Crosstalk Between the Spleen and Other Organs/Systems: Downstream Signaling Events DOI Creative Commons
Giovanni Tarantino,

Vincenzo Citro

Immuno, Journal Year: 2024, Volume and Issue: 4(4), P. 479 - 501

Published: Nov. 8, 2024

The aim of this review was to gather pieces information from available critically evaluated published articles concerning any interplay in which the spleen could be involved. For many years, has been alleged as an unnecessary biological structure, even though splenomegaly is objective finding illnesses. Indeed, previous opinion completely changed. In fact, not a passive participant or simple bystander relationship that exists between immune system and other organs. Recently, it evidenced preclinical clinical studies there are close associations parts body, leading various spleen–organ axes. Among them, gut–spleen axis, liver–spleen gut–spleen–skin brain–spleen cardio-splenic axis most explored present medical literature. Such recent sources evidence have led revolutionary new ideas being developed about spleen. What more, these observations may enable identification novel therapeutic strategies targeted at current diseases. time come make clear superfluous body part, while health operators physicians should pay more attention organ. much work remains performed assess further roles structure play.

Language: Английский

Metabolism of Natriuretic peptides and impact on insulin resistance and fat mass in healthy subjects DOI Creative Commons
Timothy C. R. Prickett,

Lynley K. Lewis,

John F. Pearson

et al.

Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 110893 - 110893

Published: Feb. 1, 2025

Language: Английский

Citations

1
Trajectories of triglyceride-glucose index changes and their association with all-cause and cardiovascular mortality: a competing risk analysis DOI Creative Commons
Jun‐Hyuk Lee, Soyoung Jeon, Hye Sun Lee

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 15, 2024

The association between changes in insulin resistance, reflected by the triglyceride-glucose (TyG) index, and mortality remains unclear. This study investigated whether longitudinal trajectories of TyG index are associated with all-cause cardiovascular disease (CVD) mortality.

Language: Английский

Citations

6
Bazi Bushen ameliorates age-related energy metabolism dysregulation by targeting the IL-17/TNF inflammatory pathway associated with SASP DOI Creative Commons
Xiaogang Shen, Mengnan Li, Yawen Li

et al.

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: April 9, 2024

Abstract Background Chronic inflammation and metabolic dysfunction are key features of systemic aging, closely associated with the development progression age-related diseases. Bazi Bushen (BZBS), a traditional Chinese medicine used to alleviate frailty, delays biological aging by modulating DNA methylation levels. However, precise mechanism its anti-aging effect remains unclear. In this study, we developed Energy Expenditure Aging Index (EEAI) estimate age. By integrating EEAI transcriptome analysis, aimed explore impact BZBS on dysregulation in naturally mice. Methods We conducted indirect calorimetry analysis five groups mice different ages utilized data construct EEAI. 12 -month-old C57BL/6 J were treated or β-Nicotinamide Mononucleotide (NMN) for 8 months. Micro-CT, Oil Red O staining, calorimetry, RNA sequencing, bioinformatics qRT-PCR performed investigate regulatory effects energy metabolism, glycolipid inflammaging. Results The results revealed that treatment effectively reversed decline expenditure enhanced overall as indicated index derived from metabolism parameters across various ages. Subsequent investigations showed reduced age-induced visceral fat accumulation hepatic lipid droplet aggregation. Transcriptomic perirenal liver pathways, such PPAR signaling pathway, fatty acid oxidation, cholesterol improved glycolysis mitochondrial respiration. Additionally, there was significant improvement inhibiting inflammation-related arachidonic acid-linoleic pathway restraining IL-17 TNF inflammatory pathways activated via senescence secretory phenotype (SASP). Conclusions has potential organs aged maintain homeostasis. This study presents novel clinical therapeutic approaches prevention

Language: Английский

Citations

4
Decoding aging clocks: New insights from metabolomics DOI
Honghao Huang, Yifan Chen, Wei Xu

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

4
The human‐specific noncoding RNA RP11‐424G14.1 functions at the intersection of sexually dimorphic pathways in inflammation, senescence, and metabolism DOI Creative Commons
Kameron Kennicott,

Yun Liang

FASEB BioAdvances, Journal Year: 2025, Volume and Issue: 7(2)

Published: Jan. 8, 2025

Abstract Sexual dimorphism is a fundamental characteristic of various physiological and pathological processes in humans, including immune responses, senescence, metabolism. Most studies on the sex bias have focused hormones or female‐biased genes, whereas male‐biased genetic factors remain understudied. Here, we show that Y‐linked noncoding RNA, RP11‐424G14.1 , expressed human male keratinocytes. Microarray study suggests NF‐κB pathway as top biological affected by knockdown, consistent with known differences inflammation. Additionally, IGFBP3 identified gene supported Conversely, female keratinocytes, repressed X‐linked long RNA XIST suggesting central role mediating sexual dimorphism. Knockdown keratinocytes inhibits cellular increased longevity females. expression dependent insulin, metabolomics analysis regulate acrylcarnitine Our identifies RP11‐424G14.1‐ coordinating immunity, With being human‐specific element, our evolving feature dimorphisms processes.

