Association between systemic immune inflammation Index and all-cause mortality in incident peritoneal dialysis-treated CKD patients: a multi-center retrospective cohort study DOI Creative Commons
Ruiying Tang,

Jiexin Chen,

Qian Zhou

et al.

BMC Nephrology, Journal Year: 2024, Volume and Issue: 25(1)

Published: Jan. 3, 2024

Abstract Background Chronic inflammatory disorders in peritoneal dialysis (PD) contribute to the adverse clinical outcome. Systemic immune inflammation index (SII) is novel and convenient measurement that positively associated with various diseases. However, scarce known regarding association between SII all-cause mortality among PD patients. Methods In this multi-center retrospective cohort study, 1,677 incident patients were enrolled. Eligible stratified into groups based on level: tertile 1(< 456.76), 2(456.76 819.03), 3(> 819.03). The primary endpoint was mortality. Both Cox regression analysis competing risk models used examine Subgroup performed assess influence of tertiles different subgroups. Results During follow-up period 30.5 ± 20.0 months, 26.0% (437/1,677) died, whom 3 group accounted for 39.1% (171/437) deaths. Patients had a higher rate than 1 2 (log-rank = 13.037, P < 0.001). significantly 80% greater (95% confidence interval:1.13 2.85; 0.013) compared multivariable analysis. model also indicated relationship remains (subdistribution hazard ratio: 1.86; 95% interval: 1.15 2.02, 0.011). Furthermore, log-transformed nearly linear ( 0.124). Conclusion A close observed undergoing PD, suggesting more attention should be paid SII, which effective practice.

Language: Английский

The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018 DOI Creative Commons
Bo Liu,

Jie Wang,

Yanyan Li

et al.

Arthritis Research & Therapy, Journal Year: 2023, Volume and Issue: 25(1)

Published: March 4, 2023

We aimed to explore the relationship between systemic immune-inflammation index (SII) and rheumatoid arthritis (RA) using NHANES from 1999 2018.We collected data database 2018. The SII is calculated counts of lymphocytes (LC), neutrophils (NC), platelets (PC). RA patients were derived questionnaire data. used weighted multivariate regression analysis subgroup RA. Furthermore, restricted cubic splines non-linear relationships.Our study included a total 37,604 patients, which 2642 (7.03%) had arthritis. After adjusting for all covariates, logistic showed that high (In-transform) levels associated with an increased likelihood (OR=1.167, 95% CI=1.025-1.328, P=0.020). interaction test revealed no significant effect on this connection. In spline model, ln-SII was non-linear. cutoff value 578.25. risk increases rapidly when exceeds value.In general, there positive correlation Our shows novel, valuable, convenient inflammatory marker can be predict in US adults.

Language: Английский

Citations

168

Association between the systemic immune-inflammation index and kidney stone: A cross-sectional study of NHANES 2007-2018 DOI Creative Commons
Xingpeng Di, Shaozhuang Liu,

Liyuan Xiang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 21, 2023

Background The incidence rate of kidney stones increased over the past decades globally, which brought medical expenditure and social burden. systemic immune-inflammatory index (SII) was initially identified as a prognosis multiple diseases. We performed an updated analysis on impact SII stones. Methods This compensatory cross-sectional study enrolled participants from National Health Nutrition Examination Survey 2007-2018. Univariate multivariate logistic regression analyses were to investigate association between Results Of 22220 participants, mean (SD) age 49.45 ± 17.36 years old, with 9.87% A fully adjusted model showed that higher than 330 x 10 9 /L parallel associated (Odds ratio [OR] = 1.282, 95% Confidence interval [CI] 1.023 1.608, P 0.034) in adults aged 20-50. However, no difference found elderly subgroup. Multiple imputation confirmed robustness our results. Conclusions Our findings suggested positively high risk US less 50. outcome compensated for previous studies still needed more large-scale prospective cohorts validation.

Language: Английский

Citations

65

Association of Systemic Immune Inflammation Index with All-Cause, Cardiovascular Disease, and Cancer-Related Mortality in Patients with Cardiovascular Disease: A Cross-Sectional Study DOI Creative Commons
Shengjue Xiao, Zhenwei Wang, Ronghua Zuo

et al.

