Journal of King Saud University - Science,
Journal Year:
2022,
Volume and Issue:
34(4), P. 102006 - 102006
Published: April 1, 2022
Microplastics
(MPs),
an
emerging
ubiquitous
pollutant
in
the
aquatic
ecosystem,
pose
serious
health
concerns
to
survival
of
fauna,
especially
top
predators
(e.g.,
mammals).
It
is
challenging
investigate
toxicological
profile
MPs
mammals
due
their
diverse
behaviour,
physico-chemical
properties,
and
other
technical
ethical
issues.
This
study
reviewed
current
burden
occurrence
various
tissues
mammals,
its
composition
(heavy
metals,
pesticides,
pathogens),
possible
effects
on
individual
population
levels
mammals.
Aquatic
are
constantly
exposed
directly
indirectly
via
food-web.
The
a
wide
range
toxic
heavy
pathogens
added
during
manufacturing
or
adsorbed
from
surrounding
environments
bioaccumulated
for
years.
Due
long
life-span
body
masses,
these
pollutants
can
cause
several
issues
that
drastically
reduce
size
ultimately
extinction,
vulnerable
populations.
Still
today
presence
deep
largely
remains
unknown
We
therefore
suggest
global
assessment
risks
associated
with
consumption
by
habitats.
Catalysts,
Journal Year:
2022,
Volume and Issue:
12(3), P. 289 - 289
Published: March 3, 2022
Endocrine
Disrupting
Compounds
(EDCs)
comprise
a
class
of
natural
or
synthetic
molecules
and
groups
substances
which
are
considered
as
emerging
contaminants
due
to
their
toxicity
danger
for
the
ecosystems,
including
human
health.
Nowadays,
presence
EDCs
in
water
wastewater
has
become
global
problem,
is
challenging
scientific
community
address
development
application
effective
strategies
removal
from
environment.
Particularly,
catalytic
photocatalytic
degradation
processes
employing
nanostructured
materials
based
on
metal
oxides,
mainly
acting
through
generation
reactive
oxygen
species,
widely
explored
eradicate
water.
In
this
review,
we
report
recent
advances
described
by
major
publications
years
focused
several
classes
EDCs,
such
plastic
components
additives,
agricultural
chemicals,
pharmaceuticals,
personal
care
products,
were
realized
using
novel
oxide-based
nanomaterials.
A
variety
doped,
hybrid,
composite
heterostructured
semiconductors
reported,
whose
performances
influenced
chemical,
structural
well
morphological
features.
Along
with
photocatalysis,
alternative
heterogeneous
advanced
oxidation
development,
combination
may
be
promising
way
toward
industrial
scale
application.
BJOG An International Journal of Obstetrics & Gynaecology,
Journal Year:
2023,
Volume and Issue:
131(4), P. 401 - 414
Published: Oct. 9, 2023
Abstract
Background
The
interaction
between
pollution
and
endometriosis
is
a
pressing
issue
that
demands
immediate
attention.
impact
of
pollution,
particularly
air
water
or
occupational
hazards,
on
hormonal
disruption
the
initiation
remains
major
issue.
Objectives
This
narrative
review
aims
to
delve
into
intricate
connection
endometriosis,
shedding
light
how
environmental
factors
contribute
onset
severity
this
disease
and,
thus,
possible
public
health
policy
implications.
Discussion
Endocrine‐disrupting
chemicals
(EDCs)
in
pollutants
dysregulate
balance,
contributing
progression
gynaecological
disorder.
Air
specifically
PM2.5
PAHs,
has
been
associated
with
an
increased
risk
by
enhancing
chronic
inflammation,
oxidative
stress,
imbalances.
Chemical
contaminants
work
exposures,
including
heavy
metals,
dioxins,
PCBs,
disrupt
regulation
potentially
endometriosis.
Mitigating
required
safeguard
women’s
reproductive
health.
requires
comprehensive
approach
involving
stringent
regulations,
sustainable
practices,
responsible
waste
management,
research
innovation,
awareness,
collaboration
among
stakeholders.
Conclusion
Public
policies
have
role
addressing
long‐term
commitment.
Environmental Health Perspectives,
Journal Year:
2022,
Volume and Issue:
130(3)
Published: March 1, 2022
Bisphenol
A
(BPA)
exposure
has
been
linked
to
miscarriages
and
pregnancy
complications
in
humans.
In
contrast,
the
potential
reproductive
toxicity
of
BPA
analogs,
including
tetrabromobisphenol
(TBBPA),
is
understudied.
Furthermore,
although
environmental
altered
immune
mediators,
effects
TBBPA
on
maternal-fetal
tolerance
during
have
not
studied.
