SGLT2 Inhibition via Empagliflozin Improves Endothelial Function and Reduces Mitochondrial Oxidative Stress: Insights From Frail Hypertensive and Diabetic Patients

Hypertension, Journal Year: 2022, Volume and Issue: 79(8), P. 1633 - 1643

Published: July 13, 2022

Frailty is a multidimensional condition often diagnosed in older adults with hypertension and diabetes, both these conditions are associated endothelial dysfunction oxidative stress. We investigated the functional role of SGLT2 (sodium glucose cotransporter 2) inhibitor empagliflozin frail diabetic hypertensive adults.

Language: Английский

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Prediabetes Increases the Risk of Frailty in Prefrail Older Adults With Hypertension: Beneficial Effects of Metformin

Hypertension, Journal Year: 2024, Volume and Issue: 81(7), P. 1637 - 1643

Published: May 16, 2024

Prediabetes has garnered increasing attention due to its association with cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and frailty among older individuals.

Language: Английский

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Association of hemoglobin, albumin, lymphocyte, and platelet score with risk of cerebrovascular, cardiovascular, and all-cause mortality in the general population: results from the NHANES 1999-2018

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: June 23, 2023

Background and aims Cardiovascular cerebrovascular disease (CCDs) contribute to leading causes of morbidity mortality in the United States America (USA). Hemoglobin, albumin, lymphocyte, platelet (HALP) score, a simple convenient indicator, could reflect combination inflammation nutritional status. This study was undertaken evaluate associations between HALP score risk cardiovascular, cerebrovascular, all-cause general population from National Health Nutrition Examination Survey (NHANES) 1999–2018. Methods We identified 21,578 participants during 1999-2018 cycles NHANES this research. calculated as hemoglobin (g/L) × albumin lymphocytes (/L)/platelets (/L). Outcomes were determined by NHANES-linked Death Index record followed until 31 December 2019. Survey-weighted Cox regression, restricted cubic spline analysis, subgroup analysis applied investigate relationships mortality. Results cohort comprised 49.2% male 50.8% female, which median age 47 years old. In multivariate survey-weighted regression adjusting for all confounders, compared with low scores, highest had lower (adjusted HR:0.80, 95% CI: 0.73, 0.89, P < 0.0001) cardiovascular HR:0.61, 0.50, 0.75, 0.0001), mediate lowest HR:0.68, 0.62, HR:0.60, 0.48, 0.0001). Restricted showed non-linear relationship (all values <0.001). Conclusion independently associated mortality, but not

Language: Английский

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Prevalence of uncontrolled hypertension and its associated factors in 50–74 years old Iranian adults: a population-based study

BMC Cardiovascular Disorders, Journal Year: 2023, Volume and Issue: 23(1)

Published: June 24, 2023

Abstract Background By the lengthening of life span, incidence chronic diseases such as hypertension and uncontrolled has increased. This study aims to determine prevalence its related factors in age group 50–74 years Shahroud, northeast Iran. Methods The data third phase Shahroud Eye Cohort Study were used this study. cohort included 4394 participants aged 50 74 from previous phases. In addition ophthalmological optometric examinations, demographic characteristics, blood biochemistry tests, pressure measurements performed phase. Individuals with a ≥ 140/90 mm/Hg (being treated or not antihypertensive medicines) defined hypertension. patients diabetes kidney disease, equal higher than 130/80 was considered Descriptive statistics multiple logistic regression analyze data. Findings Overall, out all 61.7% (95% CI: 60.3–63.2). Multiple results showed that male gender (OR: 2.1, 95% 1.5–2.9), (OR:3.2, 2.4–4.3), disease (CKD) 3.2, 2.5–4.1) increased risk while cardiovascular 0.6, 0.4–0.8) polypharmacy 0.2, 0.1–0.2) reduced Conclusion present high prevalence, gender, diabetes, CKD are associated disorder. So, it is recommended take necessary measures formulate implement immediate actions prevent control

Language: Английский

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Risk factors for falls in older adults with diabetes mellitus: systematic review and meta-analysis

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 28, 2024

To identify risk factors for falls in older adults with Type 2 Diabetes Mellitus (T2DM).

