Clinical Characteristics, Metabolic Parameters, and Risk Factors for Suicide Attempts Vary with Untreated Major Depressive Disorder Duration DOI Open Access
Ping Tong,

Yang Hang Shi,

Liang Yu

et al.

Depression and Anxiety, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 9

Published: Dec. 21, 2023

Suicidal attempts (SAs) are common in major depressive disorder (MDD). However, only few studies have so far assessed how risk factors for SAs patients with MDD might be related to the duration of untreated illness (DUI). We interviewed 1,718 drug-naive outpatients first-episode and divided them into groups that had not attempted suicide. DUI was used as an additional grouping criterion. The (20.14%; 346/1718) who a history were older longer DUI; lower educational level (middle school-educated only); more psychotic symptoms; higher scores on depression anxiety scales; BP, plasma BG, TC, LDL-C levels, but HDL-C concentrations. Anxiety symptoms, high education level, being unmarried SA DUIs <3 months; low BMI, group between 3 8 age, systolic blood pressure those > months. This study single-center cross-sectional survey, its limitations include lack outside validation. Patients without different clinical characteristics metabolic parameters, suicide vary across stages. general factor, suggesting clinicians should strengthen their assessment during diagnosis treatment.

Language: Английский

Prevalence and associated factors of anxiety and depression among patients with hypothyroidism in Southern Iran DOI Creative Commons
Tania Dehesh, Mohammad Amin Mosleh‐Shirazi, Paria Dehesh

et al.

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 20, 2025

Depression and anxiety are the main disorders in patients suffering from hypothyroidism. These can lead to increased patient suffering. Since hypothyroidism is one of most prevalent endocrine diseases, controlling metabolic variables that increase severity depression important. This study aimed assess prevalence identify their associated factors, including variables, among people with We performed a cross-sectional 1,600 Kerman, southern part Iran. The was estimated using Beck Inventory Hamilton Anxiety questionnaires, respectively. First, univariate logistic regression performed. Factors whose P-values were smaller than 0.2 included multiple for confounder adjustments. analysis SPSS version 20. rates 59% (95% CI: 53.18–62.11) 63% 58.42–67.22), found be independently high TSH, LDL, TG, FBS, TGAb, TPoAb, TC, hypertension. For depression, hypertension identified. High TGAb TPoAb but not depression. Study findings revealed large proportion suffer anxiety. also identified factors these disorders. Controlling some may decrease disorders, help better treatment, improve quality life.

Language: Английский

Citations

1
Association of major depression, schizophrenia and bipolar disorder with thyroid cancer: a bidirectional two-sample mendelian randomized study DOI Creative Commons
Rongliang Qiu, Huihui Lin, Hongzhan Jiang

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 9, 2024

Abstract Background Major depressive disease (MDD), schizophrenia (SCZ), and bipolar disorder (BD) are common psychiatric disorders, their relationship with thyroid cancer has been of great interest. This study aimed to investigate the potential causal effects MDD, SCZ, BD, cancer. Methods We used publicly available summary statistics from large-scale genome-wide association studies select genetic variant loci associated as instrumental variables (IVs), which were quality controlled clustered. Additionally, we three Mendelian randomization (MR) methods, inverse variance weighted (IVW), MR–Egger regression median estimator (WME) estimate bidirectional between disorders In addition, performed heterogeneity multivariate tests verify validity IVs. Results two-sample MR analysis determine whether there was a positive MDD risk. The results IVW (OR = 3.956 95% CI 1.177–13.299; P 0.026) WME method 5.563 0.998–31.008; 0.050) confirmed that may increase risk our revealed correlation susceptibility SCZ 1.532 1.123–2.088; 0.007). based on 1.599 1.014–2.521; 0.043) also suggested Furthermore, did not find BD incidence. reverse showed no significant relationships or ( > 0.05), ruling out possibility causality. Conclusions provides new evidence be positively while revealing These have important implications for public health policy clinical practice. Future will help elucidate biological mechanisms these associations confounders.

Language: Английский

Citations

6
Promising new pharmacological targets for depression: The search for efficacy DOI
Lucila Emiko Tsugiyama, Ruan Carlos Macêdo de Moraes,

Yaslle Andrade Cavalcante Moraes

et al.

Drug Discovery Today, Journal Year: 2023, Volume and Issue: 28(12), P. 103804 - 103804

Published: Oct. 20, 2023

Language: Английский

Citations

8
Association of anxiety disorder, depression, and bipolar disorder with autoimmune thyroiditis: A bidirectional two-sample mendelian randomized study DOI Creative Commons
Jingyang Su, Jialin Zhang, Hanyu Zhu

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 368, P. 720 - 726

Published: Sept. 21, 2024

Language: Английский

Citations

1
Metabolic syndrome patterns by gender in major depressive disorder DOI Creative Commons
Li Lü, Ling Xiong,

Zhihua Liu

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0313629 - e0313629

Published: Dec. 4, 2024

Major depressive disorder (MDD) and metabolic syndrome (MetS) are significant health challenges, with distinct gender-specific manifestations. This suggests that the clinical presentation of MetS within MDD cohort may also vary by gender. The objective this study is to explore these patterns in co-occurrence among hospitalized patients, thereby offering insights guidance for targeted interventions aimed at managing demographic. included 1,281 first hospitalization patients. Data were collected on socio-demographic characteristics general profiles. Metabolic parameters, routine biochemical markers, psychological symptoms measured analyzed. prevalence was 8.21% male patients 10.34% female no difference between genders. Gender-specific risk factors identified: males, age anxiety predictors MetS, while females, onset married linked development MetS. Additionally, severity influenced males both females. found However, influencing highlight need focused management older, females older high symptoms.

