Brain Sciences,
Journal Year:
2023,
Volume and Issue:
13(2), P. 243 - 243
Published: Jan. 31, 2023
Finding
a
link
between
hormone
and
microRNAs
(miRNAs)
is
of
great
importance
since
it
enables
the
adjustment
genetic
composition
or
cellular
functions
without
needing
gene-level
interventions.
The
dicer-mediated
cleavage
precursor
miRNAs
an
interface
miRNA
its
regulators;
any
disruption
in
this
process
can
affect
neurogenesis.
Besides,
hormonal
regulation
occur
at
molecular
levels,
both
directly,
through
binding
to
promoter
elements
miRNAs,
indirectly,
via
signaling
effects
post-transcriptional
processing
proteins.
Estrogenic
hormones
have
many
roles
regulating
brain.
This
review
discusses
their
detailed
biogenesis,
activities,
general
estrogen-dependent
regulations.
Additionally,
we
highlight
relationship
miR-29,
miR-9,
estrogens
nervous
system.
Such
could
be
possible
etiological
route
for
developing
various
neurodegenerative
disorders.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(3), P. 690 - 690
Published: Feb. 24, 2023
Menopause-related
decline
in
estrogen
levels
is
accompanied
by
a
change
adipose
tissue
distribution
from
gynoid
to
an
android
and
increased
prevalence
of
obesity
women.
These
unfavorable
phenomena
can
be
partially
restored
hormone
replacement
therapy,
suggesting
significant
role
for
the
regulation
adipocytes’
function.
Indeed,
preclinical
studies
proved
involvement
these
hormones
development,
metabolism,
inflammatory
activity.
However,
relationship
between
bidirectional.
On
one
hand-their
deficiency
leads
excessive
fat
accumulation
impairs
adipocyte
function,
on
other-adipose
obese
individuals
characterized
altered
expression
receptors
key
enzymes
involved
their
synthesis.
This
narrative
review
aims
summarize
physiology,
obesity-related
dysfunction.
Firstly,
classification,
synthesis,
modes
action
are
presented.
Next,
regulating
adipogenesis
activity
health
course
described.
Finally,
potential
therapeutic
applications
its
derivates
treatment
discussed.
Bone Research,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Feb. 18, 2024
Osteoporosis,
a
metabolic
bone
disease
characterized
by
low
mineral
density
and
deterioration
of
microarchitecture,
has
led
to
high
risk
fatal
osteoporotic
fractures
worldwide.
Accumulating
evidence
revealed
that
sexual
dimorphism
is
notable
feature
osteoporosis,
with
sex-specific
differences
in
epidemiology
pathogenesis.
Specifically,
females
are
more
susceptible
than
males
while
prone
disability
or
death
from
the
disease.
To
date,
sex
chromosome
abnormalities
steroid
hormones
have
been
proven
contribute
greatly
osteoporosis
regulating
functions
cells.
Understanding
its
related
complications
essential
for
improving
treatment
strategies
tailored
women
men.
This
literature
review
focuses
on
mechanisms
underlying
mainly
population
aging
patients,
chronic
glucocorticoid
administration,
diabetes.
Moreover,
we
highlight
implications
developing
therapeutics
preventive
screening
approaches
Additionally,
challenges
translating
bench
research
bedside
treatments
future
directions
overcome
these
obstacles
will
be
discussed.
Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
30(1)
Published: Feb. 21, 2024
Lung
cancer
is
the
leading
cause
of
cancer-related
death
worldwide.
The
sex
differences
in
occurrence
and
fatality
rates
non-small
cell
lung
(NSCLC),
along
with
its
association
estrogen
dependence,
suggest
that
receptors
(ERs)
contribute
to
development
NSCLC.
However,
influence
G
protein-coupled
receptor
(GPER1)
on
NSCLC
remains
be
determined.
Escape
from
ferroptosis
one
hallmarks
tumor
discovered
recent
years.
In
this
context,
present
study
evaluated
whether
GPER1
promotes
progression
by
preventing
ferroptosis,
underlying
mechanism
through
which
protects
against
was
also
explored.
Cells,
Journal Year:
2025,
Volume and Issue:
14(1), P. 58 - 58
Published: Jan. 6, 2025
Endometriosis
is
a
gynecologic
condition
characterized
by
the
growth
of
endometrium-like
stroma
and
glandular
elements
outside
uterine
cavity.
The
involvement
hormonal
dysregulation,
specifically
estrogen,
well
established
in
initiation,
progression,
maintenance
condition.
Evidence
also
highlights
association
between
endometriosis
altered
immune
states.
human
endometrium
highly
dynamic
tissue
that
undergoes
frequent
remodeling
response
to
regulation
during
menstrual
cycle.
