In-silico Codon Context and Synonymous Usage Analysis of Genes for Molecular Mechanisms Inducing Autophagy and Apoptosis with Reference to Neurodegenerative Disorders DOI
Rekha Khandia,

Pankaj Gurjar,

Victoria Romashchenko

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 99(3), P. 927 - 939

Published: May 10, 2024

Background: Autophagy and apoptosis are cellular processes that maintain homeostasis remove damaged or aged organelles aggregated misfolded proteins. Stress factors initiate the signaling pathways common to autophagy apoptosis. An imbalance in apoptosis, led by cascade of molecular mechanism prior both culminate into neurodegeneration. Objective: In present study, we urge investigate codon usage pattern genes which before initiating Methods: took up eleven (DAPK1, BECN1, PIK3C3 (VPS34), BCL2, MAPK8, BNIP3 L (NIX), PMAIP1, BAD, BID, BBC3, MCL1) part We analyzed dinucleotide odds ratio, bias, usage, context, rare analysis. Results: CpC GpG dinucleotides were abundant, with dominance G/C ending codons as preferred codons. Clustering analysis revealed MAPK8 had a distinct compared other envisaged genes. Both positive negative contexts observed, GAG-GAG followed CTG-GCC was most abundant pair. Of six synonymous arginine codons, two CGT CGA rarest. Conclusions: The information presented study may be used manipulate process check pathophysiology associated their dysregulation.

Language: Английский

Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation DOI Creative Commons
Dandan Liu,

Hewei Qin,

Yang Gao

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107258 - 107258

Published: June 21, 2024

Several cardiovascular illnesses are associated with aberrant activation of cellular pyroptosis, ferroptosis, necroptosis, cuproptosis, disulfidptosis and macrophage polarisation as hallmarks contributing to vascular damage abnormal cardiac function. Meanwhile, these three novel forms dysfunction closely related mitochondrial homeostasis. Mitochondria the main organelles that supply energy maintain Mitochondrial stability is maintained through a series regulatory pathways, such fission, fusion mitophagy. Studies have shown (e.g., impaired dynamics mitophagy) promotes ROS production, leading oxidative stress, which induces M1 phenotypic polarisation. Therefore, an in-depth knowledge dynamic regulation mitochondria during necessary understand disease development. This paper systematically summarises impact changes in mitophagy on regulating dysfunctions promote understanding pathogenesis diseases provide corresponding theoretical references for treating diseases.

Language: Английский

Citations

22
Current insights into transcriptional role(s) for the nutraceutical Withania somnifera in inflammation and aging DOI Creative Commons

Praful Saha,

Saiprasad Ajgaonkar,

Dishant Maniar

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: May 3, 2024

The health-beneficial effects of nutraceuticals in various diseases have received enhanced attention recent years. Aging is a continuous process wherein physiological activity an individual declines over time and characterized by indefinite hallmarks which contribute toward aging-related comorbidities include many neurodegenerative diseases, cardiac problems, diabetes, bone-degeneration, cancer. Cellular senescence homeostatic biological that has important function driving aging. Currently, growing body evidence substantiates the connection between epigenetic modifications aging process, along with diseases. These are now being recognized as promising targets for emerging therapeutic interventions. Considering almost all processes modulated RNAs, numerous RNA-binding proteins been found to be linked age-related complexities. studies shed light on ability nutraceutical Withania somnifera (Ashwagandha) influence RNA expression, stability, processing, offering insights into its mechanisms action. By targeting RNA-related pathways, may exhibit ameliorating age-associated molecular changes, gene expression signaling networks. This review summarizes potential role modulating RNA-level changes associated aging, encompassing both vitro vivo studies. Taken together, putative role(s) modulation key RNAs will provide understanding facilitate development preventive strategies employing healthy

Language: Английский

Citations

9
Crosstalk Between Autophagy and Other Forms of Programmed Cell Death DOI Creative Commons
Huaiyuan Wang, Xu Feng, Huilin He

