Journal of Autoimmunity, Journal Year: 2025, Volume and Issue: 151, P. 103371 - 103371
Published: Jan. 29, 2025
Language: Английский
Animal Research and One Health, Journal Year: 2023, Volume and Issue: 1(1), P. 92 - 114
Published: July 3, 2023
Abstract In recent years, the important role of gut microbiota in promoting animal health and regulating immune function livestock poultry has been widely reported. The issue problems causes significant economic losses each year. Probiotics postbiotics have developed as additives due to their beneficial effects balancing host microbiota, enhancing intestinal epithelial barrier, immunity, whole‐body metabolism. are composed complex ingredients, with different components compositions having effects, requiring classification for discussing mechanisms action. considerable prospects preventing various diseases industry feed medical applications. This review highlights application value probiotics potential probiotic products, emphasizing concept, mechanism action, application, improve productivity poultry.
Language: Английский
Citations
42
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 3, 2024
Accumulating studies have indicated that the gut microbiota plays a pivotal role in onset of autoimmune diseases by engaging complex interactions with host. This review aims to provide comprehensive overview existing literatures concerning relationship between and diseases, shedding light on interplay microbiota, host immune system. Furthermore, we aim summarize impacts potential mechanisms underlie primarily focusing systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, type 1 diabetes mellitus, ulcerative colitis psoriasis. The present will emphasize clinical significance applications interventions based as innovative adjunctive therapies for diseases.
Language: Английский
Citations
21
BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: March 13, 2024
Abstract Background Previous randomized controlled trials (RCTs) suggested that gut microbiota-based therapies may be effective in treating autoimmune diseases, but a systematic summary is lacking. Methods Pubmed, EMbase, Sinomed, and other databases were searched for RCTs related to the treatment of diseases with probiotics from inception June 2022. RevMan 5.4 software was used meta-analysis after 2 investigators independently screened literature, extracted data, assessed risk bias included studies. Results A total 80 14 types disease [celiac sprue, SLE, lupus nephritis (LN), RA, juvenile idiopathic arthritis (JIA), spondyloarthritis, psoriasis, fibromyalgia syndrome, MS, systemic sclerosis, type 1 diabetes mellitus (T1DM), oral lichen planus (OLP), Crohn’s disease, ulcerative colitis] included. The results showed improve symptoms and/or inflammatory factor celiac SLE LN, JIA, PSS, colitis. However, not spondyloarthritis RA. Gut relieve pain effect on impact questionnaire score significant. HbA1c T1DM, its insulin requirement does seem These did increase incidence adverse events. Conclusions several (celiac colitis).
Language: Английский
Citations
18
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 3010 - 3010
Published: March 5, 2024
This systematic review addresses the use of Lactiplantibacillus (Lactobacillus) plantarum in symptomatological intervention neurodegenerative disease. The existence gut microbiota dysbiosis has been associated with systemic inflammatory processes present disease, creating opportunity for new treatment strategies. involves modifying strains that constitute to enhance synaptic function through gut–brain axis. Recent studies have evaluated beneficial effects on motor and cognitive symptomatology, alone or combination. includes 20 research articles (n = 3 human n 17 animal models). main result this was combination produced improvements symptomatology related However, one included reported negative after administration plantarum. provides current relevant information about probiotic pathologies such as Alzheimer’s Parkinson’s disease Multiple Sclerosis.
Language: Английский
Citations
17
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3300 - 3300
Published: Feb. 7, 2023
Type 1 diabetes mellitus (T1DM) arises from the failure of pancreatic β-cells to produce adequate insulin, usually as a consequence extensive β-cell destruction. T1DM is classed an immune-mediated condition. However, processes that drive apoptosis remain be determined, resulting in prevent ongoing cellular Alteration mitochondrial function clearly major pathophysiological process underpinning loss T1DM. As with many medical conditions, there growing interest role gut microbiome, including interactions bacteria Candida albicans fungal infection. Gut dysbiosis and permeability are intimately associated raised levels circulating lipopolysaccharide suppressed butyrate levels, which can act dysregulate immune responses systemic function. This manuscript reviews broad bodies data on pathophysiology, highlighting importance alterations melatonergic pathway driving dysfunction. The suppression melatonin makes susceptible oxidative stress dysfunctional mitophagy, partly mediated by melatonin’s induction PTEN-induced kinase (PINK1), thereby suppressing mitophagy increasing autoimmune histocompatibility complex (MHC)-1. immediate precursor melatonin, N-acetylserotonin (NAS), brain-derived neurotrophic factor (BDNF) mimic, via activation BDNF receptor, TrkB. both full-length truncated TrkB play powerful roles survival, NAS another important aspect relevant destruction incorporation pathophysiology integrates wide previously disparate intercellular processes. Akkermansia muciniphila, Lactobacillus johnsonii, butyrate, shikimate pathway—including bacteriophages—contributes not only apoptosis, but also bystander CD8+ T cells, increases their effector prevents deselection thymus. microbiome therefore significant determinant dysfunction well ‘autoimmune’ effects derived cytotoxic cells. has future research treatment implications.
