Comparison of the diagnostic performance of twelve noninvasive scores of metabolic dysfunction-associated fatty liver disease

Lipids in Health and Disease, Journal Year: 2023, Volume and Issue: 22(1)

Published: Sept. 6, 2023

The absence of distinct symptoms in the majority individuals with metabolic dysfunction-associated fatty liver disease (MAFLD) poses challenges identifying those at high risk, so we need simple, efficient and cost-effective noninvasive scores to aid healthcare professionals patient identification. While most were developed for diagnosis nonalcoholic (NAFLD), consequently, objective this study was systematically assess diagnostic ability 12 (METS-IR/TyG/TyG-WC/TyG-BMI/TyG-WtHR/VAI/HSI/FLI/ZJU/FSI/K-NAFLD) MAFLD.

Language: Английский

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Association of the triglyceride-glucose index and its related parameters with frailty

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 21, 2024

Abstract Background Frailty is a dynamic geriatric condition. Limited studies have examined the association of triglyceride-glucose (TyG) index and its related indicators [TyG index, triglyceride glucose-waist to height ratio (TyG-WHtR), circumference (TyG-WC), glucose-body mass (TyG-BMI)] with frailty, potential links among them remain unclear. On basis data from National Health Nutrition Examination Survey (NHANES), this study investigated relationships TyG indices frailty. Methods This research included 7,965 participants NHANES 2003–2018. The relationship frailty was binary logistic regression analyses, restricted cubic spline (RCS), receiver operating characteristic (ROC) curve. Potential influences were further through stratified analyses interaction tests. Results prevalence in 25.59%, average 0.16 (0.00). In three analysis models, continuous associated positively addition, quartiles TyG, TyG-WC, TyG-WHtR, TyG-BMI significantly increased fully adjusted models (TyG Q4 vs. Q1, OR = 1.58, 95% CI: 1.19, 2.09, P 0.002; TyG-WC 2.40, 1.90, 3.04, < 0.001; TyG-WHtR 2.26, 1.82, 2.81, TyG- BMI 2.16, 1.76, 2.64, 0.001). According RCS analysis, linearly ROC curves revealed that (AUC: 0.654) had greater diagnostic value for than 0.604), 0.621), 0.629). All tests showed similar results. Conclusions Elevated associaed are an Reasonable control blood glucose lipids, avoidance obesity, may aid reducing occurrence middle-aged older adults.

Language: Английский

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Lipid accumulation product, poverty income ratio, and bone mineral density in U.S. adults: a mediation analysis based on NHANES (2009–2020)

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 3, 2024

This study aims to investigate the relationship between lipid accumulation product (LAP) index and total femur bone mineral density (BMD), while also examining mediating role of poverty-income ratio (PIR).

Language: Английский

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The effects of Atractylodes macrocephala extract BZEP self-microemulsion based on gut–liver axis HDL/LPS signaling pathway to ameliorate metabolic dysfunction-associated fatty liver disease in rats

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116519 - 116519

Published: April 24, 2024

To elucidate the therapeutic effects and mechanisms of Atractylodes macrocephala extract crystallize (BZEP) BZEP self-microemulsion (BZEPWR) on metabolic dysfunction-associated fatty liver disease (MAFLD) induced by "high sugar, high fat, excessive alcohol consumption" based gut-liver axis HDL/LPS signaling pathway.

