Relevant Serum Endoplasmic Reticulum Stress Biomarkers in Type 2 Diabetes and Its Complications: A Systematic Review and Meta-Analysis DOI Creative Commons
José Rafael Villafán-Bernal, Francisco Barajas‐Olmos, Iris Paola Guzmán‐Guzmán

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1564 - 1564

Published: Dec. 19, 2024

Endoplasmic reticulum stress (ERS) is activated in all cells by stressors such as hyperglycemia. However, it remains unclear which specific serum biomarkers of ERS are consistently altered type 2 diabetes (T2D). We aimed to identify that T2D and its complications, their correlation with metabolic anthropometric variables. performed a systematic review meta-analysis following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) Observational Studies (MOOSE). The risk bias was assessed using the Newcastle–Ottawa scale. Random-effects models weighted inverse variance were employed estimate standardized mean difference correlations effect size measures. Indicators heterogeneity meta-regressions evaluated. Of 1206 identified studies, 22 finally included, representing 11,953 subjects (2224 9992 non-diabetic controls). Most studies high quality. Compared controls, had higher circulating levels heat shock protein 70 (HSP70; SMD: 2.30, 95% CI 1.13–3.46; p < 0.001) secretagogin (SMD: 0.60, 95%CI 0.19–1.01; 0.001). They also peroxiredoxin-1, -2, -4, -6. Secretagogin inversely correlated HOMA-IR, yet positively HOMA-B, HbA1c, FPG. PRX4 negatively HbA1c FPG, while HSP70 HbA1c. In conclusion, six elevated human correlate glycemic control, insulin resistance, β-cell function. Emerging evidence links but further research should evaluate prognostic implications.

Language: Английский

Cardiovascular Protective Properties of GLP-1 Receptor Agonists: More than Just Diabetic and Weight Loss Drugs DOI Open Access
Richard Le, Mau T. Nguyen,

Momina A. Allahwala

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4674 - 4674

Published: Aug. 9, 2024

Owing to their potent glucose-lowering efficacy and substantial weight loss effects, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are now considered part of the frontline therapeutic options treat both type 2 diabetes mellitus nondiabetic overweight/obesity. Stemming from successful demonstration cardiometabolic modulation reduction major adverse cardiovascular events in clinical outcome trials, GLP-1 RAs have since been validated as agents with compelling protective properties. Studies spanning bench preclinical large-scale randomised controlled trials consistently corroborated benefits this pharmacological class. Most notably, there is converging evidence that they exert favourable effects on atherosclerotic ischaemic endpoints, data indicating may do so by directly modifying burden composition plaques. This narrative review examines underlying pharmacology behind RAs, particular focus disease. It also delves into mechanisms underpin putative plaque-modifying actions, addresses existing knowledge gaps challenges looks future developments field, including use combination incretin for management.

Language: Английский

Citations

11
GLP-1 receptor agonism in cardiovascular disease prevention DOI

Hanan Alaaeldin Saleh

Asia-Pacific Journal of Pharmacotherapy & Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Cardiovascular diseases (CVDs) are leading cause of mortality worldwide, closely linked to risk factors such as type 2 diabetes mellitus (T2DM) and obesity. Recent advances in therapeutic strategies have identified glucagon-like peptide-1 receptor agonists (GLP-1RAs) promising agents that extend beyond glycemic control offer significant cardiovascular benefits. This review examines the evolving role GLP-1RAs CVD prevention, focusing on their mechanisms action clinical implications. act by mimicking endogenous GLP-1 enhance insulin secretion, reduce glucagon levels, regulate blood glucose. Their impact extends improving vascular health, reducing atherosclerotic progression, mitigating inflammation, countering diabetic hyperglycemia dyslipidemia. also contribute weight reduction, a key factor alleviating risk. Results from trials real-world evidences consistently support GLP-1RA treatment lowers incidence major adverse events (MACEs), including myocardial infarction stroke, diverse patient populations. Despite potential, barriers limited awareness among healthcare professionals unequal access hinder broader adoption into clinics. Ongoing studies continue explore integration with other approaches, sodium-glucose cotransporter-2 (SGLT2) inhibitors lipid-lowering agents, optimize outcomes. underscores importance leveraging multifaceted tool global burden while addressing challenges ensure equitable long-term

Language: Английский

Citations

0
Statins as an Adjunctive Antithrombotic Agent in Thrombotic Antiphospholipid Syndrome: Mechanisms and Clinical Implications DOI Creative Commons
Tommaso Bucci, Danilo Menichelli, Ilaria Palumbo

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 353 - 353

Published: Feb. 28, 2025

The thrombotic physiopathology of antiphospholipid syndrome (APS) is complex, heterogeneous, and dynamic. While venous thromboembolism (VTE) the most common initial presentation, arterial events (ATE) become more frequent in advanced stages are associated with high morbidity mortality. Despite use oral anticoagulants (OACs), APS remains a risk recurrent thrombosis. Given their potential antithrombotic effects capable reducing both VTE ATE, statins have been proposed as an adjunctive therapy to OACs for patients However, this recommendation primarily based on studies not specifically conducted populations, only preclinical data or evidence from retrospective observational available cohorts. For these reasons, narrative review aims synthesise evaluating APS, highlighting progress made identifying areas future research.

