
Nutrition
Examination
Survey
(NHANES,
https://www.cdc.gov/nchs/nhanes/index.htm),
vital
status
derived
Death
Index
(NDI)
up
31
December
2015.
NAFLD
diagnosed
Hepatic
Steatosis
(HSI).
Multivariate
Cox
regression
Kaplan–Meier
survival
curves
were
performed
measure
hazard
ratios
(HRs)
95%
confidence
interval
(CI).
Our
investigated
relationship
between
all-cause
mortality
by
using
two-part
linear
models
penalized
splines,
as
well
splines.Results
A
total
10,787
participants
(44.14%
men)
aged
≥20
years
old
enrolled.
There
776
deaths
all
causes
after
mean
follow-up
period
5.6
years.
According
full
adjusted
analysis,
low
log2-SII
group
(quartile
1)
highest
4)
significantly
increased
(aHR
=1.86;
CI:
1.47–2.37;
p
<
0.0001).
After
controlling
for
confounders,
an
increase
risk
41%
every
unit
raised
=
1.41;
1.26–1.57;
adjusting
multiple
potential
association
nonlinear,
threshold
8.8.
no
one
below
0.90,
0.71–1.15,
0.419).
higher
death
any
cause
when
it
exceeded
1.
73,
1.49–2.02,
0.001).Conclusion
Based
US
patients,
found
that
baseline
is
mortality.
Elevated
poor
among
patients.KEY
MESSAGESUsing
large
nationally
representative
survey
adults,
demonstrated
J-shaped
NAFLD.Spline
analyses
non-linear
8.8.Higher
NAFLD.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(9), P. 8414 - 8414
Published: May 8, 2023
Childhood
obesity
represents
a
worldwide
concern
as
many
countries
have
reported
an
increase
in
its
incidence,
with
possible
cardiovascular
long-term
implications.
The
mechanism
that
links
disease
to
is
related
low-grade
inflammation.
We
designed
this
study
investigate
the
diagnostic
utility
of
inflammatory
indices
(NLR,
neutrophil-to-lymphocyte
ratio;
PLR,
platelet-to-lymphocyte
SII,
systemic
immune-inflammation
index;
SIRI,
inflammation
response
index)
obese
children
metabolic
syndrome
(MetS)
and
their
relationship
cardiometabolic
risk
biomarkers,
such
Homeostasis
Model
Assessment
Insulin
Resistance
(HOMA-IR),
triglyceride-to-high-density
lipoprotein
cholesterol
(TG:HDL-C),
non-high-density
(non-HDL-C).
A
total
191
from
one
large
Romanian
reference
center
was
included
study.
Patients
were
classified
two
groups
according
presence
(MetS
group)
or
absence
(non-MetS
syndrome.
According
our
results,
SII
index
proved
value
distinguishing
MetS
patients
among
(AUC
=
0.843,
sensitivity
0.83,
specificity
0.63).
Furthermore,
positively
associated
biomarkers
(HOMA-IR,
p
<
0.001;
TG:HDL-C,
0.002;
non-HDL-C,
0.021),
highlighting
role
additional
measure
instability
children.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 23, 2024
Abstract
The
role
of
inflammation
in
disease
promotion
is
significant,
yet
the
precise
association
between
a
newly
identified
inflammatory
biomarker
and
insulin
resistance
(IR)
mortality
remains
uncertain.
We
aim
to
explore
potential
correlation
systemic
immune-inflammation
index
(SII)
these
factors.
used
data
from
2011
2016
National
Health
Nutrition
Examination
Survey,
multivariate
logistic
regression
restricted
cubic
spline
were
employed.
Subgroup
interaction
analysis
conducted
recognize
consistency
results.
SII
was
described
by
survival
analysis.
6734
participants
enrolled,
whom
49.3%
(3318)
exhibited
IR
7.02%
experienced
mortality.
Multivariate
revealed
that
individuals
highest
quartile
(Q4)
had
significantly
increased
risk
compared
those
lowest
(Q1).
then
linear
with
an
inflection
point
407,
but
may
be
influenced
gender.
Similarly,
Q1,
people
whose
at
Q4
showed
higher
all-cause
cardiovascular
It
significant
both
mortality,
results
need
interpreted
caution.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 2, 2024
Abstract
The
systemic
immune-inflammation
index
(SII),
a
metric
reflecting
inflammatory
response
and
immune
activation,
remains
underexplored
concerning
its
correlation
with
mortality
among
rheumatoid
arthritis
(RA)
patients.