Language: Английский
Citations
23
Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 221 - 221
Published: Jan. 18, 2024
This comprehensive review article delves into the critical role of human microbiota in development and management endocrine-related diseases. We explore complex interactions between endocrine system, emphasizing implications dysbiosis for onset progression various disorders. The aims to synthesize current knowledge, highlighting recent advancements potential novel therapeutic approaches targeting microbiota-endocrine interactions. Key topics include impact on hormone regulation, its pathologies, promising avenues modulation through diet, probiotics, prebiotics, fecal transplantation. underscore importance this research advancing personalized medicine, offering insights more tailored effective treatments
Language: Английский
Citations
15
Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 106 - 106
Published: Feb. 8, 2025
Intestinal bacteria form one of the most complex microbial communities in human body, playing a crucial role maintaining host health and contributing to development various diseases. Here, we provide comprehensive overview composition function intestinal bacteria, factors affecting their homeostasis, association mechanisms with range diseases (e.g., inflammatory bowel diseases, colorectal cancer, metabolic diseases). Additionally, advanced potential disease diagnosis treatment is highlighted. Therapies, such as chemotherapy, radiotherapy, immunotherapy, are significantly impacted by research indicating that can enhance chemoimmunotherapy efficiency T cell recruitment immune infiltration. Fecal microbiota transplantation has emerged promising option for treating recurrent Clostridium difficile infections certain neurological disorders. Gut bacteria-related serum metabolites serve non-invasive indicators diagnosing CRC, while fecal immunochemical tests offer applications CRC screening. Future needed better understand causal relationships between develop more precise diagnostic tools, evaluate effectiveness safety microbiome-targeted therapies clinical treatment. This study provides deeper insights into disease, providing scientific basis innovative therapeutic strategies have transform landscape healthcare.
Language: Английский
Citations
1
Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 138 - 138
Published: Feb. 19, 2025
Background: Type 1 diabetes (T1D) is a severe chronic T-cell mediated autoimmune disease that attacks the insulin-producing beta cells of pancreas. The multifactorial nature T1D involves both genetic and environmental components, with recent research focusing on gut microbiome as crucial factor in pathogenesis. its metabolites play an important role modulating immunity autoimmunity. In years, studies have revealed significant alterations taxonomic functional composition associated development islet autoimmunity T1D. These changes include reduced production short-chain fatty acids, altered bile acid tryptophan metabolism, increased intestinal permeability consequent perturbations host (auto)immune responses. Methods/Results: this review, we summarize discuss observational, mechanistic etiological investigating elucidating intricate microbes Moreover, highlight advances intervention targeting microbiota for prevention or treatment human Conclusions: A deeper understanding evolution before after onset microbial signals conditioning may provide us essential insights exploiting prognostic therapeutic tool.
Language: Английский
Citations
1
Diabetes/Metabolism Research and Reviews, Journal Year: 2023, Volume and Issue: 40(2)
Published: May 14, 2023
Abstract Dysbiosis or imbalance of microbes in the gut has been associated with susceptibility and progression type 1 diabetes mellitus (T1DM). The present systematic review meta‐analysis examined effects probiotics, prebiotics, synbiotics on fasting blood glucose (FBG), haemoglobin A1c (HbA1c), C‐peptide, insulin requirements T1DM patients. A search for trials published up to October 2022 was conducted PubMed, EMBASE, Scopus, Google Scholar, ScienceDirect, Web Science, Central Cochrane Library. Random effect models were used synthesise quantitative data by STATA 14 . After evaluation 258 identified entries, five randomised controlled ( n = 356; mean age 11.7 years old) included. pooled size showed that FBG decreased following probiotic supplementation (weighted difference −31.24 mg/dL; 95% confidence interval −45.65, −16.83; p < 0.001), however, there no significant improvement serum HbA1c, requirements. Probiotic could be a complementary therapeutic strategy T1DM. evidence is limited; therefore, it crucial conduct more trials.
Language: Английский
Citations
18
Microorganisms, Journal Year: 2023, Volume and Issue: 11(10), P. 2580 - 2580
Published: Oct. 17, 2023
Lactobacillus johnsonii has been used as a probiotic for decades to treat wide range of illnesses, and found have specific advantages in the treatment number ailments. We reviewed potential therapeutic effects mechanisms L. various diseases based on PubMed Web Science databases. obtained information 149 from NCBI (as 14 February 2023), their comprehensive metadata, including about plasmids they contain. This review provides basic characterization different some properties Although are not fully understood yet, it is hoped that may provide evidence future studies. Furthermore, antibiotic resistance strains clear, more complete in-depth studies needed. In summary, presents significant research or prevention disease; however, proof required justify its application. An additional study genes contains also needed reduce antimicrobial dissemination.
Language: Английский
Citations
18