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 995, P. 177414 - 177414

Published: Feb. 20, 2025

Cell death occurs continuously throughout individual development. By removing damaged or senescent cells, cell not only facilitates morphogenesis during the developmental process, but also contributes to maintaining homeostasis after birth. In addition, reduces spread of pathogens by eliminating infected cells. is categorized into two main forms: necrosis and programmed death. Programmed encompasses several types, including autophagy, pyroptosis, apoptosis, necroptosis, ferroptosis, PANoptosis. Autophagy, a mechanism that maintains cellular equilibrium via breakdown reutilization proteins organelles, implicated in regulating almost all forms pathological contexts. Notably, PANoptosis are directly classified as autophagy-mediated Therefore, autophagy presents therapeutic approach for treating diseases such inflammation tumors arise from abnormalities other This review focuses on crosstalk between modalities, providing new perspectives clinical interventions inflammatory neoplastic diseases.

Language: Английский

Citations

1
Carvacrol attenuated myocardial infarction through NLRP3-mediated pyroptosis and mTOR/Nrf2/PPARγ-dependent autophagic signaling DOI

Hanna Aslam,

Faisal F. Albaqami, Najeeb Ur Rehman

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 117281 - 117281

Published: March 1, 2025

Language: Английский

Citations

1
NF-ĸB axis in diabetic neuropathy, cardiomyopathy and nephropathy: A roadmap from molecular intervention to therapeutic strategies DOI Creative Commons

Aryan Rezaee,

Parham Rahmanian,

Amirreza Nemati

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e29871 - e29871

Published: April 18, 2024

Diabetes mellitus (DM) is a metabolic illness defined by elevated blood glucose levels, mediating various tissue alterations, including the dysfunction of vital organs. can lead to many consequences that specifically affect brain, heart, and kidneys. These issues are known as neuropathy, cardiomyopathy, nephropathy, respectively. Inflammation acknowledged pivotal biological mechanism contributes development diabetes consequences. NF-κB modulates inflammation immune system at cellular level. Its abnormal regulation has been identified in several clinical situations, cancer, inflammatory bowel illnesses, cardiovascular diseases, Mellitus (DM). The purpose this review evaluate potential impact on complications associated with DM. Enhanced activity promotes inflammation, resulting harm compromised organ performance. Phytochemicals, which therapeutic molecules, potentially decline level, therefore alleviating progression problems correlated More importantly, be influenced factors, such TLR4 Highlighting these factors facilitate novel therapies future.

Language: Английский

Citations

6
Beclin 1-Mediated Autophagy Is Potentiated by an Interaction with the Neuronal Adaptor FE65 DOI Creative Commons
Wai Wa Ray Chan, Jessica Chow, Dennis Dik‐Long Chau

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 97 - 97

Published: Jan. 18, 2025

Autophagy is a vital cellular pathway in eukaryotic cells, including neurons, where it plays significant roles neurodevelopment and maintenance. A crucial step autophagy the formation of class III phosphatidylinositol 3-kinase complex 1 (PI3KC3-C1), which essential for initiating autophagosome biogenesis. Beclin key component PI3KC3-C1, its interactors have been reported to affect autophagy. The brain-enriched adaptor protein FE65 has shown interact with Alzheimer’s disease amyloid precursor (APP) alter processing APP. Additionally, implicated various pathways, We demonstrate here that positively regulates FE65, through C-terminus, 1. Notably, overexpression enhances 1-mediated autophagy, whereas this process attenuated knockout cells. Moreover, stimulatory effect on diminished by an C-terminus deletion mutant disrupts FE65–Beclin interaction. Lastly, we found FE65-Beclin interaction modulates kinase activity PI3KC3-C1 complex. Together, identified as novel interactor, potentiates

Language: Английский

Citations

0
Research Hotspots and Frontier Trends of Autophagy in Diabetic Cardiomyopathy From 2014 to 2024: A Bibliometric Analysis DOI Creative Commons
Yan Mei, Shizhao Zhang,

Pengpeng Liang

et al.