Language: Английский

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Evaluating body roundness index and systemic immune inflammation index for mortality prediction in MAFLD patients

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a major cause of liver-related morbidity and mortality, contributing to both cardiovascular non-cardiovascular deaths. The Body Roundness Index (BRI) Systemic Immune-Inflammation (SII) have emerged as predictors adverse outcomes in metabolic diseases. This study investigates the association between BRI, SII, mortality risk MAFLD patients. A nationwide retrospective cohort was conducted using data from NHANES database (January 1999–December 2018), including patients diagnosed with MAFLD. BRI SII were calculated at baseline. Cox proportional hazards models assessed these indices all-cause, cardiovascular, adjusting for confounders. Among 12,435 participants MAFLD, 3,381 (27.2%) classified into low group, 2,889 (23.2%) high 2,802 (22.5%) 3,363 (27.1%) group. Compared group demonstrated significantly higher all-cause an adjusted hazard ratio (HR) 1.89. For HR 2.31, while 1.78. exhibited highest mortality. are independent patients, their combined use enhances stratification. Integrating clinical practice could improve personalized management strategies this high-risk population.

Language: Английский

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Association Between Triglyceride–Glucose Related Index and Endometriosis Varies According to Educational Level

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 670 - 670

Published: Feb. 13, 2025

The association between the triglyceride-glucose (TyG) level, its obesity-related derivatives, and occurrence of endometriosis (EMS) remains ambiguous, particularly in individuals with higher levels education. This study sought to explore relationship TyG, EMS across various educational backgrounds. utilized a substantial dataset obtained from four cycles National Health Nutrition Examination Survey (NHANES) conducted 1999 2006. To EMS, we employed variety analytical methods, including multivariable logistic regression models, smooth curve fitting, threshold effect analysis, subgroup which were applied participants varying levels. Among 2347 participants, 203 (8.65%) diagnosed EMS. In overall population, only TyG-waist-to-height ratio (TyG-WHtR), TyG-waist circumference (TyG-WC) variables demonstrated positive However, within group high attainment, TyG-WHtR, TyG-WC, TyG-body mass index (TyG-BMI) all exhibited correlations These associations remained robust after adjustment for multiple potential confounding variables. analysis that these consistent different subgroups (p > 0.05). Furthermore, both linear nonlinear relationships observed TyG derivatives as evidenced by fittings analyses. contrast, no significant identified lower Our suggests there is variation levels, warranting further investigation. education, elevated associated prevalence Conversely, this correlation was not among those

Language: Английский

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There is a linear negative correlation between lipoprotein(a) and non-alcoholic fatty liver disease

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 12, 2025

This study aimed to investigate the relationship between lipoprotein(a) [Lp(a)] levels and non-alcoholic fatty liver disease (NAFLD), analyze its linear association subgroup differences. cross-sectional analysis was based on data from 2308 participants in National Health Nutrition Examination Survey (NHANES) III. Multivariate logistic regression models were used assess Lp(a) NAFLD, adjusting for demographic factors, lifestyle behaviors, comorbidities, biomarkers. Subgroup analyses conducted age, sex, body mass index (BMI), diabetes, hypertension. Restricted cubic spline (RCS) model explore nonlinear NAFLD. Higher significantly associated with a lower risk of In fully adjusted model, compared lowest quartile group (Q1), third fourth quartiles (Q3 Q4) had reduced risks NAFLD [Q3: OR = 0.701, 95% CI 0.511, 0.961; P 0.027; Q4: 0.605, 0.438, 0.835; 0.002]. showed that higher significant individuals aged 50 years older, those BMI ≥ 30 kg/m2, non-diabetics, RCS further confirmed negative Log10Lp(a) (P 0.029, nonlinearity 0.888). There is suggesting may serve as potential biomarker assessing risk.

Language: Английский

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The Value of TyG‐Related Indices in Evaluating MASLD and Significant Liver Fibrosis in MASLD