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 941 - 961

Published: March 1, 2023

Our research was designed to investigate the relationship between systemic immune inflammation (SII) index and all-cause, cardiovascular disease (CVD), cancer-related mortality in patients with CVD. We used National Health Nutrition Examination Survey data from 1999 2018 conduct this study. The association SII CVD, CVD examined using restricted cubic splines (RCS), Cox proportional hazard models, subgroup analysis, respectively. defined as a composite of five outcomes including coronary heart (CHD), congestive failure (CHF), angina pectoris, myocardial infarction, stroke. Additionally, link also explored. In total, 5329 participants were included. RCS showed U-curve correlation As compared individuals lowest quartile index, ratios 95% confidence intervals for across quartiles (1.202 (0.981, 1.474), 1.184 (0.967, 1.450), 1.365 (1.115, 1.672)), (1.116 (0.815, 1.527), 1.017 (0.740, 1.398), 1.220 (0.891, 1.670)), respectively, full-adjusted model. had U-shaped CHD, angina, infarction. exists CHF, However, there positive linear United States general population, curve

Language: Английский

Citations

59

The systemic immune-inflammation index was non-linear associated with all-cause mortality in individuals with nonalcoholic fatty liver disease DOI Creative Commons
Enfa Zhao, Yiping Cheng, Chunxiao Yu

et al.

Annals of Medicine, Journal Year: 2023, Volume and Issue: 55(1)

Published: April 13, 2023

Objective Systemic immune-inflammation index (SII), a novel inflammatory indicator based on platelets, neutrophils and lymphocytes, has been shown to be associated with prognostic value in several solid tumors. However, its nonalcoholic fatty liver disease (NAFLD) not reported yet. Therefore, the present study aimed investigate of SII individuals NAFLD.Methods Data was collected from 2005 2014 National Health Nutrition Examination Survey (NHANES, https://www.cdc.gov/nchs/nhanes/index.htm), vital status derived Death Index (NDI) up 31 December 2015. NAFLD diagnosed Hepatic Steatosis (HSI). Multivariate Cox regression Kaplan–Meier survival curves were performed measure hazard ratios (HRs) 95% confidence interval (CI). Our investigated relationship between all-cause mortality by using two-part linear models penalized splines, as well splines.Results A total 10,787 participants (44.14% men) aged ≥20 years old enrolled. There 776 deaths all causes after mean follow-up period 5.6 years. According full adjusted analysis, low log2-SII group (quartile 1) highest 4) significantly increased (aHR =1.86; CI: 1.47–2.37; p < 0.0001). After controlling for confounders, an increase risk 41% every unit raised = 1.41; 1.26–1.57; adjusting multiple potential association nonlinear, threshold 8.8. no one below 0.90, 0.71–1.15, 0.419). higher death any cause when it exceeded 1. 73, 1.49–2.02, 0.001).Conclusion Based US patients, found that baseline is mortality. Elevated poor among patients.KEY MESSAGESUsing large nationally representative survey adults, demonstrated J-shaped NAFLD.Spline analyses non-linear 8.8.Higher NAFLD.

Language: Английский

Citations

53

Association between systemic immune inflammation index and cataract incidence from 2005 to 2008 DOI Creative Commons
Xiang Li,

Guo-lei Du,

Shi‐Nan Wu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

Citations

3

Assessing the Relationship between Systemic Immune-Inflammation Index and Metabolic Syndrome in Children with Obesity DOI Open Access
Delia-Maria Nicoară,

Andrei-Ioan Munteanu,

Alexandra-Cristina Scutca

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8414 - 8414

Published: May 8, 2023

Childhood obesity represents a worldwide concern as many countries have reported an increase in its incidence, with possible cardiovascular long-term implications. The mechanism that links disease to is related low-grade inflammation. We designed this study investigate the diagnostic utility of inflammatory indices (NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte SII, systemic immune-inflammation index; SIRI, inflammation response index) obese children metabolic syndrome (MetS) and their relationship cardiometabolic risk biomarkers, such Homeostasis Model Assessment Insulin Resistance (HOMA-IR), triglyceride-to-high-density lipoprotein cholesterol (TG:HDL-C), non-high-density (non-HDL-C). A total 191 from one large Romanian reference center was included study. Patients were classified two groups according presence (MetS group) or absence (non-MetS syndrome. According our results, SII index proved value distinguishing MetS patients among (AUC = 0.843, sensitivity 0.83, specificity 0.63). Furthermore, positively associated biomarkers (HOMA-IR, p < 0.001; TG:HDL-C, 0.002; non-HDL-C, 0.021), highlighting role additional measure instability children.

Language: Английский

Citations

38

Monocyte-to-lymphocyte ratio predicts mortality and cardiovascular mortality in the general population DOI
Hua Yang,

Jin-Yu Sun,

Yu-Xuan Lou

et al.

