Temperature and humidity index (THI) affects salivary cortisol (HC) and dehydroepiandrosterone (DHEA) concentrations in growing bulls following stress generated by performance test procedures DOI Creative Commons
Elisa Giaretta, Paolo Mongillo,

Laura Da Dalt

et al.

Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10

Published: July 25, 2023

The hypothalamus-pituitary-adrenal axis response to a challenge was proposed for genetic selection of robust and resilient animals. As ACTH (adrenocorticotropic hormone) test hormone measurements in blood may result impractical, it be useful measure salivary hormones natural stressors, after an accurate biological validation, control factors that could contribute the response. We evaluated whether animal handling during performance affects HC DHEA secretion used selection. tested effects habituation repeated THI as putative bias. Bull calves (N = 273) undergoing were sampled at 8-9 11-13 months 101), 131), or 41). On each day (D0), isolated, conducted squeeze chute immobilized 6 min. Saliva samples collected morning feed administration (T0), min immobilization (T1) measurement. Environmental temperature relative humidity recorded every hour from 1:00 h 24:00 days before on D0. Salivary concentrations higher T1 (p < 0.01), although clear individual positive observed less than 10% subjects. mixed model revealed: (i) HC/DHEA Young bulls 0.05). (ii) time T0 sample collection significantly affected 0.01) (iii) both steroids 0.001) but not HC/DHEA. Spearman correlations suggested weakly only (ρ 0.150, p while moderate statistically significant found between 0.316, 0.001), 0.353, 0.001). procedures might identify subpopulations subjects with sensitive HPA axis. Habituation played role, lower older Chronic exposure high had minor effect visible T0. A more intense T1, which should worth further investigations.

Language: Английский

Electrochemical Sensors, Biosensors, and Optical Sensors for the Detection of Opioids and Their Analogs: Pharmaceutical, Clinical, and Forensic Applications DOI Creative Commons

Sayo O. Fakayode,

Pamela Nicole Brady,

Cidya Grant

et al.

Chemosensors, Journal Year: 2024, Volume and Issue: 12(4), P. 58 - 58

Published: April 8, 2024

Pharmaceutical opioids are intravenously or orally administered analgesics. While they effective in relieving chronic and acute pain, their narrow window of therapeutic use contributes to the high occurrence abuse. The associated abuse this family drugs can be correlated increase dependency, overdose, death users. negative effects extend beyond physical psychological experienced by user unregulated synthesis sale, which contribute socioeconomic challenges a biproduct global public health epidemic. From clinical point-of-care applications, detection real-time monitoring drug is critical fight decrease improve settings. Chromatographic separations chromatography–mass spectrometry traditional methods opioid analyses, but cost, long analysis time, absence portability highlight need for development fast, situ, analysis, community services. This review highlights recent electrochemical optical (FTIR, Raman, colorimetric, fluorescent) advances biosensors pharmaceutical illicit analysis. Specifically, an emphasis placed on metabolites biological samples vitro cellular assays diagnosis forensic applications. prospects role sensors, biosensors, sensors promoting diagnosis, study, point-of-care, services reduce harm also provided.

Language: Английский

Citations

6
Enhanced recovery after surgery-based evidence-based care plus ice stimulation for thirst management in convalescent patients following digestive surgery under general anesthesia DOI
Li Chen,

Bixi Li,

Q Gan

et al.

World Journal of Gastrointestinal Surgery, Journal Year: 2025, Volume and Issue: 17(3)

Published: Feb. 24, 2025

BACKGROUND Thirst management in convalescent patients recovering from a digestive surgery performed under general anesthesia requires attention. A simple, practical, and safe method can effectively relieve thirst symptoms such patients. AIM To evaluate the enhanced recovery after (ERAS)-based evidence-based care (EBC) plus ice stimulation therapy for of following anesthesia. METHODS total 191 convalescing between March 2020 February 2023 experiencing were selected. In total, 89 102 control research groups received routine ERAS-based EBC therapy, respectively. The data comparatively analyzed: (1) degree (thirst intensity numerical rating scale) distress (TD) (TD scale); (2) Oral mucosal wetness; (3) Unstimulated whole salivary flow rate (UWSFR); (4) Adverse reactions (palpitation, fatigue, chapped lips, nausea vomiting); (5) Nursing satisfaction. RESULTS After nursing, statistically lower group than group. Additionally, compared with group, exhibited oral wetness, higher UWSFR, fewer adverse reactions, more nursing CONCLUSION alleviate It xerostomia symptoms, reduce improve patient comfort.

Language: Английский

Citations

0
Updating on the Dual Role of Salivary Gland Epithelial Cell (SGEC) in Sjögren’s Disease DOI Creative Commons

Wen Zhu,

Yun Lu,

Yifan Zhu

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 3039 - 3053

Published: Feb. 28, 2025

Sjögren's disease, an autoimmune inflammatory currently lacks effective treatment options. The salivary gland, a crucial exocrine organ responsible for saliva production and local immune responses on mucous membranes, is frequently impaired in individuals with disease. Restoring gland function poses significant challenge researchers. Salivary epithelial cells, recognized as pivotal components of the have been increasingly implicated key initiators inflammation exhibit innate cell-like properties. On whole, SGEC plays protective role physiological state, can also participate persistence initiating factor pathological state. In review, we explore interplay between Ca+, endoplasmic reticulum (ER), mitochondrial homeostasis imbalance cells. Additionally, provide overview current literature research advancements related to Pattern Recognition Receptors (PRRs), programmed cell death, posttranslational modification (PTM), oral microecology, etc. specifically focusing their implications Given cells onset based may potential alleviate condition by addressing response glands.