Language: Английский

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Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 10, 2024

Abstract Background Hypertension and chronic kidney disease (CKD) pose significant public health challenges, sharing intertwined pathophysiological mechanisms. Prediabetes is recognized as a precursor to diabetes often accompanied by cardiovascular comorbidities such hypertension, elevating the risk of pre-frailty frailty. Albuminuria hallmark organ damage in hypertension amplifying pre-frailty, frailty, cognitive decline older adults. We explored association between albuminuria impairment frail adults with prediabetes CKD, assessing levels based on estimated glomerular filtration rate (eGFR). Methods conducted study involving consecutive patients recruited from March 2021 2023 at ASL (local unit Italian Ministry Health) Avellino, Italy, followed up after three months. Inclusion criteria comprised age over 65 years, prior diagnosis without secondary causes, prediabetes, frailty status, Montreal Cognitive Assessment (MoCA) score < 26, CKD eGFR > 15 ml/min. Results 237 completed study. examined MoCA Score, revealing inverse correlation (r: 0.8846; p 0.0001). Subsequently, we compared Score eGFR, observing difference ( These findings were further supported multivariable regression analysis, dependent variable. Conclusions Our represents pioneering effort establish function hypertensive afflicted CKD.

Language: Английский

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Physical decline and cognitive impairment in frail hypertensive elders during COVID-19

European Journal of Internal Medicine, Journal Year: 2022, Volume and Issue: 99, P. 89 - 92

Published: March 14, 2022

Language: Английский

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Diet-Related Changes of Short-Chain Fatty Acids in Blood and Feces in Obesity and Metabolic Syndrome

Biology, Journal Year: 2022, Volume and Issue: 11(11), P. 1556 - 1556

Published: Oct. 24, 2022

Obesity-related illnesses are one of the leading causes death worldwide. Metabolic syndrome has been associated with numerous health issues. Short-chain fatty acids (SCFAs) have shown to multiple effects throughout body, both directly as well through specific G protein-coupled receptors. The main SCFAs produced by gut microbiota acetate, propionate, and butyrate, which absorbed in varying degrees from large intestine, some acting mainly locally others systemically. Diet potential influence microbial composition, type amount produced. High fiber-containing foods supplements increase production SCFA-producing bacteria bodyweight-lowering effects. Dietary supplements, SCFA production, could open way for novel approaches weight loss interventions. aim this review is analyze variations fecal blood obesity metabolic a systematic search analysis existing literature.

Language: Английский

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Lower skeletal muscle mass is associated with diabetes and insulin resistance: A cross‐sectional study

Diabetes/Metabolism Research and Reviews, Journal Year: 2023, Volume and Issue: 39(7)

Published: June 29, 2023

The association between skeletal muscle mass and diabetes incidence/insulin resistance/glycated hemoglobin (HbA1C) is unknown. aim of this study was to investigate such in clinically apparently healthy males females.A cross-sectional 372,399 Korean females who completed bioelectrical impedance analysis (BIA) a health-screening programme performed. Skeletal index used as an indicator mass. (%) [appendicular (kg)/body weight (kg)X100] estimated using BIA. outcomes were incidence, homoeostasis model assessment insulin resistance (HOMA-IR), HbA1C.The mean age participants 38.92 ± 8.54 years. Multiple logistic regression revealed significant negative incidence/HOMA-IR/HbA1C after adjusting for various confounding factors. Odds ratios (95% confidence interval (CI)) incidence Q2, Q3, Q4 compared the lowest quantile (Q1) 0.95 (0.85-1.05), 0.88 (0.78-0.99), 0.79 (0.69-0.9), respectively. Beta coefficients CI) HOMA-IR Q3 with Q1 0.05 (0.03-0.07), -0.06 (-0.09∼-0.04), -0.19 (-0.22∼-0.16), HbA1C 0.02 (0.01-0.03), -0.001 (-0.01∼0.01), -0.02 (-0.03∼-0.01), respectively.This demonstrated associations resistance, levels adults.

Language: Английский

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Extended-release metformin improves cognitive impairment in frail older women with hypertension and diabetes: preliminary results from the LEOPARDESS Study

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: April 21, 2023

Abstract Background Women have a high risk of frailty independently age and menopause state. Diabetes hypertension increase the cognitive impairment. Metformin has been employed in post-menopausal women some reports shown encouraging effects terms attenuated frailty. However, impact on performance recently introduced extended-release formulation metformin never explored. Methods We studied consecutive frail hypertensive diabetic older presenting at ASL (local health authority Italian Ministry Health) Avellino, Italy, from June 2021 to August 2022, who were treated or not with metformin. included control group males diabetes regular Results A total 145 patients successfully completed study. At end 6-month follow-up, we observed significantly different compared baseline (p: 0.007). Then, follow-up groups significant differences between vs. untreated 0.041), men 0.016), 0.048). confirmed crucial role applying multivariable logistic analysis adjust for potential confounders. Conclusions evidenced, first time best our knowledge, favorable impairment hypertension.

Language: Английский

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