Radiofrequency Ablation for Locoregional Structural Incomplete Response in Differentiated Thyroid Cancer: Initial Experience in Greece

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 255 - 255

Published: Jan. 21, 2025

Background/Objectives: Structural incomplete response (SIR) (persistence/recurrence) may occur in 2–6% of low-risk differentiated thyroid cancer (DTC)-cases and 67–75% high risk. Regarding locoregional disease, surgery is the optimal therapeutic modality if smallest dimension targeted node ≥8 mm or ≥10 (central lateral compartment). In presence smaller nodes, contraindications patient’s unwillingness for reoperation, active surveillance (AS) minimally invasive treatments (MITs) be considered. Methods: We retrospectively studied eight DTC patients with SIR confirmed by ultrasound (U/S)-guided fine-needle aspiration cytology (FNAC) measurement Thyroglobulin (Tg) washout fluid. Fourteen malignant lesions were ablated radiofrequency (RF). assessed prior to RF ablation (RFA) consecutively at one month, three months and, then, every volume each lesion, serum Tg Anti-Tg antibodies calculated reduction ratio (VRR). Results: Patients followed a mean period 13.25 (range: 4–24) after RFA was performed. The reduced significantly from median 0.24 mL 0.09–0.9) 0.02 0–0.03) (p < 0.05), VRR 94.5% 78–100%) concomitant significant biochemical remission (decrease 1.05 ng/mL 0.2 ng/mL, p 0.05). patient an aggressive radioiodine (RAI)-refractory histological variant, re-recurrence documented, which successfully re-ablated RF. two patients, Horner syndrome diagnosed as complication, totally resolved within six months. Conclusions: considered effective safe MIT selective SIR, especially cases lesions. Additional prospective studies are needed, including variants towards tailored approach.

Language: Английский

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Predictive risk-scoring model for lateral lymph node metastasis in papillary thyroid carcinoma

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 19, 2025

This study aims to evaluate candidate risk factors for lateral lymph node metastasis (LLNM) and develop a predictive model identify high-risk groups among patients with papillary thyroid carcinoma (PTC). Additionally, we identified recurrence inform postoperative therapeutic decisions follow-up physicians patients. A total of 4107 (4884 lesions) who underwent dissection at our hospital from 2005 2014 were evaluated. LLNM was stratified, risk-scoring developed based on independent LLNM. Cox's proportional hazards regression used investigate the recurrence. Lateral Lymph Node (LLN) observed in 10.49% (431/4107) Multivariate analysis following predictors LLN metastasis: Age ≤ 35 years (P = 0.002), tumor size > 1.0 cm 0.000), lobe dissemination (+) CLNM 0.000). 12-point constructed predict stratified PTC patients, an area under receiver operating characteristic curve (AUROC) 0.794 (95% CI: 0.774–0.814) < 0.01). The Cox indicated that cm, (+), multifocality, Central Metastasis (CLNM), significant associated poor outcomes. Based scoring model, additional investigations comprehensive considerations are recommended score greater than 5, prophylactic cervical is performed if necessary. more aggressive treatment frequent follow-ups should be considered CLNM,

Language: Английский

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Identification of oxidative stress-related subgroups and signature genes for the prediction of prognosis and immune microenvironment in thyroid cancer

Molecular Genetics and Genomics, Journal Year: 2025, Volume and Issue: 300(1)

Published: April 30, 2025

Language: Английский

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Risk factors for death of follicular thyroid carcinoma: a systematic review and meta-analysis

Endocrine, Journal Year: 2023, Volume and Issue: 82(3), P. 457 - 466

Published: Oct. 7, 2023

Language: Английский

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Agrin is a novel oncogenic protein in thyroid cancer

Oncology Letters, Journal Year: 2023, Volume and Issue: 26(5)

Published: Sept. 25, 2023

Agrin (AGRN) is a matricellular glycoprotein involved in extracellular signal transduction. AGRN tumorigenesis and cancer progression; however, the role of thyroid (TC) remains unclear. In present study, using cell lines derived from various subtypes TC including CGTH, FTC-133 BcPAP transcriptomic data patients with TC, was analyzed by migration, invasion, viability proliferation assays as well Western blot EMT markers. expression significantly increased tumors subtypes. The highest found follicular papillary carcinoma Immunocytochemistry revealed nuclear localization normal (NTHY) cells. Silencing decreased viability, proliferation, migration invasion upregulating vimentin downregulating N-cadherin E-cadherin. Furthermore, associated neutrophil infiltration tumors. conclusion, results indicated that promoted tumorigenic phenotypes cells, while immune may represent target for future therapy requires further evaluation.