Language: Английский

Citations

0
A bibliometric analysis of the current status of salivary gland tumors DOI

Zhou Zhong-wei,

Yunlong Li,

Wang Yanan

et al.

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Exploring the impact of advanced glycation end products on diabetic salivary gland dysfunctions DOI
Heba Hassan

Glycoconjugate Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
Does COVID-19 cause xerostomia? A systematic review DOI Creative Commons
Zahra Khoshkalam, Sepideh Soheilifar,

Mohammad Hossein Khoshkalam

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: April 1, 2025

Language: Английский

Citations

0
CCL28: A Promising Biomarker for Assessing Salivary Gland Functionality and Maintaining Healthy Oral Environments DOI Creative Commons
Yuichiro Kaibori,

Saho Tamoto,

Sayoko Okuda

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(3), P. 147 - 147

Published: Feb. 27, 2024

The oral cavity serves as the primary path through which substances from outside world enter our body. Therefore, it functions a critical component of host defense. Saliva is essential for maintaining stable environment by catching harmful agents, including pathogens, allergens, and chemicals, in air or food. CCL28, highly expressed mucosal tissues, such colon salivary glands, chemokine that attracts CCR10/CCR3 expressing cells. However, role CCL28 gland formation remains unclear. In this study, we investigated structure CCL28-deficient mice. Histological analysis showed decreased staining intensity Alcian blue, detects acidic mucous, reduced expression MUC2, higher infiltration gram-positive bacteria glands addition, mice contained ectopically MUC2-expressed cells ducts cytokeratin 18, marker ductal cells, within submandibular resulting duct numbers. Additionally, several stem cell markers. These results suggest regulates saliva production via proper differentiation could be valuable biomarker function.

Language: Английский

Citations

2
Hyposalivation in patients with psoriasis: Association with severity, inflammatory, and anti‐inflammatory cytokine biomarkers of the disease DOI

Ravi Kant Sharma,

Manu Sharma,

Aneet Mahendra

et al.

Biotechnology and Applied Biochemistry, Journal Year: 2024, Volume and Issue: 71(5), P. 1170 - 1180

Published: May 28, 2024

The aim of the study is to expound effect psoriasis on salivary glands by evaluating secretion saliva and cytokine biomarkers in patients with psoriasis. This was conducted recruiting 120 subjects that included 60 diagnosed clinically active healthy controls who were age gender matched psoriatic subjects. Unstimulated whole collected from all spitting method, levels tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukin-2 (IL-2), IL-10 (IL-10) determined via enzyme-linked immunosorbent assay (BT Lab, Shanghai, China). Secretion considerably reduced than controls. concentrations pro-inflammatory cytokines (TNF-α, IFN-γ, IL-2) significantly increased, whereas level anti-inflammatory markedly decreased hyposalivation compared Our results demonstrated significant negative correlation flow rates disease severity. No correlations obtained between tested our study. Findings reflect inflammation patients. inflammatory responses gland tissues virtue increased together lower may have a role affecting unstimulated decreases severity duration disease.

Language: Английский

Citations

1
Saliva Diagnostics in Spaceflight Virology Studies—A Review DOI Creative Commons

Douglass M. Diak,

Brian Crucian,

Mayra Nelman‐Gonzalez

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(12), P. 1909 - 1909

Published: Dec. 12, 2024

Many biological markers of normal and disease states can be detected in saliva. The benefits saliva collection for research include being non-invasive, ease frequent sample collection, saving time, cost-effective. A small volume (≈1 mL) is enough these analyses that collected just a few minutes. For “dry” paper matrices, additional drying times (about 30 min) may needed, but this performed at room temperature without the need freezers specialized equipment. Together, make an ideal choice body fluid many clinical studies from diagnosis to monitoring measurable substances hospital settings, remote, other general locations including disaster areas. reasons, we have been using (dry as well wet) astronauts participating short- long-duration space missions over two decades conduct viral, stress, immunological studies. We also extended use analogs bed rest, Antarctica, closed-chamber Saliva biomarker-rich easily accessible could enable larger faster public health screenings, earlier detection, improved patient outcomes. This review summarizes our lessons learned utilizing spaceflight highlights advantages disadvantages diagnostics.

Language: Английский

Citations

1
COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic DOI Creative Commons
Luigi Bellocchio, Gianna Dipalma, Angelo Michele Inchingolo

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 12(1), P. 60 - 60

Published: Dec. 26, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by droplets aerosols from the oral cavity (O.C.) of infected subjects, as stated World Health Organization. Saliva also retains viral particles aids in spread COVID-19. Angiotensin-converting enzyme Type (ACE2) transmembrane serine protease (TMPRSS2) two numerous factors that promote SARS-CoV-2 infection, expressed O.C. structures, various mucosa types, epithelia salivary glands. A systemic might result replication cells. On other hand, cellular damage different subtypes associated with clinical signs symptoms. Factors interfering potential represent fertile ground for possible local pharmacotherapeutic interventions, which may confine virus entry O.C., finally representing a way reduce COVID-19 incidence severity.

Language: Английский

Citations

3