The International Journal of Lower Extremity Wounds,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 19, 2024
Background:
Diabetic
Foot
Ulcer
(DFU)
is
a
common
and
challenging
complication
of
diabetes
mellitus,
associated
with
high
recurrence,
hospitalization,
disability,
mortality
rates.
The
Systemic
Immune
Inflammatory
Index
(SIRI)
based
on
complete
blood
counts
has
been
shown
to
correlate
several
diseases
but
not
widely
studied
in
DFU.This
study
aimed
explore
the
relationship
between
SIRI
presence
DFU
individuals
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES).
Methods:
A
cross-sectional
analysis
was
conducted
1246
NHANES
cycles
1999-2000,
2001-2002,
2003-2004.
DFUs
were
identified
through
patient
self-reported
data.
Multivariate
logistic
regression
models
assessed
association
DFU,
adjusting
for
potential
confounders.
Subgroup
interaction
analyses
also
performed.
Results:
total
117
patients
as
having
DFU.
Elevated
levels
significantly
presence.
In
fully
adjusted
models,
1-unit
increase
24.0%
higher
odds
prevalence
(OR
=
1.24;
95%
CI:
1.07,
1.43)
revealed
consistent
associations
across
different
groups
age,
gender,
body
mass
index
(BMI),
HbA1c,
glucose,
hemoglobin
levels.
Conclusion:
findings
indicate
positive
correlation
DFUpresence.
Further
research
warranted
elucidate
mechanistic
links
clinical
utility
management.
Medicine,
Journal Year:
2024,
Volume and Issue:
103(50), P. e40869 - e40869
Published: Dec. 13, 2024
Neutrophil-to-lymphocyte
ratio
(NLR),
monocyte-to-lymphocyte
(MLR),
platelet-to-lymphocyte
(PLR)
are
newly
discovered
inflammatory
markers
in
recent
years.
To
explore
the
relationship
between
NLR,
MLR,
PLR,
and
bone
mineral
density
(BMD),
as
well
osteoporosis
(OP),
postmenopausal
patients
with
type
2
diabetes
mellitus
(T2DM).
320
T2DM
who
were
admitted
to
Department
of
Endocrinology
Metabolic
Diseases
our
hospital
from
January
2022
2024
for
treatment
included
this
retrospective
study.
The
divided
into
3
groups
according
BMD:
normal
mass
group
(n
=
109),
osteopenia
99),
OP
112).
Clinical
data
blood
laboratory
parameters
collected
patients.
PLR
calculated.
Statistically
significant
differences
found
comparison
among
(
P
<
.001).
had
higher
than
group.
negatively
correlated
BMD
at
lumbar
spine
(L1-L4),
left
femoral
neck,
hip,
respectively.
Analysis
revealed
that
elevated
levels
NLR
independent
risk
factors
results
receiver
operating
characteristic
curve
analysis
indicated
area
under
(AUC)
was
PLR.
Combined
use
resulting
an
improved
AUC
0.904.
Neutrophils
produce
mediators
such
interferon-gamma
(IFN-γ),
interleukin-6
(IL-6),
interleukin-1
(IL-1),
receptor
activator
nuclear
factor
kappa-B
ligand
(RANKL),
which
increase
number
activity
osteoclasts.
Peripheral
monocytes
play
a
vital
role
osteoclastogenesis
osteoclast
precursors.
is
can
both
serve
predictive
indicators
occurrence
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 31, 2024
The
oxidative
balance
score
(OBS)
is
a
comprehensive
concept
that
includes
20
stressors
and
can
be
used
to
assess
individual
pro-oxidant
versus
antioxidant
exposure,
the
aim
of
present
study
was
investigate
association
between
OBS
risk
diabetic
kidney
disease
(DKD),
low
estimated
glomerular
filtration
rate
(low-eGFR)
albuminuria
in
patients
with
diabetes
mellitus
(DM).
The International Journal of Lower Extremity Wounds,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 19, 2024
Background:
Diabetic
Foot
Ulcer
(DFU)
is
a
common
and
challenging
complication
of
diabetes
mellitus,
associated
with
high
recurrence,
hospitalization,
disability,
mortality
rates.
The
Systemic
Immune
Inflammatory
Index
(SIRI)
based
on
complete
blood
counts
has
been
shown
to
correlate
several
diseases
but
not
widely
studied
in
DFU.This
study
aimed
explore
the
relationship
between
SIRI
presence
DFU
individuals
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES).
Methods:
A
cross-sectional
analysis
was
conducted
1246
NHANES
cycles
1999-2000,
2001-2002,
2003-2004.
DFUs
were
identified
through
patient
self-reported
data.
Multivariate
logistic
regression
models
assessed
association
DFU,
adjusting
for
potential
confounders.
Subgroup
interaction
analyses
also
performed.
Results:
total
117
patients
as
having
DFU.
Elevated
levels
significantly
presence.
In
fully
adjusted
models,
1-unit
increase
24.0%
higher
odds
prevalence
(OR
=
1.24;
95%
CI:
1.07,
1.43)
revealed
consistent
associations
across
different
groups
age,
gender,
body
mass
index
(BMI),
HbA1c,
glucose,
hemoglobin
levels.
Conclusion:
findings
indicate
positive
correlation
DFUpresence.
Further
research
warranted
elucidate
mechanistic
links
clinical
utility
management.
