Long-Term Coronary Microvascular and Cardiac Dysfunction Following Severe COVID-19 Hospitalization DOI Open Access

Rebecka Steffen Johansson,

Daniel Loewenstein, Klara Lodin

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background Coronavirus disease 2019 (COVID-19) can lead to long-term cardiopulmonary symptoms and is associated coronary microvascular dysfunction (CMD). However, data on CMD following severe COVID-19 are lacking. Objective To determine left ventricular (LV) function presence of after COVID-19, utilizing cardiovascular magnetic resonance (CMR) stress perfusion mapping. Methods Hospitalized patients underwent CMR at 10 months follow-up (1.5T Aera, Siemens Healthineers) including cine imaging, native T1 T2, extracellular volume, adenosine Clinical were obtained from patient records. Patients compared volunteers without symptomatic ischemic heart (IHD). Results (n=37, age 56±12 years, 76% male) (n=22, 51±13 55% male, p=ns for both) included. demonstrated reduced (2.8±0.81 vs 3.4±0.69 ml/min/g, p =0.003), impaired global longitudinal strain (GLS, −17±2 −19±2 %, =0.003) circumferential (GCS, −16±3 −19±3 =0.001). There no differences in or myocardial reserve between with risk factors cardiac symptoms. Conclusion exhibit indicating CMD, LV by GLS GCS. Lack variation suggests that may be a consequence warranting further investigation elucidate mechanisms, guide potential therapeutic interventions.

Language: Английский

Long COVID: Long-Term Impact of SARS-CoV2 DOI Creative Commons

Huda Makhluf,

Henry Madany,

Kenneth Kim

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(7), P. 711 - 711

Published: March 28, 2024

Four years post-pandemic, SARS-CoV-2 continues to affect many lives across the globe. An estimated 65 million people suffer from long COVID, a term used encapsulate post-acute sequelae of infections that multiple organ systems. Known symptoms include chronic fatigue syndrome, brain fog, cardiovascular issues, autoimmunity, dysautonomia, and clotting due inflammation. Herein, we review COVID symptoms, proposed theories behind pathology, diagnostics, treatments, clinical trials underway explore treatments for viral persistence, autonomic cognitive dysfunctions, sleep disturbances, fatigue, exercise intolerance.

Language: Английский

Citations

11
Long-term Effects of SARS-CoV-2 Infection on Children’s Vasculature DOI
Dareilena Karaviti, Marietta Charakida, Dimitra Dimopoulou

et al.

The Pediatric Infectious Disease Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Background: While long coronavirus disease 2019 (COVID-19) is linked to prolonged vascular dysfunction in adults, research children remains poor. In this study, we assessed health infected with severe acute respiratory syndrome 2 about 6.8 months postinfection, comparing them healthy controls. Methods: Two hundred twenty-three were and divided into group 1, which included a positive history 2, consisted of Anthropometric measurements, lipid profile, biomarkers (interleukin-6, C-reactive protein, tumor necrosis factor-alpha soluble intracellular adhesion molecule) COVID symptoms assessed, along pulse wave velocity (PWV) measurements carotid intima-media thickness (cIMT) evaluate aortic stiffness. Results: Children 1 older (mean age: 10.8 ± 3.2 years vs. 8.5 2.8 years, P < 0.001) had higher body mass index (20.3 5.6 kg/m 18.4 3.5 , 0.001). PWV was increased (5.02 0.7 m/s 4.7 0.6, However, differences between the groups disappeared after adjusting for age, index, blood pressure. Soluble molecule-1 levels elevated moderate/severe COVID-19 infection compared controls (555.8 113.2 ng/mL 428 42.6 ng/mL, Cholesterol levels, inflammatory markers cIMT comparable groups. Long reported mainly by participants [34 (23.6%) 3 (3.8%), 0.001]. Conclusions: This study demonstrates insights long-term effects children. Evidence endothelial activation without structural arterial changes found. Persistent inflammation postinfection absent, yet approximately one-quarter experienced symptoms, indicating potential pathophysiology postacute childhood.

Language: Английский

Citations

0
The negative effects of long COVID-19 on cardiovascular health and implications for the presurgical examination DOI Creative Commons

Hannah L. Stimart,

Brittany Hipkins

Journal of Osteopathic Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

In 2019, emergence of the novel and communicable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection took scientific communities by surprise imposed significant burden on healthcare systems globally. Although advent this disease piqued interest academic centers, systems, general public, there is still much yet to be elucidated regarding epidemiology, pathophysiology, long-term impacts 2019 (COVID-19). It has been established that long COVID-19 can impact multiple organ including cardiovascular system, unfavorably. pathophysiology damage not well understood, adverse sequelae may range from chest pain arrhythmias heart failure (HF), myocardial infarction, or sudden cardiac death. For any postacute patient requiring a surgical procedure, potential for injury secondary must considered in preoperative examination.

Language: Английский

Citations

1
Long-Term Coronary Microvascular and Cardiac Dysfunction Following Severe COVID-19 Hospitalization DOI Open Access

Rebecka Steffen Johansson,

Daniel Loewenstein, Klara Lodin

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background Coronavirus disease 2019 (COVID-19) can lead to long-term cardiopulmonary symptoms and is associated coronary microvascular dysfunction (CMD). However, data on CMD following severe COVID-19 are lacking. Objective To determine left ventricular (LV) function presence of after COVID-19, utilizing cardiovascular magnetic resonance (CMR) stress perfusion mapping. Methods Hospitalized patients underwent CMR at 10 months follow-up (1.5T Aera, Siemens Healthineers) including cine imaging, native T1 T2, extracellular volume, adenosine Clinical were obtained from patient records. Patients compared volunteers without symptomatic ischemic heart (IHD). Results (n=37, age 56±12 years, 76% male) (n=22, 51±13 55% male, p=ns for both) included. demonstrated reduced (2.8±0.81 vs 3.4±0.69 ml/min/g, p =0.003), impaired global longitudinal strain (GLS, −17±2 −19±2 %, =0.003) circumferential (GCS, −16±3 −19±3 =0.001). There no differences in or myocardial reserve between with risk factors cardiac symptoms. Conclusion exhibit indicating CMD, LV by GLS GCS. Lack variation suggests that may be a consequence warranting further investigation elucidate mechanisms, guide potential therapeutic interventions.

Language: Английский

Citations

0