Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 393 - 393

Published: March 25, 2024

The aging of the global population has increased prevalence neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic quercetin, demonstrates potential for brain health. Limited research been conducted on therapeutic applications BM in This systematic review aims to project BM’s beneficial role disorders. anti-apoptotic antioxidant actions can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, increase neuroprotection. included twenty-two clinical trials demonstrated that reduce Nuclear Factor-κB phosphorylation, emotional cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, psychiatric problems. Moreover, levels pro-inflammatory biomarkers oxidative stress. Here, we highlight provides notable benefits serve a complementary approach care patients conditions associated adds growing interest natural products their by improving our understanding mechanisms underlying function neurodegeneration informing development new strategies diseases.

Language: Английский

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Neuroprotective and anti‐inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(6), P. 3169 - 3189

Published: April 14, 2024

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid‐beta plaques and neurofibrillary tangles, leading to neuronal loss. Curcumin, polyphenolic compound derived from Curcuma longa , has shown potential neuroprotective effects due its anti‐inflammatory antioxidant properties. This review aims synthesize current preclinical data on anti‐neuroinflammatory mechanisms curcumin in context AD, addressing pharmacokinetics, bioavailability, as therapeutic adjunct. An exhaustive literature search was conducted, focusing recent studies within last 10 years related curcumin's impact neuroinflammation role AD. The methodology included sourcing articles specialized databases using specific medical subject headings terms ensure precision relevance. Curcumin demonstrates significant properties modulating neuroinflammatory pathways, scavenging reactive oxygen species, inhibiting production pro‐inflammatory cytokines. Despite potential, challenges remain regarding limited bioavailability scarcity comprehensive human clinical trials. emerges promising adjunct AD multimodal benefits. However, further research required overcome establish effective dosing regimens subjects. Developing novel delivery systems formulations may enhance treatment.

Language: Английский

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Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

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Exploiting Natural Niches with Neuroprotective Properties: A Comprehensive Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1298 - 1298

Published: April 26, 2024

Natural products from mushrooms, plants, microalgae, and cyanobacteria have been intensively explored studied for their preventive or therapeutic potential. Among age-related pathologies, neurodegenerative diseases (such as Alzheimer’s Parkinson’s diseases) represent a worldwide health social problem. Since several pathological mechanisms are associated with neurodegeneration, promising strategies against aimed to target multiple processes. These approaches usually avoid premature cell death the loss of function damaged neurons. This review focuses attention on potential compounds derived natural sources, which could be exploited neuroprotective effect. Curcumin, resveratrol, ergothioneine, phycocyanin presented examples successful approaches, special focus possible improve delivery brain.

Language: Английский

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Neuroprotective effects of Withania somnifera on ischemic stroke are mediated via anti-inflammatory response and modulation of neurotransmitter levels

Neurochemistry International, Journal Year: 2024, Volume and Issue: unknown, P. 105867 - 105867

Published: Sept. 1, 2024

Language: Английский

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Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 220, P. 111960 - 111960

Published: July 5, 2024

Language: Английский

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Korean Black Ginseng Extract Alleviates Alzheimer’s Disease-Related Cognitive Impairment by Activating the Nrf2/HO-1 Pathway and Suppressing the p38 MAPK/NF-κB/STAT3 Pathways and NLRP3 Inflammasome via TLR2 and TLR4 Modulation

Journal of Ginseng Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Nano-Delivery Systems for Carotenoids: Enhancing Bioavailability and Therapeutic Potential in Neurodegenerative Diseases

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: Feb. 25, 2025

Language: Английский

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Investigate the protective effects of eicosapentaenoic acid in human astrocytes of oxidative stress damage and explore its underlying mechanisms

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 15, 2025

Language: Английский

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Natural polysaccharide-based nanodrug delivery systems for targeted treatment of rheumatoid arthritis: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143408 - 143408

Published: April 1, 2025

Language: Английский

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