International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8095 - 8095
Published: July 25, 2024
Elevated
levels
of
homocysteine
(Hcy)
and
related
metabolites
are
associated
with
Alzheimer's
disease
(AD).
Severe
hyperhomocysteinemia
causes
neurological
deficits
worsens
behavioral
biochemical
traits
AD.
Although
Hcy
is
precluded
from
entering
the
Genetic
Code
by
proofreading
mechanisms
aminoacyl-tRNA
synthetases,
thus
a
non-protein
amino
acid,
it
can
be
attached
to
proteins
via
an
Jornal Brasileiro de Patologia e Medicina Laboratorial,
Journal Year:
2006,
Volume and Issue:
42(3), P. 169 - 178
Published: June 1, 2006
Diversos
estudos
clínicos,
epidemiológicos
e
experimentais
têm
mostrado
de
maneira
incontestável
a
relação
entre
dosagem
sérica
dos
níveis
lipoproteína
alta
densidade
(HDL)
doença
cardiovascular.
Baixos
HDL
estão
presentes
em
aproximadamente
10%
da
população
representam
um
mais
freqüentes
achados
dislipidemia
nos
pacientes
com
arterial
coronariana
(DAC).
Esses
reduzidos
poderiam
ser
incapazes
efetivamente
eliminar
o
excesso
colesterol
das
paredes
vasculares,
contribuindo
para
fenômeno
inflamatório
que
caracteriza
patogênese
aterosclerose
nas
suas
fases
iniciais.
Outros
inúmeros
convincentemente
também
exerce
efeitos
diretos
sobre
os
processos
inflamatórios,
por
exemplo,
através
modulação
expressão
diversas
proteínas
fase
aguda.
Além
disso,
possui
diversos
outros
antiaterogênicos,
como
antioxidantes,
inibição
agregação
plaquetária
migração
monócitos.
O
presente
artigo
faz
uma
revisão
literatura
atual
metabolismo
principais
ações
na
prevenção
coronariana.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(21), P. 15781 - 15781
Published: Oct. 30, 2023
Patients
with
sepsis-associated
delirium
(SAD)
show
severe
neurological
impairment,
often
require
an
intensive
care
unit
(ICU)
stay
and
have
a
high
risk
of
mortality.
Hence,
useful
biomarkers
for
early
detection
SAD
are
urgently
needed.
Extracellular
vesicles
(EVs)
their
cargo
known
to
maintain
normal
physiology
but
also
been
linked
numerous
disease
states.
Here,
we
sought
identify
differentially
expressed
proteins
in
plasma
EVs
from
patients
as
potential
SAD.
Plasma
11
age-matched
septic
without
(non-SAD)
were
isolated
by
differential
centrifugation,
characterized
nanoparticle
tracking
analysis,
transmission
electron
microscopy
Western
blot
analysis.
Differential
EV
protein
expression
was
determined
mass
spectrometry
the
resulting
proteomes
Gene
Ontology
term
between-group
statistics.
As
preliminary
results
because
small
group
size,
five
distinct
showed
significantly
different
pattern
between
non-SAD
(p
≤
0.05).
In
patients,
upregulated
included
paraoxonase-1
(PON1),
thrombospondin
1
(THBS1),
full
fibrinogen
gamma
chain
(FGG),
whereas
downregulated
comprised
immunoglobulin
(IgHV3)
complement
subcomponent
(C1QC).
Thus,
significant
changes
involved
immune
system
regulation
blood
coagulation
well
lipid
metabolism
this
pilot
study.
They
might
be
indicator
pathogenesis
thus
warrant
further
examination
biomarkers,
research
is
needed
expand
on
these
findings
longitudinal
study
designs
larger
samples
comprehensive
polymodal
data
collection.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8095 - 8095
Published: July 25, 2024
Elevated
levels
of
homocysteine
(Hcy)
and
related
metabolites
are
associated
with
Alzheimer's
disease
(AD).
Severe
hyperhomocysteinemia
causes
neurological
deficits
worsens
behavioral
biochemical
traits
AD.
Although
Hcy
is
precluded
from
entering
the
Genetic
Code
by
proofreading
mechanisms
aminoacyl-tRNA
synthetases,
thus
a
non-protein
amino
acid,
it
can
be
attached
to
proteins
via
an
