Lipid Dysregulation and Delirium in Older Adults: A Review of the Current Evidence and Future Directions

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 224, P. 111299 - 111299

Published: March 12, 2025

Delirium is a complex medical condition marked by acute episodes of cognitive dysfunction and behavioral disturbances, with multifaceted etiology challenging management across various clinical settings. Older adults, particularly in postoperative contexts, are at increased risk developing delirium. Despite extensive research, single underlying pathophysiological mechanism for delirium remains elusive. However, emerging evidence suggests correlation between lipid dysregulation development elderly patients, especially This connection has led to proposed treatments targeting dyslipidemia associated neuroinflammatory effects acute-phase review aims synthesize current literature on the relationship older highlighting need further research into specific neurolipidome constituents age-related profile changes, potentially uncovering novel therapeutic strategies

Language: Английский

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Association between blood metabolites and basal cell carcinoma risk: a two-sample Mendelian randomization study

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: July 9, 2024

Background Circulating metabolites, which play a crucial role in our health, have been reported to be disordered basal cell carcinoma (BCC). Despite these findings, evidence is still lacking determine whether metabolites directly promote or prevent BCC’s progression. Therefore, study aims examine the potential effects of circulating on BCC Material and methods We conducted two−sample Mendelian randomization (MR) analysis using data from two separate genome-wide association studies (GWAS). The primary included for 123 blood GWAS with 25,000 Finnish individuals, while secondary had 249 114,000 UK Biobank participants.GWAS were obtained FinnGen consortium analysis. Sensitivity analyses performed assess heterogeneity pleiotropy. Results In analysis, significant causal relationships found between six metabolic traits inverse variance weighted (IVW) method after multiple testing [P < 4 × 10−4 (0.05/123)]. Four discovered significantly linked significance level P 2 (0.05/249). that all are Polyunsaturated Fatty Acids (PUFAs) their degree unsaturation. Conclusion Our research has revealed direct link susceptibility This discovery implies screening prevention BCC.

Language: Английский

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Associations of human blood metabolome with optic neurodegenerative diseases: a bi-directionally systematic mendelian randomization study

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 4, 2024

Metabolic disruptions were observed in patients with optic neurodegenerative diseases (OND). However, evidence for the causal association between metabolites and OND is limited. Two-sample Mendelian randomization (MR). Summary data 128 blood was selected from three genome-wide study (GWASs) involving 147,827 participants of European descent. GWASs Data glaucoma (20906 cases 391275 controls) age-related macular degeneration (AMD, 9721 381339 came FinnGen consortium. A bi-directional MR conducted to assess causality, a Mediation further applied explore indirect effect, phenome-wide analysis then performed identify possible side-effects therapies. All results underwent correction multiple testing rigorous sensitivity analyses. We identified N-acetyl glycine, serine, uridine linked an elevated risk glaucoma. 1-arachidonic-glycerol-phosphate-ethanolamine, 4-acetamido butanoate, o-methylascorbate, saturated fatty acids, monounsaturated VLDL cholesterol, serum total X-11,529 reduced There 4 AMD, including tryptophan betaine, 4-androsten-3beta-17beta-diol disulfate, apolipoprotein B, cholesterol. discovered IOP, AS, T2D as factors, while BMI, GCIPL AMD factors. And 6 showed associations factors same direction their glaucoma/AMD. Phenome-wide indicated that had protective/adverse effects on other diseases. By integrating genomics metabolomics, this supports new insights into intricate mechanisms, helps prevent screen AMD.

Language: Английский

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Causal relationship between mitochondrial function and delirium: a bidirectional two‐sample Mendelian randomisation analysis

Psychogeriatrics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 10, 2024

Previous studies have suggested a potential link between delirium and mitochondrial function. Consequently, this Mendelian randomisation (MR) study aimed to further investigate their causal relationship.

Language: Английский

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