Language: Английский

Citations

1
Metabolic Psychiatry: A Conceptual Framework Targeting Metabolic Dysfunction in Psychiatric Disease DOI Open Access
Shebani Sethi, Michael Berk, Ana C. Andreazza

et al.

Published: Dec. 13, 2024

An intricate link exists between metabolic dysfunction and psychiatric disease. Documented deficits in systemic brain metabolism are seen several major mental illnesses: schizophrenia (SZ), bipolar disorder (BD), depressive (MDD). We apply lessons from neurology on signaling the central nervous system periphery, plasticity, impact of targeting bioenergetic Targeting this energetic may lead to wide-ranging treatment strategies. The epidemics obesity, syndrome, insulin resistance, coupled with global illness, represent an unmet need gap care. While life saving, some common medications can impart undesirable side effects already vulnerable system. increased prevalence abnormalities among patients illness evidence shared environmental genetic risk factors have led a growing interest understanding underlying biological mechanisms. These suggest that addressing dysfunction, centrally or peripherally, is critical managing illness. Therefore, we propose incorporation framework into standard clinical assessment. emerging field psychiatry explores physiologic molecular changes underpinning disease aim identify potential therapeutic prevention targets. This perspective piece provides conceptual for psychiatry, linking cerebral glucose hypometabolism, oxidative stress, mitochondrial neural network instability provide synopsis current state knowledge, where our gaps lie, future directions incorporating mechanisms

Language: Английский

Citations

1
Altered resting-state brain activity in major depressive disorder comorbid with subclinical hypothyroidism: A regional homogeneity analysis DOI Creative Commons
Shuai Zhao, Jin-dan Wu, Xiaomei Liu

et al.

Brain Research Bulletin, Journal Year: 2023, Volume and Issue: 202, P. 110754 - 110754

Published: Sept. 6, 2023

Major depressive disorder (MDD), a common mental worldwide, frequently coexists with various physical illnesses, and recent studies have shown an increased prevalence of subclinical hypothyroidism (SHypo) among MDD patients. However, the neural mechanisms shared unique to these disorders associated alterations in brain function remain largely unknown. This study investigated potential underlying comorbid SHypo.Thirty patients (non-comorbid group), 30 SHypo (comorbid 26 SHypo, healthy controls were recruited for resting-state functional magnetic resonance imaging (rs-fMRI). We used regional homogeneity (ReHo) examine differences internal cerebral activity across four groups.Compared non-comorbid group, group exhibited significantly higher ReHo values right orbital part middle frontal gyrus (ORBmid) bilateral gyrus; decreased temporal gyrus, thalamus, superior insula. Within serum TSH levels negatively insula; Insula retardation factor score; ORBmid positively correlated anxiety/somatization scores.These findings provide valuable clues exploring between important implications understanding pathophysiological comorbidity two disorders.

Language: Английский

Citations

3
Prevalence and factors associated with metabolic syndrome in first hospitalization for major depression disorder patients DOI Creative Commons

Zhongyu Tang,

Yanping Zhen,

Lin Zhang

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 19, 2023

Abstract Major depressive disorder (MDD) is a common and socially burdensome psychiatric with causal complex relationship metabolic syndrome (MetS), which often co-morbid. However, the prevalence risk factors for MetS in patients MDD are inconclusive. The purpose of this study to investigate influencing first hospitalization patients. A total 981 were included. Sociodemographic general clinical data collected from patients, while metabolism-related parameters also measured, psychological symptoms assessed. Our found that population was 9.68%. had higher levels more severe symptoms. We identified its severity separately: age onset MDD, symptoms, thyroid stimulating hormone (TSH) development MetS, whereas TSH MetS. results suggest not highly prevalent but certain may increase likelihood severity, these findings could be beneficial intervention care

Language: Английский

Citations

3
Prevalence and associated factors of obesity in patients with major depressive disorder at different ages of onset DOI

X J Liu,

Xue Tian,

Lina Wang

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: March 15, 2024

Language: Английский

Citations

0
Identifying influencing factors of metabolic syndrome in patients with major depressive disorder: A real-world study with Bayesian network modeling DOI
Han Qi, Rui Liu,

Cheng-Cheng Dong

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 362, P. 308 - 316

Published: July 4, 2024

Language: Английский

Citations

0