International Journal of Cardiology, Journal Year: 2023, Volume and Issue: 379, P. 118 - 126

Published: March 9, 2023

Language: Английский

Citations

37

Association between systemic immune-inflammation index and insulin resistance and mortality DOI Creative Commons

Xiaoqi Deng,

Dichuan Liu,

Miao Li

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 23, 2024

Abstract The role of inflammation in disease promotion is significant, yet the precise association between a newly identified inflammatory biomarker and insulin resistance (IR) mortality remains uncertain. We aim to explore potential correlation systemic immune-inflammation index (SII) these factors. used data from 2011 2016 National Health Nutrition Examination Survey, multivariate logistic regression restricted cubic spline were employed. Subgroup interaction analysis conducted recognize consistency results. SII was described by survival analysis. 6734 participants enrolled, whom 49.3% (3318) exhibited IR 7.02% experienced mortality. Multivariate revealed that individuals highest quartile (Q4) had significantly increased risk compared those lowest (Q1). then linear with an inflection point 407, but may be influenced gender. Similarly, Q1, people whose at Q4 showed higher all-cause cardiovascular It significant both mortality, results need interpreted caution.

Language: Английский

Citations

11

Association of the systemic immune-inflammation index with all-cause and cardiovascular mortality in individuals with rheumatoid arthritis DOI Creative Commons
Xiaoshuang Yin, Yu Zhang,

Jinmei Zou

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 2, 2024

Abstract The systemic immune-inflammation index (SII), a metric reflecting inflammatory response and immune activation, remains underexplored concerning its correlation with mortality among rheumatoid arthritis (RA) patients. This study aimed to delineate the association between SII both all-cause cardiovascular within cohort of American adults diagnosed RA, utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 1999 2018. investigation extracted NHANES cycles 2018, identifying RA patients through questionnaire responses. was computed based on complete blood counts, employing formula: (platelets × neutrophils) / lymphocytes. optimal cutoff value for significant survival outcomes determined using maximally selected rank statistics. Multivariable Cox proportional hazards models assessed relationship levels (all-cause cardiovascular) patients, subgroup analyses examining potential modifications by clinical confounders. Additionally, restricted cubic spline (RCS) were conducted explore linearity SII-mortality association. encompassed 2070 whom 287 exhibited higher (≥ 919.75) 1783 lower (< 919.75). Over median follow-up duration 108 months, 602 participants died. After adjustments demographic, socioeconomic, lifestyle variables, associated 1.48-fold increased risk (hazard ratio [HR] = 1.48, 95% confidence interval [CI] 1.21–1.81, P < 0.001) 1.51-fold (HR 1.51, CI 1.04–2.18, 0.030) compared SII. Kaplan–Meier corroborated significantly reduced rates ( 0.0001 0.0004). RCS confirmed positive nonlinear rates. In conclusion, offers straightforward indicator equilibrium detrimental innate inflammation beneficial adaptive immunity. Our investigation, comprehensive nationally representative sample, reveals that elevated independently forecast greater all causes, as well cardiovascular-specific mortality, in individuals suffering RA. These insights underscore relevance an affordable readily accessible biomarker. Its incorporation into regular practice could enhance precision assessment forecasting facilitating more tailored effective management strategies. Specifically, high be identified stringent management, including closer monitoring, interventions, aggressive pharmacological treatments mitigate their mortality.

Language: Английский

Citations

10

Association between life's essential 8 and Parkinson's disease: a case–control study DOI Creative Commons
Jiaxin Fan,

Yanfeng Wang,

Xingzhi Guo

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 1, 2025

Abstract Objectives Life's essential 8 (LE8) is an emerging approach for accessing and quantifying cardiovascular health (CVH), but the effect on Parkinson's disease (PD) still unclear. This study aimed to elucidate association between LE8 metrics PD in US adults. Methods Data of 26,975 participants were extracted from last 7 National Health Nutrition Examination Survey (NHANES) cycles (2005–2018). The calculated according American Heart Association criterion, divided into 3 groups using tertile range. Multivariate logistic regression models constructed explore PD. Sensitivity analysis was conducted verify robustness. A nonlinear linkage evaluated via restricted cubic spline (RCS). stability this validated by subgroup interaction test. Results total eligible (including 271 cases 26,704 non-PD cases) included study. multivariate revealed a reverse continuous with ORs 0.97 (unadjusted model [95% CI: 0.96–0.98, P < 0.01], partially adjusted 0.97–0.98, fully 0.95–0.98, 0.01]). Compared those low group, high group 0.37 (95% 0.27–0.50, 0.01) unadjusted model, 0.51 0.36–0.72, 0.32–0.81, model. sensitivity ensured robustness observed LE8-PD association. relationship ( nonlinearity RCS analysis. showed that participants'gender might impact strength metrics-PD = 0.029). Conclusions CVH, as delineated metrics, reversely associated dose–response pattern, more pronounced female compared male. These findings highlight potential guide targeted strategies addressing gender-based CVH disparities, offering beneficial insights tertiary prevention

Language: Английский

Citations

1