This
study
aimed
to
delineate
the
association
between
SII
both
all-cause
cardiovascular
within
cohort
of
American
adults
diagnosed
RA,
utilizing
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
1999
2018.
investigation
extracted
NHANES
cycles
2018,
identifying
RA
patients
through
questionnaire
responses.
was
computed
based
on
complete
blood
counts,
employing
formula:
(platelets
×
neutrophils)
/
lymphocytes.
optimal
cutoff
value
for
significant
survival
outcomes
determined
using
maximally
selected
rank
statistics.
Multivariable
Cox
proportional
hazards
models
assessed
relationship
levels
(all-cause
cardiovascular)
patients,
subgroup
analyses
examining
potential
modifications
by
clinical
confounders.
Additionally,
restricted
cubic
spline
(RCS)
were
conducted
explore
linearity
SII-mortality
association.
encompassed
2070
whom
287
exhibited
higher
(≥
919.75)
1783
lower
(<
919.75).
Over
median
follow-up
duration
108
months,
602
participants
died.
After
adjustments
demographic,
socioeconomic,
lifestyle
variables,
associated
1.48-fold
increased
risk
(hazard
ratio
[HR]
=
1.48,
95%
confidence
interval
[CI]
1.21–1.81,
P
<
0.001)
1.51-fold
(HR
1.51,
CI
1.04–2.18,
0.030)
compared
SII.
Kaplan–Meier
corroborated
significantly
reduced
rates
(
0.0001
0.0004).
RCS
confirmed
positive
nonlinear
rates.
In
conclusion,
offers
straightforward
indicator
equilibrium
detrimental
innate
inflammation
beneficial
adaptive
immunity.
Our
investigation,
comprehensive
nationally
representative
sample,
reveals
that
elevated
independently
forecast
greater
all
causes,
as
well
cardiovascular-specific
mortality,
in
individuals
suffering
RA.
These
insights
underscore
relevance
an
affordable
readily
accessible
biomarker.
Its
incorporation
into
regular
practice
could
enhance
precision
assessment
forecasting
facilitating
more
tailored
effective
management
strategies.
Specifically,
high
be
identified
stringent
management,
including
closer
monitoring,
interventions,
aggressive
pharmacological
treatments
mitigate
their
mortality.
BMC Public Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 1, 2025
Abstract
Objectives
Life's
essential
8
(LE8)
is
an
emerging
approach
for
accessing
and
quantifying
cardiovascular
health
(CVH),
but
the
effect
on
Parkinson's
disease
(PD)
still
unclear.
This
study
aimed
to
elucidate
association
between
LE8
metrics
PD
in
US
adults.
Methods
Data
of
26,975
participants
were
extracted
from
last
7
National
Health
Nutrition
Examination
Survey
(NHANES)
cycles
(2005–2018).
The
calculated
according
American
Heart
Association
criterion,
divided
into
3
groups
using
tertile
range.
Multivariate
logistic
regression
models
constructed
explore
PD.
Sensitivity
analysis
was
conducted
verify
robustness.
A
nonlinear
linkage
evaluated
via
restricted
cubic
spline
(RCS).
stability
this
validated
by
subgroup
interaction
test.
Results
total
eligible
(including
271
cases
26,704
non-PD
cases)
included
study.
multivariate
revealed
a
reverse
continuous
with
ORs
0.97
(unadjusted
model
[95%
CI:
0.96–0.98,
P
<
0.01],
partially
adjusted
0.97–0.98,
fully
0.95–0.98,
0.01]).
Compared
those
low
group,
high
group
0.37
(95%
0.27–0.50,
0.01)
unadjusted
model,
0.51
0.36–0.72,
0.32–0.81,
model.
sensitivity
ensured
robustness
observed
LE8-PD
association.
relationship
(
nonlinearity
RCS
analysis.
showed
that
participants'gender
might
impact
strength
metrics-PD
=
0.029).
Conclusions
CVH,
as
delineated
metrics,
reversely
associated
dose–response
pattern,
more
pronounced
female
compared
male.
These
findings
highlight
potential
guide
targeted
strategies
addressing
gender-based
CVH
disparities,
offering
beneficial
insights
tertiary
prevention