Language: Английский

Citations

0
Participation in Healthy Ageing Centres in Bosnia and Herzegovina Is Associated with Increased Physical Activity, Social Interactions, and Life Satisfaction Among Older People: A Cross-Sectional Study DOI Creative Commons
Daniela Pamias-Lopez, Tara Keck

Journal of Ageing and Longevity, Journal Year: 2025, Volume and Issue: 5(1), P. 5 - 5

Published: Feb. 7, 2025

Background: The global population is experiencing a demographic shift towards older ages, which has the potential to increase prevalence of ageing-related diseases and associated healthcare costs. Promoting healthy ageing behaviours, such as physical social activity, been shown reduce disability frailty among people improve their life satisfaction. To this aim, several Healthy Ageing Centres have established across nine municipalities in Bosnia Herzegovina support behaviours populations. This cross-sectional study hypothesises that participation these centres will be with an behaviours. Methods: exploratory compares Centre members (n = 399) non-members 55) assess if interactions, Results: Members at had higher satisfaction, exercised for significantly longer, engaged activities more frequently than non-members. No differences were found diet, alcohol consumption or loneliness levels. Conclusions: present highlights positive attending Centres, suggesting establishment populations could beneficial supporting ageing.

Language: Английский

Citations

0
Changes in insulin, adiponectin and lipid concentrations with age are associated with frailty and reduced quality of life in dogs DOI Creative Commons
Brennen McKenzie, Matthew Peloquin, Jessica L. Graves

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 13, 2025

Language: Английский

Citations

0
Regulatory Roles of Exosomes in Aging and Aging-Related Diseases DOI

Nanyin Xiao,

Li Qiao, Guangyu Liang

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Relationship Between Metabolic Age Determined by Bioimpedance and Insulin Resistance Risk Scales in Spanish Workers DOI Open Access
Ignacio Ramírez-Gallegos, Pedro Juan Tárraga López, Hernán Paublini

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 945 - 945

Published: March 8, 2025

Introduction: Metabolic age (MA) is the difference between an individual’s actual and of their body based on physiological biological factors. It indicator that reflects a person’s physical state, regardless chronological age. Insulin resistance (IR) health disorder in which tissues exhibit reduced response to circulating glucose uptake stimulated by insulin. Objective: The aim this study evaluate association MA, determined through bioelectrical impedance analysis, risk IR, assessed using validated scales, cohort Spanish workers. Methodology: A descriptive cross-sectional was conducted 8590 workers assess MA set sociodemographic variables, habits, IR scales such as Triglyceride–Glucose Index (TyG Index), Score for Resistance (METS-IR), Single Point Sensitivity Estimator (SPISE). Results: All analyzed variables were associated with values, strongest associations observed scale values (OR 4.88 [95% CI 4.12–5.65] METS-IR, 4.42 3.70–5.15] SPISE, 3.42 2.97–3.87] TyG Index) activity. Conclusions: influenced age, sex, social class; habits smoking, activity, adherence Mediterranean diet; values.

Language: Английский

Citations

0
Assessing the impact of insulin resistance trajectories on cardiovascular disease risk using longitudinal targeted maximum likelihood estimation DOI Creative Commons
Yanjun Feng, Liangying Yin, Haoran Huang

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 10, 2025

Abstract Background Cardiovascular disease (CVD) is closely associated with Insulin Resistance (IR). However, there limited research on the relationship between trajectories of IR and CVD incidence, considering both time-invariant time-varying confounders. We employed advanced causal inference methods to evaluate longitudinal impact risk. Methods The data for this study were extracted from a Chinese nationwide cohort, named China Health Retirement Longitudinal Study (CHARLS). Triglyceride-glucose (TyG) index TyG body mass (BMI) used as surrogate markers IR, their changes recorded exposures. targeted maximum likelihood estimation (LTMLE) was how dynamic shifts in (i.e., increase, decrease, etc.) influence long-term risk, adjusting Results A total 3,966 participants included analysis, 2,152 (54.3%) being female. average age at baseline 58.28 years. Over course 7-year follow-up period, 499 (12.6%) developed CVD. Four distinct TyG-BMI identified: low stable, increasing, decreasing, high stable. LTMLE analyses revealed individuals ‘high stable’ ‘increasing’ groups had significantly higher risk developing compared those ‘low group, while ‘decreasing’ group showed no significant differences. Specifically, when exposure set TyG-BMI, odds 1.694 (95% CI: 1.361–2.108) times than group. Similar trends observed across other models, ORs 1.708 1.367–2.134) Model 2, 1.389 (1.083–1.782) 3, 1.675 (1.185–2.366) 4, 1.375 CI:1.07 − 1.768) 5. When changed index, results remained consistent, slightly lower magnitude ratios. Conclusions High stable increasing consistently exhibited ratios (ORs) comparing index. Early identification could provide insights preventing later life.

Language: Английский

Citations

0