Methylations in dilated cardiomyopathy and heart failure

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 11, 2025

Dilated cardiomyopathy (DCM) is characterized by impaired expansion or contraction of the left both ventricles in absence abnormal load conditions (such as primary valve disease) severe coronary artery disease that can lead to ventricular remodeling. Genetic mutations, infections, inflammation, autoimmune diseases, exposure toxins, and endocrine neuromuscular factors have all been implicated causation DCM. Cardiomyopathy, particularly DCM, often has genetic underpinnings, with established suspected origins. Up 40% DCM cases involve probable confirmed variations. The significance RNA modification pathogenesis hypertension, cardiac hypertrophy, atherosclerosis well-established. Of late, methylation garnered attention for its involvement This review examines biological mechanisms effects heart failure.

Language: Английский

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MyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction-Regulating Proteins in a Rat Model of HFpEF.

PubMed, Journal Year: 2025, Volume and Issue: 16(3), P. e13843 - e13843

Published: June 1, 2025

Heart failure with preserved ejection fraction (HFpEF) is associated exercise intolerance, accompanied by alterations in the peripheral skeletal muscle (SKM). We have recently shown that titin, a giant sarcomere protein, hyperphosphorylated HFpEF. MuRF1 muscle-specific ubiquitin E3-ligase interacts titin. Blocking this interaction via small molecules (MyoMed205) can improve function and mitochondrial activity This study aimed to investigate impact of MyoMed205 on titin phosphorylation its association changes structure function. Obese ZSF1 rats established HFpEF received rat chow (n = 15) or without were compared lean littermates 15), serving as controls. After 12 weeks, vitro SKM force, atrophy titin-as well contractile protein expression-were evaluated (soleus extensor digitorum longus [EDL]). Statistical analysis was performed multiple unpaired t-test one-way ANOVA. In HFpEF, hyperphosphorylation 13% EDL (p 0.09) 14% 0.03) soleus evident. driven part an increase S11878 (EDL: +68%, p 0.004; Sol: +23.8%, 0.03), which linked myofiber (r -0.68, 0.006) decline maximal specific force -0.54, 0.008). EDL, significant expression related (MuRF1 [+24.9%, 0.02], GDF8 [+20.6%, 0.09]) calcium handling (slow troponin C [-46%, fast I [+35.8%, 0.02]) found All above-mentioned effects almost completely abolished treatment, significantly elevated visible (+19.7%, pcon 0.04, pHFpEF 0.01). Titin may negatively integrity reduced mass. Further studies are necessary confirm direct role evaluate therapeutic potential

Language: Английский

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Post-Myocardial Infarction Rehabilitation: The Absence in the Rehabilitation Process of the Diaphragm Muscle

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 3201 - 3210

Published: July 1, 2024

Myocardial infarction (MI) is one of the leading causes death worldwide. There can be many reasons that cause MI, such as a sedentary lifestyle, disordered diet, harmful habits smoking and alcoholism, concomitant congenital or acquired systemic pathologies. Patients who survive acute event suffer functional alteration multiple body systems. The various cardiology associations recommend starting rehabilitation process, pursuing main objective improving patient's health status. A negative consequence linked to MI dysfunction breathing muscle, diaphragm. diaphragm essential not only for respiratory mechanisms but also adequate production cardiac pressures. Post-MI patients present reduction in performance this condition become risk factor further relapses onset heart failure. article reviews path post-MI patients, highlight absence given recovery text diaphragmatic adaptation importance including targeted training muscle process.

Language: Английский

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The Importance of the Diaphragm Muscle in Cardiac Rehabilitation after Myocardial Infarction

Published: Feb. 21, 2024

Cardiovascular disease (CVD) is the leading cause of death worldwide. Cardiac rehabilitation (CR) has proven to be effective in reducing rate recurrence and as secondary prevention (evidence-based intervention) patients who have suffered from myocardial infarction (MI). CR a multidisciplinary path which patient followed pharmacologically, psychological, nutritional, nursing physiotherapy point view. Post-MI present reduction performance diaphragm muscle, main inspiratory this condition can become risk factor for further relapses or onset heart failure. Despite solidity international guidelines CR, latter are lacking specifically indicating an evaluation training regarding muscles post-MI not undergone cardiac surgery. The article reviews information on adaptation highlights need clearer indications process that gives importance diaphragm.

Language: Английский

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