Canadian Journal of Gastroenterology and Hepatology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Triglyceride glucose (TyG) and its related index (TyG-body mass index, TyG-BMI) are recognized as markers for nonalcoholic fatty liver disease (NAFLD), but their associations with metabolic dysfunction-associated steatotic (MASLD) significant fibrosis (SLF) risk less studied. Therefore, this study explores the effectiveness of these indices in assessing MASLD SLF U.S. population. Methods: Utilizing data from National Health Nutrition Examination Survey (NHANES), a cross-sectional involving 5520 participants general population was performed. This research measured demographic, anthropometric, biochemical, comorbid, lifestyle characteristics, all which considered factors MASLD/SLF. Results: Upon controlling confounding variables, only TyG-BMI found to have consistent positive association SLF. Specifically, each standard deviation increase, odds ratio (OR) 95% confidence interval (CI) were 4.44 (3.64-9.26, p trend < 0.001) 2.48 (2.15-2.87, Significant interactions identified among age, sex, associated TyG-BMI. The also had threshold effect on at cutoff point 180.71. Furthermore, area under receiver operating characteristic curve (AUC) revealed that better predicted (AUC 0.820, CI 0.810-0.831; AUC 0.729, 0.703-0.756, respectively). In addition, integrated discrimination improvement (IDI), decision analysis (DCA), net reclassification (NRI) demonstrated satisfactory predictive ability Conclusions: Within large dataset, independently both score cohort. Its efficacy consistently surpassed TyG other noninvasive models, indicating has potential early identification risk.

Language: Английский

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Expression and clinical significance of serum lncRNA H19 in patients with metabolic dysfunction-associated fatty liver disease

Medicine, Journal Year: 2025, Volume and Issue: 104(11), P. e41838 - e41838

Published: March 14, 2025

Long non-coding RNA H19 (lncRNA H19) plays an important role in lipid metabolism, however, its relationship with metabolic dysfunction-associated fatty liver disease (MAFLD) remains unclear. The aim of this study is to investigate the expression and clinical significance serum lncRNA patients MAFLD. This enrolled MAFLD a control group healthy subjects from January 2023 March 2024. levels were quantified using real-time quantitative polymerase chain reaction. significantly higher compared ( P < .05). Moreover, there was positive correlation between body mass index, triglyceride, total cholesterol (TC), low-density lipoprotein cholesterol, fasting blood glucose uric acid (all Conversely, negative observed high-density (HDL-C; = .009). Additionally, significant associations found alanine aminotransferase, aspartate gamma-glutamyl transpeptidase stiffness measurement(all optimal cutoff value for diagnosing 1.15, area under curve receiver operating characteristic 0.83, sensitivity specificity be 87.7% 72.5%, respectively. exhibits risk factors, function, fibrosis, can serve as potential diagnostic biomarker

Language: Английский

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Association between the indicators of insulin resistance and periodontitis: a study using data from the National Health and Nutrition Examination Survey 2009–2014

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 19, 2025

The rising obesity rates are accompanied by an increasing prevalence of insulin resistance (IR) associated with obesity. To ascertain the best index for replacing IR, this study aimed to investigate possible association between which was assessed using Homeostatic Model Assessment Insulin Resistance (HOMA-IR), and triglyceride-glucose (TyG) its derived indexes periodontitis. indicators IR periodontitis via multivariate-adjusted logistic regression analyses data from National Health Nutrition Examination Survey (NHANES) 2009-2014. In addition, subgroup receiver operating characteristic curve were conducted explore influencing factors. Our encompassed 1,588 participants, 41.0% diagnosed Based on multivariate analysis, a higher TyG-waist-to-height ratio (WHtR) (odds [OR] = 1.14, 95% confidence interval [CI]: 1.02-1.27, P 0.0244) HOMA-IR score (OR 1.00, CI: 1.00-1.00, 0.0028) increased risk Conversely, TyG index, TyG-adjusted body mass waist circumference (WC) not According further interaction result analyses, sex affected TyG-WC, TyG-WHtR (P < 0.05 interaction). Moreover, influence age regulated both score. terms diagnostic accuracy, area under analysis revealed that slightly outperformed TyG-body TyG-WC. Thus, they can be robust markers assessing IR-related risk. A consistent positive found odds prevalence. Hence, significantly in cross-sectional study. However, prospective studies needed determine whether predict occurrence

Language: Английский

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