Language: Английский

Citations

0
Endoplasmic Reticulum Stress and Its Role in Metabolic Reprogramming of Cancer DOI Creative Commons

Salvatore Zarrella,

Maria Rosaria Miranda, Verdiana Covelli

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 221 - 221

Published: March 24, 2025

Background/Objectives: Endoplasmic reticulum (ER) stress occurs when ER homeostasis is disrupted, leading to the accumulation of misfolded or unfolded proteins. This condition activates protein response (UPR), which aims restore balance trigger cell death if cannot be achieved. In cancer, plays a key role due heightened metabolic demands tumor cells. review explores how metabolomics can provide insights into stress-related alterations and their implications for cancer therapy. Methods: A comprehensive literature was conducted analyze recent findings on stress, metabolomics, metabolism. Studies examining profiling cells under conditions were selected, with focus identifying potential biomarkers therapeutic targets. Results: Metabolomic studies highlight significant shifts in lipid metabolism, synthesis, oxidative management stress. These are crucial adaptation survival. Additionally, targeting pathways has shown preclinical models, suggesting new strategies. Conclusions: Understanding impact provides valuable opportunities drug development. Metabolomics-based approaches may help identify novel targets, enhancing effectiveness antitumor therapies.

Language: Английский

Citations

0
Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions DOI Creative Commons
Zoofa Zayani, Arash Matinahmadi, Alireza Tavakolpournegari

et al.

Stresses, Journal Year: 2025, Volume and Issue: 5(2), P. 26 - 26

Published: April 4, 2025

Cellular stressors have been demonstrated to exert a substantial influence on the functionality of organelles, thereby impacting cellular homeostasis and contributing development disease pathogenesis. This review aims examine impact diverse stressors, including environmental, chemical, biological, physical factors, critical organelles such as cell membrane, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, membrane-less organelles. The intricate molecular mechanisms underlying stress responses, encompassing oxidative stress, protein misfolding, metabolic reprogramming, capacity elicit adaptive responses or culminate in pathological conditions. interplay between these organelle dysfunction has implicated myriad diseases, neurodegenerative disorders, cancer, immune-related pathologies. A comprehensive understanding by which respond can offer valuable insights into therapeutic strategies aimed at mitigating damage.

Language: Английский

Citations

0
Therapeutic potential of natural flavonoids in atherosclerosis through endothelium-protective mechanisms: An update DOI
Chao Zhong,

Keke Deng,

Xiaoya Lang

et al.

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108864 - 108864

Published: April 1, 2025

Language: Английский

Citations

0
Roles of Mitochondrial Quality Control in the Pathogenesis of Atherosclerosis DOI Creative Commons

Zakareya M. Alsalman,

Qiongjun Zhu, Jiayi Hu

et al.

Cardiovascular Innovations and Applications, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 1, 2025

Mitochondrial quality control (MQC) mechanisms – including biogenesis, dynamics, mitophagy, proteostasis, the unfolded protein response, and mitochondrial-derived vesicles play critical roles in development of atherosclerosis. Dysregulation these processes can lead to mitochondrial dysfunction, subsequently initiation a pathological cascade characterized by oxidative stress, chronic inflammation, accumulation lipids within arterial walls. Specifically, ROS overproduction redox state imbalance are key molecular aspects that exacerbate damage, create self-perpetuating cycle cellular injury disease progression. Emerging therapeutic strategies targeting modulation MQC have promise attenuating atherosclerotic progression restoring balance fusion fission enhancing clearance damaged mitochondria, improving homeostasis. Advancing understanding regulators interaction networks pathways might facilitate precision-targeted therapies. However, substantial challenges persist translating insights into clinical applications. This review explores relationship between atherosclerosis, focusing on associated potential avenues for intervention.

Language: Английский

Citations

0
IL-17A exacerbates synovial inflammation in osteoarthritis via activation of endoplasmic reticulum stress DOI

Wen Sun,

Xueyan Li, Liyuan Zhang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 145, P. 113733 - 113733

Published: Dec. 10, 2024

Language: Английский

Citations

1
Relevant Serum Endoplasmic Reticulum Stress Biomarkers in Type 2 Diabetes and Its Complications: A Systematic Review and Meta-Analysis DOI Creative Commons
José Rafael Villafán-Bernal, Francisco Barajas‐Olmos, Iris Paola Guzmán‐Guzmán

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1564 - 1564

Published: Dec. 19, 2024

Endoplasmic reticulum stress (ERS) is activated in all cells by stressors such as hyperglycemia. However, it remains unclear which specific serum biomarkers of ERS are consistently altered type 2 diabetes (T2D). We aimed to identify that T2D and its complications, their correlation with metabolic anthropometric variables. performed a systematic review meta-analysis following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) Observational Studies (MOOSE). The risk bias was assessed using the Newcastle–Ottawa scale. Random-effects models weighted inverse variance were employed estimate standardized mean difference correlations effect size measures. Indicators heterogeneity meta-regressions evaluated. Of 1206 identified studies, 22 finally included, representing 11,953 subjects (2224 9992 non-diabetic controls). Most studies high quality. Compared controls, had higher circulating levels heat shock protein 70 (HSP70; SMD: 2.30, 95% CI 1.13–3.46; p < 0.001) secretagogin (SMD: 0.60, 95%CI 0.19–1.01; 0.001). They also peroxiredoxin-1, -2, -4, -6. Secretagogin inversely correlated HOMA-IR, yet positively HOMA-B, HbA1c, FPG. PRX4 negatively HbA1c FPG, while HSP70 HbA1c. In conclusion, six elevated human correlate glycemic control, insulin resistance, β-cell function. Emerging evidence links but further research should evaluate prognostic implications.

Language: Английский

Citations

0