Molecular Therapy,
Journal Year:
2024,
Volume and Issue:
32(3), P. 580 - 608
Published: Jan. 29, 2024
Cardiovascular
disease
(CVD)
continues
to
impose
a
significant
global
health
burden,
necessitating
the
exploration
of
innovative
treatment
strategies.
Ribonucleic
acid
(RNA)-based
therapeutics
have
emerged
as
promising
avenue
address
complex
molecular
mechanisms
underlying
CVD
pathogenesis.
We
present
comprehensive
review
current
state
RNA
in
context
CVD,
focusing
on
diverse
modalities
that
bring
about
transient
or
permanent
modifications
by
targeting
different
stages
biology
central
dogma.
Considering
immense
potential
therapeutics,
we
identified
common
gene
targets
could
serve
interventions
for
prevalent
Mendelian
caused
single
mutations,
well
acquired
CVDs
developed
over
time
due
various
factors.
These
offer
opportunities
develop
RNA-based
treatments
tailored
specific
genetic
and
pathways,
presenting
novel
precise
approach
pathogenesis
both
types
cardiovascular
conditions.
Additionally,
discuss
challenges
associated
with
delivery
strategies
achieve
targeted
system.
This
highlights
combat
paving
way
future
advancements
therapeutics.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 2126 - 2126
Published: Feb. 27, 2025
Melanoma
is
the
deadliest
form
of
skin
cancer,
and
its
treatment
poses
significant
challenges
due
to
aggressive
nature
resistance
conventional
therapies.
Long
non-coding
RNAs
(lncRNAs)
represent
a
new
frontier
in
search
for
suitable
targets
control
melanoma
progression
invasiveness.
Indeed,
lncRNAs
exploit
wide
range
regulatory
functions
along
chromatin
remodeling,
gene
transcription,
post-transcription,
transduction,
post-transduction
ultimately
tune
multiple
cellular
processes.
The
understanding
this
intricate
flexible
network
orchestrated
by
pathological
conditions
can
strategically
support
rational
identification
promising
targets,
speeding
up
setup
therapeutics
integrate
currently
available
approaches.
Here,
most
recent
findings
on
involved
will
be
analyzed.
In
particular,
functional
links
between
their
mechanisms
action
some
frequently
underestimated
features,
like
different
subcellular
localizations,
highlighted.
BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY,
Journal Year:
2025,
Volume and Issue:
unknown, P. 123 - 140
Published: March 20, 2025
Background:
Cardiovascular
diseases
(CVDs)
are
a
leading
cause
of
mortality
globally,
necessitating
novel
biomarkers
for
diagnosis
and
treatment.
Long
non-coding
RNAs
(lncRNAs)
have
emerged
as
significant
regulatory
molecules
in
cardiovascular
biology,
yet
comprehensive
bibliometric
analyses
this
area
lacking.
Objective:
This
study
aims
to
conduct
analysis
lncRNAs
CVD
identify
publication
trends,
key
contributors,
thematic
developments
from
2008
2023.
Methods:
A
systematic
search
was
performed
across
PubMed,
Scopus,
Web
Science
using
the
keywords
"((Long
RNA)
OR
(lncRNA))
AND
(Cardiovascular
disease)
disorders)
(Biomarkers)."
total
33,805
records
were
retrieved,
with
duplicates
removed,
resulting
29,545
unique
records.
After
screening,
341
relevant
articles
selected
VOSviewer.
Results:
publications
analyzed,
involving
54
countries/regions,
548
institutions,
1744
authors
177
journals.
The
United
States
(84
publications)
China
(61
contributors.
Zhengzhou
University
had
highest
output,
while
Guo
Wei
most
prolific
author.
Keyword
revealed
focus
on
lncRNAs'
roles
occurrence,
development,
diagnosis,
treatment,
prognosis
CVD.
