Exposure to Antibiotics and Neurodevelopmental Disorders: Could Probiotics Modulate the Gut–Brain Axis? DOI Creative Commons

Tamara Diamanti,

Roberta Prete, Natalia Battista

et al.

Antibiotics, Journal Year: 2022, Volume and Issue: 11(12), P. 1767 - 1767

Published: Dec. 7, 2022

In order to develop properly, the brain requires intricate interconnection of genetic factors and pre-and postnatal environmental events. The gut-brain axis has recently raised considerable interest for its involvement in regulating development functioning brain. Consequently, alterations gut microbiota composition, due antibiotic administration, could favor onset neurodevelopmental disorders. Literature data suggest that modulation is often altered individuals affected by It been shown animal studies metabolites released an imbalanced axis, leads function deficits social behavior. Here, we report potential effects before after birth, relation risk developing We also review role probiotics treating gastrointestinal disorders associated with dysbiosis their possible effect ameliorating disorder symptoms.

Language: Английский

Neuroinflammation and Oxidative Stress in the Pathogenesis of Autism Spectrum Disorder DOI Open Access
Noriyoshi Usui, Hikaru Kobayashi, Shoichi Shimada

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5487 - 5487

Published: March 13, 2023

Autism spectrum disorder (ASD) is a neurodevelopmental (NDD) characterized by impairments in social communication, repetitive behaviors, restricted interests, and hyperesthesia/hypesthesia caused genetic and/or environmental factors. In recent years, inflammation oxidative stress have been implicated the pathogenesis of ASD. this review, we discuss pathophysiology ASD, particularly focusing on maternal immune activation (MIA). MIA one common risk factors for onset ASD during pregnancy. It induces an reaction pregnant mother’s body, resulting further placenta fetal brain. These negative cause developing brain subsequently behavioral symptoms offspring. addition, also effects anti-inflammatory drugs antioxidants basic studies animals clinical Our review provides latest findings new insights into involvements

Language: Английский

Citations

104
Mental health challenges faced by autistic people DOI
Meng‐Chuan Lai

Nature Human Behaviour, Journal Year: 2023, Volume and Issue: 7(10), P. 1620 - 1637

Published: Oct. 20, 2023

Language: Английский

Citations

28
The Triad of Blood–Brain Barrier Integrity: Endothelial Cells, Astrocytes, and Pericytes in Perinatal Stroke Pathophysiology DOI Open Access

Tania Garcia-Martínez,

Denise Gala Gornatti,

Marina Ortiz

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1886 - 1886

Published: Feb. 22, 2025

Pediatric stroke, a significant cause of long-term neurological deficits in children, often arises from disruptions within neurovascular unit (NVU) components. The NVU, dynamic ensemble astrocytes, endothelial cells, pericytes, and microglia, is vital for maintaining cerebral homeostasis regulating vascular brain development. Its structural integrity, particularly at the blood-brain barrier (BBB), depends on intercellular junctions basement membrane, which together restrict paracellular transport shield systemic insults. Dysfunction this intricate system increasingly linked to pediatric stroke related cerebrovascular conditions. Mutations disrupting cell adhesion or pericyte-endothelial interactions can compromise BBB stability, leading pathological outcomes such as intraventricular hemorrhage germinal matrix, hallmark immaturity. Additionally, inflammation, ferroptosis, necroptosis, autophagy are key cellular processes influencing damage repair. Excessive activation these mechanisms exacerbate NVU injury, whereas targeted therapeutic modulation offers potential pathways mitigate support recovery. This review explores molecular underlying dysfunction, disruption, subsequent injury stroke. Understanding interplay between genetic mutations, environmental stressors, dynamics provides new insights into pathogenesis. susceptibility matrix rupture further emphasizes critical role integrity early Targeting inflammatory death presents promising strategies preserve function improve affected neonates.

Language: Английский

Citations

1
Trophoblast‐specific Deptor knockdown enhances trophoblast nutrient transport and fetal growth in mice DOI Open Access

Lance G. A. Nunes,

Rodrigo Barbano Weingrill,

Sam Blessen J. Fredrick

et al.

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(4)

Published: March 5, 2025

Silencing of DEP-domain containing mTOR-interacting protein (DEPTOR), an endogenous inhibitor the mammalian target rapamycin (mTOR) pathway, increases mTOR signaling and System A/L amino acid transport activity in cultured primary human trophoblast cells. However, there is no evidence supporting regulatory role DEPTOR placental function vivo. We hypothesized that trophoblast-specific Deptor knockdown (KD) mice signaling, transport, enhances fetal growth. generated DeptorKD transgenic mice, at embryonic day 18.5, placentas were analyzed to confirm efficiency, specificity, pathway levels. Trophoblast plasma membrane (TPM) expression also determined. examined relationship between birthweight levels collected term from appropriate for gestational age (AGA) large (LGA) pregnancies. Reducing RNA increased transporter expression/activity, growth mice. Similarly, LGA displayed decreased levels, inversely correlated BMI. This first report showing sufficient activate a master regulator function, which TPM A L activity. propose mechanistically linked Furthermore, modulation may represent promising approach improve outcomes pregnancies characterized by abnormal

Language: Английский

Citations

1
Early life stress impairs brain and mental development during childhood increasing the risk of developing psychiatric disorders DOI Creative Commons