Journal of Multidisciplinary Healthcare, Journal Year: 2025, Volume and Issue: Volume 18, P. 837 - 860

Published: Feb. 1, 2025

In recent years, the investigation of autophagy mechanisms has gained prominence as a key focus for understanding pathogenesis and therapeutic potential diabetic cardiomyopathy. This study aims to present an overview current state, major research areas, emerging trends in related cardiomyopathy through bibliometric analysis, offering scientific foundation future research. The Web Science Core Collection served data source this study, from which full-text publications were extracted. Using CiteSpace 6.3.R1, VOSviewer v1.6.18, R-Bibliometrix, analysis evaluated output across dimensions such subjects, countries, institutions, journals, authors, co-cited references, generating comprehensive visual map. A total 367 met inclusion criteria. Between 2014 2024, volume articles demonstrated consistent upward trajectory. Research on predominantly spans disciplines biology medicine. China Fourth Military Medical University emerged leading contributors among 41 countries 505 institutions. Sun Dongdong was identified most prolific author, while Jia GH frequently cited. Key journals field include Biochimica et Biophysica Acta - Molecular Basis Disease Frontiers Cardiovascular Medicine, Circulation recorded highest number co-citations. cited reference experimental by Xie ZL. Current focuses autophagy, cardiomyopathy, oxidative stress, their underlying mechanisms. role reached stable phase development. Future investigations should prioritize mechanistic studies emphasize clinical application novel pharmacological interventions, thereby advancing strategies contributing improved human health outcomes.

Language: Английский

Citations

0
Pyruvate dehydrogenase alleviates macrophage autophagy in Hcy-induced ApoE<sup>-/-</sup> mice DOI Creative Commons

Qiujun Liu,

Li Feng,

Shutong Hu

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Macrophages play a protective role in atherosclerosis, whereas homocysteine (Hcy) is recognized as an independent risk factor for atherosclerosis. Defects macrophage autophagy contribute to the formation of atherosclerotic plaques, and dysregulated energy metabolism closely linked process autophagy. However, regulation by pyruvate dehydrogenase (PDH), key component PDH complex involved metabolic homeostasis, remains poorly understood context atherosclerosis induced Hcy. In our study, proteomic profiling identifies 748 upregulated proteins 760 downregulated Hcy-treated macrophages. KEGG pathway analysis reveals significant enrichment differentially expressed metabolism-related pathways, including those related biosynthesis amino acids, carbon metabolism, glycolysis/gluconeogenesis. Additionally, we explore mediating Hcy-induced ApoE -/- mice. The results show marked reduction expression activity macrophages, leading impaired Notably, activation enhances assembly initiator ULK1-FIP200-Atg13 through modulation AMPK/mTOR signaling pathway, suggesting potential therapeutic target

Language: Английский

Citations

0
Interplay Between Polyphenols and Autophagy: Insights From an Aging Perspective DOI Creative Commons
Alejandro Ponce‐Mora, Nelson Bautista Salazar, Alicia Domenech‐Bendaña

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(3)

Published: March 19, 2025

The relationship between polyphenols and autophagy, particularly in the context of aging, presents a promising avenue for therapeutic interventions age-related diseases. A decline autophagy is associated with aging-related affections, an increasing number studies suggest that this enhancement linked to cellular resilience longevity. This review delves into multifaceted roles homeostasis potential modulate autophagic pathways. We revised most updated literature regarding modulatory effects on cardiovascular, liver, kidney diseases, highlighting their potential. highlight role as modulators combat thus contributing improving quality life aging populations. better understanding interplay will help pave way future research clinical applications field longevity medicine.

Language: Английский

Citations

0
Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology DOI Creative Commons
Luwen Zhang, Wei Wang,

Xincan Liu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 2, 2025

Cardiovascular disease poses a significant risk to human health and remains the leading cause of illness death globally, with its incidence continuing rise. The intricate pathophysiological mechanisms CVDs include inflammation, oxidative stress, autophagy, myocardial fibrosis. In light these underlying mechanisms, traditional Chinese medicine (TCM) constituents have demonstrated distinct advantages in managing CVDs. By exerting synergistic effects across multiple components targets, can modulate inflammatory response, mitigate regulate excessive enhance fibrosis repair. This article reviews latest advancements understanding how TCM compounds signaling pathways involved treatment

Language: Английский

Citations

0