Conclusion:
provides
insights
into
research
landscape
CVD,
highlighting
influential
authors,
collaborative
networks.
findings
underscore
importance
suggest
potential
areas
future
investigation
BMC Molecular and Cell Biology,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: May 15, 2024
Oxidative
stress
is
implicated
in
the
pathogenesis
of
heart
failure.
Dual
oxidase
1
(DUOX1)
might
be
important
failure
development
through
its
mediating
role
oxidative
stress.
This
study
was
designed
to
evaluate
potential
DUOX1
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Oct. 10, 2024
Abstract
This
study
explored
the
significance
of
long
non-coding
RNAs
(lncRNAs),
particularly
their
role
in
maintaining
dystrophin
protein
stability
and
regulating
myocyte
proliferation
differentiation.
The
investigation
focused
on
DMD/mdx
mouse
skeletal
muscle
primary
myoblasts,
aiming
to
identify
lncRNAs
potential
as
biomarkers
therapeutic
targets
for
Duchenne
muscular
dystrophy
(DMD).
Utilizing
CLC
Genomics
Workbench
software,
554
differentially
expressed
were
identified
mice
compared
wild-type
(WT)
control.
Among
them,
373
upregulated,
181
downregulated.
highlighted
specific
(e.g.,
5930430L01Rik,
Gm10143,
LncRNA1490,
LncRNA580)
regulatory
roles
DMD
key
genes
like
IGF1
,
FN1
TNNI1
MYOD1
.
By
predicting
miRNA
connections
with
lncRNA
mRNA
(ceRNA
network)
using
tools
such
miRNet,
miRSYSTEM
miRCARTA,
revealed
indirect
regulation
Dystrophin
IGF1R
UTRN
by
(e.g.
2310001H17Rik-203,
C130073E24Rik-202,
LncRNA2767,
5930430L01Rik
LncRNA580).
These
findings
suggest
that
may
play
crucial
development
progression
through
influence
gene
expression,
providing
valuable
insights
interventions.
Cell Biology and Toxicology,
Journal Year:
2024,
Volume and Issue:
40(1)
Published: June 26, 2024
Abstract
Objective
The
primary
objective
of
this
investigation
is
to
delve
into
the
involvement
long
noncoding
RNA
(lncRNA)
SPACA6P-AS
in
breast
cancer
(BC)
development,
focusing
on
its
expression
pattern,
association
with
clinical-pathological
features,
impact
prognosis,
as
well
molecular
and
immunological
implications.
Methods
Bioinformatics
analysis
was
conducted
utilizing
sequencing
data
1083
BC
patients
from
TCGA
database.
Functional
exploration
carried
out
through
construction
survival
curves,
GO
KEGG
enrichment
analysis,
single-sample
gene
set
(ssGSEA).
Furthermore,
functionality
validated
vitro
cell
experiments
vivo
nude
mouse
model
experiments.
Results
showed
a
remarkable
increase
levels
tissues
(
p
<
0.001)
demonstrated
close
relationship
poor
prognosis
(overall
HR
=
1.616,
progression-free
interval
1.40,
disease-specific
1.54).
Enrichment
revealed
that
could
biological
functions
such
protease
regulation,
endopeptidase
inhibitor
activity,
taste
receptor
transduction,
maturity-onset
diabetes
young
pathway.
ssGSEA
indicated
negative
correlation
between
immune
infiltration
like
dendritic
cells
neutrophils,
while
positive
observed
central
memory
T
helper
2
cells.
illustrated
silencing
significantly
inhibited
proliferation,
migration,
invasion
capabilities
In
also
highlighted
silenced
exhibited
enhanced
promoting
proliferation
autologous
CD3
+
cytokine
secretion.
These
discoveries
elucidate
potential
multifaceted
roles
BC,
including
modulating
tumor
microenvironment.
Conclusion
high
lncRNA
closely
linked
may
facilitate
progression
by
influencing
specific
processes,
signaling
pathways,
regulatory
role
positions
it
prospective
biomarker
target
for
therapeutic
approaches
diagnosis
intervention.