Language: Английский

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Long Non-Coding RNAs as Determinants of Thyroid Cancer Phenotypes: Investigating Differential Gene Expression Patterns and Novel Biomarker Discovery

Biology, Journal Year: 2024, Volume and Issue: 13(5), P. 304 - 304

Published: April 27, 2024

Thyroid Cancer (TC) is the most common endocrine malignancy, with increasing incidence globally. Papillary thyroid cancer (PTC), a differentiated form of TC, accounts for approximately 90% TC and occurs predominantly in women childbearing age. Although responsive to current treatments, recurrence PTC by middle age much more refractive treatment. Undifferentiated particularly anaplastic (ATC), aggressive subtype, characterized it being resistant unresponsive all therapeutic surgical interventions. Further, ATC one lethal malignancies across types. Despite differences needs vs. undifferentiated subtypes, there critical unmet need identification molecular biomarkers that can aid early diagnosis, prognosis, actionable targets intervention. Advances field genomics have enabled elucidation differential gene expression patterns between tumors healthy tissue. A novel category molecules, known as non-coding RNAs, themselves be differentially expressed, extensively contribute up- downregulation protein coding genes, serving master orchestrators regulated dysregulated patterns. These RNAs been identified their roles driving carcinogenic at various stages tumor development become attractive study. The specific genes are expressed give insight into mechanisms drive patterns, filling gaps deciphering cellular processes modulate outside well-known driver mutations.

Language: Английский

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Long‐term oncological outcomes of follicular thyroid cancer in adolescents and young adults: A nationwide population‐based study

World Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: July 7, 2024

Abstract Background Follicular thyroid carcinoma (FTC) in adolescents and young adults (AYAs) is rare data on long‐term oncological outcomes are scarce. This study aimed to describe the recurrence survival rates of AYAs with FTC, identify risk factors for recurrence. Methods a retrospective cohort combining two national databases, including all patients aged 15–39 years, diagnosed FTC The Netherlands between 2000 2016. Age, sex, tumor size, focality, positive margins, angioinvasion, pT‐stage, pN‐stage were included Cox proportional hazard model Results We 192 patients. Median age was 31.0 years (IQR 24.7–36.3) male female ratio 1:4.1. Most presented minimally invasive (MI‐FTC) (95%). Five synchronous metastases (2.6%), locoregional (1%) three distant (1.6%). During median follow‐up 12.0 developed (1.6%), which one patient local (33%), (67%). died during (2.6%). Cause death not captured. A could be performed due low number recurrences. Conclusions generally characterized as low‐risk tumor, it exhibits very rate, high overall survival, typically presents MI‐FTC without metastases. These findings underscore favorable prognosis AYAs.

Language: Английский

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A Rare Case of Biopsy-Proven Sacral Mass Metastatic From Follicular Thyroid Cancer With a Literature Review

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Thyroid cancer with metastatic disease to the pelvis is extremely rare. The patient in our case, an 86-year-old male, presented after total thyroidectomy for follicular thyroid (FTC) symptoms of recurrent urinary tract infections and retentions, surprisingly leading discovery a large sacral mass on CT abdomen pelvis. biopsy showed carcinoma morphology immunohistochemistry be consistent FTC. In due symptomatology, prostate was initially considered high differential primary source rather than cancer. too surgery, he referred radiation oncologist therapy mass.

Language: Английский

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Comparison of prognosis between oncocytic thyroid carcinoma and follicular thyroid carcinoma: a population-based propensity score matching analysis

European Archives of Oto-Rhino-Laryngology, Journal Year: 2024, Volume and Issue: 282(2), P. 993 - 1003

Published: Sept. 11, 2024

Language: Английский

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Prognostic Factors for Cancer-Specific Survival and Disease-Free Interval in 130 Patients with Follicular Thyroid Carcinoma: Single Institution Experience

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2817 - 2817

Published: Dec. 14, 2024

Background: Follicular thyroid carcinoma (FTC) is categorized into three groups: minimally invasive FTC (MIFTC), encapsulated angioinvasive (EAIFTC), and widely (WIFTC). the second most common type of tumor, though it remains relatively rare in general population. This study aimed to examine prognosis prognostic factors patients with follicular carcinoma. Methods: Data were obtained from a tertiary referral center for 130 patients, covering period 1995 2020. Clinical data included demographic characteristics, tumor features, surgery, recurrence, vital status. Descriptive statistical methods, Kaplan–Meier survival curves, Cox proportional hazard regression used analysis identify independent predictors. Results: Distant metastases occurred 12 during follow-up period. The 5-year, 10-year, 15-year, 20-year cancer-specific (CSS) rates 98.1%, 92.3%, 83.5%, 79.8%, respectively. Independent unfavorable CSS (hazard ratio [HR] 3.63, 95% CI 1.29–10.18), multifocality (HR 6.7, 1.37–32.72), presence distant 2.29, 1.08–4.84). When disease-free interval (DFI) was considered, 85.3%, 82.0%, 76.6%, DFI 2.53, 1.02–6.28) 7.69, 1.07–55.17). Conclusions: 10-year rate favorable. Factors associated poorer include metastases, WIFTC, multifocality. linked disease recurrence are WIFTC

Language: Английский

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