Preserving the Biodiversity of Common Beans in Caserta's Rural Areas: Biochemical and Genetic Traits of ‘Cerato’ and ‘Curniciello’ Dry Beans DOI
Nicola Landi, Laura Alberico, Angela Clemente

et al.

Published: Jan. 1, 2023

Italy represents a territory rich of common bean landraces, most them still uncharacterized. Thus, here, the proximal composition and metabolic profiles (fatty acid composition, total free amino acids) as well polyphenols antioxidant capacities both ‘Cerato’ ‘Curniciello’ dry beans, cultivated in Caserta’s rural areas (Southern Italy) were evaluated, comparison with other local known beans. The average vintages values exhibit lower content crude proteins (21.18 vs 23.41 g/100 g), lipids (1.27 2.08 acids (16.01 vs. 17.89 g) respect to although slight statistical differences found between two different harvest years analysed (2020-2021). Two essential fatty (n-6 linoleic n-3 alpha-linolenic) oleic abundant (~90% total). Subsequently, trypsin chymotrypsin inhibitory activities without beans boiling treatment (2 h) α-amylase α-glucosidase investigated, considering their capability decrease protein carbohydrates intake assimilation. In addition, AFLP analysis landraces exhibits polymorphic patterns useful for authentication traceability.Overall, these data represent starting point promote cultivation consumption contributing preserve culinary traditions Italian biodiversity.

Language: Английский

Impact of Gut Microbiome Interventions on Glucose and Lipid Metabolism in Metabolic Diseases: A Systematic Review and Meta-Analysis DOI Creative Commons

Alexandra Laura Mederle,

Mirabela Dima,

Emil Robert Stoicescu

et al.

Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1485 - 1485

Published: Nov. 14, 2024

Background: The gut microbiome is increasingly recognized as a key player in metabolic health, influencing glucose and lipid metabolism through various mechanisms. However, the efficacy of microbiota-targeted interventions, such probiotics, prebiotics, fecal microbiota transplantation (FMT), diet-based treatments, remains unclear for specific outcomes. In this study, aim was to evaluate impact these interventions on parameters individuals with diseases diabetes mellitus (DM), obesity, syndrome. Methods: This systematic review meta-analysis included 41 randomized controlled trials that investigated effects treatments fasting glucose, glycated hemoglobin (HbA1c), homeostatic model assessment insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density (HDL-C), triglycerides. A comprehensive search conducted using databases like PubMed, Google Scholar, Scopus, focusing targeting microbiota. performed random-effects models, effect sizes calculated each outcome. Risk bias assessed Cochrane Bias tool. Results: Gut significantly reduced HbA1c, HOMA-IR, LDL-C, triglycerides, moderate heterogeneity observed across studies. also led modest increases HDL-C levels. Probiotic synbiotic showed most consistent benefits improving both profiles, while FMT yielded mixed results. Short-term rapid microbial shifts but less pronounced improvements, whereas longer-term had more substantial benefits. Conclusions: it demonstrated can improve outcomes, offering potential therapeutic strategy managing diseases. effectiveness varies depending type, duration, population characteristics, highlighting need further long-term studies assess sustained modulation health.

Language: Английский

Citations

1
Dietary legumes and gut microbiome: a comprehensive review DOI
Aslıhan Özdemir, Zehra Büyüktuncer

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Nov. 28, 2024

The gut microbiome plays a crucial role in human health, affecting metabolic, immune, and cognitive functions. While the impact of various dietary components on is well-studied, effect legumes remains less explored. This review examines influence legume consumption composition, diversity, metabolite production, based 10 21 animal studies. Human studies showed mixed results, with some showing increased microbial diversity others finding no significant changes. However, was linked to increases beneficial bacteria like Bifidobacterium Faecalibacterium. Animal generally indicated enhanced composition changes, though these varied by type host's health. Some highlighted legume-induced shifts associated better metabolic Overall, emphasizes complexity legume-microbiome interactions need for standardized methodologies longitudinal have potential positively affect microbiome, effects are nuanced depend context. Future research should investigate long-term impacts stability its broader health implications, particularly disease prevention strategies.

Language: Английский

Citations

1
Nutritional, metabolic and genetic profiling of ‘Cerato’ and ‘Curniciello’ bean landraces from Caserta, Southern Italy DOI
Nicola Landi, Laura Alberico, Angela Clemente

et al.

Food Bioscience, Journal Year: 2023, Volume and Issue: 55, P. 102975 - 102975

Published: July 29, 2023

Language: Английский

Citations

2
НУТРИЦЕВТИЧНА ПІДТРИМКА В КОМПЛЕКСНОМУ ЛІКУВАННІ ПАЦІЄНТІВ ІЗ ЦУКРОВИМ ДІАБЕТОМ 2 ТИПУ DOI Open Access
Н. А. Кравчун, Олена Дорош,

Юрій Караченцев

et al.