The
present
study
investigated
whether
resulted
higher
rates
loss
mice,
lower
number
regulatory
T
cells
(Tregs),
indoleamine
2,3
deoxygenase
1
(Ido1)
expression,
which
provided
evidence
for
mechanisms
related
pregnancy.The
purpose
this
investigation
was
characterize
mice
percentage
Tregs
Ido1
expression
DNA
methylation.Analysis
fetal
resorption
quantification
maternal
by
flow
cytometry
were
performed
allogeneic
syngeneic
pregnancies.
mRNA
protein
methylation
placentas
from
control
BPA-
TBBPA-exposed
analyzed
using
real-time
quantitative
polymerase
chain
reaction,
immunofluorescence,
bisulfite
sequencing
analyses.BPA
hemorrhaging
early
allogeneic,
but
syngeneic,
conceptuses.
pregnancies,
associated
with
Treg
number.
Importantly,
these
differences
IDO1
trophoblast
giant
mean
embryonic
day
9.5
mice.BPA-
TBBPA-induced
perturbed
IDO1-dependent
tolerance.
https://doi.org/10.1289/EHP10640.
Lab on a Chip,
Journal Year:
2024,
Volume and Issue:
24(6), P. 1727 - 1749
Published: Jan. 1, 2024
The
effects
of
endocrine-disrupting
compounds
(EDCs)
on
the
placenta,
a
critical
gestational
organ
for
xenobiotic
protection,
are
well
reported;
however,
models
to
determine
role
EDCs
in
placental
disruption
limited.
Life,
Journal Year:
2024,
Volume and Issue:
14(3), P. 402 - 402
Published: March 18, 2024
We
are
exposed
to
a
mixture
of
environmental
man-made
and
natural
xenobiotics.
experience
wide
spectrum
exposure
in
our
lifetime,
including
the
effects
xenobiotics
on
gametogenesis
gametes
that
undergo
fertilization
as
starting
point
individual
development
and,
moreover,
utero
exposure,
which
can
itself
cause
first
somatic
or
germline
mutation
necessary
for
breast
cancer
(BC)
initiation.
Most
metabolized
or/and
bioaccumulate
biomagnify
tissues
cells,
tissues,
so
xenobiotic
metabolism
plays
an
important
role
BC
initiation
progression.
Many
considerations
necessitate
more
valuable
explanation
regarding
molecular
mechanisms
action
act
genotoxic
epigenetic
carcinogens.
Thus,
exposomics
exposome
concept
based
diversity
range
exposures
physical
factors,
synthetic
chemicals,
dietary
components,
psychosocial
stressors,
well
their
associated
biologic
processes
pathways.
Existing
evidence
risk
(BCR)
suggests
food-borne
chemical
carcinogens,
air
pollution,
ionizing
radiation,
socioeconomic
status
closely
related
carcinogenesis.
The
aim
this
review
was
depict
dynamics
kinetics
several
involved
development,
emphasizing
new
omics
fields
exposomics,
such
toxicogenomics,
epigenomics
interactomics,
metagenomics,
nutrigenomics,
nutriproteomics,
nutrimiRomics.
mainly
focused
food
nutrition,
endocrine-disrupting
chemicals
(EDCs),
development.
Overall,
cell
tissue
accumulation
biotransformation
lead
modifications
composition
morphology,
DNA
damage
genomic
instability,
epimutations,
RNA-mediated
extracellular
vesicle
effects,
aberrant
blood
methylation,
stimulation
epithelial-mesenchymal
transition
(EMT),
disruption
cell-cell
junctions,
reorganization
actin
cytoskeleton,
metabolic
reprogramming,
overexpression
mesenchymal
genes.
Moreover,
into
cells
impacts
almost
all
known
carcinogenic
Conversely,
food,
there
many
bioactive
compounds
with
anti-cancer
potential,
exerting
pro-apoptotic
roles,
inhibiting
cycle
progression
proliferation,
migration,
invasion,
damage,
stress
conditions.
conclude
has
high
potential
demonstrate
how
acts
double-edged
sword,
promoting
suppressing
tumorigenesis
BC.
Experimental Cell Research,
Journal Year:
2023,
Volume and Issue:
427(1), P. 113574 - 113574
Published: March 31, 2023
Bisphenol
A
(BPA)
is
a
harmful
endocrine
disrupting
compound
that
alters
not
only
classical
cellular
mechanisms
but
also
epigenetic
mechanisms.
Evidence
suggests
BPA-induced
changes
in
microRNA
expression
can
explain,
part,
the
observed
at
both
molecular
and
levels.
BPA
toxic
to
granulosa
cells
(GCs)
as
it
activate
apoptosis,
which
known
contribute
increased
follicular
atresia.
miR-21
crucial
antiapoptotic
regulator
GCs,
yet
exact
function
toxicity
model
remains
unclear.
was
found
induce
bovine
GC
apoptosis
through
activation
of
several
intrinsic
factors.
reduced
live
counts,
late
apoptosis/necrosis,
apoptotic
transcripts
(BAX,
BAD,
BCL-2,
CASP-9,
HSP70),
BAX/Bcl-2
ratio
HSP70
protein
level,
induced
caspase-9
activity
12
h
post-exposure.
inhibition
early
and,
while
did
influence
transcript
levels
or
activity,
elevate
same
manner
BPA.
Overall,
this
study
shows
plays
role
regulating
mitochondrial
apoptosis;
however,
make
more
sensitive
Therefore,
by
GCs
independent.