Similarly,
shares
this
propensity,
compounded
unclear
pathogenic
mechanisms,
presenting
unique
challenges
defining
its
etiology
pathology.
Here,
we
provide
lens
understand
interplay
estrogen
innate
adaptive
systems
throughout
cycle
pathogenesis
endometriosis.
Estrogen
closely
linked
many
inflammatory
immunomodulatory
states,
affecting
both
tissue-resident
circulatory
cells.
This
review
summarizes
estrogenic
interactions
with
specific
myeloid
lymphoid
cells,
highlighting
their
implications
progression
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(19), P. 14673 - 14673
Published: Sept. 28, 2023
Ovarian
cancer
is
one
of
the
most
common
cancers
in
women
and
concerning
issues
gynecological
oncology
recent
years.
It
postulated
that
many
factors
may
contribute
to
development
ovarian
cancer,
including
hormonal
imbalance.
Estrogens
are
a
group
hormones
have
an
important
role
both
physiological
pathological
processes.
In
they
regulate
proliferation,
invasiveness
epithelial
mesenchymal
transition.
Estrogen
signaling
also
takes
part
regulation
biology
tumor
microenvironment.
This
review
summarizes
information
connected
with
estrogen
receptors,
estrogens
their
association
Moreover,
this
includes
about
changes
receptor
expression
upon
exposition
various
environmental
chemicals.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
276, P. 116300 - 116300
Published: April 6, 2024
Bisphenol
AF
(BPAF),
an
analogue
of
bisphenol
A
(BPA),
is
commonly
found
in
manufacturing
industries
and
known
for
its
endocrine-disrupting
properties.
Despite
potential
similarities
adverse
effects
with
BPA,
limited
toxicological
data
exist
specifically
BPAF
impact
on
male
reproductive
physiology.
This
mini-review
aims
to
elucidate
the
influence
system,
focusing
estrogenic
effects,
hypothalamus-pituitary-gonad
(HPG)
axis,
steroidogenesis,
spermatogenesis,
transgenerational
toxicity.
Additionally,
we
outline
current
insights
into
mechanisms
underlying
BPAF-induced
disorders.
exposure,
either
directly
or
maternally,
has
been
associated
detrimental
functions,
including
damage
blood-testis
barrier
(BTB)
structure,
disruptions
testis
dysfunction,
decreased
anogenital
distance
(AGD),
defects
sperm
semen
quality.
Mechanistically,
altered
gene
expression
HPG
deficits
steroidogenesis
pathway,
activation
aromatase
cascade
induced
by
reactive
oxygen
species
(ROS),
ERK
signaling,
immunological
responses
collectively
contribute
system.
Given
high
prevalence
issues
infertility,
along
widespread
environmental
distribution
bisphenols,
this
study
provides
valuable
negative
BPAF.
The
findings
underscore
importance
considering
safe
use
compound,
urging
further
exploration
regulatory
attention
decrease
risks
exposure.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
176, P. 116862 - 116862
Published: June 7, 2024
Problems,
such
as
toxic
side
effects
and
drug
resistance
of
chemoradiotherapy,
target
therapy
immunotherapy
accompanying
the
current
anti-cancer
treatments,
have
become
bottlenecks
limiting
clinical
benefit
for
patients.
Therefore,
it
is
urgent
to
find
promising
strategies
with
higher
efficacy
lesser
effects.
Baicalein,
a
flavonoid
component
derived
from
Chinese
medicine
scutellaria
baicalensis,
has
been
widely
studied
its
remarkable
activity
in
multiple
types
malignancies
both
at
molecular
cellular
levels.
Baicalein
exerts
anti-tumor
by
inhibiting
angiogenesis,
invasion
migration,
inducing
cell
apoptosis
cycle
arrest,
well
regulating
autophagy,
metabolism,
tumor
microenvironment
cancer
stem
cells
no
obvious
The
role
classic
signaling
pathways,
PI3K/AKT/mTOR,
MAPK,
AMPK,
Wnt/β-catenin,
JAK/STAT3,
MMP-2/-9,
highlighted
major
targets
baicalein
exerting
anti-malignant
potential.
Besides,
can
regulate
relevant
non-coding
RNAs,
lncRNAs,
miRNAs
circ-RNAs,
inhibit
tumorigenesis
progression.
In
addition
mentioned
commonalities,
shows
some
specific
characteristics
types.
Moreover,
preclinical
studies
combination
chemoradiotherapy
pave
way
ahead
developing
an
adjunct
treatment
chemoradiotherapy.
Our
aim
summary
different
mechanisms
based
on
vitro
vivo
experiments,
hoping
providing
proof
serving
effective
safe
compound
clinic
future.