PROBLEMS OF ENDOCRINE PATHOLOGY, Journal Year: 2024, Volume and Issue: 81(1), P. 66 - 76

Published: March 14, 2024

Потреба у нутрицевтичній підтримці при лікуванні пацієнтів із ЦД 2 типу для необхідного глікемічного контролю є актуальним напрямком сфері охорони здоров'я. Протягом останнього десятиліття терапія значно поліпшилася завдяки впровадженню ряду нових антигіперглікемічних препаратів, які широко застосовуються в клінічній практиці. Однак, синтетичні цукрознижуючі засоби мають негативні побічні ефекти тривалому використанні певних груп пацієнтів. У той же час, ліки, отримані з природних джерел, демонструють широкий спектр структурних та фізико-хімічних характеристик, були адаптовані через еволюцію селективного зв'язування функціональними макромолекулами організмі людини. Проведеним дослідженням доведено, що комплексна додаванням добавки дієтичної «Омнідіа», яка приймалася по 3 капсули тричі на добу за 30-60 хвилин до прийому їжі протягом 12 тижнів, надавала антигіперглікемічний і гіполіпідемічний типу. Також рослинний засіб «Омнідіа» добре переноситься пацієнтами не викликає побічних ефектів застосуванні. Додавання комплексного лікування хворих окремих дозволило знизити дозу цукрознижувальних препаратів інсуліну.

Citations

0
Functional foods for treating patients with diabetes: An overview of previous systematic reviews and meta-analyses and future prospects DOI
Hidetaka Hamasaki

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 43 - 76

Published: Jan. 1, 2024

Language: Английский

Citations

0
Short-chain fatty acids and their impact on human health – a review DOI Creative Commons
Michał Czachajda, Alicja Góral,

Kamila Duszyńska

et al.

Medycyna Ogólna i Nauki o Zdrowiu, Journal Year: 2024, Volume and Issue: 30(3), P. 181 - 185

Published: July 12, 2024

1. Gill PA, Bogatyrev A, van Zelm MC, et al. Delivery of Acetate to the Peripheral Blood after Consumption Foods High in Short-Chain Fatty Acids. Mol Nutr Food Res. 2021;65(4):1–10. doi:10.1002/mnfr.202000953. CrossRef Google Scholar

Language: Английский

Citations

0
Effects of Abelmoschus manihot (L.) and its combination with irbesartan in the treatment of diabetic nephropathy via the gut–kidney axis DOI Creative Commons
Hongmei Yu, Haitao Tang,

Rengui Saxu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 28, 2024

Background Clinical observations have recently shown that Abelmoschus manihot (L.) in the form of Huangkui capsule (HKC) and combination with irbesartan (EB) is an effective therapy for diabetic nephropathy (DN) patients type 2 diabetes (T2D). The present study aims to explore mechanisms underlying therapeutic efficacies HKC its EB DN via gut-kidney axis. Methods HKC, EB, their or vehicle were administered db/db mice, which animal model T2D DN. Comparative analyses gut microbiota, serum metabolites, kidney transcriptomics before after drug administration performed. Results After treatment 4 weeks, urinary albumin-to-creatinine ratios decreased significantly mice In terms abundances Faecalitalea, Blautia, Streptococcus increased but those Bacteroidetes, Firmicutes, Enterobacteriaceae, Desulfovibrio decreased. Parallelly, mainly including quercetin 3′-glucuronide L-dopa, elevated while cortisol cytochalasin B reduced. Furthermore, S100a8 , S100a9 Trem1 Mmp7 genes kidneys downregulated. These altered elements associated proteinuria/albuminuria reduction. However, had no effects on changes blood pressure specific differentially expressed kidneys. Conclusion provides experimental evidence regulates circulating renal gene activities, are useful better understanding action A. through

Language: Английский

Citations

0
Preserving the Biodiversity of Common Beans in Caserta's Rural Areas: Biochemical and Genetic Traits of ‘Cerato’ and ‘Curniciello’ Dry Beans DOI
Nicola Landi, Laura Alberico, Angela Clemente

et al.

Published: Jan. 1, 2023

Italy represents a territory rich of common bean landraces, most them still uncharacterized. Thus, here, the proximal composition and metabolic profiles (fatty acid composition, total free amino acids) as well polyphenols antioxidant capacities both ‘Cerato’ ‘Curniciello’ dry beans, cultivated in Caserta’s rural areas (Southern Italy) were evaluated, comparison with other local known beans. The average vintages values exhibit lower content crude proteins (21.18 vs 23.41 g/100 g), lipids (1.27 2.08 acids (16.01 vs. 17.89 g) respect to although slight statistical differences found between two different harvest years analysed (2020-2021). Two essential fatty (n-6 linoleic n-3 alpha-linolenic) oleic abundant (~90% total). Subsequently, trypsin chymotrypsin inhibitory activities without beans boiling treatment (2 h) α-amylase α-glucosidase investigated, considering their capability decrease protein carbohydrates intake assimilation. In addition, AFLP analysis landraces exhibits polymorphic patterns useful for authentication traceability.Overall, these data represent starting point promote cultivation consumption contributing preserve culinary traditions Italian biodiversity.

Language: Английский

Citations

0