Nanako Nakama,

Noriyoshi Usui,

Miyuki Doi

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 126, P. 110783 - 110783

Published: May 4, 2023

Language: Английский

Citations

22
The Role of Bcl11 Transcription Factors in Neurodevelopmental Disorders DOI Creative Commons
Franziska A. Seigfried, Stefan Britsch

Biology, Journal Year: 2024, Volume and Issue: 13(2), P. 126 - 126

Published: Feb. 17, 2024

Neurodevelopmental disorders (NDDs) comprise a diverse group of diseases, including developmental delay, autism spectrum disorder (ASD), intellectual disability (ID), and attention-deficit/hyperactivity (ADHD). NDDs are caused by aberrant brain development due to genetic environmental factors. To establish specific curative therapeutic approaches, it is indispensable gain precise mechanistic insight into the cellular molecular pathogenesis NDDs. Mutations

Language: Английский

Citations

8
The circadian system: A neglected player in neurodevelopmental disorders DOI Creative Commons

Ahmed A. Bouteldja,

Danae Penichet, Lalit K. Srivastava

et al.

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(2), P. 3858 - 3890

Published: May 30, 2024

Abstract Patients with neurodevelopmental disorders, such as autism spectrum disorder, often display abnormal circadian rhythms. The role of the system in these disorders has gained considerable attention over last decades. Yet, it remains largely unknown how disruptions occur and to what extent they contribute disorders' development. In this review, we examine dysregulation observed patients animal models disorders. Second, explore whether rhythm constitute a risk factor for from studies humans model organisms. Lastly, focus on impact psychiatric medications rhythms potential benefits chronotherapy. literature reveals that altered sleep–wake cycles melatonin rhythms/levels heterogeneous manner, organisms used study appear support dysfunction may be an inherent characteristic Furthermore, pre‐clinical clinical evidence indicates disruption at environmental genetic levels behavioural changes Finally, suggest medications, particularly those prescribed attention‐deficit/hyperactivity disorder schizophrenia, can have direct effects chronotherapy leveraged offset some side effects. This review highlights is likely core pathological feature further research required elucidate relationship.

Language: Английский

Citations

8
Advances in the role of the GADD45 family in neurodevelopmental, neurodegenerative, and neuropsychiatric disorders DOI Creative Commons

Mengbing Huang,

Ji Wang, Wei Liu

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Jan. 25, 2024

The growth arrest and DNA damage inducible protein 45 (GADD45) family comprises stress-induced nuclear proteins that interact with demethylases to facilitate demethylation, thereby regulating diverse cellular processes including oxidative stress, repair, apoptosis, proliferation, differentiation, inflammation, neuroplasticity by modulating the expression patterns of specific genes. Widely expressed in central nervous system, GADD45 plays a pivotal role various neurological disorders, rendering it potential therapeutic target for system diseases. This review presented comprehensive overview mechanisms action associated each member (GADD45α, GADD45β, GADD45γ) neurodevelopmental, neurodegenerative, neuropsychiatric while also explored strategies harness these intervention treatment. Future research should prioritize development effective modulators targeting clinical trials aimed at treating

Language: Английский

Citations

6
Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis DOI Creative Commons
Zahra Atarodi Kashani, Reza Pakzad, Farzaneh Rashidi Fakari

et al.

Open Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: Jan. 1, 2023

Abstract Today, in the modern world, people are often exposed to electromagnetic waves, which can have undesirable effects on cell components that lead differentiation and abnormalities proliferation, deoxyribonucleic acid (DNA) damage, chromosomal abnormalities, cancers, birth defects. This study aimed investigate effect of waves fetal childhood abnormalities. PubMed, Scopus, Web Science, ProQuest, Cochrane Library, Google Scholar were searched 1 January 2023. The Cochran’s Q -test I 2 statistics applied assess heterogeneity, a random-effects model was used estimate pooled odds ratio (OR), standardized mean difference (SMD), for different outcomes, meta-regression method utilized factors affecting heterogeneity between studies. A total 14 studies included analysis, outcomes investigated were: change gene expression, oxidant parameters, antioxidant DNA damage parameters umbilical cord blood fetus developmental disorders, development disorders. Totally, events more common parents who been EMFs compared those not (SMD 95% confidence interval [CI], 0.25 [0.15–0.35]; , 91%). Moreover, disorders (OR, 1.34; CI, 1.17–1.52; 0%); cancer 1.14; 1.05–1.23; 60.1%); 2.10; 1.00–3.21; changes expression (mean [MD], 1.02; 0.67–1.37; 93%); (MD, 0.94; 0.70–1.18; 61.3%); 1.01; 0.17–1.86; 91.6%) than not. According meta-regression, publication year has significant (coefficient: 0.033; 0.009–0.057). Maternal exposure fields, especially first trimester pregnancy, due high level stem cells their sensitivity this radiation, biochemical examined shown increased oxidative stress reactions, protein embryonic In addition, parental ionizing non-ionizing radiation enhancement cell-based cancers such as speech problems childhood.

Language: Английский

Citations

13
Maternal environmental enrichment protects neonatal brains from hypoxic-ischemic challenge by mitigating brain energetic dysfunction and modulating glial cell responses DOI Creative Commons
Luz Elena Durán–Carabali, Felipe Kawa Odorcyk, Lucas Kich Grün

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 374, P. 114713 - 114713

Published: Feb. 5, 2024

Language: Английский

Citations

4